Epidemiology And Molecular Pathology Of Prion Diseases

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Molecular Pathology of the Prions

Author : Harry F. Baker
Publisher : Springer Science & Business Media
ISBN 13 : 1592591345
Total Pages : 292 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Molecular Pathology of the Prions by : Harry F. Baker

Download or read book Molecular Pathology of the Prions written by Harry F. Baker and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.

Epidemiology and Molecular Pathology of Prion Diseases

Author : Markus Glatzel
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (428 download)

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Book Synopsis Epidemiology and Molecular Pathology of Prion Diseases by : Markus Glatzel

Download or read book Epidemiology and Molecular Pathology of Prion Diseases written by Markus Glatzel and published by . This book was released on 2004 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Prion Diseases

Author :
Publisher : Elsevier
ISBN 13 : 0444639535
Total Pages : 512 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Human Prion Diseases by :

Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Prions in Humans and Animals

Author : Beat Hörnlimann
Publisher : Walter de Gruyter
ISBN 13 : 3110200171
Total Pages : 743 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Prions in Humans and Animals by : Beat Hörnlimann

Download or read book Prions in Humans and Animals written by Beat Hörnlimann and published by Walter de Gruyter. This book was released on 2009-05-08 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial team, representing the fields of medicine, veterinary medicine and molecular biology, brought together 80 internationally respected authors for this translation and new edition of the successful German publication, not only from relevant research fields, but also from industry and public health institutions. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Further contributions from Gerald A. H. Wells, a veterinary pathologist who described BSE and recognised its similarity to scrapie, thus recording the first cases in 1986 of the most important animal epidemic of modern times, and Robert G. Will, a medical neurologist and epidemiologist who discovered the emergence of the variant form of Creutzfeldt-Jakob disease in 1996, underscore the strength of this author team. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.

Prion Diseases

Author : Martin H. Groschup
Publisher : Boom Koninklijke Uitgevers
ISBN 13 : 9783211835302
Total Pages : 316 pages
Book Rating : 4.8/5 (353 download)

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Book Synopsis Prion Diseases by : Martin H. Groschup

Download or read book Prion Diseases written by Martin H. Groschup and published by Boom Koninklijke Uitgevers. This book was released on 2000-12-28 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.

Advancing Prion Science

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309168597
Total Pages : 125 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advancing Prion Science by : Institute of Medicine

Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-03-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Prion Biology

Author : Stanley B. Prusiner
Publisher : Perspectives Cshl
ISBN 13 : 9781621820932
Total Pages : 0 pages
Book Rating : 4.8/5 (29 download)

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Book Synopsis Prion Biology by : Stanley B. Prusiner

Download or read book Prion Biology written by Stanley B. Prusiner and published by Perspectives Cshl. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book exam

Neurodegenerative Diseases

Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 1461406536
Total Pages : 421 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad

Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Prion Diseases of Humans and Animals

Author : Stanley B. Prusiner
Publisher : Prentice Hall
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prion Diseases of Humans and Animals by : Stanley B. Prusiner

Download or read book Prion Diseases of Humans and Animals written by Stanley B. Prusiner and published by Prentice Hall. This book was released on 1992 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:

PrPSc Prions: State of the Art

Author : Joaquín Castilla
Publisher : MDPI
ISBN 13 : 3038973084
Total Pages : 211 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis PrPSc Prions: State of the Art by : Joaquín Castilla

Download or read book PrPSc Prions: State of the Art written by Joaquín Castilla and published by MDPI. This book was released on 2018-11-07 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "PrP^Sc prions: state of the art" that was published in Pathogens

Neurodegenerative Diseases

Author : G. Jolles
Publisher : Academic Press
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neurodegenerative Diseases by : G. Jolles

Download or read book Neurodegenerative Diseases written by G. Jolles and published by Academic Press. This book was released on 1994-11-14 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years, the considerable progress made in biochemistry, virology, molecular biology and genetics has revealed some of the intimate mechanisms of the neurodegenerative diseases. The present volume is an attempt to review the latest data in the field to illuminate new avenues for future research. This volume gathers together chapters and discussions on the etiology and pathogenesis of the neurodegenerative diseases. Apoptosis of programmed cell death as well as other genetic implications are discussed; special attention is given to the coexistence and interconnection of genetic and environmental factors. There is extensive coverage of prions responsible for bovine spongiform encephalopathy, Cruetzfeld-Jacob disease and kuru. The various aspects of non-conventional transmissible agents are thoroughly reviewed. Further contributions deal with the role of growth factors as well as of free radicals. Consideration is given to the molecular mechanisms of Alzheimer's disease, in particular the role of tau protein. Finally, several pharmacological models now available, which throw light upon aspects of Parkinson's disease, Huntington's chorea and multiple sclerosis, are examined and discussed. It is hoped that recent scientific advances will lead to the discovery of new drugs to fill the current therapeutic void. There are hopes of an early indication of this in the case of amyotrophic lateral sclerosis.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prion Diseases

Author : John Collinge (MD.)
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prion Diseases by : John Collinge (MD.)

Download or read book Prion Diseases written by John Collinge (MD.) and published by . This book was released on 1997 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists,veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide the most up-to-date and authoritative summary available of the field. Contents include human and animal prion diseases; pathology and cell biology of prion diseases; and prion protein structure.

Neuropathology

Author :
Publisher : Academic Press
ISBN 13 : 0128026154
Total Pages : 640 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neuropathology by :

Download or read book Neuropathology written by and published by Academic Press. This book was released on 2017-10-24 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathology, Volume 145, the latest release in the Handbook of Clinical Neurology series, includes all the major topics found in a typical neuropathology text, but differentiates itself by providing a thorough overview of the morphological background of neurological disorders for researchers and clinicians who do not specialize in pathology or its clinicopathological aspects. This volume offers strong coverage of brain imaging and advances in molecular pathology and genetics, and is particularly timely given the amount of neuropathological research currently taking place. Provides a resource for the non-pathologist, aiding primary clinicians and researchers in the interpretation of patient symptoms and research findings Includes standard neuropathology, but extends to clinicopathology, imaging and molecular pathology/genetics Presents an interdisciplinary approach that can be applied in everyday clinic and research efforts

Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence

Author : C.J. Peters
Publisher : Springer
ISBN 13 : 9783211243350
Total Pages : 216 pages
Book Rating : 4.2/5 (433 download)

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Book Synopsis Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence by : C.J. Peters

Download or read book Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence written by C.J. Peters and published by Springer. This book was released on 2005-09-27 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

Imaging in Neurodegenerative Disorders

Author : Luca Saba
Publisher : Oxford University Press, USA
ISBN 13 : 0199671613
Total Pages : 585 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Imaging in Neurodegenerative Disorders by : Luca Saba

Download or read book Imaging in Neurodegenerative Disorders written by Luca Saba and published by Oxford University Press, USA. This book was released on 2015 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

Handbook of Ataxia Disorders

Author : Thomas Klockgether
Publisher : CRC Press
ISBN 13 : 9781420002065
Total Pages : 716 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Handbook of Ataxia Disorders by : Thomas Klockgether

Download or read book Handbook of Ataxia Disorders written by Thomas Klockgether and published by CRC Press. This book was released on 2000-08-18 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely reference presents, for the first time, new findings in molecular genetics that are applicable to the epidemiology, pathogenesis, neuropathology, clinical features, and management of ataxia-bridging the gap between scientific and clinical practice. Organized by the distinctive ataxia disorders, their pathogenesis, and management-facilitating quick and efficient diagnoses! Providing complementary sections on the anatomy of the spinocerebellar system, its normal function, and a history of ataxia research and management, the Handbook of Ataxia Disorders clarifies the impact of identifying the molecular causes of ataxia offers in-depth analysis of dominant and recessive and nonhereditary ataxia disorders explores the vital connection between the genotypes and phenotypes of various degenerative ataxia disorders and more! Written by more than 60 international experts and supplemented with over 2600 literature references, photographs, micrographs, drawings, and tables, the Handbook of Ataxia Disorders is an essential and useful reference for clinical neurologists and neuropathologists, neuropediatricians, geneticists, physiatrists, and medical school students in these disciplines.