Engineering Improvements For Epicardial Drug Delivery Systems

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Engineering Improvements for Epicardial Drug Delivery Systems

Author : Shahrin Islam
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (113 download)

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Book Synopsis Engineering Improvements for Epicardial Drug Delivery Systems by : Shahrin Islam

Download or read book Engineering Improvements for Epicardial Drug Delivery Systems written by Shahrin Islam and published by . This book was released on 2019 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular diseases continue have a large disease burden despite advancements in technology, therapeutic modalities, and prevention efforts. For various cardiovascular pathologies, epicardial drug delivery systems have shown promise. Our group has developed a replenishable epicardial drug delivery device called Therepi that allows for repeat administrations of therapeutics without necessitating multiple invasive surgeries. The purpose of this thesis is to improve upon the Therepi device and utilize the platform to study the effects of specific therapeutics on cardiac function in a preclinical small animal myocardial infarction (MI) model. I first show that the fibrous capsule that forms around the polycarbonate membrane interface of the first iteration Therepi device post-implantation can impede transport of therapeutics from the device to the heart. Then, I utilize a modified version of Therepi without the polycarbonate membrane to study the effects of repeat administrations of FSTL1, a promising protein with great therapeutic potential, on cardiac function post-MI. Results from this study indicate that removal of the polycarbonate membrane reduces the formation of a fibrous capsule and that repeat administrations of FSTL1 improve cardiac function after MI. Following this, I utilize a computational macroscale model of Therepi to study the effect of important design parameters such as loading conditions, biomaterial geometry and orientation relative to the cardiac fibers on drug delivery to the myocardium. The simulations highlight the significance of the cardiac fiber anisotropy as a crucial factor in governing drug distribution on the epicardial surface and limiting factor for penetration into the myocardium. The multiscale model can be useful for rapid iteration of different device concepts and determination which designs for epicardial drug delivery may be optimal and most promising for the ultimate therapeutic goal. In the future, the findings from this thesis will be further investigated to develop an improved version of Therepi that allows for better device-tissue adhesion, conformability, and transport. The effects of repeat administrations of FSTL1 from the Therepi device will be elucidated further to mechanistically understand how cardiac function is improved through this strategy.

Drug Delivery

Author : Yitzhak Rosen
Publisher : CRC Press
ISBN 13 : 1466565950
Total Pages : 602 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Drug Delivery by : Yitzhak Rosen

Download or read book Drug Delivery written by Yitzhak Rosen and published by CRC Press. This book was released on 2017-09-19 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

Engineering Multivalent Systems for Improved Drug Delivery, Allergy Diagnosis, and Bioprocess Development

Author : Franklin Mejia
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (125 download)

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Book Synopsis Engineering Multivalent Systems for Improved Drug Delivery, Allergy Diagnosis, and Bioprocess Development by : Franklin Mejia

Download or read book Engineering Multivalent Systems for Improved Drug Delivery, Allergy Diagnosis, and Bioprocess Development written by Franklin Mejia and published by . This book was released on 2021 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polymers for Vascular and Urogenital Applications

Author : Shalaby W. Shalaby
Publisher : CRC Press
ISBN 13 : 1420076949
Total Pages : 277 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Polymers for Vascular and Urogenital Applications by : Shalaby W. Shalaby

Download or read book Polymers for Vascular and Urogenital Applications written by Shalaby W. Shalaby and published by CRC Press. This book was released on 2012-05-03 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a carefully crafted, multidisciplinary, skillfully focused format, Polymers for Vascular and Urogenital Applications covers attributes of polymers used for vascular, urological, and gynecological materials. It provides a brief analysis of how the use of polymers in vascular and urogenital applications has evolved in the past five decades and outlines their common and specific functional requirements. The book provides a brief description of the evolving role of a particular family of materials and presents topics in highly integrated, well-balanced, authoritatively prepared segments on materials processing and in vitro and in vivo evaluation, complete with case studies. Features Includes contributions from authors representing a diverse technical group of clinicians with strong science or engineering backgrounds and research interests Supplies a comprehensive link between polymeric biomaterials and their application Provides a brief description of the evolving role of a particular family of materials Discusses recent developments in applications and the rationale for present and future clinical significance This book not only integrates clinical needs with current and future research responses but also provides a comprehensive overview to foster future innovation. It illustrates how two important and dissimilar areas in medicine can be interrelated by shared biomaterials and explores the clinical paradigm that establishes the driving force for innovation.

5th International Conference on Biomedical Engineering in Vietnam

Author : Vo Van Toi
Publisher : Springer
ISBN 13 : 3319117769
Total Pages : 538 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis 5th International Conference on Biomedical Engineering in Vietnam by : Vo Van Toi

Download or read book 5th International Conference on Biomedical Engineering in Vietnam written by Vo Van Toi and published by Springer. This book was released on 2014-11-18 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

Drug Delivery Systems, Third Edition

Author : Vasant V. Ranade
Publisher : CRC Press
ISBN 13 : 1439806187
Total Pages : 610 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Drug Delivery Systems, Third Edition by : Vasant V. Ranade

Download or read book Drug Delivery Systems, Third Edition written by Vasant V. Ranade and published by CRC Press. This book was released on 2011-04-25 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery technologies represent a vast, vital area of research and development in pharmaceuticals. The demand for innovative drug delivery systems continues to grow, driving a variety of new developments. Drug Delivery Systems, Third Edition provides a comprehensive review of the latest research and development on drug delivery systems. Coverage includes liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery. Each chapter provides a table of marketed and investigational products with numerous practical examples. The book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives. This third edition contains a chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. Written in a straightforward manner, the authors provide a global perspective on current and future advances and market opportunities. Supplying a cogent overview of the field and extensive guidance on where to get more information, it is an essential resource for anyone venturing into this area of drug development.

Nanoengineering Materials for Biomedical Uses

Author : Emilio I. Alarcon
Publisher : Springer Nature
ISBN 13 : 3030312615
Total Pages : 208 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Nanoengineering Materials for Biomedical Uses by : Emilio I. Alarcon

Download or read book Nanoengineering Materials for Biomedical Uses written by Emilio I. Alarcon and published by Springer Nature. This book was released on 2019-11-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills the gap between fundamental and applied research in the use of nanomaterials in biomedical applications, covering the most relevant areas, such as the fundamental concepts of the preparation of nanostructures and regulatory requirements for their safe use in biomedical devices. It also critically discusses what has been achieved in the field, and what needs to be urgently addressed and reviews the state-of-the-art medical uses of nanomaterials for treating damaged organs and tissues. Combining the expertise of clinical researchers working in the field of tissue engineering and novel materials, the book explores the main topics regarding the characterization of materials, specific organ-oriented biomaterials and their applications, as well as regulations and safety. Further, it also examines recent advances, difficulties, and clinical requirements in terms of human bone, cornea, heart, skin and the nervous system, allowing readers to gain a clear and comprehensive understanding of current nanomaterial use in biomedical applications and devices, together with the challenges and future trends. This book is a valuable tool for multidisciplinary scientists and experts interested in fundamental concepts and synthetic routes for preparing nanomaterials. It is also of interest to students and researchers involved in cross-disciplinary research in nanomaterials for clinical applications and offers practical insights for clinicians as well as engineers and materials scientists working in nanoengineering.

Cardiac Tissue Engineering

Author : Milica Radisic
Publisher : Humana Press
ISBN 13 : 9781493910465
Total Pages : 0 pages
Book Rating : 4.9/5 (14 download)

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Book Synopsis Cardiac Tissue Engineering by : Milica Radisic

Download or read book Cardiac Tissue Engineering written by Milica Radisic and published by Humana Press. This book was released on 2014-07-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.

Molecular Interventions and Local Drug Delivery

Author : Elazer R. Edelman
Publisher : Bailliere Tindall Limited
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Interventions and Local Drug Delivery by : Elazer R. Edelman

Download or read book Molecular Interventions and Local Drug Delivery written by Elazer R. Edelman and published by Bailliere Tindall Limited. This book was released on 1995 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances continue to be made in elucidating the cellular and molecular mechanisms of cardiovascular diseases. Recent technical innovations - in molecular therapies and local drug delivery - now permit clinicians to exploit information on pathophysiology in order to treat these conditions more effectively. In this significant new work, Elazer Edelman and Robert Levy bring together a team of authorities in the field, integrating basic and clinical research data with state-of-the-art engineering and technology, to give the cardiovascular physician a clear, readable and up-to-the-minute resource of invaluable information, in the first systematic and comprehensive review of this area.

5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary

Download 5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary PDF Online Free

Author : Ákos Jobbágy
Publisher : Springer Science & Business Media
ISBN 13 : 3642235085
Total Pages : 1477 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis 5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary by : Ákos Jobbágy

Download or read book 5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary written by Ákos Jobbágy and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 1477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the 5th European Conference of the International Federation for Medical and Biological Engineering (EMBEC), held in Budapest, 14-18 September, 2011. The scientific discussion on the conference and in this conference proceedings include the following issues: - Signal & Image Processing - ICT - Clinical Engineering and Applications - Biomechanics and Fluid Biomechanics - Biomaterials and Tissue Repair - Innovations and Nanotechnology - Modeling and Simulation - Education and Professional

Cardiac Regeneration and Repair

Author : Ren-Ke Li
Publisher : Elsevier
ISBN 13 : 0857096710
Total Pages : 509 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Cardiac Regeneration and Repair by : Ren-Ke Li

Download or read book Cardiac Regeneration and Repair written by Ren-Ke Li and published by Elsevier. This book was released on 2014-02-17 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineering Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

Advanced Drug Delivery Systems in the Management of Cancer

Author : Kamal Dua
Publisher : Elsevier
ISBN 13 : 0323900798
Total Pages : 572 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua

Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Encyclopedia of Tissue Engineering and Regenerative Medicine

Author :
Publisher : Academic Press
ISBN 13 : 0128137002
Total Pages : 1436 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Tissue Engineering and Regenerative Medicine by :

Download or read book Encyclopedia of Tissue Engineering and Regenerative Medicine written by and published by Academic Press. This book was released on 2019-06-03 with total page 1436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Tissue Engineering and Regenerative Medicine, Three Volume Set provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Multifunctional Theranostic Nanomedicines in Cancer

Author : Malay K. Das
Publisher : Academic Press
ISBN 13 : 0128217006
Total Pages : 428 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Multifunctional Theranostic Nanomedicines in Cancer by : Malay K. Das

Download or read book Multifunctional Theranostic Nanomedicines in Cancer written by Malay K. Das and published by Academic Press. This book was released on 2021-03-16 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment

Biomedical Index to PHS-supported Research

Author :
Publisher :
ISBN 13 :
Total Pages : 866 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1990 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Nanotechnology

Author :
Publisher : Academic Press
ISBN 13 : 0128141700
Total Pages : 222 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cancer Nanotechnology by :

Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Regulation of Coronary Blood Flow

Author : Michitoshi Inoue
Publisher : Springer Science & Business Media
ISBN 13 : 4431683674
Total Pages : 330 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue

Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.