Engineering And Application Of Pluripotent Stem Cells

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Engineering and Application of Pluripotent Stem Cells

Author : Ulrich Martin
Publisher : Springer
ISBN 13 : 3319735918
Total Pages : 232 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Engineering and Application of Pluripotent Stem Cells by : Ulrich Martin

Download or read book Engineering and Application of Pluripotent Stem Cells written by Ulrich Martin and published by Springer. This book was released on 2018-02-28 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening. This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Stem Cell Engineering

Author : Gerhard M. Artmann
Publisher : Springer Science & Business Media
ISBN 13 : 3642118658
Total Pages : 566 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Stem Cell Engineering by : Gerhard M. Artmann

Download or read book Stem Cell Engineering written by Gerhard M. Artmann and published by Springer Science & Business Media. This book was released on 2010-10-29 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Stem Cells and the Future of Regenerative Medicine

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309170427
Total Pages : 112 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine

Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Stem Cells

Author : Mary Clarke
Publisher : Garland Science
ISBN 13 : 1000062651
Total Pages : 966 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Stem Cells by : Mary Clarke

Download or read book Stem Cells written by Mary Clarke and published by Garland Science. This book was released on 2020-07-27 with total page 966 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

Stem Cell Manufacturing

Author : Joaquim M.S. Cabral
Publisher : Elsevier
ISBN 13 : 0444632662
Total Pages : 342 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Stem Cell Manufacturing by : Joaquim M.S. Cabral

Download or read book Stem Cell Manufacturing written by Joaquim M.S. Cabral and published by Elsevier. This book was released on 2016-07-24 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. Presents the first ‘Flowchart‘ of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book

Stem Cells in Clinical Practice and Tissue Engineering

Author : Rakesh Sharma
Publisher : BoD – Books on Demand
ISBN 13 : 1789230101
Total Pages : 353 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Stem Cells in Clinical Practice and Tissue Engineering by : Rakesh Sharma

Download or read book Stem Cells in Clinical Practice and Tissue Engineering written by Rakesh Sharma and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Stem Cell and Tissue Engineering

Author : Song Li
Publisher : World Scientific
ISBN 13 : 9814317055
Total Pages : 473 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Stem Cell and Tissue Engineering by : Song Li

Download or read book Stem Cell and Tissue Engineering written by Song Li and published by World Scientific. This book was released on 2011 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

Pluripotent Stem Cells

Author : Uma Lakshmipathy
Publisher : Humana Press
ISBN 13 : 9781627033497
Total Pages : 292 pages
Book Rating : 4.0/5 (334 download)

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Book Synopsis Pluripotent Stem Cells by : Uma Lakshmipathy

Download or read book Pluripotent Stem Cells written by Uma Lakshmipathy and published by Humana Press. This book was released on 2013-04-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human pluripotent stem cells such as human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) with their unique developmental plasticity hold immense potential as cellular models for drug discovery and in regenerative medicine as a source for cell replacement. While hESC are derived from a developing embryo, iPSC are generated with forced expression of key transcription factors to convert adult somatic cells to ESC-like cells, a process termed reprogramming. Using iPSC overcomes ethical issues concerning the use of developing embryos and it can be generated from patient-specific or disease-specific cells for downstream applications. Pluripotent Stem Cells: Methods and Protocols highlights the best methods and systems for the entire work flow. Divided into four convenient sections, topics include a focus on producing iPSC from diverse somatic sources, media systems for expanding ESC and iPSC with detailed protocols for directed differentiation into specific lineages, commonly used cellular and molecular characterization methods , and the potential application of labeled stem cells with specific methods for cloning, gene delivery and cell engineering. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Pluripotent Stem Cells: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further our knowledge of this essential cellular feature.

Advances in Application of Stem Cells: From Bench to Clinics

Author : Firdos Alam Khan
Publisher : Springer Nature
ISBN 13 : 3030781011
Total Pages : 320 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Advances in Application of Stem Cells: From Bench to Clinics by : Firdos Alam Khan

Download or read book Advances in Application of Stem Cells: From Bench to Clinics written by Firdos Alam Khan and published by Springer Nature. This book was released on 2021-09-14 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of stem cell biology is expanding with a continued surge of new information related to its applications. Over past few years, stem cells have been extensively used in cell therapy, tissue engineering, in vitro drug testing among others. At the moment there is no single book available which comprehensively describes the significance of various application of stem cells derived from embryonic and adult sources from lab to clinics. In this edited volume, we discuss basics and advanced topics of stem cells to help researchers, students and professional find the most important information in a single source of updated information about stem cells and relevant applications. This book is divided in 12 chapters and covers topics such as in vitro cell culture, 3D cell culture, cell therapy, tissue engineering, cell factory, cell functionality, in vitro drug testing, organ development, autologous transplantation, allogeneic transplantation, adult stem cells, multipotent stem cells, induced pluripotent stem cells, a pluripotent and embryonic stem cells.

Bioreactor Systems for Tissue Engineering II

Author : Cornelia Kasper
Publisher : Springer
ISBN 13 : 3642160514
Total Pages : 331 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Bioreactor Systems for Tissue Engineering II by : Cornelia Kasper

Download or read book Bioreactor Systems for Tissue Engineering II written by Cornelia Kasper and published by Springer. This book was released on 2010-10-17 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative Sources of Adult Stem Cells: Human Amniotic Membrane, by S. Wolbank, M. van Griensven, R. Grillari-Voglauer, and A. Peterbauer-Scherb; * Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications, by P. Moretti, T. Hatlapatka, D. Marten, A. Lavrentieva, I. Majore, R. Hass and C. Kasper; * Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells, by J. W. Kuhbier, B. Weyand, C. Radtke, P. M. Vogt, C. Kasper and K. Reimers; * Induced Pluripotent Stem Cells: Characteristics and Perspectives, by T. Cantz and U. Martin; * Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology, by D. Pei, J. Xu, Q. Zhuang, H.-F. Tse and M. A. Esteban; * Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells, by C. Weber, S. Pohl, R. Poertner, P. Pino-Grace, D. Freimark, C. Wallrapp, P. Geigle and P. Czermak; * Cartilage Engineering from Mesenchymal Stem Cells, by C. Goepfert, A. Slobodianski, A.F. Schilling, P. Adamietz and R. Poertner; * Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine, by S. Fuchs, E. Dohle, M. Kolbe, C. J. Kirkpatrick; * Basic Science and Clinical Application of Stem Cells in Veterinary Medicine, by I. Ribitsch, J. Burk, U. Delling, C. Geißler, C. Gittel, H. Jülke, W. Brehm; * Bone Marrow Stem Cells in Clinical Application: Harnessing Paracrine Roles and Niche Mechanisms, by R. M. El Backly, R. Cancedda; * Clinical Application of Stem Cells in the Cardiovascular System, C. Stamm, K. Klose, Y.-H. Choi

Engineering of Stem Cells

Author : Ulrich Martin
Publisher : Springer
ISBN 13 : 3540888063
Total Pages : 249 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Engineering of Stem Cells by : Ulrich Martin

Download or read book Engineering of Stem Cells written by Ulrich Martin and published by Springer. This book was released on 2009-09-25 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: I am very pleased to present this volume on engineering stem cells in Advances in Biochemical Engineering and Biotechnology. This volume stays abreast of recent developments in stem cell biology and the high expectations concerning the dev- opment of stem cell based regenerative therapies. Regenerative medicine is the focus of current biomedical research, with unique challenges related to scientific, technical and ethical issues of stem cell research, and the potential added value of connecting biomedicine with enabling techno- gies such as materials sciences, mechanical- and nano-engineering. Research activities in regenerative medicine include strategies in endogenous regeneration of injured or degenerated tissues by means of gene therapy or cell transplantation, as well as complex approaches to replace or reconstruct lost or malformed tissue structures, by applying tissue engineering approaches. In most cases, the speci- ized functional cell types of interest cannot be isolated from the diseased organ or expanded to a sufficient degree, and various stem and progenitor cell types rep- sent the only applicable cell source. In almost all cases, stem cells have to be engineered, sometimes for functional improvement, in many cases to produce large numbers of cells, and frequently to achieve efficient and specific differentiation in the cell type(s) of interest.

Stem Cell Engineering

Author : David Schaffer
Publisher : CRC Press
ISBN 13 : 143987204X
Total Pages : 233 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Stem Cell Engineering by : David Schaffer

Download or read book Stem Cell Engineering written by David Schaffer and published by CRC Press. This book was released on 2012-11-20 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the potential of stem cells is recognized, their proliferation and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell replacement therapies to minimize contamination with residual cells that can give rise to side effects. How can engineers make contributions to address these challenges? With contributions from pioneers and experts, Stem Cell Engineering: Principles and Practices highlights recent advances in the understanding of the cellular and molecular composition of the stem cell niche, as well as approaches to build upon this basic information to direct stem cell differentiation into therapeutically valuable lineages. The growing recognition of stem cells as an important and exciting field will continue to draw investigators with diverse backgrounds—from biology, engineering, and the physical sciences—and thereby enable further progress in these and other new directions. This book discusses advances made during the last decade that have led to increasingly defined culture systems for growing stem cells, starting from co-culture with feeder cells in the presence of serum to growth on synthetic substrates in defined medium. In addition to highlighting many recent advances, it underscores the need for future work.

Biology and Engineering of Stem Cell Niches

Author : Ajaykumar Vishwakarma
Publisher : Academic Press
ISBN 13 : 0128027568
Total Pages : 644 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biology and Engineering of Stem Cell Niches by : Ajaykumar Vishwakarma

Download or read book Biology and Engineering of Stem Cell Niches written by Ajaykumar Vishwakarma and published by Academic Press. This book was released on 2017-03-22 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Engineering Strategies for Regenerative Medicine

Author : Tiago G. Fernandes
Publisher : Academic Press
ISBN 13 : 0128166703
Total Pages : 284 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Engineering Strategies for Regenerative Medicine by : Tiago G. Fernandes

Download or read book Engineering Strategies for Regenerative Medicine written by Tiago G. Fernandes and published by Academic Press. This book was released on 2019-11-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine. Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development. Considers how engineering strategies can accelerate novel advances in regenerative medicine Takes an interdisciplinary approach, integrating different aspects of research, technology and application Provides up-to-date coverage on this rapidly developing area of medicine Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry

Application of Genetic Engineering and Human Pluripotent Stem Cells to Deriving and Manipulating the Immune System

Author : Lauren Randolph
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Application of Genetic Engineering and Human Pluripotent Stem Cells to Deriving and Manipulating the Immune System by : Lauren Randolph

Download or read book Application of Genetic Engineering and Human Pluripotent Stem Cells to Deriving and Manipulating the Immune System written by Lauren Randolph and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Human pluripotent stem cell technology and novel genetic engineering strategies rank among the most revolutionary tools for regenerative medicine and cell therapy applications to emerge in the past two decades. Leveraging these technologies, this research aims to expand our understanding of human hematopoietic development and immune rejection. Comparative analysis revealed disparities in male and female cells undergoing the first stage of in vitro hematopoietic development. This analysis uncovered reduced endogenous vascular endothelial growth factor secretion as a possible cause of sex dependent cell development that was recused by addition of vascular endothelial growth factor during differentiation. Further examination of this and subsequent stages of differentiation demonstrated forward programming mediated by early overexpression of a single transcription factor, SOX17, was sufficient for robust generation of CD34+VEC+ endothelial progenitors followed by CD34+ hematopoietic progenitors via an endothelial to hematopoietic transition. The development of a novel all-in-one transposon plasmid system, XLone, enabled this work by allowing footprint-free, precise temporal and tunable control of exogenous gene expression without silencing. Finally, this study employed CRISPR-Cas9 to immunoengineer hPSCs with universal immune tolerance for cardiac regenerative medicine. Preliminary results conveyed that a knockout of B2M and overexpression of inhibitory HLA-E or HLA-G fusion proteins resulted in immune protection from cytotoxic T-cells and NK cells for cardiac muscle cells derived in vitro from human pluripotent stem cell. This body of work not only advances our understanding of critical drivers of human hematopoietic and immune development, but also provides proof of concept for the application of immunoengineered stem cells for cardiac regenerative therapies.

Handbook of Stem Cell Applications

Author : Khawaja H. Haider
Publisher : Springer Nature
ISBN 13 : 9819971195
Total Pages : 1422 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Handbook of Stem Cell Applications by : Khawaja H. Haider

Download or read book Handbook of Stem Cell Applications written by Khawaja H. Haider and published by Springer Nature. This book was released on with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pluripotent Stem Cells

Author : Minoru Tomizawa
Publisher : BoD – Books on Demand
ISBN 13 : 9535124714
Total Pages : 534 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Pluripotent Stem Cells by : Minoru Tomizawa

Download or read book Pluripotent Stem Cells written by Minoru Tomizawa and published by BoD – Books on Demand. This book was released on 2016-07-20 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.