Endotoxin Detection And Control In Pharma Limulus And Mammalian Systems

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Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems

Author : Kevin L. Williams
Publisher : Springer
ISBN 13 : 3030171485
Total Pages : 869 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems by : Kevin L. Williams

Download or read book Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems written by Kevin L. Williams and published by Springer. This book was released on 2019-07-24 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.

Pyrogens

Author : Frederick C. Pearson
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Pyrogens by : Frederick C. Pearson

Download or read book Pyrogens written by Frederick C. Pearson and published by . This book was released on 1985 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endotoxins: Structure, Function and Recognition

Author : Xiaoyuan Wang
Publisher : Springer Science & Business Media
ISBN 13 : 9048190789
Total Pages : 415 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Endotoxins: Structure, Function and Recognition by : Xiaoyuan Wang

Download or read book Endotoxins: Structure, Function and Recognition written by Xiaoyuan Wang and published by Springer Science & Business Media. This book was released on 2010-06-30 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

Biology and Conservation of Horseshoe Crabs

Author : John T. Tanacredi
Publisher : Springer Science & Business Media
ISBN 13 : 0387899596
Total Pages : 658 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Biology and Conservation of Horseshoe Crabs by : John T. Tanacredi

Download or read book Biology and Conservation of Horseshoe Crabs written by John T. Tanacredi and published by Springer Science & Business Media. This book was released on 2009-06-04 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Horseshoe crabs, those mysterious ancient mariners, lured me into the sea as a child along the beaches of New Jersey. Drawn to their shiny domed shells and spiked tails, I could not resist picking them up, turning them over and watching the wondrous mechanical movement of their glistening legs, articulating with one another as smoothly as the inner working of a clock. What was it like to be a horseshoe crab, I wondered? What did they eat? Did they always move around together? Why were some so large and others much smaller? How old were they, anyway? What must it feel like to live underwater? What else was out there, down there, in the cool, green depths that gave rise to such intriguing creatures? The only way to find out, I reasoned, would be to go into the ocean and see for myself, and so I did, and more than 60 years later, I still do.

Researching animal research

Author : Gail Davies
Publisher : Manchester University Press
ISBN 13 : 1526165767
Total Pages : 304 pages
Book Rating : 4.5/5 (261 download)

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Book Synopsis Researching animal research by : Gail Davies

Download or read book Researching animal research written by Gail Davies and published by Manchester University Press. This book was released on 2024-01-09 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year around 80 million scientific procedures are carried out on animals globally. These experiments have the potential to generate new understandings of biology and clinical treatments. They also give rise to ongoing societal debate. This book demonstrates how the humanities and social sciences can contribute to understanding what is created through animal procedures – including constitutional forms of research governance, different institutional cultures of care, the professional careers of scientists and veterinarians, collaborations with patients and publics, and research animals, specially bred for experiments or surplus to requirements. Developing the idea of the animal research nexus, this book explores how connections and disconnections are made between these different elements, how these have reshaped each other historically, and how they configure the current practice and policy of UK animal research.

Advances in the Biology, Aquaculture, and Conservation of Threatened Marine Species and their Application in Human Health and Nutrition

Download Advances in the Biology, Aquaculture, and Conservation of Threatened Marine Species and their Application in Human Health and Nutrition PDF Online Free

Author : Anthony Lee Dellinger
Publisher : Frontiers Media SA
ISBN 13 : 2889761495
Total Pages : 335 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Advances in the Biology, Aquaculture, and Conservation of Threatened Marine Species and their Application in Human Health and Nutrition by : Anthony Lee Dellinger

Download or read book Advances in the Biology, Aquaculture, and Conservation of Threatened Marine Species and their Application in Human Health and Nutrition written by Anthony Lee Dellinger and published by Frontiers Media SA. This book was released on 2022-05-23 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3

Author : Wanda M. Haschek-Hock
Publisher : Elsevier
ISBN 13 : 0443161542
Total Pages : 974 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3 by : Wanda M. Haschek-Hock

Download or read book Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3 written by Wanda M. Haschek-Hock and published by Elsevier. This book was released on 2023-02-24 with total page 974 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. Provides updated and revised chapters for in-depth discussions of toxicologic pathology for the protection of the environment and food supplies Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

FDA Biotechnology Inspection Guide

Author : United States. Food and Drug Administration
Publisher :
ISBN 13 :
Total Pages : 62 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis FDA Biotechnology Inspection Guide by : United States. Food and Drug Administration

Download or read book FDA Biotechnology Inspection Guide written by United States. Food and Drug Administration and published by . This book was released on 1991 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Microbial Limit and Bioburden Tests

Author : Lucia Clontz
Publisher : CRC Press
ISBN 13 : 9781420053494
Total Pages : 280 pages
Book Rating : 4.0/5 (534 download)

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Book Synopsis Microbial Limit and Bioburden Tests by : Lucia Clontz

Download or read book Microbial Limit and Bioburden Tests written by Lucia Clontz and published by CRC Press. This book was released on 2008-10-14 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of pharmaceutical microbiology has experienced numerous technological advances, accompanied by the publication of new and harmonized compendial methods. It is therefore imperative for those who are responsible for monitoring the microbial quality of pharmaceutical/biopharmaceutical products to keep abreast of the latest changes. Microbial Limit and Bioburden Tests: Validation Approaches and Global Requirements guides readers through the various microbiological methods listed in the compendia with easy-to-follow diagrams and approaches to validations of such test methodologies. Includes New and Updated Material Now in its second edition, this work is the culmination of research and discussions with technical experts, as well as USP and FDA representatives on various topics of interest to the pharmaceutical microbiologist and those responsible for the microbial quality of products, materials, equipment, and manufacturing facilities. New in this edition is an entire chapter dedicated to the topic of biofilms and their impact on pharmaceutical and biopharmaceutical operations. The subject of rapid methods in microbiology has been expanded and includes a discussion on the validation of alternative microbiological methods and a case study on microbial identification in support of a product contamination investigation. Substantially updated and revised, this book assists readers in understanding the fundamental issues associated with pharmaceutical microbiology and provides them with tools to create effective microbial contamination control and microbial testing programs for the areas under their responsibility.

Microbiome of Finfish and Shellfish

Author : Arvind Diwan
Publisher : Springer Nature
ISBN 13 : 9819908523
Total Pages : 301 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Microbiome of Finfish and Shellfish by : Arvind Diwan

Download or read book Microbiome of Finfish and Shellfish written by Arvind Diwan and published by Springer Nature. This book was released on 2023-11-13 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book helps us to understand the importance of the microbiome associated with finfish and shellfish inhabiting different locations and varied environmental and biological situations. It covers modern molecular tools for identifying microbiome composition and their precise identification at the species level. The book also covers the molecular structural composition of individual microbes, metabolite resources from microbiome species, their functional properties, and production aspects. Notable, the book covers the microbiome applications in the gut systems of finfish and shellfish to the digestion, nutrition, growth, reproduction, immune system, and vulnerability of the host to diseases. It also reviews diversity and functional properties, relationships with diseases, health status, data on species-specific metagenomics, and probiotic research. It highlights the relevance of microbial communities for the development of new and innovative bio-products to build bio and pharmaceutical industries, including aquaculture. This book is an invaluable source for researchers and professionals involved in fishery science, fisheries and aquaculture, fish biotechnology, and fish microbiology and pathology

Dictionary of Pharmaceutical Medicine

Author : Gerhard Nahler
Publisher : Springer Science & Business Media
ISBN 13 : 3709140161
Total Pages : 186 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Dictionary of Pharmaceutical Medicine by : Gerhard Nahler

Download or read book Dictionary of Pharmaceutical Medicine written by Gerhard Nahler and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dictionary is aimed primarily at the beginners entering the new discipline of Pharmaceutical Medicine, an area comprising aspects of toxicology, pharmacology, pharmaceutics, epidemiology, statistics, drug regulatory and legal affairs, medicine and marketing. But also more experienced colleagues in departments engaged in clinical development as well as researchers and marketing experts in the pharmaceutical industry will find concise and up-to-date information. The book is completed by a list of a about 1000 abbreviations encountered in pharmaceutical medicine and a compilation of important addresses of national and international health authorities.

Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems

Author : Mohammed Zourob
Publisher : Springer Science & Business Media
ISBN 13 : 0387751130
Total Pages : 980 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems by : Mohammed Zourob

Download or read book Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems written by Mohammed Zourob and published by Springer Science & Business Media. This book was released on 2008-09-03 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems will cover the up-to-date biosensor technologies used for the detection of bacteria. Written by the world's most renowned and learned scientists each in their own area of expertise, Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems is the first title to cover this expanding research field.

Characterization of Nanoparticles Intended for Drug Delivery

Author : Jeffrey D. Clogston
Publisher : Springer Nature
ISBN 13 : 107163786X
Total Pages : 315 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Characterization of Nanoparticles Intended for Drug Delivery by : Jeffrey D. Clogston

Download or read book Characterization of Nanoparticles Intended for Drug Delivery written by Jeffrey D. Clogston and published by Springer Nature. This book was released on with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals

Author : P.L. Chambers
Publisher : Springer Science & Business Media
ISBN 13 : 3642690831
Total Pages : 407 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals by : P.L. Chambers

Download or read book Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals written by P.L. Chambers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of cure in patients with disseminated malignancies, such as stage IV Hodgkin's disease or childhood acute lymphocytic leukemia. In other disseminated forms of neoplasia, induction of a remission, a substantial palliation and a prolongation of survival have been achieved. In many instances of localised disease, where surgery with or without radiotherapy are the primary form of treatment, anticancer drugs have been used with success as adjuvant therapy for distant microscopic disease. With these spectacular achievements, secondary malignancies, in particular acute non-lymphocytic leukemia (ANLL), has become of major concern. Incidence Acute leukemia is the most frequent form of secondary neoplasia in patients treated for cancer (Penn 1981). In one large series, 5. 9% of all ANLL could be attributed to previous chemotherapy (Kapadia et al. 1980).

Integration of Pharmaceutical Discovery and Development

Author : Ronald T. Borchardt
Publisher : Springer Science & Business Media
ISBN 13 : 0306473844
Total Pages : 627 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Integration of Pharmaceutical Discovery and Development by : Ronald T. Borchardt

Download or read book Integration of Pharmaceutical Discovery and Development written by Ronald T. Borchardt and published by Springer Science & Business Media. This book was released on 2006-01-19 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

WHO Expert Committee on Biological Standardization

Author : WHO Expert Committee on Biological Standardization. Meeting
Publisher : World Health Organization
ISBN 13 : 9241209771
Total Pages : 241 pages
Book Rating : 4.2/5 (412 download)

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Book Synopsis WHO Expert Committee on Biological Standardization by : WHO Expert Committee on Biological Standardization. Meeting

Download or read book WHO Expert Committee on Biological Standardization written by WHO Expert Committee on Biological Standardization. Meeting and published by World Health Organization. This book was released on 2013 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents the recommendations of a WHO Expert Committee commissioned to coordinate activities leading to the adoption of international recommendations for the production and control of vaccines and other biologicals and the establishment of international biological reference materials. The report starts with a discussion of general issues brought to the attention of the Committee and provides information on the status and development of reference materials for various antibodies, antigens, blood products and related substances, cytokines, growth factors, endocrinological substances and in vitro diagnostic devices. The second part of the report, of particular relevance to manufacturers and national regulatory authorities, contains revised WHO recommendations for production and control of live attenuated influenza vaccines and for production and control of pneumococcal conjugate vaccines. New WHO guidelines on the regulatory evaluation of similar biotherapeutic medicines are also provided. Also included are a list of recommendations, guidelines and other documents for biological substances used in medicine, and of international standards and reference reagent for biological substances.

Bacterial Lipopolysaccharides

Author : Yuriy A. Knirel
Publisher : Springer Science & Business Media
ISBN 13 : 3709107334
Total Pages : 440 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Bacterial Lipopolysaccharides by : Yuriy A. Knirel

Download or read book Bacterial Lipopolysaccharides written by Yuriy A. Knirel and published by Springer Science & Business Media. This book was released on 2011-07-13 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling.