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Endogenous Neuroprotection In The Respiratory Control System
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Book Synopsis Endogenous Neuroprotection by : Bernhard Schaller
Download or read book Endogenous Neuroprotection written by Bernhard Schaller and published by Nova Publishers. This book was released on 2008 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endogenous neuoprotection is a phenomenon where a brief episode of ischemia renders the brain resistant against a subsequent longer-asting ischemia event. Experimentally, the author was able to model hypoxic preconditioning in animal model. Increasing knowledge of this endogenous neuroprotectin by ischemic tolerance may help to minimize neuronal damage following ischemic stroke and hypoxic encephalopathy. This book is, therefore, the first overview of this important topic and will certainly influence further investigations in clinical and neuroscience research.
Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : E. S. Vizi
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by E. S. Vizi and published by Springer Science & Business Media. This book was released on 2008-04-15 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the biology of brain function is a great challenge and a major goal of modern science. The brain is one of the last great frontiers in science, and the unraveling of its mysteries is comparable in complexity to efforts in space exploration. A fundamental goal of neuroscience is to understand how neurons generate behavior and the pathophysiology of different mental and neurological diseases. The aim of this book is to describe recent discoveries about the basic operations of the brain and to provide an introduction to the adaptations for specific types of information processing.
Book Synopsis Genetic Aberrancies and Neurodegenerative Disorders by : M.P. Mattson
Download or read book Genetic Aberrancies and Neurodegenerative Disorders written by M.P. Mattson and published by Elsevier. This book was released on 2000-01-28 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested.
Book Synopsis Neuroprotection by : Raymond Chuen-Chung Chang
Download or read book Neuroprotection written by Raymond Chuen-Chung Chang and published by BoD – Books on Demand. This book was released on 2019-08-28 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.
Book Synopsis The Trigemino-Cardiac Reflex: Beyond the Diving Reflex by : Bernhard Schaller
Download or read book The Trigemino-Cardiac Reflex: Beyond the Diving Reflex written by Bernhard Schaller and published by Frontiers Media SA. This book was released on 2018-01-16 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: The trigemino-cardiac reflex (TCR) is a well established brain-stem reflex and commonly manifests as bradycardia, asystole, hypotension and / or apnea. This phenomenon was extensively explored in the recent past. However, the area related to its exact bio-physiological mechanism, neuro-anatomical linkages, clinical implications, its role in non neurological events and future directions should need to be further investigated. Therefore, this present research topic on TCR would mainly focus on various aspects of TCR and present a comprehensive and exhaustive overview about a phenomena that gains more and more interest during the last few years. Our goal is to present models about the different aspects of the TCR to develop in-depth understanding of TCR.
Book Synopsis Subcellular Fractions: Advances in Research and Application: 2011 Edition by :
Download or read book Subcellular Fractions: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Subcellular Fractions: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Subcellular Fractions. The editors have built Subcellular Fractions: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Subcellular Fractions in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Subcellular Fractions: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Book Synopsis Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu by : M. Naoi
Download or read book Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu written by M. Naoi and published by Gulf Professional Publishing. This book was released on 2002-09-25 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences. The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.
Book Synopsis Delta Opioid Receptor Pharmacology and Therapeutic Applications by : Emily M. Jutkiewicz
Download or read book Delta Opioid Receptor Pharmacology and Therapeutic Applications written by Emily M. Jutkiewicz and published by Springer. This book was released on 2018-09-27 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.
Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Book Synopsis The Handbook of Neuroprotection by : Kewal K. Jain
Download or read book The Handbook of Neuroprotection written by Kewal K. Jain and published by Springer. This book was released on 2019-05-15 with total page 865 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.
Book Synopsis Importance of Oxidative Stress and Antioxidant System in Health and Disease by :
Download or read book Importance of Oxidative Stress and Antioxidant System in Health and Disease written by and published by BoD – Books on Demand. This book was released on 2023-05-31 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is a major contributor to the etiology of chronic disorders like cancer, diabetes, neurodegenerative diseases, and cardiovascular diseases. Long-term exposure to elevated levels of pro-oxidant substances can lead to structural damage in mitochondrial DNA as well as functional changes in a number of enzymes and cellular components, which can lead to abnormalities in gene expression. Modern lifestyles, which include eating processed food, exposure to a variety of chemicals, and not exercising, are significant factors in the development of oxidative stress. However, the ability of medicinal plants with antioxidant capabilities to cure or prevent a number of human illnesses in which oxidative stress appears to be a contributing factor has been demonstrated. A growing body of research links free radicals to the etiology of many diseases, supporting the use of antioxidants as a promising therapeutic strategy for the management of pathologies caused by free radicals. Despite these remarkable advances, there is still much to learn about the relationship between free radicals and antioxidants. Understanding the principles behind pathological and physiological disorders caused by free radicals is crucial. Importance of Oxidative Stress and Antioxidant System in Health and Disease contributes to understanding the fundamental principles of oxidative stress and the effects of antioxidants on disease and health.
Book Synopsis Central Nervous System Acting Drugs – Molecular Mechanisms of Neuroprotection and Neurodegeneration by : Nesrine Salah El Dine El Sayed
Download or read book Central Nervous System Acting Drugs – Molecular Mechanisms of Neuroprotection and Neurodegeneration written by Nesrine Salah El Dine El Sayed and published by Frontiers Media SA. This book was released on 2023-04-14 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oxidative Stress and Neuroprotection by : S.H. Parvez
Download or read book Oxidative Stress and Neuroprotection written by S.H. Parvez and published by Springer Science & Business Media. This book was released on 2006-12-26 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with basic and clinical aspects of monoamine oxidase (MAO) subtypes A and B highlighting its importance in neurological and psychiatric diseases. Consequently the therapeutic actions of MAO-A and -B inhibitors in Parkinson’s disease (PK) and depression are the focus of several chapters. As MAO is the basis of the development of the "oxidative stress hypothesis" of PD, several chapters are devoted to iron and iron-induced oxidative stress in various experimental studies and clinical conditions. Based on these findings, new compounds have been developed which not only block MAO, but are in addition, either inhibitors of acetylcholine esterase or have iron chelating properties. The aspect of "preclinical" and "clinical" neuro protection as well as MAO neuroprotection are additional topics covered in this book. MAO, iron and neuroprotection are seen in the framework of general anti Parkinson’s therapy with chapters on levodopa, dopaminergic receptor agonists and clinical issues.
Book Synopsis Frontiers in Pharmacology of Neurotransmitters by : Puneet Kumar
Download or read book Frontiers in Pharmacology of Neurotransmitters written by Puneet Kumar and published by Springer Nature. This book was released on 2020-10-29 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.
Book Synopsis Fuhrman & Zimmerman's Pediatric Critical Care E-Book by : Jerry J. Zimmerman
Download or read book Fuhrman & Zimmerman's Pediatric Critical Care E-Book written by Jerry J. Zimmerman and published by Elsevier Health Sciences. This book was released on 2021-02-05 with total page 2653 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the highly specialized field of caring for children in the PICU, Fuhrman and Zimmerman's Pediatric Critical Care is the definitive reference for all members of the pediatric intensive care team. Drs. Jerry J. Zimmerman and Alexandre T. Rotta, along with an expert team of editors and contributors from around the world, have carefully updated the 6th Edition of this highly regarded text to bring you the most authoritative and useful information on today's pediatric critical care—everything from basic science to clinical applications. - Contains highly readable, concise chapters with hundreds of useful photos, diagrams, algorithms, and clinical pearls. - Uses a clear, logical, organ-system approach that allows you to focus on the development, function, and treatment of a wide range of disease entities. - Features more international authors and expanded coverage of global topics including pandemics, sepsis treatment in underserved communities, specific global health concerns by region. - Covers current trends in sepsis-related mortality and acute care after sepsis, as well as new device applications for pediatric patients. - Provides ultrasound videos and more than 500 board-style review questions and answers on Expert Consult. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Book Synopsis Molecular Chaperones and Neurodegeneration by : Cintia Roodveldt
Download or read book Molecular Chaperones and Neurodegeneration written by Cintia Roodveldt and published by Frontiers Media SA. This book was released on 2017-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.
