Endocrine Disrupters

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Environmental Endocrinology and Endocrine Disruptors

Author : Rosario Pivonello
Publisher : Springer Nature
ISBN 13 : 3030390446
Total Pages : 532 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Environmental Endocrinology and Endocrine Disruptors by : Rosario Pivonello

Download or read book Environmental Endocrinology and Endocrine Disruptors written by Rosario Pivonello and published by Springer Nature. This book was released on 2023-04-20 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.

Toxic Bodies

Author : Nancy Langston
Publisher : Yale University Press
ISBN 13 : 0300162995
Total Pages : 253 pages
Book Rating : 4.3/5 (1 download)

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Book Synopsis Toxic Bodies by : Nancy Langston

Download or read book Toxic Bodies written by Nancy Langston and published by Yale University Press. This book was released on 2010-03-02 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor—a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways. In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.

Challenges in Endocrine Disruptor Toxicology and Risk Assessment

Author : Alexandra Fucic
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017412
Total Pages : 539 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Challenges in Endocrine Disruptor Toxicology and Risk Assessment by : Alexandra Fucic

Download or read book Challenges in Endocrine Disruptor Toxicology and Risk Assessment written by Alexandra Fucic and published by Royal Society of Chemistry. This book was released on 2020-12-08 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Endocrine Disruption and Human Health

Author : Philippa D. Darbre
Publisher : Academic Press
ISBN 13 : 0128219882
Total Pages : 536 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2021-09-19 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology

Endocrine-Disrupting Chemicals

Author : Andrea C. Gore
Publisher : Springer Science & Business Media
ISBN 13 : 159745107X
Total Pages : 361 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Endocrine-Disrupting Chemicals by : Andrea C. Gore

Download or read book Endocrine-Disrupting Chemicals written by Andrea C. Gore and published by Springer Science & Business Media. This book was released on 2007-06-08 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.

Endocrine Disruptors, Brain, and Behavior

Author : Heather B. Patisaul
Publisher : Oxford University Press
ISBN 13 : 0190669039
Total Pages : 336 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Endocrine Disruptors, Brain, and Behavior by : Heather B. Patisaul

Download or read book Endocrine Disruptors, Brain, and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017-04-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Endocrine Disruption in Fish

Author : David E. Kime
Publisher : Springer Science & Business Media
ISBN 13 : 1461549434
Total Pages : 402 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Endocrine Disruption in Fish by : David E. Kime

Download or read book Endocrine Disruption in Fish written by David E. Kime and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring". Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.

Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies

Author : Muhammad Sajid Hamid Akash
Publisher : Springer
ISBN 13 : 9783030459253
Total Pages : 0 pages
Book Rating : 4.4/5 (592 download)

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Book Synopsis Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies by : Muhammad Sajid Hamid Akash

Download or read book Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies written by Muhammad Sajid Hamid Akash and published by Springer. This book was released on 2021-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Endocrine Disruptors in the Environment

Author : Sushil K. Khetan
Publisher : John Wiley & Sons
ISBN 13 : 1118852931
Total Pages : 410 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Endocrine Disruptors in the Environment by : Sushil K. Khetan

Download or read book Endocrine Disruptors in the Environment written by Sushil K. Khetan and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruptors in the Environment A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone- signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.

Hormonally Active Agents in the Environment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309064198
Total Pages : 453 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Hormonally Active Agents in the Environment by : National Research Council

Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Environmental Impacts on Reproductive Health and Fertility

Author : Tracey J. Woodruff
Publisher : Cambridge University Press
ISBN 13 : 9780521519526
Total Pages : 262 pages
Book Rating : 4.5/5 (195 download)

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Book Synopsis Environmental Impacts on Reproductive Health and Fertility by : Tracey J. Woodruff

Download or read book Environmental Impacts on Reproductive Health and Fertility written by Tracey J. Woodruff and published by Cambridge University Press. This book was released on 2010-01-28 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.

Count Down

Author : Shanna H. Swan
Publisher : Simon and Schuster
ISBN 13 : 1982113677
Total Pages : 304 pages
Book Rating : 4.9/5 (821 download)

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Book Synopsis Count Down by : Shanna H. Swan

Download or read book Count Down written by Shanna H. Swan and published by Simon and Schuster. This book was released on 2022-02-08 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: An award-winning scientist, in this urgent, thought-provoking and meticulously researched book, shows how chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale.

Sicker, Fatter, Poorer

Author : Leonardo Trasande
Publisher : Houghton Mifflin
ISBN 13 : 1328553493
Total Pages : 245 pages
Book Rating : 4.3/5 (285 download)

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Book Synopsis Sicker, Fatter, Poorer by : Leonardo Trasande

Download or read book Sicker, Fatter, Poorer written by Leonardo Trasande and published by Houghton Mifflin. This book was released on 2019 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.

Endocrine Disrupters in Wastewater and Sludge Treatment Processes

Author : J. W. Birkett
Publisher : IWA Publishing
ISBN 13 : 9781843390312
Total Pages : 320 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Endocrine Disrupters in Wastewater and Sludge Treatment Processes by : J. W. Birkett

Download or read book Endocrine Disrupters in Wastewater and Sludge Treatment Processes written by J. W. Birkett and published by IWA Publishing. This book was released on 2002-12-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disrupting Chemicals (EDCs) have been shown to produce changes in the endocrine system of organisms that lead to increases in cancers and abnormalities in reproductive structure and function. Recent research has highlighted the existence of hormonally active compounds in sewage and industrial effluents and their potential for recycling back into the environment - including drinking water supplies- through point sources and non-point sources. Endocrine Disrupters in Wastewater and Sludge Treatment Processes presents the latest research on EDCs, covering the sources, fate, and transport of EDCs in sewage and industrial effluents, and sludge treatment and disposal options in light of effects on receiving environments. In addition, the authors review current legislation, future research needs, and potential management strategies for endocrine disrupters in the environment.

Endocrine Disruptors, Brain, and Behavior

Author : Heather B. Patisaul
Publisher : Oxford University Press
ISBN 13 : 0199935734
Total Pages : 273 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Endocrine Disruptors, Brain, and Behavior by : Heather B. Patisaul

Download or read book Endocrine Disruptors, Brain, and Behavior written by Heather B. Patisaul and published by Oxford University Press. This book was released on 2017 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. This work focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. It provides an overall synthesis of the EDC field including its historical roots, major hypotheses, key findings, public health policy implications, and research gaps.

Review of the Environmental Protection Agency's State-of-the-science Evaluation of Nonmonotonic Dose-response Relationships as They Apply to Endocrine Disruptors

Download Review of the Environmental Protection Agency's State-of-the-science Evaluation of Nonmonotonic Dose-response Relationships as They Apply to Endocrine Disruptors PDF Online Free

Author : National Research Council (U.S.). Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse
Publisher :
ISBN 13 : 9780309297547
Total Pages : 0 pages
Book Rating : 4.2/5 (975 download)

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Book Synopsis Review of the Environmental Protection Agency's State-of-the-science Evaluation of Nonmonotonic Dose-response Relationships as They Apply to Endocrine Disruptors by : National Research Council (U.S.). Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse

Download or read book Review of the Environmental Protection Agency's State-of-the-science Evaluation of Nonmonotonic Dose-response Relationships as They Apply to Endocrine Disruptors written by National Research Council (U.S.). Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation.

Bisphenol A

Author : Natalie Gassman
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162066
Total Pages : 195 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Bisphenol A by : Natalie Gassman

Download or read book Bisphenol A written by Natalie Gassman and published by Royal Society of Chemistry. This book was released on 2022-01-12 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bisphenol A (BPA) is a high production volume endocrine-disrupting chemical present in numerous consumer products. Extensive use of BPA has led to wide-spread contamination in the air, soil, and water, leading to ubiquitous human exposure. Research into BPA has grown exponentially over the past ten years, with numerous modes of action being identified that impact human health and disease development. While BPA has estrogenic effects, emerging literature has identified several non-receptor mediated modes of action, such as epigenetic reprogramming, that can affect the long-term health of the population. This book highlights the multiple modes of action BPA can use to reprogram cells genetically and metabolically. By compiling critical studies in BPA and outlining the connections and disparities in the literature to build a broader understanding of this complex endocrine-disrupting chemical and its impact on the environment and human health, this book is an ideal resource for postgraduates and researchers in a range of disciplines from toxicology to epigenetics and cancer epidemiology.