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Enantioselective Total Synthesis Of Callipeltoside A
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Book Synopsis Enantioselective Total Synthesis of Callipeltoside A by : Essa Hsinyi Hu
Download or read book Enantioselective Total Synthesis of Callipeltoside A written by Essa Hsinyi Hu and published by . This book was released on 2002 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design and Development of New Enantioselective Organocatalytic Transformations, a Two-step Synthesis of Carbohydrates and Progress Toward the Total Synthesis of Callipeltoside C by : Alan Bowers Northrup
Download or read book Design and Development of New Enantioselective Organocatalytic Transformations, a Two-step Synthesis of Carbohydrates and Progress Toward the Total Synthesis of Callipeltoside C written by Alan Bowers Northrup and published by . This book was released on 2005 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Total Synthesis of Callipeltoside A by : Michael E. Danielson
Download or read book A Total Synthesis of Callipeltoside A written by Michael E. Danielson and published by . This book was released on 2003 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward a Total Synthesis of Callipeltoside A by : Hongyu Zhao
Download or read book Studies Toward a Total Synthesis of Callipeltoside A written by Hongyu Zhao and published by . This book was released on 2000 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Callipeltoside C. by : David Matthew Shaw
Download or read book Studies Towards the Total Synthesis of Callipeltoside C. written by David Matthew Shaw and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Callipeltoside A and Dictyostatin by : Arndt Meyer
Download or read book Total Synthesis of Callipeltoside A and Dictyostatin written by Arndt Meyer and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Total Synthesis of (-)-16-Hydroxytriptolide by : Bob Lui
Download or read book Enantioselective Total Synthesis of (-)-16-Hydroxytriptolide written by Bob Lui and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Enantioselective Total Synthesis of (-)-16-hydroxytriptolide" by Bob, Lui, 呂思奇, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled ENANTIOSELECTIVE TOTAL SYNTHESIS OF (-)-16-HYDROXYTRIPTOLIDE Submitted by Lui Bob for the degree of Doctor of Philosophy at The University of Hong Kong in August 2005 (-)-16-Hydroxytriptolide, a natural product isolated from the Chinese medicinal plant Tripterygium wilfordii Hook F (Lei Gong Teng), shows potent immunosuppressive, antileukemic, and antineuropathic activities. The goal of this project is to develop an enantioselective total synthesis of (-)-16-hydroxytriptolide. The results are summarized as follows. (1) A convergent and efficient synthetic scheme towards ()-16-hydroxytriptolide ()-3.19a has been developed using 2-methylanisole as the starting material. This route involves 21 steps in a 1.8% total yield. The key steps include (i) radical cyclization of ()-3.1 mediated by Mn(OAc) -2HO, (ii) 3 2 α,β-unsaturated γ-lactone construction of ()-3.3, (iii) side-chain installation by Sonogashira coupling from ()-Q5, and (iv) triepoxide construction from ()-3.12. (2) Following a similar synthetic scheme as that of ()-16-hydroxytriptolide, the enantioselective synthesis of (-)-16-hydroxytriptolide has been accomplished. This route involves 21 steps in a 2.4% total yield. The chirality of the trans-ring juncture of the tricyclic core was established by diastereoselective radical cyclization using (+)-8-phenylmenthol as the chiral auxiliary (73% yield, 34:1 dr). The chiral induction of side chain at C-15 was achieved by asymmetric hydrogenation (90% yield, 5.3:1 dr). (3) α-Halogenation reactions of 1,3-dicarbonyl compounds have been investigated to improve the synthetic efficiency of ()-16-hydroxytriptolide. The effect of Lewis acids was examined. In the absence of Lewis acid, the α-bromination of 1,3-dicarbonyl compounds 4.1f afforded both di-brominated 4.4f and mono-brominated products 4.3f in poor yield and selectivity (45%, 4.3f:4.4f = 1.5:1). However, when the α-bromination reaction was carried out in the presence of 0.3 equiv of Mg(ClO ) at room temperature, both the yield and the selectivity of 4 2 α-monobromination improved significantly (85%, 4.3f:4.4f = 14.8:1). (4) In connection to the asymmetric radical cyclization of 5.1 using (+)-8-phenylmenthol as the chiral auxiliary, a one-pot synthesis of its precursor, (S)-(-)-pulegone, has been developed. The reaction of LiClO (0.1 equiv), IBX (3 equiv), and (S)-(-)-citronellol in EtOAc under reflux for 17 h followed by basic treatment, led to a high chemical yield (90%) of (S)-(-)-pulegone. This provides an efficient and economical means to afford (+)-8-phenylmenthol for our (-)-16-hydroxytriptolide synthesis. OMe OMe O OMe H H Cl CO Me CO Me 2 (-)-3.3 (-)-Q5 O (-)-3.1 OH OMe O HO HO C H O O H O O (-)-3.19a (-)-3.12 O O O O O O Ph OEt Ph OEt Ph OEt Br Br Br 4.3f 4.4f 4.1f DOI: 10.5353/th_b3636945 Subjects: Terpenes Organic compounds - Synthesis Medicinal plants - Analysis
Book Synopsis Enantioselective Chemical Synthesis by : Elias J. Corey
Download or read book Enantioselective Chemical Synthesis written by Elias J. Corey and published by Elsevier. This book was released on 2013-10-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages
Book Synopsis Studies Toward an Enantioselective Total Synthesis of (-)- Aleurodiscal by : Todd M. Heidelbaugh
Download or read book Studies Toward an Enantioselective Total Synthesis of (-)- Aleurodiscal written by Todd M. Heidelbaugh and published by . This book was released on 1996 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis I. Enantioselective Total Synthesis Of (-)-Triptolide by : Xiangyang Ye
Download or read book I. Enantioselective Total Synthesis Of (-)-Triptolide written by Xiangyang Ye and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "I. Enantioselective Total Synthesis of (-)-triptolide: II. Synthesis of Triptolide Analogs" by 葉向華, Xiangyang, Ye, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3123963 Subjects: Terpenes Organic chemistry - Synthesis
Book Synopsis Enantioselective Total Synthesis of (+)-isolaurepinnacin and Enantioselective Total Synthesis of ( - )-ptilomycalin A by : Paul Allan Renhowe
Download or read book Enantioselective Total Synthesis of (+)-isolaurepinnacin and Enantioselective Total Synthesis of ( - )-ptilomycalin A written by Paul Allan Renhowe and published by . This book was released on 1995 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I, the Enantioselective Total Synthesis of Antiulcerogenic Compound ( - ) Cassioside by : Yugang Liu
Download or read book Part I, the Enantioselective Total Synthesis of Antiulcerogenic Compound ( - ) Cassioside written by Yugang Liu and published by . This book was released on 1997 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis An Enantioselective Total Synthesis of Tremulenediol A and Tremulenolide A and Development of the [Rh(CO)2Cl]2-catalyzed Direct, Stereoselective Allylic Alkylation of Unsymmetrical Substrates by : Brandon Lee Ashfeld
Download or read book An Enantioselective Total Synthesis of Tremulenediol A and Tremulenolide A and Development of the [Rh(CO)2Cl]2-catalyzed Direct, Stereoselective Allylic Alkylation of Unsymmetrical Substrates written by Brandon Lee Ashfeld and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Total Synthesis of (+)- KB343 by : Cheng Bi
Download or read book Enantioselective Total Synthesis of (+)- KB343 written by Cheng Bi and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Formal Enantioselective Total Synthesis of ( - ) -clavosolide A by : Jesse Dwayne Carrick
Download or read book Progress Towards the Formal Enantioselective Total Synthesis of ( - ) -clavosolide A written by Jesse Dwayne Carrick and published by . This book was released on 2008 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Enantioselective Total Synthesis of Quadrigemine H by : Leonard Sung
Download or read book Studies Toward the Enantioselective Total Synthesis of Quadrigemine H written by Leonard Sung and published by . This book was released on 2008 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic efforts toward the [3+1] quadrigemine alkaloids are described in this dissertation. Chapter 1 reviews the quadrigemine alkaloids from a historical perspective and discusses methods for the construction of their highly congested vicinal and diaryl all-carbon quaternary stereocenters. The application of these methods is featured in the presentation of the enantioselective syntheses of hodgkinsine and quadrigemine C.
Book Synopsis Enantioselective Total Synthesis of Shahamin K and Enantioselective Total Synthesis of Quadrigemine C, and Psycholeine by : Alec Donald Lebsack
Download or read book Enantioselective Total Synthesis of Shahamin K and Enantioselective Total Synthesis of Quadrigemine C, and Psycholeine written by Alec Donald Lebsack and published by . This book was released on 2002 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: