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Author : Anita Karegar
Publisher :
ISBN 13 :
Total Pages : 428 pages
Book Rating : 4.:/5 (181 download)
Download or read book Electrochemical, Multi-analyte Biosensor Array for Neurotransmitter Detection written by Anita Karegar and published by . This book was released on 2007 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alexander Chuan Sun
Publisher :
ISBN 13 :
Total Pages : 119 pages
Book Rating : 4.:/5 (14 download)
Download or read book Point-of-Care and High-Density Array Electrochemical Biosensors written by Alexander Chuan Sun and published by . This book was released on 2018 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of numerous advances towards miniaturization in several diverse fields including chemistry, nanofabrication, microfluidics, and electronics, point-of-care (PoC) biosensors have become a promising tool to combat the most life-threatening and expensive health issues affecting the world today. PoC technology helps solve these problems by allowing for diagnostic tools typically restricted to centralized facilities to be brought closer to the point of diagnosis for faster and more frequent testing in both clinical and remote settings. While many biosensor types exist, electrochemical-based detection has the advantage that it is inherently compatible with circuits, requiring only electrodes for transduction, allowing it fully to benefit from both Moore's Law scaling and the well-established semiconductor manufacturing industry to produce miniaturized, cost-effective, and portable devices. However, there has been a lack of successful PoC electrochemical platforms capable of running multiple diagnostic tests or multi-analyte assays due to the difficultly of balancing power and area constraints of the circuitry with maintaining the required sensitivity. Therefore, in this dissertation, the circuit and system design of two electrochemical biosensor platforms are presented that explore the challenges of implementing both multi-technique and multi-analyte biosensors at the PoC. The first is a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone technologies to enable personal health monitoring. By repurposing components from one mode to the next, the biosensor is able to efficiently reconfigure itself into three different measurement modes allowing it to run a variety of assays. Each distinct mode is able to match the performance of state-of-the-art single technique biosensors, while all being integrated onto a single device at a fraction of the size. The 3.9x1.65 cm2 module was used with a modular smartphone for a variety of real-world point-of-care applications. Scaling the sensors further for high-density multi-analyte testing, a 4,096-pixel electrochemical biosensor array in 180 nm CMOS is presented. It uses a coulostatic discharge sensing technique and interdigitated electrode (IDE) geometry design to reduce the size of the readout circuitry. Each biopixel contains an IDE with a 13 aA low-leakage readout circuit directly underneath. Compared to standard electrodes, the implemented IDEs along with their inherent 3-D trenches achieve an amplification factor of 10.5x from redox cycling. The array's sensor density is comparable to state-of-the-art arrays, all without augmenting the sensors with complex post-processing. The simultaneous detection of anti-Rubella and anti-Mumps antibodies in human serum is demonstrated.
Author : Raluca-Ioana Stefan
Publisher : CRC Press
ISBN 13 : 9780824706623
Total Pages : 320 pages
Book Rating : 4.7/5 (66 download)
Download or read book Electrochemical Sensors in Bioanalysis written by Raluca-Ioana Stefan and published by CRC Press. This book was released on 2001-08-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Covers the most recent methods and materials for the construction, validation, analysis, and design of electrochemical sensors for bioanalytical, clinical, and pharmaceutical applications--emphasizing the latest classes of enantioselective electrochemical sensors as well as electrochemical sensors for in vivo and in vitro diagnosis, for DNA assay and HIV detection, and as detectors in flow systems. Contains current techniques for the assay or biochemical assay of biological fluids and pharmaceutical compounds."
Author : Xueji Zhang
Publisher : Academic Press
ISBN 13 : 008055489X
Total Pages : 625 pages
Book Rating : 4.0/5 (85 download)
Download or read book Electrochemical Sensors, Biosensors and their Biomedical Applications written by Xueji Zhang and published by Academic Press. This book was released on 2011-04-28 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book broadly reviews the modem techniques and significant applications of chemical sensors and biosensors. Chapters are written by experts in the field – including Professor Joseph Wang, the most cited scientist in the world and renowned expert on sensor science who is also co-editor. Each chapter provides technical details beyond the level found in typical journal articles, and explores the application of chemical sensors and biosensors to a significant problem in biomedical science, also providing a prospectus for the future.This book compiles the expert knowledge of many specialists in the construction and use of chemical sensors and biosensors including nitric oxide sensors, glucose sensors, DNA sensors, hydrogen sulfide sensors, oxygen sensors, superoxide sensors, immuno sensors, lab on chip, implatable microsensors, et al. Emphasis is laid on practical problems, ranging from chemical application to biomedical monitoring and from in vitro to in vivo, from single cell to animal to human measurement. This provides the unique opportunity of exchanging and combining the expertise of otherwise apparently unrelated disciplines of chemistry, biological engineering, and electronic engineering, medical, physiological. Provides user-oriented guidelines for the proper choice and application of new chemical sensors and biosensors Details new methodological advancements related to and correlated with the measurement of interested species in biomedical samples Contains many case studies to illustrate the range of application and importance of the chemical sensors and biosensors
Author : Hidenori Akiyama
Publisher : Springer
ISBN 13 : 4431560955
Total Pages : 491 pages
Book Rating : 4.4/5 (315 download)
Download or read book Bioelectrics written by Hidenori Akiyama and published by Springer. This book was released on 2016-09-19 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on bioelectrics, a new multidisciplinary field encompassing engineering and biology with applications to the medical, environmental, food, energy, and biotechnological fields. At present, 15 universities and institutes in Japan, the USA and the EU comprise the International Consortium of Bioelectrics, intended to advance this novel and important research field. This book will serve as an introductory resource for young scientists and also as a textbook for use by both undergraduate and graduate students – the world’s first such work solely devoted to bioelectrics.
Author : Ali A. Ensafi
Publisher : Elsevier
ISBN 13 : 0128164921
Total Pages : 388 pages
Book Rating : 4.1/5 (281 download)
Download or read book Electrochemical Biosensors written by Ali A. Ensafi and published by Elsevier. This book was released on 2019-07-25 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. Describes several electrochemical methods used as detection techniques with biosensors Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more
Author : Serge Cosnier
Publisher : CRC Press
ISBN 13 : 9814411477
Total Pages : 405 pages
Book Rating : 4.8/5 (144 download)
Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Author : Fan Xia
Publisher : Springer Nature
ISBN 13 : 9819956447
Total Pages : 269 pages
Book Rating : 4.8/5 (199 download)
Download or read book Electrochemical Biosensors for Whole Blood Analysis written by Fan Xia and published by Springer Nature. This book was released on 2023-10-02 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates recent advances in developing sensitive and selective electrochemical biosensors for their whole blood application. Known to be a cutting-edge and fast-growing technology, electrochemical biosensors demonstrate their potential in laboratories, industries, and healthcare to achieve specific and direct target detection in complex media, and have become an emerging technology for guiding personalized medicine. The book first demonstrates methods and models to cover the detection of a variety of target molecules in whole blood, including ions, small molecules, nucleic acids, proteins, cells, etc. Then, it provides comments on various detection strategies employed to improve sensors' sensitivity, specificity, selectivity, and reproducibility as well as presenting the laws and principles. In addition, it summarizes achievements and challenges from recent years. Finally, it provides future perspectives and opportunities in electrochemical biosensors including point of care detection, molecular diagnostics and the integration of this sensor platform with multidisciplinary technologies, towards the ultimate goal of personalized medicine. The book integrates abundant viewpoints from multiple sciences and is helpful and valuable to a wide readership in the various fields of biochemistry, biophysics, bioengineering, and pharmaceutics.
Author : Stéphane Marinesco
Publisher : Humana Press
ISBN 13 : 9781627033695
Total Pages : 0 pages
Book Rating : 4.0/5 (336 download)
Download or read book Microelectrode Biosensors written by Stéphane Marinesco and published by Humana Press. This book was released on 2013-04-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For molecules that are not directly electroactive, it is necessary to modify a microelectrode by grafting polymeric or enzymatic membranes capable of translating a local concentration into an electrical current, which is a concept referred to as biosensing. In Microelectrode Biosensors, experts in the field cover the topic of electrochemical biosensor technology as applied to the neurosciences. The volume opens with a section addressing the specific issue of manufacturing biosensors that can be implanted in the central nervous system for neurotransmitter detection, and it then continues with sections on recent studies where biosensors have made a difference in bringing a new level of understanding of signaling mechanisms in neuroscience as well as recent developments in biosensor technology that have not yet been applied to implantable microelectrodes but may have great potential. Written for the Neuromethods series, this work contains the kind of detailed descriptions and implementation advice necessary to achieve successful results. Focused and cutting-edge, Microelectrode Biosensors serves to inspire the wider neuroscience and physiology community to adopt these powerful methods in their own applications in order to move the field forward with the widespread advances that will most likely flow from the adoption of biosensing as part of the standard laboratory toolkit.
Author : Adrian C. Michael
Publisher : CRC Press
ISBN 13 : 1420005863
Total Pages : 540 pages
Book Rating : 4.4/5 (2 download)
Download or read book Electrochemical Methods for Neuroscience written by Adrian C. Michael and published by CRC Press. This book was released on 2006-12-13 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical techniques. Today, these methods provide neurochemical information that is not accessible by other means. The growing recognition of the versatility of electrochemi
Author : JuKyung Lee
Publisher :
ISBN 13 :
Total Pages : 147 pages
Book Rating : 4.:/5 (15 download)
Download or read book Hypersensitive Electrochemical Biosensors Based on Nanowell Array Structures for Point of Care Technology written by JuKyung Lee and published by . This book was released on 2016 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are sensitive indicators of pathogenic processes and pharmaceutical responses. Most of these biomarkers are present in the body with extremely low concentration and should be accurately and continually monitored to evaluate the dynamic physiological responses upon exposure to pathogens or drugs. However, conventional assays such as Enzyme linked immuno-sorbent assay (ELISA) and mass spectrometry can only take static and one time measurements, the process is long, expensive, and requires specialist equipment. Therefore, there is need for an advanced sensing system that is cost-effective, portable, and capable of simultaneously detecting very low levels of specific biomarkers with stable and reusable point of care technology (POCT). The goal of this thesis is to develop hyper sensitive biosensors based on electrochemical detection to recognize analytes a using nanowell array (NWA) electrode technology. NWA electrodes have been shown to enable faster detection of biomolecules with reproducibility much better than other approaches. In this thesis, I used fabricated a NWA on a 6-inch Si wafer by krypton-fluoride (KrF) stepper semiconductor process in order to develop NWA sensor through a combination of low cost and high throughput nano-pattern. Finally 57 uniform and homogeneous NWA electrodes were obtained on a 6-inch wafer. Second, to validate this NWA as a biosensor, several biomarkers were detected and monitored. In this part, first, NWA as immunosensor, antibody was immobilized on the NWA, and alkaline phosphatase (ALP) for bone monitoring and stress induced protein 1 (STIP-1) as ovarian cancer monitoring were used as antigen. Specific current and impedance were measured to quantify these analytes binding to the electrode. The Limit of detection (LOD) and the sensitivity & selectivity is highly increased compared with conventional micro-sized electrodes with reducing non-specific binding. Finally, these results suggest that wafer-scale NWA biosensor is useful for sensing application field for point of care technology because their structure provides for an advantage for detecting molecular binding events.
Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1839624310
Total Pages : 256 pages
Book Rating : 4.8/5 (396 download)
Download or read book Biosensors written by and published by BoD – Books on Demand. This book was released on 2021-05-05 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers novel and current strategies for biosensing, from the use of nanomaterials and biological functionalized surfaces to the mathematical assessment of novel biosensors and their potential use as wearable devices for continuous monitoring. Biosensing technologies can be used in the medical field for the early detection of disease, monitoring effectiveness of treatments, detecting nervous system signals for controlling robotic prosthesis, and much more. This book includes eleven chapters that examine and discuss several strategies of biosensing, proposing mathematical designs that address the latest reported technologies.
Author : Mehmet Sengun Ozsoz
Publisher : CRC Press
ISBN 13 : 9814241776
Total Pages : 568 pages
Book Rating : 4.8/5 (142 download)
Download or read book Electrochemical DNA Biosensors written by Mehmet Sengun Ozsoz and published by CRC Press. This book was released on 2012-04-23 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the basic electrochemical applications of DNA in various areas, from basic principles to the most recent discoveries. The book comprises theoretical and experimental analysis of various properties of nucleic acids, research methods, and some promising applications. The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticle and nanotubes; nanomaterial-based electrochemical DNA detection; electrochemical detection of microorganism-based DNA biosensors; gold nanoparticle-based electrochemical DNA biosensors; electrochemical detection of the aptamer-target interaction; nanoparticle-induced catalysis for DNA biosensing; basic terms regarding electrochemical DNA (nucleic acids) biosensors; screen-printed electrodes for electrochemical DNA detection; application of field-effect transistors to label free electrical DNA biosensor arrays; and electrochemical detection of nucleic acids using branched DNA amplifiers.
Author : Zvi Liron
Publisher : Springer Science & Business Media
ISBN 13 : 146151231X
Total Pages : 322 pages
Book Rating : 4.4/5 (615 download)
Download or read book Novel Approaches in Biosensors and Rapid Diagnostic Assays written by Zvi Liron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the medical, food, and environmental fields there is a continuous demand for inexpensive and sensitive analytical devices that are reliable, rapid, capable of high-throughput screening, and have low cost per test unit. Small and portable biosensor devices are designed to fulfill most of these requirements, and can be used in laboratory and on-site field testing. This volume discusses major issues in optical, acoustic and electrochemical-based biosensors, biochips, sensing recognition elements, and biosensors for medical and environmental applications. The papers presented at the conference represent basic and applied research studies in the fields of diagnostic assays and biosensor development. Novel technologies, such as arrays of sensors using high-density fiber optics to sense labeled or unlabeled oligonucleotides, and patterned arrays of recognition elements, demonstrated the capability of biosensors to analyze multiple analytes.
Author : Josh R. Branen
Publisher :
ISBN 13 : 9781109861167
Total Pages : 209 pages
Book Rating : 4.8/5 (611 download)
Download or read book Multianalyte Detection of Food Pathogens/toxins Through Enzymatic Bio-nanotransduction on an Electrochemical Biosensor Array written by Josh R. Branen and published by . This book was released on 2006 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The system was capable of detecting and distinguishing three species of specific IgG molecules at a level of 0.2 ng. The system was also shown to be capable of detecting mixed protein and DNA targets. The flexibility of this system was substantiated through the simultaneous detection of Escherichia coli O157 microorganisms and Staphylococcal enterotoxin B (SEB) using a labeled secondary antibody approach.
Author : Paolo Bollella
Publisher : MDPI
ISBN 13 : 3039438875
Total Pages : 504 pages
Book Rating : 4.0/5 (394 download)
Download or read book Biosensors – Recent Advances and Future Challenges written by Paolo Bollella and published by MDPI. This book was released on 2021-01-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.
Author : Mengjia Hu
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.:/5 (12 download)
Download or read book Development of Electrochemical Sensors Suitable for in Vivo Detection for Neurotransmitters written by Mengjia Hu and published by . This book was released on 2016 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The electrochemical method of redox cycling was exploited to achieve new discoveries in neurotransmitter detection and to advance its suitability toward in vivo use. Redox cycling has advantages in signal amplification, selectivity of species based on their electrochemical reaction mechanisms, and limited or no background subtraction. Distinction of dopamine from norepinephrine in a mixture with an electrochemical method at unmodified electrodes was demonstrated for the first time in vitro. This ability resulted from a series of fundamental studies of redox cycling behavior of the catecholamines (dopamine, norepinephrine and epinephrine) using different electrode configurations. Taking advantage of the ECC{u2019} mechanism associated with their electrochemical oxidation and the substantially different rate constants for the first order intramolecular cyclization reaction, the catecholamines can be distinguished by monitoring the current at collector electrodes activated at different distances from the generator. In vitro detection of dopamine in the presence of multiple electrochemically-active interfering species (ascorbic acid, uric acid, L 3,4 dihydroxyphenylalanine, homovanillic acid, 3 methoxytyramine and 5 hydroxyindoleacetic acid) has also been investigated for future in vivo applications. Selective detection of physiological concentrations of dopamine at the collector electrodes using microfabricated electrode arrays was shown (with detection limits of 0.730 ± 0.013 μM and 0.086 ± 0.002 μM for dopamine with and without the presence of interfering species, respectively). In addition, two types of unique neural probes (co-planar and vertical edge microelectrode arrays) were designed with the purpose to implement the redox cycling approach in vivo. An innovative design was used to minimize the number of masks for eight layers of electrodes. Different microfabrication procedures were evaluated, with further work still needed for optimization. Also, analysis of anodic stripping voltammetry of silver-containing nanoparticles modified on electrode surfaces, performed as an interest in expanding the detection to other important neurochemicals, showed that commonly used drop-casting techniques deposit nanoparticles non-uniformly. More reproducible modification methods are needed. The work in this dissertation demonstrates the capabilities of redox cycling for multi-neurotransmitter analysis and sets the foundation for development of novel neural probes for implementing the approach. This method may also be used to obtain mechanisms and kinetics beyond the ones investigated here.
