Electric Cell Substrate Impedance Sensing And Cancer Metastasis

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Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

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Author : Wen G. Jiang
Publisher : Springer Science & Business Media
ISBN 13 : 9400749279
Total Pages : 261 pages
Book Rating : 4.4/5 (7 download)

Book Synopsis Electric Cell-Substrate Impedance Sensing and Cancer Metastasis by : Wen G. Jiang

Download or read book Electric Cell-Substrate Impedance Sensing and Cancer Metastasis written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2012-09-14 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology, cancer biology, and other areas of chemistry, medicinal chemistry, life and medical science. Written by experts in the area of cell impedance sensing, including the Nobel Laureate Dr Ivar Giaever, this books covers the background of electric cell-substrate impedance sensing, their applications in cell based investigations, particularly in the area of cancer biology. This book is the first on this technology platform and will be a highly useful reference for molecular and cell biologists, cancer biologists, chemists and biochemists, clinical researchers who work in the areas of cell biology, molecular biology, toxicology, pharmaceutical industry, life science and medical research.

Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

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Author :
Publisher : Springer
ISBN 13 : 9789400749283
Total Pages : 270 pages
Book Rating : 4.7/5 (492 download)

Book Synopsis Electric Cell-Substrate Impedance Sensing and Cancer Metastasis by :

Download or read book Electric Cell-Substrate Impedance Sensing and Cancer Metastasis written by and published by Springer. This book was released on 2012-09-15 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Development of Screen-printed Impedance Biocensor for Characterization of Cancer Cells

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Author : Ahmad Fairuzabadi bin Mohd Mansor
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (973 download)

Book Synopsis Development of Screen-printed Impedance Biocensor for Characterization of Cancer Cells by : Ahmad Fairuzabadi bin Mohd Mansor

Download or read book Development of Screen-printed Impedance Biocensor for Characterization of Cancer Cells written by Ahmad Fairuzabadi bin Mohd Mansor and published by . This book was released on 2016 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electric Cell-Substrate Impedance Sensing (ECIS) is currently gaining widespread application in biomedical field such as cell monitoring. The ability to monitor growth and death of mammalian cells has made this technique more and more popular in drug discovery. Currently chemotherapy treatment subject patients to trial and error therapy, resulting in unoptimized dosage and unnecessary pain for patients. Optimal treatment effectiveness can only be accomplished when the chemotherapy dosage is individualized to each patient. In this study, a silver/silver chloride screen-printed impedance biosensor on glass was developed to characterize A549 lung cancer cell growth in the presence of collagen I, Bovine as substrate coating. The sensor comprise of Interdigital Electrodes Structures (IDEs) with variable spacing. The sensor's optimum spacing between electrodes has been simulated using COMSOL Multiphysics. The sensor was fabricated and incorporated with a culture well made of polydimethylsiloxane (PDMS). A549 cells were cultured in the chambers and impedance measurements were taken at 12 hours intervals for 120 hours. Cell Index (CI) were calculated from the impedance measurement and plotted against time together with the growth profile of the cells using conventional method. A549 cells were also treated with chemotherapy drug; Paclitaxel and its response were monitored over 5 days. Experimental results using biosensor show a similar trend with conventional growth profile of cells in T-flask. Significant reduction in Cell Index (CI) was observed after exposure to Paclitaxel indicating the reliability of the impedance biosensor. Lower spacing between the electrodes has been found to be more sensitive, producing higher Cell Index during cell growth. This work indicates that silver/silver chloride screen printed sensor offers a low cost solution for personalized sensors as it provides a rapid, real time, continuous, reliable method for chemotherapy drug screening.

Using Electric Cell-substrate Impedance Sensing (ECIS) to Measure Properties of an Individual Adherent Cell

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Author : Pahnit Seriburi
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (439 download)

Book Synopsis Using Electric Cell-substrate Impedance Sensing (ECIS) to Measure Properties of an Individual Adherent Cell by : Pahnit Seriburi

Download or read book Using Electric Cell-substrate Impedance Sensing (ECIS) to Measure Properties of an Individual Adherent Cell written by Pahnit Seriburi and published by . This book was released on 2008 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors

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Author : Maximilian Oberleitner
Publisher : Springer
ISBN 13 : 331945384X
Total Pages : 370 pages
Book Rating : 4.3/5 (194 download)

Book Synopsis Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors by : Maximilian Oberleitner

Download or read book Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors written by Maximilian Oberleitner and published by Springer. This book was released on 2017-09-26 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.

Evaluation of Electric Cell-substrate Impedance Sensing (ECIS) for the Detection of Biological and Chemical Toxins

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Author : Bhavana Mohanraj
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (115 download)

Book Synopsis Evaluation of Electric Cell-substrate Impedance Sensing (ECIS) for the Detection of Biological and Chemical Toxins by : Bhavana Mohanraj

Download or read book Evaluation of Electric Cell-substrate Impedance Sensing (ECIS) for the Detection of Biological and Chemical Toxins written by Bhavana Mohanraj and published by . This book was released on 2010 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Label-Free Monitoring of Cells in vitro

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Author : Joachim Wegener
Publisher : Springer Nature
ISBN 13 : 3030324338
Total Pages : 286 pages
Book Rating : 4.0/5 (33 download)

Book Synopsis Label-Free Monitoring of Cells in vitro by : Joachim Wegener

Download or read book Label-Free Monitoring of Cells in vitro written by Joachim Wegener and published by Springer Nature. This book was released on 2019-11-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to label-free, non-invasive monitoring of cell-based assays and it comprises the most widely applied techniques. Each approach is described and critically evaluated by an expert in the field such that researchers get an overview on what is possible and where the limitations are. The book provides the theoretical basis for each technique as well as the most successful and exciting applications. Label-free bioanalytical techniques have been known for a long time as valuable tools to monitor adsorption processes at the solid-liquid interface in general – and biomolecular interaction analysis (BIA) in particular. The underlying concepts have been progressively transferred to the analysis of cell-based assays. The strength of these approaches is implicitly given with the name 'label-free': the readout is independent of any label, reagent or additive that contaminates the system under study and potentially affects its properties. Thus, label-free techniques provide an unbiased analytical perspective in the sense that the sample is not manipulated by additives but pure. They are commonly based on physical principles and read changes in integral physical properties of the sample like refractive index, conductivity, capacitance or elastic modulus to mention just a few. Even though it is not implied in the name, label-free approaches usually monitor the cells under study non-invasively meaning that the amplitude of the signal (e.g. electric field strength, mechanical elongation) that is used for the measurement is too low to interfere or affect. In contrast to label-based analytical techniques that are commonly restricted to a single reading at a predefined time point, label-free approaches allow for a continuous observation so that the dynamics of the biological system or reaction become accessible.

Tools, Techniques and Protocols for Monitoring Environmental Contaminants

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Author : Satinder Kaur Brar
Publisher : Elsevier
ISBN 13 : 012814680X
Total Pages : 432 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Tools, Techniques and Protocols for Monitoring Environmental Contaminants by : Satinder Kaur Brar

Download or read book Tools, Techniques and Protocols for Monitoring Environmental Contaminants written by Satinder Kaur Brar and published by Elsevier. This book was released on 2019-06-04 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tools, Techniques and Protocols for Monitoring Environmental Contaminants describes information on the strategic integration of available monitoring methods with molecular techniques, with a focus on omics (DNA, RNA and protein based) and molecular imprinted polymer and nanomaterial based advanced biosensors for environmental applications. It discusses the most commonly practiced analytic techniques, such as HPLC, MS, GCMS and traditional biosensors, giving an overview of the benefits of advanced biosensors over commonly practiced methods in the rapid and reliable assessment of environmental contaminants. As environmental contaminants have become one of the serious concerns in terms of their rapid growth and monitoring in the environment, which is often limited due to costly and laborious methods, this book provides a comprehensive update on their removal, the challenges they create for environmental regulatory agencies, and their diverse effects on terrestrial and aquatic environments. Provides methods for assessing and monitoring environmental contaminants Includes recent advancement in molecular techniques Outlines rapid environmental monitoring methods Explains the use of biosensors for environmental monitoring Reviews monitoring methods beyond conventional analytic techniques

Tight Junctions in Cancer Metastasis

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Author : Tracey A. Martin
Publisher : Springer Science & Business Media
ISBN 13 : 9400760280
Total Pages : 315 pages
Book Rating : 4.4/5 (7 download)

Book Synopsis Tight Junctions in Cancer Metastasis by : Tracey A. Martin

Download or read book Tight Junctions in Cancer Metastasis written by Tracey A. Martin and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Central Nervous System Metastasis, the Biological Basis and Clinical Considerations

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Author : Diane Palmieri
Publisher : Springer Science & Business Media
ISBN 13 : 9400752911
Total Pages : 234 pages
Book Rating : 4.4/5 (7 download)

Book Synopsis Central Nervous System Metastasis, the Biological Basis and Clinical Considerations by : Diane Palmieri

Download or read book Central Nervous System Metastasis, the Biological Basis and Clinical Considerations written by Diane Palmieri and published by Springer Science & Business Media. This book was released on 2012-12-30 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.

Bioelectronics and Medical Devices

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Author : Dr. Kunal Pal
Publisher : Woodhead Publishing
ISBN 13 : 0081024215
Total Pages : 1006 pages
Book Rating : 4.0/5 (81 download)

Book Synopsis Bioelectronics and Medical Devices by : Dr. Kunal Pal

Download or read book Bioelectronics and Medical Devices written by Dr. Kunal Pal and published by Woodhead Publishing. This book was released on 2019-06-15 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioelectronics and Medical Devices: From Materials to Devices-Fabrication, Applications and Reliability reviews the latest research on electronic devices used in the healthcare sector, from materials, to applications, including biosensors, rehabilitation devices, drug delivery devices, and devices based on wireless technology. This information is presented from the unique interdisciplinary perspective of the editors and contributors, all with materials science, biomedical engineering, physics, and chemistry backgrounds. Each applicable chapter includes a discussion of these devices, from materials and fabrication, to reliability and technology applications. Case studies, future research directions and recommendations for additional readings are also included. The book addresses hot topics, such as the latest, state-of the-art biosensing devices that have the ability for early detection of life-threatening diseases, such as tuberculosis, HIV and cancer. It covers rehabilitation devices and advancements, such as the devices that could be utilized by advanced-stage ALS patients to improve their interactions with the environment. In addition, electronic controlled delivery systems are reviewed, including those that are based on artificial intelligences. Presents the latest topics, including MEMS-based fabrication of biomedical sensors, Internet of Things, certification of medical and drug delivery devices, and electrical safety considerations Presents the interdisciplinary perspective of materials scientists, biomedical engineers, physicists and chemists on biomedical electronic devices Features systematic coverage in each chapter, including recent advancements in the field, case studies, future research directions, and recommendations for additional readings

Bone Metastases

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Author : Vassilios Vassiliou
Publisher : Springer Science & Business Media
ISBN 13 : 9400775695
Total Pages : 479 pages
Book Rating : 4.4/5 (7 download)

Book Synopsis Bone Metastases by : Vassilios Vassiliou

Download or read book Bone Metastases written by Vassilios Vassiliou and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.

Measuring Biological Impacts of Nanomaterials

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Author : Joachim Wegener
Publisher : Springer
ISBN 13 : 3319248235
Total Pages : 221 pages
Book Rating : 4.3/5 (192 download)

Book Synopsis Measuring Biological Impacts of Nanomaterials by : Joachim Wegener

Download or read book Measuring Biological Impacts of Nanomaterials written by Joachim Wegener and published by Springer. This book was released on 2016-02-02 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.

The Effect of Reduced DHHC2 Expression on Cancer Cell Migration

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Author : Carissa Chrobak
Publisher :
ISBN 13 :
Total Pages : 68 pages
Book Rating : 4.:/5 (987 download)

Book Synopsis The Effect of Reduced DHHC2 Expression on Cancer Cell Migration by : Carissa Chrobak

Download or read book The Effect of Reduced DHHC2 Expression on Cancer Cell Migration written by Carissa Chrobak and published by . This book was released on 2017 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: The palmitoyl acyltransferase, DHHC2, has been shown to affect the metastatic behavior of cancer cells. The loss of expression in certain cancer cells, including liver, colon, and breast, is correlated to increase metastasis. Over expression of DHHC2 has been shown to inhibit proliferation, migration, and invasion in hepatocellular carcinoma cell lines, suggesting a putative tumor suppressor function for DHHC2. To explore its potential role as a tumor suppressor in cervical adenocarcinoma cells, we examined its localization and effect on cellular migration using immunofluorescence and electrical cell-substrate impedance sensing (ECIS) wound healing assays, respectively. Our results show a correlation between reduced DHHC2 expression and an increase rate of wound closure and a decrease in barrier function of cells in a monolayer. These data support the idea that DHHC2 has a tumor suppressor function in adenocarcinoma cells. -- Abstract.

1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering

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Author : Fong-Chin Su
Publisher : Springer
ISBN 13 : 3319122622
Total Pages : 290 pages
Book Rating : 4.3/5 (191 download)

Book Synopsis 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering by : Fong-Chin Su

Download or read book 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering written by Fong-Chin Su and published by Springer. This book was released on 2014-09-23 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the 9th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2014). The proceedings address a broad spectrum of topics from Bioengineering and Biomedicine, like Biomaterials, Artificial Organs, Tissue Engineering, Nanobiotechnology and Nanomedicine, Biomedical Imaging, Bio MEMS, Biosignal Processing, Digital Medicine, BME Education. It helps medical and biological engineering professionals to interact and exchange their ideas and experiences.

Frontiers in Anti-Cancer Drug Discovery Volume 10

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Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 9811401918
Total Pages : 252 pages
Book Rating : 4.8/5 (114 download)

Book Synopsis Frontiers in Anti-Cancer Drug Discovery Volume 10 by : Atta-ur-Rahman

Download or read book Frontiers in Anti-Cancer Drug Discovery Volume 10 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2019-05-31 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry,in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The tenth volume of the series features chapters covering the following topics: - Challenges in the Management of Hepatoblastoma - The Emerging Role of Monocarboxylate Transporter-1 in Cancer - In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery - Recent Advances in the Development of Mesoporous Anti-Cancer Drug Nanocarriers - Polyphenols and Cancer - Glioblastoma Multiforme - Cutting Edge Targeting Strategies Utilizing Nanotechnology in Breast Cancer Therapy.

Reviews in Breast Cancer

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Author : Claudia Mello-Thoms
Publisher : Frontiers Media SA
ISBN 13 : 2832525520
Total Pages : 279 pages
Book Rating : 4.8/5 (325 download)

Book Synopsis Reviews in Breast Cancer by : Claudia Mello-Thoms

Download or read book Reviews in Breast Cancer written by Claudia Mello-Thoms and published by Frontiers Media SA. This book was released on 2023-06-07 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: