Effective Regulation Of Peptide Hormones

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Effective Regulation of Peptide Hormones

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Author : Feihua Cao
Publisher :
ISBN 13 :
Total Pages : 386 pages
Book Rating : 4.:/5 (953 download)

Book Synopsis Effective Regulation of Peptide Hormones by : Feihua Cao

Download or read book Effective Regulation of Peptide Hormones written by Feihua Cao and published by . This book was released on 2012 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the work described in this thesis, peptidylglycine a-amidating monooxygenase (PAM) was extracted from human H889 and DMS53 small cell lung cancer (SCLC) cells, PC-3 prostate cancer cells and SW1783 glioblastoma cells. Optimization of PAM assay conditions was carried out to maximize PAM activity. The extracted enzymes and optimized assay conditions provided a platform to assess substrate and inhibitor kinetic parameters and to compare the enzyme specificities of PAM from different human cancer sources, as well as differences between human PAM and commercial frog PAM. Potent and selective PAM inhibitors were then developed on the basis of structure-activity-relationships as well as the recognition by PAM of the peptide chain of natural substrates. Furthermore, a direct, rapid, efficient and sensitive HPLC method was developed in order to carry out whole cell inhibition studies and to directly monitor the inhibitory effects on natural hormone and prohormone levels. This method includes online extraction, separation, derivatization and fluorescence detection of peptide hormones, and in principle could be used for any peptide hormone with a free primary amine for fluorescamine tagging. Calcitonin (CT) and its prohormones were studied due to their high expression in DMS53 cells. This is the first time that the levels of CT and its prohormones, CTG, CTGK and CTGKK, have been separated and quantified separately. The detection limits of the present HPLC method were determined to be around 1 ng/mL of cell medium. This method was then applied to whole cell inhibition studies, and this is the first time that inhibitors of CT biosynthesis in human cancer cells were studied, allowing the direct observation of the effects on CT levels and its prohormones. As CPE and PAM are involved in the specific cleavage of C-terminal basic amino acids and the last step of peptide bioactivation, respectively, CPE was also targeted to moderate CT levels. The newly developed whole cell PAM inhibition assay allowed direct determination of the effects of PAM and CPE inhibition on CT production.

Peptide and Protein Hormones

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Author : Dr. Wolfgang König
Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Peptide and Protein Hormones by : Dr. Wolfgang König

Download or read book Peptide and Protein Hormones written by Dr. Wolfgang König and published by . This book was released on 1993 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Incorporates the developments in the field during the 25 years since the last major overview of peptide and protein hormones. Reviews the most important features of the hormones, including structure/activity relationships. Also describes their medical use, noting that western society encourages an overabundance of aggressive stress hormones, and that the role of doctors is to return them into balance with cooperative sex hormones. Of particular use to researchers, students, and practitioners is a special listing of the hormones according to a network of structural similarity and regulating cascades. Annotation copyright by Book News, Inc., Portland, OR

Cellular Peptide Hormone Synthesis and Secretory Pathways

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Author : Jens F. Rehfeld
Publisher : Springer Science & Business Media
ISBN 13 : 3642118364
Total Pages : 245 pages
Book Rating : 4.6/5 (421 download)

Book Synopsis Cellular Peptide Hormone Synthesis and Secretory Pathways by : Jens F. Rehfeld

Download or read book Cellular Peptide Hormone Synthesis and Secretory Pathways written by Jens F. Rehfeld and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.

Peptide and Protein Hormones

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Author : Wolfgang König
Publisher : Wiley-Blackwell
ISBN 13 : 9783527284177
Total Pages : 285 pages
Book Rating : 4.2/5 (841 download)

Book Synopsis Peptide and Protein Hormones by : Wolfgang König

Download or read book Peptide and Protein Hormones written by Wolfgang König and published by Wiley-Blackwell. This book was released on 1993-06-01 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an up-to-date review on the most interesting features of peptide and protein hormones. It describes the medical uses of hormones and points out structure activity relationships. A particularly useful feature is the special listing of the hormones according to a network of structure similarity and regulating cascades. The main sections are: - Gonadoliberin, Thyroliberin, Gonadotropins, Thyrotropin - Parathyroid Hormone and the Calcitonin Family - Corticoliberin - Proopiomelanocortin Cascade - Blood Pressure Regulating Peptides - Cholecystokinin and Gastrin - Secretin Family with growth hormones, prolactin, insulin and relaxin - Neurotensin - Motilin - Pancreatic Spasmolytic Peptide Students and specialists in peptide chemistry, medicinal chemistry, pharmacology, pharmacy and genetics will find invaluable insights in this book.

Cellular Peptide Hormone Synthesis and Secretory Pathways

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Author : Jens F. Rehfeld
Publisher : Springer
ISBN 13 : 9783642118357
Total Pages : 239 pages
Book Rating : 4.1/5 (183 download)

Book Synopsis Cellular Peptide Hormone Synthesis and Secretory Pathways by : Jens F. Rehfeld

Download or read book Cellular Peptide Hormone Synthesis and Secretory Pathways written by Jens F. Rehfeld and published by Springer. This book was released on 2010-10-22 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.

Peptide Hormone Regulation and Synthesis

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Author : Karine Caron
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (144 download)

Book Synopsis Peptide Hormone Regulation and Synthesis by : Karine Caron

Download or read book Peptide Hormone Regulation and Synthesis written by Karine Caron and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trends in Regulatory Peptides

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Author : Hubert Vaudry
Publisher : Frontiers Media SA
ISBN 13 : 2889455378
Total Pages : 282 pages
Book Rating : 4.8/5 (894 download)

Book Synopsis Trends in Regulatory Peptides by : Hubert Vaudry

Download or read book Trends in Regulatory Peptides written by Hubert Vaudry and published by Frontiers Media SA. This book was released on 2018-07-24 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory peptides represent the most diverse and versatile family of messenger molecules. They are produced by all living organisms from bacteria to mammals. They are involved in a wide variety of biological functions. Biologically active peptides and their receptors thus constitute an unlimited source of inspiration for the development of innovative drugs and cosmetics. The present eBook is a unique collection of research articles and reviews that provide a representative examplification of the latest progress in regulatory peptide research.

Hormone Metabolism and Signaling in Plants

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Author : Jiayang Li
Publisher : Academic Press
ISBN 13 : 0128115637
Total Pages : 618 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Hormone Metabolism and Signaling in Plants by : Jiayang Li

Download or read book Hormone Metabolism and Signaling in Plants written by Jiayang Li and published by Academic Press. This book was released on 2017-04-19 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Hormones: Biosynthesis and Mechanisms of Action is based on research funded by the Chinese government’s National Natural Science Foundation of China (NSFC). This book brings a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions. With growing understanding of hormone biology comes new outlooks on how mankind values and utilizes the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner. This book is a comprehensive description of all major plant hormones: how they are synthesized and catabolized; how they are perceived by plant cells; how they trigger signal transduction; how they regulate gene expression; how they regulate plant growth, development and defense responses; and how we measure plant hormones. This is an exciting time for researchers interested in plant hormones. Plants rely on a diverse set of small molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone auxin, hormones have always been the frontiers of plant biology. Although the physiological functions of most plant hormones have been studied for decades, the last 15 to 20 years have seen a dramatic progress in our understanding of the molecular mechanisms of hormone actions. The publication of the whole genome sequences of the model systems of Arabidopsis and rice, together with the advent of multidisciplinary approaches has opened the door to successful experimentation on plant hormone actions. Offers a comprehensive description of all major plant hormones including the recently discovered strigolactones and several peptide hormones Contains a chapter describing how plant hormones regulate stem cells Offers a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions Discusses the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner

Growth Hormone in Adults

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Author : Anders Juul
Publisher : Cambridge University Press
ISBN 13 : 9780521641883
Total Pages : 536 pages
Book Rating : 4.6/5 (418 download)

Book Synopsis Growth Hormone in Adults by : Anders Juul

Download or read book Growth Hormone in Adults written by Anders Juul and published by Cambridge University Press. This book was released on 2000-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.

Hormonal Regulation of Growth

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Author : Herwig Frisch
Publisher :
ISBN 13 :
Total Pages : 332 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Hormonal Regulation of Growth by : Herwig Frisch

Download or read book Hormonal Regulation of Growth written by Herwig Frisch and published by . This book was released on 1989 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Designing Foods

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Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309037956
Total Pages : 384 pages
Book Rating : 4.3/5 (9 download)

Book Synopsis Designing Foods by : National Research Council

Download or read book Designing Foods written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This lively book examines recent trends in animal product consumption and diet; reviews industry efforts, policies, and programs aimed at improving the nutritional attributes of animal products; and offers suggestions for further research. In addition, the volume reviews dietary and health recommendations from major health organizations and notes specific target levels for nutrients.

Gut Hormones

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Author : Stephen Robert Bloom
Publisher :
ISBN 13 :
Total Pages : 640 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Gut Hormones by : Stephen Robert Bloom

Download or read book Gut Hormones written by Stephen Robert Bloom and published by . This book was released on 1981 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Neuroendocrinology

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Author : Michael Wilkinson
Publisher : Cambridge University Press
ISBN 13 : 1316645193
Total Pages : 207 pages
Book Rating : 4.3/5 (166 download)

Book Synopsis Clinical Neuroendocrinology by : Michael Wilkinson

Download or read book Clinical Neuroendocrinology written by Michael Wilkinson and published by Cambridge University Press. This book was released on 2019-01-03 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Solid-Phase Peptide Synthesis

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Author : Gregg B. Fields
Publisher : Academic Press
ISBN 13 :
Total Pages : 828 pages
Book Rating : 4.X/5 (4 download)

Book Synopsis Solid-Phase Peptide Synthesis by : Gregg B. Fields

Download or read book Solid-Phase Peptide Synthesis written by Gregg B. Fields and published by Academic Press. This book was released on 1997-10-21 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides

Human Biochemistry

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Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 032391053X
Total Pages : 883 pages
Book Rating : 4.3/5 (239 download)

Book Synopsis Human Biochemistry by : Gerald Litwack

Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior

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Author : Elena Choleris
Publisher : Cambridge University Press
ISBN 13 : 0521190355
Total Pages : 409 pages
Book Rating : 4.5/5 (211 download)

Book Synopsis Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior by : Elena Choleris

Download or read book Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior written by Elena Choleris and published by Cambridge University Press. This book was released on 2013-04-11 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comparative overview of the effects of neuropeptides on behavior, examining parallel findings in both humans and non-human animals.

Peptide Hormone Receptors

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Author : Mohammed Y. Kalimi
Publisher :
ISBN 13 :
Total Pages : 740 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Peptide Hormone Receptors by : Mohammed Y. Kalimi

Download or read book Peptide Hormone Receptors written by Mohammed Y. Kalimi and published by . This book was released on 1987 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: