Effect of exercise on the mRNA expression of growth factors, metabolic genes and myosin heavy chain isoforms in skeletal muscles of the rat

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Author :
Publisher : diplom.de
ISBN 13 : 3832482938
Total Pages : 124 pages
Book Rating : 4.8/5 (324 download)

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Book Synopsis Effect of exercise on the mRNA expression of growth factors, metabolic genes and myosin heavy chain isoforms in skeletal muscles of the rat by : Antonios Matsakas

Download or read book Effect of exercise on the mRNA expression of growth factors, metabolic genes and myosin heavy chain isoforms in skeletal muscles of the rat written by Antonios Matsakas and published by diplom.de. This book was released on 2004-09-27 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaltsangabe:Abstract: Skeletal muscle is a complex and heterogeneous tissue capable of remarkable adaptation in response to various stimuli such as exercise training. Molecular biology approaches have made a large contribution to our current understanding of how mechanical loading can alter gene expression and muscle protein synthesis rates in skeletal muscle. The steady-state level of a given mRNA is a function of both its rate of synthesis and its rate of degradation, implying that the rate of change in response to a cellular stimulus is dependent on the dynamics of mRNA turnover. Changes in muscle mRNA steady-state levels can be taken as an index of changes in gene expression, constituting currently one of the best described and understood molecular events that underlie muscle plasticity. The discovery of new growth factors involved in the regulation of muscle development provides a better understanding of the molecular mechanisms involved in the adaptation of skeletal muscle to exercise training. Since it has been shown that changes in contractile function can be brought about by switching on one subset and repressing another subset of genes, it was hypothesized that the steady state level of multiple mRNAs (growth factors and metabolic genes) involved in regulatory functions in a muscle which is frequently recruited during exercise is different between endurance trained versus untrained rats. Recent scientific data indicate that myostatin constitutes a limiting factor in normal muscle development playing a crucial role in skeletal muscle hypertrophy. Nevertheless, there are only scarce data so far about the role of myostatin in the exercise-induced skeletal muscle adaptation. The transient changes in regulatory and structural gene expression provide the molecular basis of the adaptability of the skeletal muscle to exercise stimulus. To get an insight into the molecular mechanisms of skeletal muscle adaptation, the main objective of this study was to examine the effect of both the short- and long- term effect of exercise (five day of swimming vs. chronic wheel running) on IGF-I and MSTN (positive and negative skeletal muscle regulators respectively) mRNA contents in male Wistar rats. Potential increase of positive and/or decrease of negative regulators of muscle growth lead to enhanced muscle-progenitor proliferation providing a new perspective in the mechanism of muscle adaptability. It was hypothesized that exercise training could be [...]

Exercise Metabolism

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Publisher : Human Kinetics
ISBN 13 : 9780736041034
Total Pages : 320 pages
Book Rating : 4.0/5 (41 download)

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Book Synopsis Exercise Metabolism by : Mark Hargreaves

Download or read book Exercise Metabolism written by Mark Hargreaves and published by Human Kinetics. This book was released on 2006 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference for biochemists, sport nutritionists, exercise physiologists, and graduate students in those disciplines. Provides information on the metabolic processes that take place during exercise, examining in depth the mobilization and utilization of substrates during physical activity. Focuses primarily on the skeletal muscle, but also discusses the roles of the liver and adipose tissue. Annotation copyright by Book News, Inc., Portland, OR

Skeletal Muscle Development

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Publisher : Humana Press
ISBN 13 : 9781493972821
Total Pages : 226 pages
Book Rating : 4.9/5 (728 download)

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Book Synopsis Skeletal Muscle Development by : James G. Ryall

Download or read book Skeletal Muscle Development written by James G. Ryall and published by Humana Press. This book was released on 2017-08-25 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume presents a wide range of techniques that go beyond the standard assays typically used to assess Myogenesis. The content included addresses assays to analyze skeletal muscle gene expression, proliferating muscle cells, the process of myoblast fusion, muscle development (in vivo), as well as muscle repair. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Skeletal Muscle Development serves as an ideal guide to the study of this highly complex yet carefully regulated process.>

Cumulated Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1666 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Thyroid and Heart Failure

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Publisher : Springer Science & Business Media
ISBN 13 : 8847011434
Total Pages : 264 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Thyroid and Heart Failure by : Giorgio Iervasi

Download or read book Thyroid and Heart Failure written by Giorgio Iervasi and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.

Skeletal Muscle Plasticity in Health and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 1402051778
Total Pages : 372 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Skeletal Muscle Plasticity in Health and Disease by : Roberto Bottinelli

Download or read book Skeletal Muscle Plasticity in Health and Disease written by Roberto Bottinelli and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of striated muscle tissue to adapt to changes in activity or in working conditions is extremely high. In some ways it is comparable to the ability of the brain to learn. The interest in muscle adaptation is increasing in relation to the idea that physical fitness helps in the prevention of disease, may counteract the loss of physical performance and generally improves wellbeing. Plasticity is the word used since the late 1970’s to indicate collectively all the processes and mechanisms which form the background of muscle adaptation. This book aims to provide a systematic updating of the available knowledge on molecular and cellular mechanisms, as well as on changes at whole muscle level. The book means to be a guide and a help for people who enter the field as PhD or medical students, but is also a tool for refreshing and updating knowledge for people already active in the field in basic sciences as well as in applied disciplines such as neurology, sports science and rehabilitation.

Reviews of Physiology, Biochemistry and Pharmacology

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Publisher : Springer Science & Business Media
ISBN 13 : 354036207X
Total Pages : 223 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Reviews of Physiology, Biochemistry and Pharmacology by :

Download or read book Reviews of Physiology, Biochemistry and Pharmacology written by and published by Springer Science & Business Media. This book was released on 2007-05-02 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: [Reviews of Physiology, Biochemistry, and Pharmacology, Volume 146> Text reviews four research abstracts. Discusses tumor-inhibiting platinum complexes, protein targeting, transport of organic anions, and molecular basis of skeletal muscle plasticity.

The Biology of Exercise

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Publisher : Perspectives Cshl
ISBN 13 : 9781621821656
Total Pages : 408 pages
Book Rating : 4.8/5 (216 download)

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Book Synopsis The Biology of Exercise by : Michael J. Joyner

Download or read book The Biology of Exercise written by Michael J. Joyner and published by Perspectives Cshl. This book was released on 2017 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered. The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health.

Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells

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Publisher : Frontiers Media SA
ISBN 13 : 2889198324
Total Pages : 261 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells by : Carlos Hermano J. Pinheiro

Download or read book Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells written by Carlos Hermano J. Pinheiro and published by Frontiers Media SA. This book was released on 2016-05-25 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.

The Neurolab Spacelab Mission

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Publisher : Lyndon B. Johnson Space Center
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis The Neurolab Spacelab Mission by : Jay C. Buckey

Download or read book The Neurolab Spacelab Mission written by Jay C. Buckey and published by Lyndon B. Johnson Space Center. This book was released on 2003 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers solutions and best practices to respond to recurrent problems and contemporary challenges in the field Since the publication of the first edition of Environmental Impact Assessment in 2003, both the practice and theory of impact assessment have changed substantially. Not only has the field been subject to a great deal of new regulations and guidelines, it has also evolved tremendously, with a greater emphasis on strategic environmental, sustainability, and human health impact assessments. Moreover, there is a greater call for impact assessments from a global perspective. This Second Edition, now titled Impact Assessment to reflect its broader scope and the breadth of these many changes, offers students and practitioners a current guide to today's impact assessment practice. Impact Assessment begins with an introduction and then a chapter reviewing conventional approaches to the field. Next, the book is organized around recurrent problems and contemporary challenges in impact assessment process design and management, enabling readers to quickly find the material they need to solve tough problems, including: How to make impact assessments more influential, rigorous, rational, substantive, practical, democratic, collaborative, ethical, and adaptive How each problem and challenge-reducing process would operate at the regulatory and applied levels How each problem can be approached for different impact assessment types-sustainability assessment, strategic environmental assessment, project-level EIA, social impact assessment, ecological impact assessment, and health impact assessment How to link and combine impact assessment processes to operate in situations with multiple overlapping problems, challenges, and impact assessment types How to connect and combine impact assessment processes Each chapter first addresses the topic with current theory and then demonstrates how that theory is applied, presenting requirements, guidelines, and best practices. Summaries at the end of each chapter provide a handy tool for structuring the design and evaluation of impact assessment processes and documents. Readers will find analyses and new case studies that address such issues as multi-jurisdictional impact assessment, climate change, cumulative effects assessment, follow-up, capacity building, interpreting significance, and the siting of major industrial and waste facilities. Reflecting current theory and standards of practice, Impact Assessment is appropriate for both students and practitioners in the field, enabling them to confidently respond to a myriad of new challenges in the field.

Humans in Spaceflight

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Publisher : AIAA
ISBN 13 : 9781563471803
Total Pages : 328 pages
Book Rating : 4.4/5 (718 download)

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Book Synopsis Humans in Spaceflight by : Arnauld E. Nicogossian

Download or read book Humans in Spaceflight written by Arnauld E. Nicogossian and published by AIAA. This book was released on 1997-03-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third volume in the Space Biology and Medicine series addresses the major issues concerning humans in space, such as metabolism, the immune system, neurosensory and sensory motor functions, gravitational biology, radiation, pharmacokinetics and much more. It is composed of two parts: Effects of Microgravity and Effects of Other Spaceflight Factors. As in the previous two volumes, the contributing authors are experts in their respective fields.

Chemical Abstracts

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Publisher :
ISBN 13 :
Total Pages : 2540 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chemical Abstracts by :

Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2540 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Index to PHS-supported Research

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Publisher :
ISBN 13 :
Total Pages : 912 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1989 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Journal of Rehabilitation Research & Development

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ISBN 13 :
Total Pages : 920 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Journal of Rehabilitation Research & Development by :

Download or read book Journal of Rehabilitation Research & Development written by and published by . This book was released on 2008 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Physiologic Basis of Respiratory Disease

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Publisher : PMPH-USA
ISBN 13 : 9781550092363
Total Pages : 824 pages
Book Rating : 4.0/5 (923 download)

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Book Synopsis Physiologic Basis of Respiratory Disease by : Qutayba Hamid

Download or read book Physiologic Basis of Respiratory Disease written by Qutayba Hamid and published by PMPH-USA. This book was released on 2005 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "the complete text and illustrations ... in fully searchable PDF files."--Page 4 of cover.

Journal of Rehabilitation R & D

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Publisher :
ISBN 13 :
Total Pages : 552 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Journal of Rehabilitation R & D by :

Download or read book Journal of Rehabilitation R & D written by and published by . This book was released on 2008 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: