Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Dynamics Of Blood Cell Suspensions In Microflows
Download Dynamics Of Blood Cell Suspensions In Microflows full books in PDF, epub, and Kindle. Read online Dynamics Of Blood Cell Suspensions In Microflows ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Dynamics of Blood Cell Suspensions in Microflows by : Annie Viallat
Download or read book Dynamics of Blood Cell Suspensions in Microflows written by Annie Viallat and published by CRC Press. This book was released on 2019-12-09 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood microcirculation is essential to our bodies for the successful supply of nutrients, waste removal, oxygen delivery, homeostasis, controlling temperature, wound healing, and active immune surveillance. This book provides a physical introduction to the subject and explores how researchers can successfully describe, understand, and predict behaviours of blood flow and blood cells that are directly linked to these important physiological functions. Using practical examples, this book explains how the key concepts of physics are related to blood microcirculation and underlie the dynamic behavior of red blood cells, leukocytes, and platelets. This interdisciplinary book will be a valuable reference for researchers and graduate students in biomechanics, fluid mechanics, biomedical engineering, biological physics, and medicine. Features: The first book to provide a physical perspective of blood microcirculation Draws attention to the potential of this physical approach for novel applications in medicine Edited by specialists in this field, with chapter contributions from subject area specialists
Book Synopsis Dynamics of Blood Cell Suspensions in Microflows by : Annie Viallat
Download or read book Dynamics of Blood Cell Suspensions in Microflows written by Annie Viallat and published by CRC Press. This book was released on 2019-12-09 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to provide a physical perspective of blood microcirculation Draws attention to the potential of this physical approach for novel applications in medicine Edited by specialists in this field, with chapter contributions from subject area specialists
Book Synopsis Biological Flow in Large Vessels by : Valerie Deplano
Download or read book Biological Flow in Large Vessels written by Valerie Deplano and published by John Wiley & Sons. This book was released on 2022-06-01 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines recent methods used for blood flow modeling and associated in vivo experiments, conducted using experimental data from medical imaging. Different strategies are proposed, from small-scale models to complex 3D modeling using modern computational codes. The geometries are wide-ranging and deal with the narrowing and widening of sections (stenoses, aneurysms), bifurcations, geometries associated with prosthetic elements, and even cases of vessels with smaller dimensions than those of the blood cells circulating in them. Biological Flow in Large Vessels provides answers to the question of how medical and biomechanical knowledge can be combined to address clinical problems. It offers guidance for further development of numerical models, as well as experimental protocols applied to clinical research, with tools that can be used in real-time and at the patient's bedside, for decision-making support, predicting the progression of pathologies, and planning personalized interventions.
Book Synopsis Biomechanics of the Aorta by : T. Christian Gasser
Download or read book Biomechanics of the Aorta written by T. Christian Gasser and published by Elsevier. This book was released on 2024-06-18 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures. Represents a comprehensive means for those involved in the aortic research and the related developments in the industry Introduces the most recent imaging technologies to characterize factors, such as aortic geometry, mechanical properties of the aortic tissue, and the local cellular activity in the vessel wall Synthesizes advances in vascular biomechanics, medical imaging and computational finite element fluid and solid models to increase understanding of aorta function
Book Synopsis Microcirculation-on-a-chip by : Sergey S. Shevkoplyas
Download or read book Microcirculation-on-a-chip written by Sergey S. Shevkoplyas and published by . This book was released on 2006 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The primary physiological function of the cardiovascular system, i.e. the delivery of oxygen and nutrients to and the removal of metabolic waste products from living tissues, is performed by the microcirculation. It is also where key events of the immune response such as leukocyte margination, rolling and subsequent diapedesis take place. Microvascular blood flow dynamics have a major impact on all of these vital processes. We used silicon micromachining and polydimethylsiloxane replica molding to create microchannel networks with dimensions and topology similar to the real microcirculation. These networks provide high quality of imaging and unprecedented control over all hemodynamically relevant parameters. We reproduced and documented a number of key blood flow dynamics and phenomena characteristic of the microcirculation in vivo using whole blood and blood cell suspensions of varying composition. This suggests the possibility to use this system as a convenient microfluidic platform for experimental studies of the mechanics of the microcirculation. The impact of blood cell rheology and interactions, plasma composition, network architecture and channel wall surface properties on microvascular network blood flow dynamics can now be addressed without interference from active biological regulation. This system will, for the first time, provide a viable bridge between computer simulations and experiments in vivo. Finally, we created a simple microfluidic device that takes advantage of plasma skimming and leukocyte margination to provide positive, continuous flow selection of leukocytes directly from microliter samples of whole blood. It produces a 34-fold enrichment of the leukocyte-to-erythrocyte ratio and requires no preliminary labeling of cells. This effortless, efficient and inexpensive technology can be used as a lab-on-a-chip component for initial whole blood sample preparation. Its integration into microanalytical devices that require leukocyte enrichment will enable accelerated transition of these devices into the field for point-of-care clinical testing.
Book Synopsis Study of Dynamics of Blood in Microcirculation by :
Download or read book Study of Dynamics of Blood in Microcirculation written by and published by . This book was released on 2015 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood is the primary transport medium in the human body that delivers necessary substances such as nutrients and oxygen to the cells, transports metabolic waste products away from those same cells and responds to injury and inflammation. It is complex in the microstructural and mechanical sense, being multiphase non-Newtonian viscoelastic fluid. The physical nature of blood as a multiphase fluid is intimately related to its biological functions. For flow at micron scales, the concentration of red blood cells (RBCs) is higher near the center of the channel and a red cell-free layer is found near the endothelial wall. White blood cells and platelets are also distributed nonuniformly in flow, but in contrast to red cells they are preferentially found near the walls of the flow channel, a phenomenon called "margination''. Origins of the flow-induced segregation and margination is not understood and is of great application in targeted drug delivery, diagnostics, cell sorting and filtration and many other microfluidic applications. The simulation results and subsequent theoretical development done in this work points, for the first time, towards a unified understanding of how physical parameters of particles like blood component or drug carriers can affect their margination propensity and result in flow induced segregation. Most importantly, the mechanistic nature of the simplified drift-diffusion theory presented here leads to substantial and systematic insight into the origin of margination; this study will complement detailed simulations and experiments in guiding the development of technologies involving blood and other multicomponent suspensions at microscales. A novel model for RBC is presented which comprehensively captures its key membrane properties and reveal multiple dynamical modes of single RBC in shear flow. We discovered some new RBC motions and present a comprehensive phase diagram of RBC dynamics. In simulation of RBC suspension with long-chained polymer additives, polymers are seen to suppress endothelial wall-induced migration to the center of channel and shear-induced diffusion of RBCs resulting in reduced cell-free layer thickness and paradoxically the resistance to flow; explaining beneficial hemodynamic effect and improved survival seen upon addition of polymers in animal models.
Book Synopsis Preparation of Space Experiments by : Vladimir Pletser
Download or read book Preparation of Space Experiments written by Vladimir Pletser and published by BoD – Books on Demand. This book was released on 2020-09-02 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how researchers design, prepare, develop, test and fly their science experiments on microgravity platforms before sending them to space. All preparation phases are explained and presented, including aircraft parabolic flights as part of spaceflight preparation. Twenty international authors, all experts in their own microgravity research field, contribute to chapters describing their experience to prepare experiments before space flights. Fields covered are Physical Sciences and Life Sciences. Physical Sciences covers fluid physics (vibration effects on diffusion; red blood cell dynamics; cavitation in microgravity; capillary driven flows) and material sciences (electromagnetic levitator onboard International Space Station). Life Sciences includes human physiology (sampling earlobe blood; human cardiovascular experiments; tumours in space) and neurophysiology (dexterous manipulation of objects in weightlessness).
Book Synopsis Particle and Blood Cell Dynamics in Oscillatory Flows Final Report by :
Download or read book Particle and Blood Cell Dynamics in Oscillatory Flows Final Report written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Our aim has been to uncover fundamental aspects of the suspension and dislodgement of particles in wall-bounded oscillatory flows, in flows characterized by Reynolds numbers en- compassing the situation found in rivers and near shores (and perhaps in some industrial processes). Our research tools are computational and our coverage of parameter space fairly broad. Computational means circumvent many complications that make the measurement of the dynamics of particles in a laboratory setting an impractical task, especially on the broad range of parameter space we plan to report upon. The impact of this work on the geophysical problem of sedimentation is boosted considerably by the fact that the proposed calculations can be considered ab-initio, in the sense that little to no modeling is done in generating dynamics of the particles and of the moving fluid: we use a three-dimensional Navier Stokes solver along with straightforward boundry conditions. Hence, to the extent that Navier Stokes is a model for an ideal incompressible isotropic Newtonian fluid, the calculations yield benchmark values for such things as the drag, buoyancy, and lift of particles, in a highly controlled environment. Our approach will be to make measurements of the lift, drag, and buoyancy of particles, by considering progressively more complex physical configurations and physics.
Author :University of Minnesota. Institute for Mathematics and Its Applications Publisher : ISBN 13 : Total Pages :34 pages Book Rating :4.:/5 (123 download)
Book Synopsis Feedback, Delays and the Origin of Blood Cell Dynamics by : University of Minnesota. Institute for Mathematics and Its Applications
Download or read book Feedback, Delays and the Origin of Blood Cell Dynamics written by University of Minnesota. Institute for Mathematics and Its Applications and published by . This book was released on 1990 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Numerical Study of Microfluidic Effects and Red Blood Cell Dynamics in 'deterministic Lateral Displacement' Geometries by : Rohan Ranganath Vernekar
Download or read book Numerical Study of Microfluidic Effects and Red Blood Cell Dynamics in 'deterministic Lateral Displacement' Geometries written by Rohan Ranganath Vernekar and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nonlinear Dynamical Analysis of Microvascular Red Blood Cell Flow by : Devkumar Ram Sainani
Download or read book Nonlinear Dynamical Analysis of Microvascular Red Blood Cell Flow written by Devkumar Ram Sainani and published by . This book was released on 1996 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microvascular Mechanics by : Jen-Shih Lee
Download or read book Microvascular Mechanics written by Jen-Shih Lee and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: . . . we do not know a truth without knowing its cause. Aristotle Perhaps the greatest hope that may be entertained for a scientific work, whether experimental or theoretical, is that it leads to new thoughts and new avenues of investigation on the part of its readers. In microvascular mechanics, the interplay of rheology, anatomy, and cellular and organ function has only just begun to be addressed. To understand the operational behavior of microcirculation, there is a need to integrate studies at the cellular or molecu lar level with a quantitative, biomechanical description of the circulatory system. The symposium entitled "Frontiers in Cardiopulmonary Mechanics" held in June 1988 at the University of Virginia was intended to provide a fundamental approach to the description of the circulation from the per spective of microvascular mechanics and to examine new methodology that may advance this effort. This book arose out ofthe work presented at the symposium. Aristotle expressed well the need to pursue the causes of a phenomenon in order to achieve a truthful understanding of its nature. In this spirit has each of the quantitative sciences progressed, and in this spirit we hope that this book will provide some understanding of the microvascular events and bio mechanical mechanisms underlying the behavior of circulation in general, and of pulmonary and skeletal muscle microcirculation in particular. The integrated treatment of pulmonary and systemic microcirculation provided here is intended to encourage the cross-fertilization of these two research fields.
Book Synopsis Design of a Numerical Model for Simulation of Blood Microcirculation and Study of Sickle Cell Disease by : François Thomas Le Floch-Yin
Download or read book Design of a Numerical Model for Simulation of Blood Microcirculation and Study of Sickle Cell Disease written by François Thomas Le Floch-Yin and published by . This book was released on 2010 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel occlusion remain one of the least understood stages of the disease, which focuses the attention of medical research. A novel methodology has been developed to address sickle cell disease, based on highly descriptive mathematical models for blood flow in the capillaries. The main focus of our original sickle cell model is the coupling between oxygen delivery and red blood cell dynamics, which is crucial to understanding sickle cell crises and is unique to this blood disease. Based on an original physical description of polymerizing sickle hemoglobin (HbS), an extensive study of blood dynamics was initiated through simulations of red cells deforming within the capillary vessels. Our investigations relied on the use of a large mathematical system of equations describing oxygen transfer, blood plasma dynamics and red cell membrane mechanics. Abnormal dynamics were characterized in terms of resistance to blood flow (apparent viscosity), and oxygen delivery performance. The results presented in this thesis describe successfully qualitative and quantitative aspects of blood dynamics preceding sickle cell crises, through a detailed comparison of normal blood with sickle cell blood. Potential therapeutical directions were successfully identified, and assessed through simulations and systematic analysis of our results. This research is expected to spur the development of innovative strategies to study sickle cell disease, and also raise interest in other related fields of blood research, promoting analysis-driven development of new therapeutical directions.
Download or read book Microcirculation written by John Grayson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recogmuon recogmtIon of the microcirculation as an ideal interdisciplinary meeting place for the life sciences is really a postwar phenomenon. The European and the American Societies more than any other organizations launched the idea, and the success of the European Society's International Meetings gave impetus to a growth of interest from a handful of specialists to the wide interdisciplinary study which microcirculation now represents. The meeting held in Canada in June 1975 was, however, the first truly international meeting devoted to the microcirculation. It, too, was a success from every point of view, and the exchange of knowledge and new ideas was rewarding. It is our present hope that the tradition of European meetings with their characteristic European flavor will continue, but larded by larger, international congresses conceived on a worldwide basis. For the present conference we were fortunate in the presence of Dr. B. Zweifach. He was once referred to as the "father of the microcircula tion." This claim, unfortunately, I cannot accept. That honor probably belongs to Harvey, who by one of the most brilliant strokes of inductive reasoning in medical history inferred the existence of capillaries though he could not see them. Ben Zweifach's role was rather that of the midwife, presiding at the birth rather than the conception. The baby he delivered long years ago has since thriven lustily and its growth is in no small measure due to the continuing zeal of Zweifach and his associates.
Book Synopsis Dynamics of Microcapsules and Red Blood Cells in Time-dependent Shear Flow by : Mengye Zhao
Download or read book Dynamics of Microcapsules and Red Blood Cells in Time-dependent Shear Flow written by Mengye Zhao and published by . This book was released on 2011 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents a three-dimensional numerical study on the dynamics of deformable capsules in sinusoidally oscillating shear flow. For this study, we consider capsules of spherical and oblate spheroid resting shapes. For spherical resting shapes, we find identical deformation response during positive and negative vorticity. However, the deformation response becomes unequal and shows complex behavior for nonspherical resting shapes. The average elongation is higher in the retarding phase of the shear flow than in the accelerating phase. Primarily two types of dynamics are observed for nonspherical shapes: a clockwise/counter-clockwise swinging motion in response to the altering flow direction that occurs at both high and low values of shear rate amplitudes, and a continuous/unidirectional tumbling motion that occurs at intermediate values. The unidirectional tumbling motion occurs despite the fact that the time-average vorticity is zero. Such a tumbling motion is accompanied by a continuous tank-treading motion of the membrane in the opposite direction. We obtain phase diagram that shows existence of two critical shear rates and two oscillation frequencies. The unidirectional tumbling motion occurs in the intermediate range, and the clockwise/counter-clockwise swinging motion occurs otherwise. We also find that the dynamics is highly sensitive to the initial condition. A swinging is generally observed when the capsule is released aligned with the extensional or compressional axis of the shear flow, and a tumbling is observed otherwise. These results suggest the possibility of chaotic behavior of cells in time-dependent flows. We provide explanations of such complex dynamics by analyzing the coupling between the shape and angular oscillation and the imposed flow oscillation.
Book Synopsis Numerical Simulation of Flow Behaviors of Cells in Microvessels Using Dissipative Particle Dynamics by : Lanlan Xiao
Download or read book Numerical Simulation of Flow Behaviors of Cells in Microvessels Using Dissipative Particle Dynamics written by Lanlan Xiao and published by . This book was released on 2016 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Then, blood flow in microvessel was modeled as a suspension of multiple deformable RBCs. The cell distribution in the cross section revealed that RBCs migrate away from the wall to the tube center, resulting in a cell-free layer near the wall and blunt velocity profile. Also, the well-known Fahraeus and Fahraeus-Lindqvist effects were reproduced. Elevated aggregation strength and deformability can enhance the cell-free layer thickness and hence cause a reduced relative apparent viscosity and an increased discharge hematocrit. Following the analysis on the blood flow, the effects of flowing RBCs on the adhesion of CTC in microvessels were examined. It can be found that in the microvessel with a diameter of 5/3 of the CTC size, the CTC has a larger number of receptor-ligand bonds formed on the cell surface with the hematocrit due to a growing wall-directed force. But in a larger microvessel, an enhanced lift force at higher hematocrit detaches the initial adherent CTC quickly. CTC was found to move more slowly than the blood stream in smaller microvessels, which inhibits the CTC firm adhesion. The presence of CTC adhesion considerably increases blood flow resistance. In addition, the large deformation induced by a high flow rate and the occurrence of aggregation facilitates the CTC adhesion. Finally, a single cell passing through a narrow slit was simulated to investigate the effect of the cell deformability on the cell transmigration through the slit. When the slit width decreases to 2/3 of the cell diameter, the spherical cell becomes jammed despite reducing its elasticity modulus by 10 times. However, transforming the cell from a spherical to ellipsoidal shape and increasing the cell surface area only by 9.3% can enable the cell to pass the narrow slit. Therefore, the cell shape and surface area increase play a more important role than the cell elasticity in cell transit across the narrow slit.
Book Synopsis Flow Dynamics and Tissue Engineering of Blood Vessels by : Arindam Bit
Download or read book Flow Dynamics and Tissue Engineering of Blood Vessels written by Arindam Bit and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow Dynamics and Tissue Engineering of Blood Vessels explores the physical phenomena of vessel compliance and its influence on blood flow dynamics, followed by the modification of flow structures in the presence of diseases within the vessel wall or diseased blood content. This volume also illustrates the progress of tissue engineering for the intervention of re-engineered blood vessels. Blood vessel organoid models, their controlling aspects, and blood vessels based on microfluidic platforms are illustrated following on from the understanding of flow physics of blood on a similar platform. Part of Series in Physics and Engineering in Medicine and Biology.
