Drugs Looking For Diseases

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Drugs Looking for Diseases

Author : R. Vos
Publisher : Springer Science & Business Media
ISBN 13 : 940113796X
Total Pages : 398 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Drugs Looking for Diseases by : R. Vos

Download or read book Drugs Looking for Diseases written by R. Vos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: We all know how much time, effort and money it takes to develop a new drug. Hundreds of chemical compounds have to be synthesized and thousands of different activities in biology, physiology, pharmacology, clinical investigation, management and marketing have to be initiated and coordinated. Each new drug starts a voyage of discovery through an unmapped terrain which is shrouded in mist and beset by pitfalls, as Dr. Rein Vos puts it in his absorbing inside story of the development of the beta-adrenoceptor blocking agents and the calcium antagonists. Indeed we know, for example, how long it took before the theory of Ahlquist of the alpha and beta adrenergic receptors was widely accepted. Similarly, it suffices to memorize shortly the difficulty of expanding the new concept of calcium antagonism through the national German boundaries into the world. This shows how laborious and complex pharmaceutical progress is, and we all will benefit from a deeper understanding of the process of innovative drug research.

Rare Diseases and Orphan Products

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Pills, Potions and Poisons : How Drugs Work

Author : Trevor Stone
Publisher : OUP Oxford
ISBN 13 : 9780191587849
Total Pages : 502 pages
Book Rating : 4.5/5 (878 download)

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Book Synopsis Pills, Potions and Poisons : How Drugs Work by : Trevor Stone

Download or read book Pills, Potions and Poisons : How Drugs Work written by Trevor Stone and published by OUP Oxford. This book was released on 2000-03-16 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: About half of all the medicines prescribed by doctors are not taken by their patients. One of the reasons most commonly given by patients for not taking drugs is that they feel unhappy about taking medicines which they do not understand and of which they are afraid. This book attempts to rectify this problem by showing in clear, non-technical language how medicines and other drugs work in the body to reduce the effects of disease. Most chapters include fascinating background information on how some of our most important drugs were discovered, along with intriguing and often amusing anecdotes about the drugs and the people behind their discovery. Each chapter also includes a summary of the key points together with illustrations, photographs or diagrams to summarise the main groups and how they work in the body. The book covers all the major groups of drugs, with complete listings of all the drugs available in the UK and the USA, so that the reader can locate his or her specific drug and read about the actions of the drugs in that group. The various chapters cover drugs used to treat high blood pressure, heart disease, diabetes, nausea, vomiting, diarrhoea, constipation, ulcers, cancers, infections, impotence, incontinence, arthritis, osteoporosis, as well as hormone replacement therapy, oral contraceptives and drugs used in disorders of the brain such as schizophrenia, depression, Parkinson's disease, Alzheimer's disease and epilepsy. There is also a chapter on drugs which are abused such as cannabis, alcohol, nicotine and ecstasy, and a chapter covering some of the poisons we encounter, such as carbon monoxide, arsenic, sheep dip, and the venoms of snakes, spiders, scorpions and marine organisms. Here, then, a fascinating survey of how chemicals have their effects in the body. It shows how drugs work and explains why it is that taking some medicines for many years is far safer than suffering the long-term effects of disease. Pills, Potions and Poisons is an entertaining read that should also help to improve your health and quality of life.

The Future of Drug Discovery

Author : Tamas Bartfai
Publisher : Academic Press
ISBN 13 : 0124095194
Total Pages : 377 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis The Future of Drug Discovery by : Tamas Bartfai

Download or read book The Future of Drug Discovery written by Tamas Bartfai and published by Academic Press. This book was released on 2013-05-18 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book for all those who care about the development needs for drugs for disease. Provides an in-depth, broad perspective on the crisis in drug industry Exposes the disconnect between what society needs and what the drug companies are working on Analyses and projects over 10 years into the future Explains what it means for scientists and society Determines what is needed to be done to make sure that the industry responds to society's needs, remains commercially attractive and answers the question as to who decides which diseases to treat

Orphan Drugs and Rare Diseases

Author : David C Pryde
Publisher : Royal Society of Chemistry
ISBN 13 : 1782624201
Total Pages : 350 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Orphan Drugs and Rare Diseases by : David C Pryde

Download or read book Orphan Drugs and Rare Diseases written by David C Pryde and published by Royal Society of Chemistry. This book was released on 2014-07-30 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orphan drugs are designated drug substances that are intended to treat rare or ‘orphan’ diseases. More than 7000 rare diseases are known that collectively affect some 6-7% of the developed world’s population; however, individually, any single, rare disease may only affect a handful of people making them commercially unattractive for the biopharmaceutical industry to target. Ground breaking legislation, starting with the Orphan Drug Act that was passed in the US in 1983 to provide financial incentives for companies to develop orphan drugs, has sparked ever increasing interest from biopharmaceutical companies to tackle rare diseases. These developments have made rare diseases, and the orphan drugs that treat them, sufficiently attractive to pharmaceutical development and many pharmaceutical companies now have research units dedicated to this area of research. It is therefore timely to review the area of orphan drugs and some of the basic science, drug discovery and regulatory factors that underpin this important, and growing, area of biomedical research. Written by a combination of academic and industry experts working in the field, this text brings together expert authors in the regulatory, drug development, genetics, biochemistry, patient advocacy group, medicinal chemistry and commercial domains to create a unique and timely reference for all biomedical researchers interested in finding out more about orphan drugs and the rare diseases they treat. Providing an up-to-date monograph, this book covers the basic science, drug discovery and regulatory elements behind orphan drugs and will appeal to medicinal and pharmaceutical chemists, biochemists and anyone working within the fields of rare disease research and drug development or pharmaceuticals in industry or academia.

Description and Analysis of the VA National Formulary

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309183537
Total Pages : 280 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Description and Analysis of the VA National Formulary by : Institute of Medicine

Download or read book Description and Analysis of the VA National Formulary written by Institute of Medicine and published by National Academies Press. This book was released on 2000-10-03 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The VA National Formulary generated controversy, which motivated congressional scrutiny and a directive to the VA to commission this report reviewing the experience with the National Formulary and formulary system. This Institute of Medicine committee was pleased to assist the Congress with this review, in part because the committee saw in the VHA example an opportunity to understand and anticipate problems that all publicly funded programs are likely to encounter in this new age of pharmaceuticals. The Congress asked the committee to review the restrictiveness of the National Formulary, its impact on the costs and quality of care in the VHA, and how it compared to formularies and drug management practices in the private sector and in other public programs, especially Medicaid. Detailed in the pages that follow, the committee's findings and conclusions on these questions are, the committee believes, highly instructive, though not always in the ways that we anticipated.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 288 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Drugs for Life

Author : Joseph Dumit
Publisher : Duke University Press
ISBN 13 : 0822348713
Total Pages : 277 pages
Book Rating : 4.8/5 (223 download)

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Book Synopsis Drugs for Life by : Joseph Dumit

Download or read book Drugs for Life written by Joseph Dumit and published by Duke University Press. This book was released on 2012-09-03 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Challenges our understanding of health, risks, facts, and clinical trials [Payot]

Drug Repurposing

Author : Farid A. Badria
Publisher : BoD – Books on Demand
ISBN 13 : 1839685204
Total Pages : 236 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Drug Repurposing by : Farid A. Badria

Download or read book Drug Repurposing written by Farid A. Badria and published by BoD – Books on Demand. This book was released on 2020-12-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Drugs Looking for Diseases

Author : R. Vos
Publisher :
ISBN 13 : 9789401137973
Total Pages : 416 pages
Book Rating : 4.1/5 (379 download)

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Book Synopsis Drugs Looking for Diseases by : R. Vos

Download or read book Drugs Looking for Diseases written by R. Vos and published by . This book was released on 1990-12-31 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Coronary Artery Disease: Therapeutics and Drug Discovery

Author : Miao Wang
Publisher : Springer Nature
ISBN 13 : 981152517X
Total Pages : 345 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Coronary Artery Disease: Therapeutics and Drug Discovery by : Miao Wang

Download or read book Coronary Artery Disease: Therapeutics and Drug Discovery written by Miao Wang and published by Springer Nature. This book was released on 2020-04-03 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.

Rare Diseases and Orphan Drugs

Author : Jules J. Berman
Publisher : Academic Press
ISBN 13 : 0124200095
Total Pages : 407 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis Rare Diseases and Orphan Drugs by : Jules J. Berman

Download or read book Rare Diseases and Orphan Drugs written by Jules J. Berman and published by Academic Press. This book was released on 2014-05-26 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common. Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseases Stresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathology Discusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchers Offers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases

Anatomy of an Epidemic

Author : Robert Whitaker
Publisher : Crown
ISBN 13 : 0307452425
Total Pages : 418 pages
Book Rating : 4.3/5 (74 download)

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Book Synopsis Anatomy of an Epidemic by : Robert Whitaker

Download or read book Anatomy of an Epidemic written by Robert Whitaker and published by Crown. This book was released on 2011-08-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with bonus material, including a new foreword and afterword with new research, this New York Times bestseller is essential reading for a time when mental health is constantly in the news. In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Interwoven with Whitaker’s groundbreaking analysis of the merits of psychiatric medications are the personal stories of children and adults swept up in this epidemic. As Anatomy of an Epidemic reveals, other societies have begun to alter their use of psychiatric medications and are now reporting much improved outcomes . . . so why can’t such change happen here in the United States? Why have the results from these long-term studies—all of which point to the same startling conclusion—been kept from the public? Our nation has been hit by an epidemic of disabling mental illness, and yet, as Anatomy of an Epidemic reveals, the medical blueprints for curbing that epidemic have already been drawn up. Praise for Anatomy of an Epidemic “The timing of Robert Whitaker’s Anatomy of an Epidemic, a comprehensive and highly readable history of psychiatry in the United States, couldn’t be better.”—Salon “Anatomy of an Epidemic offers some answers, charting controversial ground with mystery-novel pacing.”—TIME “Lucid, pointed and important, Anatomy of an Epidemic should be required reading for anyone considering extended use of psychiatric medicine. Whitaker is at the height of his powers.” —Greg Critser, author of Generation Rx

Modern Methods of Clinical Investigation

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309042860
Total Pages : 241 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Modern Methods of Clinical Investigation by : Institute of Medicine

Download or read book Modern Methods of Clinical Investigation written by Institute of Medicine and published by National Academies Press. This book was released on 1990-02-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The very rapid pace of advances in biomedical research promises us a wide range of new drugs, medical devices, and clinical procedures. The extent to which these discoveries will benefit the public, however, depends in large part on the methods we choose for developing and testing them. Modern Methods of Clinical Investigation focuses on strategies for clinical evaluation and their role in uncovering the actual benefits and risks of medical innovation. Essays explore differences in our current systems for evaluating drugs, medical devices, and clinical procedures; health insurance databases as a tool for assessing treatment outcomes; the role of the medical profession, the Food and Drug Administration, and industry in stimulating the use of evaluative methods; and more. This book will be of special interest to policymakers, regulators, executives in the medical industry, clinical researchers, and physicians.

Results from the ... National Survey on Drug Use and Health

Author : National Survey on Drug Use and Health (U.S.)
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (7 download)

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Book Synopsis Results from the ... National Survey on Drug Use and Health by : National Survey on Drug Use and Health (U.S.)

Download or read book Results from the ... National Survey on Drug Use and Health written by National Survey on Drug Use and Health (U.S.) and published by . This book was released on 2002 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drugs, Brains, and Behavior

Author :
Publisher :
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Drugs, Brains, and Behavior by :

Download or read book Drugs, Brains, and Behavior written by and published by . This book was released on 2007 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Selection and Use of Essential Medicines

Author : WHO Expert Committee on the Selection and Use of Essential Medicines
Publisher : WHO
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis The Selection and Use of Essential Medicines by : WHO Expert Committee on the Selection and Use of Essential Medicines

Download or read book The Selection and Use of Essential Medicines written by WHO Expert Committee on the Selection and Use of Essential Medicines and published by WHO. This book was released on 2004 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents the recommendations of the WHO Expert Committee responsible for updating the WHO Model List of Essential Medicines. The first part contains a progress report on the new procedures for updating the Model List and the development of the WHO Essential Medicines Library. It continues with a section on changes made in revising the Model List followed by a review of some sections such as hypertensive medicines and fast track procedures for deleting items. Annexes include the 13th version of the Model List and items on the list sorted according to their 5-level Anatomical Therapeutic Chemical classification codes.