Drug Interactions In Infectious Diseases Mechanisms And Models Of Drug Interactions

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Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

Author : Manjunath P. Pai
Publisher : Springer
ISBN 13 : 3319724223
Total Pages : 326 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions by : Manjunath P. Pai

Download or read book Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions written by Manjunath P. Pai and published by Springer. This book was released on 2018-03-05 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.

Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions

Author : Manjunath P. Pai
Publisher : Springer
ISBN 13 : 3319724169
Total Pages : 565 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions by : Manjunath P. Pai

Download or read book Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions written by Manjunath P. Pai and published by Springer. This book was released on 2018-03-19 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Antimicrobial Drug Interactions,” delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.

Drug Interactions in Infectious Diseases

Author : Stephen C. Piscitelli
Publisher : Springer Science & Business Media
ISBN 13 : 1592599249
Total Pages : 534 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Drug Interactions in Infectious Diseases by : Stephen C. Piscitelli

Download or read book Drug Interactions in Infectious Diseases written by Stephen C. Piscitelli and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 25 years, the world’s population has witnessed an explosion in kno- edge about infectious diseases. The global population is coming to the realization that diseases long recognized to cause substantial suffering, such as malaria, tuberculosis, schistosomiasis, and hepatitis, can be diagnosed and treated, and that transmission can be prevented using tools that are available, and which may be becoming increasingly affordable. The global population is recognizing that few infections are local: the travel of humans, other animals, insects, and food transport pathogens around the world, often with astonishing rapidity. New pathogens are appearing, either newly recognized or newly developing, such as severe acute respiratory syndrome (SARS), avian inf- enza, metapneumovirus, or hepatitis C, which are causing human morbidity and m- tality. Finally, there is growing fear that dangerous pathogens may be intentionally introduced into human populations by deranged individuals or terrorist organizations. The potential to use drugs or biologic agents to treat and prevent infectious diseases has increased dramatically over the past quarter century as we have learned more about the biology of many of these agents, and as we have developed techniques to discover new agents by high throughput screening programs and by sophisticated drug design and synthesis.

Drug Interactions in Infectious Diseases

Author : Stephen C. Piscitelli
Publisher : Springer Science & Business Media
ISBN 13 : 9781617792137
Total Pages : 692 pages
Book Rating : 4.7/5 (921 download)

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Book Synopsis Drug Interactions in Infectious Diseases by : Stephen C. Piscitelli

Download or read book Drug Interactions in Infectious Diseases written by Stephen C. Piscitelli and published by Springer Science & Business Media. This book was released on 2011-09-08 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The third edition features five new chapters that cover material not addressed in previous editions. These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide and ketolide agents. A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development. These chapters address material that cannot be retrieved easily in the medical literature. The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references. The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions. Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation. This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features • Definitive reference source of up-to-date information on antimicrobial drug interactions • Informative tables on the degree of interaction for specific antimicrobial agents • In-depth discussion of mechanisms and potential mechanistic pathways of interaction • New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents • New chapter on probe-cocktail studies as a research tool to study drug-drug interactions • Inclusion of new antimicrobial agents and their associated drug interactions • First rate chapters on study design and analysis, and drug-food interactions • A fresh perspective on drug-cytokine interactions • Authoritative chapter on regulatory considerations of drug interactions during drug development

Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs

Author : Tony K. L. Kiang
Publisher : Springer
ISBN 13 : 9811021139
Total Pages : 135 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs by : Tony K. L. Kiang

Download or read book Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs written by Tony K. L. Kiang and published by Springer. This book was released on 2016-12-21 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today.

The ESC Textbook of Cardiovascular Medicine

Author : A. John Camm
Publisher :
ISBN 13 : 9780198824879
Total Pages : 3198 pages
Book Rating : 4.8/5 (248 download)

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Book Synopsis The ESC Textbook of Cardiovascular Medicine by : A. John Camm

Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Interactions and Their Mechanisms

Author : Ivan H. Stockley
Publisher :
ISBN 13 : 9780853691198
Total Pages : 82 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Drug Interactions and Their Mechanisms by : Ivan H. Stockley

Download or read book Drug Interactions and Their Mechanisms written by Ivan H. Stockley and published by . This book was released on 1977 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug-Drug Interactions

Author : Dong Hyun Kim
Publisher : Mdpi AG
ISBN 13 : 9783036520353
Total Pages : 242 pages
Book Rating : 4.5/5 (23 download)

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Book Synopsis Drug-Drug Interactions by : Dong Hyun Kim

Download or read book Drug-Drug Interactions written by Dong Hyun Kim and published by Mdpi AG. This book was released on 2021-09-17 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can also be suggested. In the case of the substance targeted for interaction, not only the DDIs but also the herb-drug or food-drug interactions have been reported to be clinically relevant in terms of adverse side effects. Reporting examples of drug interactions on a marketed drug or studies on new mechanisms will be very helpful for preventing the side effects of the patient taking these drugs. This Special Issue aims to highlight current progress in understanding both the clinical and nonclinical interactions of commercial drugs and the elucidation of the mechanisms of drug interactions.

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Author : H.Gerhard Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 3540898905
Total Pages : 576 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Drug Discovery and Evaluation: Methods in Clinical Pharmacology by : H.Gerhard Vogel

Download or read book Drug Discovery and Evaluation: Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Mechanisms of Drug Interactions

Author : Patrick F. D'Arcy
Publisher : Springer Science & Business Media
ISBN 13 : 3642610153
Total Pages : 373 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Mechanisms of Drug Interactions by : Patrick F. D'Arcy

Download or read book Mechanisms of Drug Interactions written by Patrick F. D'Arcy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years a number of excellent books have classified and detailed drug drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering intestinal absorption or bioavailability; those involving hepatic metabolising enzymes; those involving competition or antagonism for receptor sites, and drug interactions modifying excretory mechanisms. Such books have presented extensive tables of interactions and their management. Although of considerable value to clinicians, such publica tions have not, however, been so expressive about the individual mechanisms that underlie these interactions. It is within this sphere of "mechanisms" that this present volume specialises. It deals with mechanisms of in vitro and in vivo, drug-drug, drug food and drug-herbals interactions and those that cause drugs to interfere with diagnostic laboratory tests. We believe that an explanation of the mechanisms of such interactions will enable practitioners to understand more fully the nature of the interactions and thus enable them to manage better their clinical outcome. If mechanisms of interactions are better understood, then it may be pos sible for the researcher to develop meaningful animal/biochemical/tissue cul ture or physicochemical models to which new molecules could be exposed during their development stages. The present position, which largely relies on patients experiencing adverse interactions before they can be established or documented, can hardly be regarded as satisfactory. This present volume is classified into two major parts; firstly, pharmacoki netic drug interactions and, secondly, pharmacodynamic drug interactions.

Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials

Author : Tony K.L. Kiang
Publisher : Adis
ISBN 13 : 9783319381930
Total Pages : 0 pages
Book Rating : 4.3/5 (819 download)

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Book Synopsis Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials by : Tony K.L. Kiang

Download or read book Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials written by Tony K.L. Kiang and published by Adis. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

Drug Interactions

Author : Ivan H. Stockley
Publisher :
ISBN 13 : 9780632998432
Total Pages : 495 pages
Book Rating : 4.9/5 (984 download)

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Book Synopsis Drug Interactions by : Ivan H. Stockley

Download or read book Drug Interactions written by Ivan H. Stockley and published by . This book was released on 1981 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Infectious Diseases and Arthropods

Author : Jerome Goddard
Publisher : Springer
ISBN 13 : 3319758748
Total Pages : 277 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Infectious Diseases and Arthropods by : Jerome Goddard

Download or read book Infectious Diseases and Arthropods written by Jerome Goddard and published by Springer. This book was released on 2018-05-04 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the exception of a few tropical medicine schools worldwide, current medical education programs include almost zero discussion of the interface between infectious diseases and entomology. That is why this book was initially published in the first edition almost 17 years ago. The third edition of this valuable infectious disease entomology book updates all existing chapters with the newest scientific developments described in the medical and entomological literature in addition to covering 10 entirely new topics not addressed in previous editions, which include: · arthropod identification controversies · early beginnings of public health and disease control · red-meat allergy · updates on vaccine development for dengue and malaria · discussion of Chikungunya and Zika viruses · American Boutonnneuse Fever · the newest controversies in Lyme disease · recent findings of viruses in ticks · bed bug bite reactions · Morgellons disease (an imaginary infectious disease)

Diagnosis and Treatment of Fungal Infections

Author : Duane R. Hospenthal
Publisher : Springer Nature
ISBN 13 : 3031358031
Total Pages : 426 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Diagnosis and Treatment of Fungal Infections by : Duane R. Hospenthal

Download or read book Diagnosis and Treatment of Fungal Infections written by Duane R. Hospenthal and published by Springer Nature. This book was released on 2023-09-14 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis and Treatment of Fungal Infections, 3rd Edition contains the latest research and clinical evidence on fungal infections in humans. Updated again by globally recognized experts, this concise text is divided into sections dedicated to the patient approach, laboratory and radiological diagnosis, systemic antifungal agents, mycoses, and instructive cases. It is a concise but comprehensive resource for use in conjunction with patient care duties and in teaching. It is the perfect guide for hospital-based primary care physicians, oncologists, critical care specialists, and infectious disease fellows with limited training or experience in the identification and management of fungal infections.

Modeling and Control of Infectious Diseases in the Host

Author : Esteban A. Hernandez-Vargas
Publisher : Academic Press
ISBN 13 : 0128130520
Total Pages : 256 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Modeling and Control of Infectious Diseases in the Host by : Esteban A. Hernandez-Vargas

Download or read book Modeling and Control of Infectious Diseases in the Host written by Esteban A. Hernandez-Vargas and published by Academic Press. This book was released on 2019-02-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

Organ Donation and Transplantation

Author : Georgios Tsoulfas
Publisher : BoD – Books on Demand
ISBN 13 : 1789233402
Total Pages : 454 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Organ Donation and Transplantation by : Georgios Tsoulfas

Download or read book Organ Donation and Transplantation written by Georgios Tsoulfas and published by BoD – Books on Demand. This book was released on 2018-07-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most interesting and at the same time most challenging fields of medicine and surgery has been that of organ donation and transplantation. It is a field that has made tremendous strides during the last few decades through the combined input and efforts of scientists from various specialties. What started as a dream of pioneers has become a reality for the thousands of our patients whose lives can now be saved and improved. However, at the same time, the challenges remain significant and so do the expectations. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care of these patients.The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of organ donation and transplantation.

Handbook of Drug-Nutrient Interactions

Author : Joseph I. Boullata
Publisher : Springer Science & Business Media
ISBN 13 : 160327362X
Total Pages : 824 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Handbook of Drug-Nutrient Interactions by : Joseph I. Boullata

Download or read book Handbook of Drug-Nutrient Interactions written by Joseph I. Boullata and published by Springer Science & Business Media. This book was released on 2010-03-17 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years since publication of the first edition of the Handbook of Drug-Nutrient Interactions new perspectives have emerged and new data have been generated on the subject matter. Providing both the scientific basis and clinical relevance with appropriate recommendations for many interactions, the topic of drug-nutrient interactions is significant for clinicians and researchers alike. For clinicians in particular, the book offers a guide for understanding, identifying or predicting, and ultimately preventing or managing drug-nutrient interactions to optimize patient care. Divided into six sections all chapters have been revised or are new to this edition. Chapters balance the most technical information with practical discussions and include outlines that reflect the content; discussion questions that can guide the reader to the critical areas covered in each chapter, complete definitions of terms with the abbreviation fully defined and consistent use of terms between chapters. The editors have performed an outstanding service to clinical pharmacology and pharmaco-nutrition by bringing together a multi-disciplinary group of authors. Handbook of Drug-Nutrient Interactions, Second Edition is a comprehensive up-to-date text for the total management of patients on drug and/or nutrition therapy but also an insight into the recent developments in drug-nutrition interactions which will act as a reliable reference for clinicians and students for many years to come.