Drug Drug Interaction Primer

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Drug-Drug Interaction Primer

Author : Neil B. Sandson
Publisher : American Psychiatric Pub
ISBN 13 : 1585626775
Total Pages : 409 pages
Book Rating : 4.5/5 (856 download)

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Book Synopsis Drug-Drug Interaction Primer by : Neil B. Sandson

Download or read book Drug-Drug Interaction Primer written by Neil B. Sandson and published by American Psychiatric Pub. This book was released on 2008-05-20 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating -- even entertaining -- approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient's trimethoprim-sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity. An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction(s) occurred, and each derives from sound clinical evidence -- not merely extrapolations from drug characteristics -- to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents -- as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book's other features: Reorganization by medical subspecialty -- psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology -- better facilitates clinical application. Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein. DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins. Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed. These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner's skills.

Handbook of Drug Interactions

Author : Ashraf Mozayani
Publisher : Humana Press
ISBN 13 : 9781617374241
Total Pages : 663 pages
Book Rating : 4.3/5 (742 download)

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Book Synopsis Handbook of Drug Interactions by : Ashraf Mozayani

Download or read book Handbook of Drug Interactions written by Ashraf Mozayani and published by Humana Press. This book was released on 2010-10-28 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents. Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

The People's Guide To Deadly Drug Interactions

Author : Joe Graedon, MS
Publisher : Macmillan
ISBN 13 : 9780312155100
Total Pages : 472 pages
Book Rating : 4.1/5 (551 download)

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Book Synopsis The People's Guide To Deadly Drug Interactions by : Joe Graedon, MS

Download or read book The People's Guide To Deadly Drug Interactions written by Joe Graedon, MS and published by Macmillan. This book was released on 1997-04-15 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Did You Know? Eating too much broccoli could be deadly if you also take the popluar blood thinner called Coumadin (warfarin)? Grapefruit juice, when used to wash down certain atihistamines, immune suppressors, or blood pressure drugs, can cause blood levels of these powerful drugs to soar? The result: serious side effects. Birth control pills might be rendered ineffective by the following substances: barbituates, antibiotics, anti-fungal drugs, tuberculosis drugs, certain anticonvulsants? Is Your Life In Danger? Everyone has taken more than one pill simultaneously. Yet every time you combine drugs with prescription medicines, foods, vitamins, minerals, herbs or alcohol you explose yourself to the risk of a potentially dangerous interaction. Deadly Drug Interactions Can Help You. Over 200 easy-to-understand charts with information on medications for pain relief, allergies, asthma, arthritis, heart problems, depression, diabetes, contraception, ulcers and much more. Descriptions of the symptoms of interactions. Specific concerns of women, children and older people. Vital information of Lanoxin, Cardizem, Prozac, Mevacor, Ortho-Novum, Tagamet, Coumadin, Dilatin, Cipro, Synthroid, Procardia, and scores of other commonly prescribed medicines.

Concise Guide to Drug Interaction Principles for Medical Practice

Author : Kelly L. Cozza
Publisher : American Psychiatric Publishing
ISBN 13 :
Total Pages : 88 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Concise Guide to Drug Interaction Principles for Medical Practice by : Kelly L. Cozza

Download or read book Concise Guide to Drug Interaction Principles for Medical Practice written by Kelly L. Cozza and published by American Psychiatric Publishing. This book was released on 2003 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia—coupled with prolonged human life spans—has made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.

Drug Interactions

Author : Ivan H. Stockley
Publisher :
ISBN 13 :
Total Pages : 1018 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Interactions by : Ivan H. Stockley

Download or read book Drug Interactions written by Ivan H. Stockley and published by . This book was released on 1996 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a source book of adverse drug reactions covering their clinical importance, mechanisms and management. This fourth edition has been revised from an extensive database. Major interaction mechanisms are followed by alphabetically-arranged material covering all the drug groups. As with prior editions, there is a series of monographs with a consistent plan devised to offer quick and easy reading. Both British and American drug names have been used throughout the book and bibliogrpahies are provided for those who wish to use the book as a reference source.

Drug-Drug Interactions for Therapeutic Biologics

Author : Honghui Zhou
Publisher : John Wiley & Sons
ISBN 13 : 1118630211
Total Pages : 272 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Drug-Drug Interactions for Therapeutic Biologics by : Honghui Zhou

Download or read book Drug-Drug Interactions for Therapeutic Biologics written by Honghui Zhou and published by John Wiley & Sons. This book was released on 2013-05-10 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.

Handbook of Drug Interaction and the Mechanism of Interaction

Author : Qutaiba A. Ibrahim
Publisher : Xlibris Corporation
ISBN 13 : 1465301925
Total Pages : 305 pages
Book Rating : 4.4/5 (653 download)

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Book Synopsis Handbook of Drug Interaction and the Mechanism of Interaction by : Qutaiba A. Ibrahim

Download or read book Handbook of Drug Interaction and the Mechanism of Interaction written by Qutaiba A. Ibrahim and published by Xlibris Corporation. This book was released on 2011-09-28 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook is offered as a general summary of information for physicians, pharmacists, nurses and other health professionals. Inappropriate administration of interacting drugs to patients can result in severe injury or death.

The Top 100 Drug Interactions

Author : Philip D. Hansten
Publisher : H & H Publishing Company
ISBN 13 : 9780981944005
Total Pages : 0 pages
Book Rating : 4.9/5 (44 download)

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Book Synopsis The Top 100 Drug Interactions by : Philip D. Hansten

Download or read book The Top 100 Drug Interactions written by Philip D. Hansten and published by H & H Publishing Company. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Manual of Adverse Drug Interactions

Author : J.P. Griffin
Publisher : Elsevier
ISBN 13 : 0080525830
Total Pages : 665 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis A Manual of Adverse Drug Interactions by : J.P. Griffin

Download or read book A Manual of Adverse Drug Interactions written by J.P. Griffin and published by Elsevier. This book was released on 1997-11-17 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship. Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions. The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders. If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.

Drug Interaction Facts

Author :
Publisher :
ISBN 13 :
Total Pages : 1174 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Interaction Facts by :

Download or read book Drug Interaction Facts written by and published by . This book was released on 1996 with total page 1174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adverse Drug Interactions

Author : Lakshman Delgoda Karalliedde
Publisher : CRC Press
ISBN 13 : 0429586337
Total Pages : 678 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Adverse Drug Interactions by : Lakshman Delgoda Karalliedde

Download or read book Adverse Drug Interactions written by Lakshman Delgoda Karalliedde and published by CRC Press. This book was released on 2016-04-05 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adverse Drug Interactions: A Handbook for Prescribers assists clinicians by providing key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use. Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted.

A Pharmacology Primer

Author : Terrence P. Kenakin
Publisher : Gulf Professional Publishing
ISBN 13 : 9780124041615
Total Pages : 234 pages
Book Rating : 4.0/5 (416 download)

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Book Synopsis A Pharmacology Primer by : Terrence P. Kenakin

Download or read book A Pharmacology Primer written by Terrence P. Kenakin and published by Gulf Professional Publishing. This book was released on 2004 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know more about the basic theories, principles and practical applications of pharmacology.

Enzyme- and Transporter-Based Drug-Drug Interactions

Author : K. Sandy Pang
Publisher : Springer Science & Business Media
ISBN 13 : 1441908404
Total Pages : 742 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Enzyme- and Transporter-Based Drug-Drug Interactions by : K. Sandy Pang

Download or read book Enzyme- and Transporter-Based Drug-Drug Interactions written by K. Sandy Pang and published by Springer Science & Business Media. This book was released on 2009-12-17 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.

Pocket Guide to Evaluations of Drug Interactions

Author : Frederic J. Zucchero
Publisher : American Pharmaceutical Association
ISBN 13 : 9780917330933
Total Pages : 468 pages
Book Rating : 4.3/5 (39 download)

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Book Synopsis Pocket Guide to Evaluations of Drug Interactions by : Frederic J. Zucchero

Download or read book Pocket Guide to Evaluations of Drug Interactions written by Frederic J. Zucchero and published by American Pharmaceutical Association. This book was released on 1999 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: A condensed version of Evaluations of Drug Interactions, designed to facilitate quick access to the information most frequently needed by busy health practitioners. It contains 952 drug interaction monographs organized by drug class. Most monographs contain eight concise pieces of information and the volume is indexed by generic names.

Drug Interactions

Author : Joseph A. Albanese
Publisher : McGraw-Hill Companies
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Interactions by : Joseph A. Albanese

Download or read book Drug Interactions written by Joseph A. Albanese and published by McGraw-Hill Companies. This book was released on 1978 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug-Drug Interactions: Scientific and Regulatory Perspectives

Author :
Publisher : Academic Press
ISBN 13 : 0080581358
Total Pages : 324 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Drug-Drug Interactions: Scientific and Regulatory Perspectives by :

Download or read book Drug-Drug Interactions: Scientific and Regulatory Perspectives written by and published by Academic Press. This book was released on 1997-11-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug drug interactions, the prediction of drug drug interaction potential of new drugs, and the avoidance of clinically significant drug drug interaction in patients. Provides useful references on the science of drug-drug interactions Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint Contains original data from academic and industrial laboratories Presents an overview of regulatory agency positions

Drug Interactions

Author : Philip D. Hansten
Publisher :
ISBN 13 : 9780812109443
Total Pages : 480 pages
Book Rating : 4.1/5 (94 download)

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Book Synopsis Drug Interactions by : Philip D. Hansten

Download or read book Drug Interactions written by Philip D. Hansten and published by . This book was released on 1985 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: A reference text for clinicians, pharmacologists, and physicians provides summaries of the human in vivo interactions of drug with other medications. The text assumes a basic understanding of pharmacological and physiological principles, and delineates current knowledge on the mechanisms of drug-drug interaction, clinical significance, and precautions to be exercised during drug therapy. The drug-drug interactions are arranged by drug or drug class, but, when appropriate, interactions for a given drug may be given in several locations in the text. All of the drug-drug interaction covered have been assigned to 1 of 3 categories of clinical significance (viz., major, moderate, or minor) based on the severity of the potential interaction. The interactions are listed under 16 drug categories: antiarrhythmics, oral anticogulants, general anticoagulants, antidiabetics, antihypertensive, anti-infective, anti-neoplastic, digitalis drug, diuretics, monoamine oxidase inhibitors, tricylic antidepressants,and drug interactions with ethanol, hormones, phenothiazine, and salicylate. (wz).