Drug Discovery In Cancer Epigenetics

Download Drug Discovery In Cancer Epigenetics full books in PDF, epub, and Kindle. Read online Drug Discovery In Cancer Epigenetics ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Drug Discovery in Cancer Epigenetics

Author : Gerda Egger
Publisher : Academic Press
ISBN 13 : 0128024925
Total Pages : 498 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Drug Discovery in Cancer Epigenetics by : Gerda Egger

Download or read book Drug Discovery in Cancer Epigenetics written by Gerda Egger and published by Academic Press. This book was released on 2015-11-19 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Epigenetics for Drug Discovery

Author : Nessa Carey
Publisher : Royal Society of Chemistry
ISBN 13 : 1849738823
Total Pages : 338 pages
Book Rating : 4.8/5 (497 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics for Drug Discovery by : Nessa Carey

Download or read book Epigenetics for Drug Discovery written by Nessa Carey and published by Royal Society of Chemistry. This book was released on 2015-11-20 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide an invaluable guide to epigenetics, one of the fastest moving fields in drug discovery, for medicinal chemists working in academia and in the pharmaceutical industry.

Epigenetic Cancer Therapy

Author : Steven Gray
Publisher : Elsevier
ISBN 13 : 0323917151
Total Pages : 773 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Epigenetic Cancer Therapy by : Steven Gray

Download or read book Epigenetic Cancer Therapy written by Steven Gray and published by Elsevier. This book was released on 2023-05-03 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution Features chapter contributions from leading experts in the field

Epigenetic Drug Discovery

Author : Wolfgang Sippl
Publisher : John Wiley & Sons
ISBN 13 : 3527343148
Total Pages : 504 pages
Book Rating : 4.5/5 (273 download)

DOWNLOAD NOW!

Book Synopsis Epigenetic Drug Discovery by : Wolfgang Sippl

Download or read book Epigenetic Drug Discovery written by Wolfgang Sippl and published by John Wiley & Sons. This book was released on 2019-03-25 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

DOWNLOAD NOW!

Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Epigenetic Approaches in Drug Discovery, Development and Treatment

Author : Shibashish Giri
Publisher : Frontiers Media SA
ISBN 13 : 2889639320
Total Pages : 130 pages
Book Rating : 4.8/5 (896 download)

DOWNLOAD NOW!

Book Synopsis Epigenetic Approaches in Drug Discovery, Development and Treatment by : Shibashish Giri

Download or read book Epigenetic Approaches in Drug Discovery, Development and Treatment written by Shibashish Giri and published by Frontiers Media SA. This book was released on 2020-08-07 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Establishment of a normal phenotype involves dynamic epigenetic regulation of gene expression that when affected contributes to human diseases. On a molecular level, epigenetic regulation is marked by specific covalent modifications (acetylation, methylation, phosphorylation, sumoylation, PARylation and ubiquitylation) of DNA and its associated histones. Studies also suggest the influence of such epigenetic modifications on non-coding RNA expression implicated in normal and diseased phenotypes. Epigenetic control of genetic expression is a reversible process essential for normal development and function of an organism. Alteration of epigenetic regulation leads to various disease forms such as cancer, diabetes, inflammation and neuropsychiatric disorders. Assessing these alterations provides a deeper insight into the changes induced in the genome, which is often informative for identifying disease subtypes or developing suitable treatments. Therefore, epigenetics proves to be a key area of clinical investigation in diagnosis, prognosis, and treatment of complex diseases. Genetic mutations, environmental stress, pathogens and drugs of abuse are some of the predominant factors that induce and impact changes on chromatin, which directly dictate a diseased phenotype. It is essential to consider the interaction between genetic and epigenetic factors to understand the molecular mechanisms of complex human diseases for safer and efficient drug development. Furthermore, genetic variation in absorption, distribution, metabolism, and excretion (ADME) genes is insufficient to account for interindividual variability of drug response. Therefore, current efforts aim to identify epigenetic components of ADME gene regulation, which include phase-I and phase-II enzymes, uptake transporters, efflux transporters and nuclear receptors involved in regulation of ADME genes. Monitoring circulatory epigenetic biomarkers in liquid biopsies (blood, saliva, urine, cerebrospinal fluid) of disease-associated and drug-associated epigenetic alterations may prove useful for decision support for routine clinical treatment and drug discovery. Hence, recent drug discovery efforts on targeting the epigenome, has emerged an area of interest with several new drugs being developed, tested and some already approved by the US Food and Drug Administration (FDA). These new insights into the complexities of epigenetic regulation are key contributors to our basic understanding of this process in human health and disease, which will provide scope for innovative drug therapies. It is of urgency to aid the present understanding of epigenomics driven diseased outcomes, with the expectation that further studies will identify early markers of disease and targets for therapeutics.

Epigenetics in Cancer: Mechanisms and Drug Development

Author : Xiao Zhu
Publisher : Frontiers Media SA
ISBN 13 : 2889743764
Total Pages : 183 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics in Cancer: Mechanisms and Drug Development by : Xiao Zhu

Download or read book Epigenetics in Cancer: Mechanisms and Drug Development written by Xiao Zhu and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Epigenetics in Precision Medicine

Author : Jose Luis Garcia-Gimenez
Publisher : Elsevier
ISBN 13 : 0323858058
Total Pages : 616 pages
Book Rating : 4.3/5 (238 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics in Precision Medicine by : Jose Luis Garcia-Gimenez

Download or read book Epigenetics in Precision Medicine written by Jose Luis Garcia-Gimenez and published by Elsevier. This book was released on 2021-11-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Epigenetics and Disease

Author : Susan M. Gasser
Publisher : Springer Science & Business Media
ISBN 13 : 3764389893
Total Pages : 276 pages
Book Rating : 4.7/5 (643 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics and Disease by : Susan M. Gasser

Download or read book Epigenetics and Disease written by Susan M. Gasser and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

Epigenetics in Cancer: Mechanisms and Drug Development - Volume II

Author : Xiao Zhu
Publisher : Frontiers Media SA
ISBN 13 : 2832530419
Total Pages : 141 pages
Book Rating : 4.8/5 (325 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics in Cancer: Mechanisms and Drug Development - Volume II by : Xiao Zhu

Download or read book Epigenetics in Cancer: Mechanisms and Drug Development - Volume II written by Xiao Zhu and published by Frontiers Media SA. This book was released on 2023-09-27 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Epigenetic Targets in Drug Discovery

Author : Wolfgang Sippl
Publisher : Wiley-VCH
ISBN 13 : 9783527323555
Total Pages : 314 pages
Book Rating : 4.3/5 (235 download)

DOWNLOAD NOW!

Book Synopsis Epigenetic Targets in Drug Discovery by : Wolfgang Sippl

Download or read book Epigenetic Targets in Drug Discovery written by Wolfgang Sippl and published by Wiley-VCH. This book was released on 2009-08-03 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.

Cancer Epigenetics

Author : Antonio Giordano
Publisher : John Wiley & Sons
ISBN 13 : 9781118005736
Total Pages : 448 pages
Book Rating : 4.0/5 (57 download)

DOWNLOAD NOW!

Book Synopsis Cancer Epigenetics by : Antonio Giordano

Download or read book Cancer Epigenetics written by Antonio Giordano and published by John Wiley & Sons. This book was released on 2011-10-07 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

DNA and Histone Methylation as Cancer Targets

Author : Atsushi Kaneda
Publisher : Springer
ISBN 13 : 3319597868
Total Pages : 624 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!

Book Synopsis DNA and Histone Methylation as Cancer Targets by : Atsushi Kaneda

Download or read book DNA and Histone Methylation as Cancer Targets written by Atsushi Kaneda and published by Springer. This book was released on 2017-09-04 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

Epigenetics Territory and Cancer

Author : Parvin Mehdipour
Publisher : Springer
ISBN 13 : 9401796394
Total Pages : 539 pages
Book Rating : 4.4/5 (17 download)

DOWNLOAD NOW!

Book Synopsis Epigenetics Territory and Cancer by : Parvin Mehdipour

Download or read book Epigenetics Territory and Cancer written by Parvin Mehdipour and published by Springer. This book was released on 2015-03-18 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.

Epigenetic Biomarkers and Diagnostics

Author : José Luis García-Giménez
Publisher : Academic Press
ISBN 13 : 0128019212
Total Pages : 696 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Epigenetic Biomarkers and Diagnostics by : José Luis García-Giménez

Download or read book Epigenetic Biomarkers and Diagnostics written by José Luis García-Giménez and published by Academic Press. This book was released on 2015-12-07 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Advances in Cancer Research

Author :
Publisher : Elsevier
ISBN 13 : 9780080471013
Total Pages : 432 pages
Book Rating : 4.4/5 (71 download)

DOWNLOAD NOW!

Book Synopsis Advances in Cancer Research by :

Download or read book Advances in Cancer Research written by and published by Elsevier. This book was released on 2011-07-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development – Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.

Epigenetic Therapy of Cancer

Author : Michael Lübbert
Publisher : Springer Science & Business Media
ISBN 13 : 3642384048
Total Pages : 325 pages
Book Rating : 4.6/5 (423 download)

DOWNLOAD NOW!

Book Synopsis Epigenetic Therapy of Cancer by : Michael Lübbert

Download or read book Epigenetic Therapy of Cancer written by Michael Lübbert and published by Springer Science & Business Media. This book was released on 2013-12-12 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.