Drug Discovery And Development For Alzheimers Disease 2000

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Drug Discovery and Development for Alzheimer's Disease, 2000

Author : Howard M. Fillit, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826115349
Total Pages : 297 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Drug Discovery and Development for Alzheimer's Disease, 2000 by : Howard M. Fillit, MD

Download or read book Drug Discovery and Development for Alzheimer's Disease, 2000 written by Howard M. Fillit, MD and published by Springer Publishing Company. This book was released on 2002-01-03 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Drug Design and Discovery in Alzheimer’s Disease

Author : Atta-ur-Rahman
Publisher : Elsevier
ISBN 13 : 0128039604
Total Pages : 784 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Drug Design and Discovery in Alzheimer’s Disease by : Atta-ur-Rahman

Download or read book Drug Design and Discovery in Alzheimer’s Disease written by Atta-ur-Rahman and published by Elsevier. This book was released on 2015-06-27 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Alzheimer's Disease Drug Development

Author : Jeffrey L. Cummings
Publisher :
ISBN 13 : 9781108975759
Total Pages : pages
Book Rating : 4.9/5 (757 download)

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Book Synopsis Alzheimer's Disease Drug Development by : Jeffrey L. Cummings

Download or read book Alzheimer's Disease Drug Development written by Jeffrey L. Cummings and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Alzheimer's Disease Drug Development: A Research and Development Ecosystem captures the complexity of Alzheimer's disease (AD) drug develop and provides a comprehensive set of perspectives from the many stakeholders involved in discovering and developing new therapies for AD. There is no greater unmet therapeutic need for humanity than effective therapies for brain disorders. The suffering caused by these conditions and other neurodegenerative disorders is overwhelming and is burdened with substantial stigma. Therefore, I have devoted my professional life to changing the way brain disorders such as schizophrenia, depression, AD, among others are not only treated, but also viewed by society. From my time with the National Institutes of Health, Janssen and Johnson & Johnson where I serve as the Global Head of Science for Minds, my colleagues and I recognize there is still much to uncover about brain disorders due to the rich complexity of the brain and the challenges in accessing it. But that is not a reason to stop - especially as we enter the golden age of neuroscience, driven largely by scientific breakthroughs and accelerated regulatory pathways"--

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Author : Adeboye Adejare
Publisher : Academic Press
ISBN 13 : 0128028114
Total Pages : 316 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders by : Adeboye Adejare

Download or read book Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders written by Adeboye Adejare and published by Academic Press. This book was released on 2016-09-20 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Frontiers in Clinical Drug Research - Alzheimer Disorders

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681083396
Total Pages : 207 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Frontiers in Clinical Drug Research - Alzheimer Disorders by : Atta-ur-Rahman

Download or read book Frontiers in Clinical Drug Research - Alzheimer Disorders written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2017-07-31 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimer’s disease research.

Developing Therapeutics for Alzheimer's Disease

Author : Michael S. Wolfe
Publisher : Academic Press
ISBN 13 : 0128021640
Total Pages : 676 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Developing Therapeutics for Alzheimer's Disease by : Michael S. Wolfe

Download or read book Developing Therapeutics for Alzheimer's Disease written by Michael S. Wolfe and published by Academic Press. This book was released on 2016-05-27 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Emerging Drugs and Targets for Alzheimer's Disease

Author : Ana Martínez
Publisher : Royal Society of Chemistry
ISBN 13 : 1849730636
Total Pages : 343 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Emerging Drugs and Targets for Alzheimer's Disease by : Ana Martínez

Download or read book Emerging Drugs and Targets for Alzheimer's Disease written by Ana Martínez and published by Royal Society of Chemistry. This book was released on 2010 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Frontiers in Clinical Drug Research - Dementia: Volume 1

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 9811410933
Total Pages : 261 pages
Book Rating : 4.8/5 (114 download)

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Book Synopsis Frontiers in Clinical Drug Research - Dementia: Volume 1 by : Atta-ur-Rahman

Download or read book Frontiers in Clinical Drug Research - Dementia: Volume 1 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2020-06-02 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, - the loss of brain function associated with Alzheimer’s disease and other related medical conditions. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for dementia and related disorders. This volume includes the following reviews: - Meeting the Challenges of Falls and Hip Fractures in People with Alzheimer’s Disease - Cholesterol in Brain Health and Pathologies - Advances in the Treatment of Mild Cognitive Impairment (MCI) and Dementia - Analytical Methods in Alzheimer’s Disease Drug Discovery - Targeting Alzheimer’s Disease through Nanomedicine - Current Challenges in Alzheimer’s Disease Research - Metals Linked to Alzheimer's Disease

Biomarkers for Alzheimer's Disease Drug Development

Author : Robert Perneczky
Publisher : Springer Nature
ISBN 13 : 1071637746
Total Pages : 345 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Biomarkers for Alzheimer's Disease Drug Development by : Robert Perneczky

Download or read book Biomarkers for Alzheimer's Disease Drug Development written by Robert Perneczky and published by Springer Nature. This book was released on 2024 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zusammenfassung: This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer's disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer's disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer's Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease

Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309373263
Total Pages : 128 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders by : Institute of Medicine

Download or read book Financial Incentives to Encourage Development of Therapies That Address Unmet Medical Needs for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2015-10-22 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders, in collaboration with the IOM Forum on Drug Discovery, Development, and Translation, convened a workshop on January 20-21, 2015, to explore policy changes that might increase private sector investment in research and development innovation that fills unmet medical needs for central nervous system (CNS) disorders. Workshop participants strategized about how to incentivize companies to fortify their CNS drug development programs, shrinking obstacles that currently deter ventures. Representatives from academia, government agencies, patient groups, and industry gathered to share information and viewpoints, and to brainstorm about budget-neutral policy changes that could help widen the pipeline toward drugs that address unmet needs for CNS disorders. This report summarizes the presentations and discussion of the workshop.

BACE

Author : Varghese John
Publisher : John Wiley & Sons
ISBN 13 : 0470594071
Total Pages : 284 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis BACE by : Varghese John

Download or read book BACE written by Varghese John and published by John Wiley & Sons. This book was released on 2010-03-05 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.

Alzheimer's Disease

Author : Xudong Huang
Publisher :
ISBN 13 : 9780645001709
Total Pages : pages
Book Rating : 4.0/5 (17 download)

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Book Synopsis Alzheimer's Disease by : Xudong Huang

Download or read book Alzheimer's Disease written by Xudong Huang and published by . This book was released on 2020-12-31 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomarkers for Alzheimer’s Disease Drug Development

Author : Robert Perneczky
Publisher : Humana
ISBN 13 : 9781071637739
Total Pages : 0 pages
Book Rating : 4.6/5 (377 download)

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Book Synopsis Biomarkers for Alzheimer’s Disease Drug Development by : Robert Perneczky

Download or read book Biomarkers for Alzheimer’s Disease Drug Development written by Robert Perneczky and published by Humana. This book was released on 2024-03-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer’s Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease.

Preclinical and Clinical Issues in Alzheimer's Disease Drug Research and Development

Author :
Publisher :
ISBN 13 :
Total Pages : 100 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Preclinical and Clinical Issues in Alzheimer's Disease Drug Research and Development by :

Download or read book Preclinical and Clinical Issues in Alzheimer's Disease Drug Research and Development written by and published by . This book was released on 2015 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pathy's Principles and Practice of Geriatric Medicine

Author : Alan J. Sinclair
Publisher : John Wiley & Sons
ISBN 13 : 1119954142
Total Pages : 3453 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Pathy's Principles and Practice of Geriatric Medicine by : Alan J. Sinclair

Download or read book Pathy's Principles and Practice of Geriatric Medicine written by Alan J. Sinclair and published by John Wiley & Sons. This book was released on 2012-03-13 with total page 3453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of the comprehensive and renowned textbook Principles and Practice of Geriatric Medicine offers a fully revised and updated review of geriatric medicine. It covers the full spectrum of the subject, features 41 new chapters, and provides up-to-date, evidence-based, and practical information about the varied medical problems of ageing citizens. The three editors, from UK, USA and France, have ensured that updated chapters provide a global perspective of geriatric medicine, as well as reflect the changes in treatment options and medical conditions which have emerged since publication of the 4th edition in 2006. The book includes expanded sections on acute stroke, dementia, cardiovascular disease, and respiratory diseases, and features a new section on end-of-life care. In the tradition of previous editions, this all-encompassing text continues to be a must-have text for all clinicians who deal with older people, particularly geriatric medical specialists, gerontologists, researchers, and general practitioners. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store. Praise for the 4th edition: "...an excellent reference for learners at all clinical and preclinical levels and a useful contribution to the geriatric medical literature." —Journal of the American Medical Association, November 2006 5th edition selected for 2012 Edition of Doody's Core TitlesTM

Nutraceuticals and Natural Product Derivatives

Author : Mohammad Fahad Ullah
Publisher : John Wiley & Sons
ISBN 13 : 1119436672
Total Pages : 450 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Nutraceuticals and Natural Product Derivatives by : Mohammad Fahad Ullah

Download or read book Nutraceuticals and Natural Product Derivatives written by Mohammad Fahad Ullah and published by John Wiley & Sons. This book was released on 2019-03-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

Animal Models of Dementia

Author : Peter Paul De Deyn
Publisher : Humana Press
ISBN 13 : 9781607618973
Total Pages : 732 pages
Book Rating : 4.6/5 (189 download)

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Book Synopsis Animal Models of Dementia by : Peter Paul De Deyn

Download or read book Animal Models of Dementia written by Peter Paul De Deyn and published by Humana Press. This book was released on 2010-12-01 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.