Drug Development Supported by Informatics

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Publisher : Springer
ISBN 13 : 9789819748273
Total Pages : 0 pages
Book Rating : 4.7/5 (482 download)

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Book Synopsis Drug Development Supported by Informatics by : Hiroko Satoh

Download or read book Drug Development Supported by Informatics written by Hiroko Satoh and published by Springer. This book was released on 2024-12-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state-of-the-art of chemoinformatics, bioinformatics, materials informatics and measurement/metrology informatics to improve the correlation with the functionality, efficacy, safety and quality of compounds for drugs with good physical properties and activity values. Recently, "AI drug discovery", drug discovery research utilizing artificial intelligence technology such as machine learning has attracted much attention. This book provides an overview of the four applied informatics fields and their applications in drug development for a wide spectrum of readers from learners to professional scientists in academica and industry. It focuses on the basic research stage of drug development with contributions from experts at the forefront of these fields. The authors hope that this book will be of assistance to explore new opportunities for collaboration between pharmaceutical science and informatics.

Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications

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Publisher : IGI Global
ISBN 13 : 1466603100
Total Pages : 442 pages
Book Rating : 4.4/5 (666 download)

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Book Synopsis Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications by : Gasmelseid, Tagelsir Mohamed

Download or read book Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications written by Gasmelseid, Tagelsir Mohamed and published by IGI Global. This book was released on 2012-03-31 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the context of integrated health management domains, pharmacoinformatics aims at maximizing the benefits from the use of information systems and technologies for the provision of decision support tools necessary for improved drug management, use, and administration practices. Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications offers the latest the field has to offer to practitioners and academics alike, presented through theoretical frameworks, case studies, and future directions. This vital resource gathers an integrated pattern of high quality publications from around the world providing current, cutting-edge, and provocative scientific work in the three domains of pharmacoinformatics: decision making domains, knowledge utilization and representation environment, and the technological and infrastructural context.

Functional Informatics in Drug Discovery

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Publisher : CRC Press
ISBN 13 : 9781420015683
Total Pages : 160 pages
Book Rating : 4.0/5 (156 download)

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Book Synopsis Functional Informatics in Drug Discovery by : Sergey Ilyin

Download or read book Functional Informatics in Drug Discovery written by Sergey Ilyin and published by CRC Press. This book was released on 2007-08-27 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical

Data Science and Medical Informatics in Healthcare Technologies

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Publisher : Springer Nature
ISBN 13 : 9811630291
Total Pages : 91 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Data Science and Medical Informatics in Healthcare Technologies by : Nguyen Thi Dieu Linh

Download or read book Data Science and Medical Informatics in Healthcare Technologies written by Nguyen Thi Dieu Linh and published by Springer Nature. This book was released on 2021-06-19 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights a timely and accurate insight at the endeavour of the bioinformatics and genomics clinicians from industry and academia to address the societal needs. The contents of the book unearth the lacuna between the medication and treatment in the current preventive medicinal and pharmaceutical system. It contains chapters prepared by experts in life sciences along with data scientists for examining the circumstances of health care system for the next decade. It also highlights the automated processes for analyzing data in clinical trial research, specifically for drug development. Additionally, the data science solutions provided in this book help pharmaceutical companies to improve on what had historically been manual, costly and laborious process for cross-referencing research in clinical trials on drug development, while laying the groundwork for use with a full range of other drugs for the conditions ranging from tuberculosis, to diabetes, to heart attacks and many others.

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design

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Publisher : Academic Press
ISBN 13 : 0128205474
Total Pages : 398 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Concepts and Experimental Protocols of Modelling and Informatics in Drug Design by : Om Silakari

Download or read book Concepts and Experimental Protocols of Modelling and Informatics in Drug Design written by Om Silakari and published by Academic Press. This book was released on 2020-11-05 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling. Presents exercises with solutions to aid readers in validating their own protocol Brings a thorough interpretation of results of each exercise to help readers compare them to their own study Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study

CADD and Informatics in Drug Discovery

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Publisher : Springer Nature
ISBN 13 : 9819913160
Total Pages : 370 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis CADD and Informatics in Drug Discovery by : Mithun Rudrapal

Download or read book CADD and Informatics in Drug Discovery written by Mithun Rudrapal and published by Springer Nature. This book was released on 2023-05-12 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book updates knowledge on recent advances in computational, biophysical and bioinformatics tools/techniques and their practical applications in modern drug design and discovery paradigm. It also encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas; presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, R&D personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, de novo drug design, pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and systems biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to various stakeholders working in the pharmaceutical and biotechnology industries (R&D), the academic as well as research sectors.

Chemoinformatics for Drug Discovery

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Publisher : John Wiley & Sons
ISBN 13 : 1118743091
Total Pages : 483 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Chemoinformatics for Drug Discovery by : Jürgen Bajorath

Download or read book Chemoinformatics for Drug Discovery written by Jürgen Bajorath and published by John Wiley & Sons. This book was released on 2013-09-25 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoinformatics strategies to improve drug discovery results With contributions from leading researchers in academia and the pharmaceutical industry as well as experts from the software industry, this book explains how chemoinformatics enhances drug discovery and pharmaceutical research efforts, describing what works and what doesn't. Strong emphasis is put on tested and proven practical applications, with plenty of case studies detailing the development and implementation of chemoinformatics methods to support successful drug discovery efforts. Many of these case studies depict groundbreaking collaborations between academia and the pharmaceutical industry. Chemoinformatics for Drug Discovery is logically organized, offering readers a solid base in methods and models and advancing to drug discovery applications and the design of chemoinformatics infrastructures. The book features 15 chapters, including: What are our models really telling us? A practical tutorial on avoiding common mistakes when building predictive models Exploration of structure-activity relationships and transfer of key elements in lead optimization Collaborations between academia and pharma Applications of chemoinformatics in pharmaceutical research experiences at large international pharmaceutical companies Lessons learned from 30 years of developing successful integrated chemoinformatic systems Throughout the book, the authors present chemoinformatics strategies and methods that have been proven to work in pharmaceutical research, offering insights culled from their own investigations. Each chapter is extensively referenced with citations to original research reports and reviews. Integrating chemistry, computer science, and drug discovery, Chemoinformatics for Drug Discovery encapsulates the field as it stands today and opens the door to further advances.

Chemoinformatics

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Publisher : Springer Science & Business Media
ISBN 13 : 1592598021
Total Pages : 530 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Chemoinformatics by : Jürgen Bajorath

Download or read book Chemoinformatics written by Jürgen Bajorath and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the literature, several terms are used synonymously to name the topic of this book: chem-, chemi-, or chemo-informatics. A widely recognized de- nition of this discipline is the one by Frank Brown from 1998 (1) who defined chemoinformatics as the combination of “all the information resources that a scientist needs to optimize the properties of a ligand to become a drug. ” In Brown’s definition, two aspects play a fundamentally important role: de- sion support by computational means and drug discovery, which distinguishes it from the term “chemical informatics” that was introduced at least ten years earlier and described as the application of information technology to ch- istry (not with a specific focus on drug discovery). In addition, there is of course “chemometrics,” which is generally understood as the application of statistical methods to chemical data and the derivation of relevant statistical models and descriptors (2). The pharmaceutical focus of many developments and efforts in this area—and the current popularity of gene-to-drug or si- lar paradigms—is further reflected by the recent introduction of such terms as “discovery informatics” (3), which takes into account that gaining kno- edge from chemical data alone is not sufficient to be ultimately successful in drug discovery. Such insights are well in accord with other views that the boundaries between bio- and chemoinformatics are fluid and that these d- ciplines should be closely combined or merged to significantly impact b- technology or pharmaceutical research (4).

Clinical Research Informatics

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Publisher : Springer Science & Business Media
ISBN 13 : 1848824475
Total Pages : 415 pages
Book Rating : 4.8/5 (488 download)

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Book Synopsis Clinical Research Informatics by : Rachel Richesson

Download or read book Clinical Research Informatics written by Rachel Richesson and published by Springer Science & Business Media. This book was released on 2012-02-15 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the book is to provide an overview of clinical research (types), activities, and areas where informatics and IT could fit into various activities and business practices. This book will introduce and apply informatics concepts only as they have particular relevance to clinical research settings.

Rare Diseases and Orphan Products

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Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Quantitative Molecular Pharmacology and Informatics in Drug Discovery

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Publisher : John Wiley & Sons
ISBN 13 : 9780471988618
Total Pages : 438 pages
Book Rating : 4.9/5 (886 download)

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Book Synopsis Quantitative Molecular Pharmacology and Informatics in Drug Discovery by : Michael Lutz

Download or read book Quantitative Molecular Pharmacology and Informatics in Drug Discovery written by Michael Lutz and published by John Wiley & Sons. This book was released on 2000-01-10 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide. * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and, * provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays. Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.

Artificial Intelligence in Medicine

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Publisher : Springer
ISBN 13 : 303021642X
Total Pages : 431 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Artificial Intelligence in Medicine by : David Riaño

Download or read book Artificial Intelligence in Medicine written by David Riaño and published by Springer. This book was released on 2019-06-19 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 17th Conference on Artificial Intelligence in Medicine, AIME 2019, held in Poznan, Poland, in June 2019. The 22 revised full and 31 short papers presented were carefully reviewed and selected from 134 submissions. The papers are organized in the following topical sections: deep learning; simulation; knowledge representation; probabilistic models; behavior monitoring; clustering, natural language processing, and decision support; feature selection; image processing; general machine learning; and unsupervised learning.

Building a National Framework for the Establishment of Regulatory Science for Drug Development

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Publisher : National Academies Press
ISBN 13 : 0309209595
Total Pages : 94 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Building a National Framework for the Establishment of Regulatory Science for Drug Development by : Institute of Medicine

Download or read book Building a National Framework for the Establishment of Regulatory Science for Drug Development written by Institute of Medicine and published by National Academies Press. This book was released on 2011-02-15 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food and Drug Administration (FDA) is tasked with ensuring the safety and effectiveness of medicine. FDA's science base must be strong enough to make certain that regulatory decisions are based on the best scientific evidence. The IOM held a public workshop on February 26, 2010, to examine the state of regulatory science and to consider approaches for enhancing it.

Informatics In Drug Discovery and Development

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Publisher : CRC Press
ISBN 13 : 9781574444797
Total Pages : 600 pages
Book Rating : 4.4/5 (447 download)

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Book Synopsis Informatics In Drug Discovery and Development by : Herschel Weintraub

Download or read book Informatics In Drug Discovery and Development written by Herschel Weintraub and published by CRC Press. This book was released on 2009-04 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Open Access Databases and Datasets for Drug Discovery

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Publisher : John Wiley & Sons
ISBN 13 : 3527830480
Total Pages : 357 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Open Access Databases and Datasets for Drug Discovery by : Antoine Daina

Download or read book Open Access Databases and Datasets for Drug Discovery written by Antoine Daina and published by John Wiley & Sons. This book was released on 2023-09-27 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Open Access Databases and Datasets for Drug Discovery Timely resource discussing the future of data-driven drug discovery and the growing number of open-source databases With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process. Contributed to and edited by experts with long-time experience in the field, Open Access Databases and Datasets for Drug Discovery includes information on: An extensive listing of open access databases and datasets for computer-aided drug design PubChem as a chemical database for drug discovery, DrugBank Online, and bioisosteric replacement for drug discovery supported by the SwissBioisostere database The Protein Data Bank (PDB) and macromolecular structure data supporting computer-aided drug design, and the SWISS-MODEL repository of 3D protein structures and models PDB-REDO in computational aided drug design (CADD), and using Pharos/TCRD for discovering druggable targets Unmatched in scope and thoroughly reviewing small and large open data sources relevant for rational drug design, Open Access Databases and Datasets for Drug Discovery is an essential reference for medicinal and pharmaceutical chemists, and any scientists involved in the drug discovery and drug development.

Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 111953030X
Total Pages : 6057 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set by :

Download or read book Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set written by and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 6057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Informatics in Drug Discovery

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Publisher :
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.:/5 (615 download)

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Book Synopsis Informatics in Drug Discovery by : Sitharthan Kamalakran

Download or read book Informatics in Drug Discovery written by Sitharthan Kamalakran and published by . This book was released on 2004 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: