Drug Delivery In Oncology

Download Drug Delivery In Oncology full books in PDF, epub, and Kindle. Read online Drug Delivery In Oncology ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Advanced Drug Delivery Systems in the Management of Cancer

Author : Kamal Dua
Publisher : Elsevier
ISBN 13 : 0323900798
Total Pages : 574 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua

Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. - Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer - Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers - Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Nanoparticle Drug Delivery Systems for Cancer Treatment

Author : Hala Gali-Muhtasib
Publisher : CRC Press
ISBN 13 : 1000681416
Total Pages : 192 pages
Book Rating : 4.0/5 (6 download)

DOWNLOAD NOW!

Book Synopsis Nanoparticle Drug Delivery Systems for Cancer Treatment by : Hala Gali-Muhtasib

Download or read book Nanoparticle Drug Delivery Systems for Cancer Treatment written by Hala Gali-Muhtasib and published by CRC Press. This book was released on 2020-02-19 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Systemic Drug Delivery Strategies

Author : Mansoor M. Amiji
Publisher : Academic Press
ISBN 13 : 0323909256
Total Pages : 590 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Systemic Drug Delivery Strategies by : Mansoor M. Amiji

Download or read book Systemic Drug Delivery Strategies written by Mansoor M. Amiji and published by Academic Press. This book was released on 2021-08-21 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Comprehensive treaty covering all aspects of immuno-oncology (IO) - Novel strategies for delivery of IO therapeutics and vaccines - Forecasting on the future of nanotechnology and drug delivery for IO

Nanobiotechnology in Diagnosis, Drug Delivery and Treatment

Author : Mahendra Rai
Publisher : John Wiley & Sons
ISBN 13 : 1119671795
Total Pages : 416 pages
Book Rating : 4.1/5 (196 download)

DOWNLOAD NOW!

Book Synopsis Nanobiotechnology in Diagnosis, Drug Delivery and Treatment by : Mahendra Rai

Download or read book Nanobiotechnology in Diagnosis, Drug Delivery and Treatment written by Mahendra Rai and published by John Wiley & Sons. This book was released on 2020-11-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.

Nanoscience in Medicine Vol. 1

Author : Hemant Kumar Daima
Publisher : Springer Nature
ISBN 13 : 303029207X
Total Pages : 503 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Nanoscience in Medicine Vol. 1 by : Hemant Kumar Daima

Download or read book Nanoscience in Medicine Vol. 1 written by Hemant Kumar Daima and published by Springer Nature. This book was released on 2020-01-10 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book takes a systematic approach to address the gaps relating to nanomedicine and bring together fragmented knowledge on the advances on nanomaterials and their biomedical applicability. In particular, it demonstrates an exclusive compilation of state of the art research with a focus on fundamental concepts, current trends, limitations, and future directions of nanomedicine.

Nanobiomaterials in Cancer Therapy

Author : Alexandru Grumezescu
Publisher : William Andrew
ISBN 13 : 0323428630
Total Pages : 0 pages
Book Rating : 4.3/5 (234 download)

DOWNLOAD NOW!

Book Synopsis Nanobiomaterials in Cancer Therapy by : Alexandru Grumezescu

Download or read book Nanobiomaterials in Cancer Therapy written by Alexandru Grumezescu and published by William Andrew. This book was released on 2016-05-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials in Cancer Therapy

Stimuli-responsive Drug Delivery Systems

Author : Amit Singh
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014669
Total Pages : 376 pages
Book Rating : 4.7/5 (88 download)

DOWNLOAD NOW!

Book Synopsis Stimuli-responsive Drug Delivery Systems by : Amit Singh

Download or read book Stimuli-responsive Drug Delivery Systems written by Amit Singh and published by Royal Society of Chemistry. This book was released on 2018-07-09 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.

Drug Delivery Systems in Cancer Therapy

Author : Dennis M. Brown
Publisher : Humana Press
ISBN 13 : 9781617372384
Total Pages : 0 pages
Book Rating : 4.3/5 (723 download)

DOWNLOAD NOW!

Book Synopsis Drug Delivery Systems in Cancer Therapy by : Dennis M. Brown

Download or read book Drug Delivery Systems in Cancer Therapy written by Dennis M. Brown and published by Humana Press. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Frontiers of Engineering

Author : National Academy of Engineering
Publisher : National Academies Press
ISBN 13 : 0309487501
Total Pages : 125 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!

Book Synopsis Frontiers of Engineering by : National Academy of Engineering

Download or read book Frontiers of Engineering written by National Academy of Engineering and published by National Academies Press. This book was released on 2019-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents papers on the topics covered at the National Academy of Engineering's 2018 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2018 symposium was held September 5-7 and hosted by MIT Lincoln Laboratory in Lexington, Massachusetts. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.

Stealth Liposomes

Author : Danilo D. Lasic
Publisher : CRC Press
ISBN 13 : 1351414011
Total Pages : 324 pages
Book Rating : 4.3/5 (514 download)

DOWNLOAD NOW!

Book Synopsis Stealth Liposomes by : Danilo D. Lasic

Download or read book Stealth Liposomes written by Danilo D. Lasic and published by CRC Press. This book was released on 2018-05-04 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines stealth liposomes from a multidisciplinary approach, which includes theoretical polymer physics, organic synthesis, colloid science, and biology. Discussions include theory, chemistry, biochemistry, pharmacology, preclinical studies in model systems, and medical applications in humans.

Nanopharmaceuticals: Principles and Applications Vol. 3

Author : Vinod Kumar Yata
Publisher : Springer Nature
ISBN 13 : 3030471209
Total Pages : 352 pages
Book Rating : 4.0/5 (34 download)

DOWNLOAD NOW!

Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata

Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Cancer Nanotheranostics

Author : Muthupandian Saravanan
Publisher : Springer Nature
ISBN 13 : 3030743306
Total Pages : 362 pages
Book Rating : 4.0/5 (37 download)

DOWNLOAD NOW!

Book Synopsis Cancer Nanotheranostics by : Muthupandian Saravanan

Download or read book Cancer Nanotheranostics written by Muthupandian Saravanan and published by Springer Nature. This book was released on 2021-10-05 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is an interdisciplinary research field that integrates chemistry, engineering, biology, and medicine. Nanomaterials offer tremendous opportunity as well as challenges for researchers. Of course, cancer is one of the world's most common health problems, responsible for many deaths. Exploring efficient anticancer drugs could revolutionize treatment options and help manage cancer mortality. Nanomedicine plays a significant role in developing alternative and more effective treatment strategies for cancer theranostics. This book mainly focuses on the emerging trends using nanomaterials and nanocomposites as alternative anticancer material’s. The book is divided into three main topic areas: how to overcome existing traditional approaches to combat cancer, applying multiple mechanisms to target the cancer cells, and how nanomaterials can be used as effective carriers. The contents highlight recent advances in interdisciplinary research on processing, morphology, structure, and properties of nanostructured materials and their applications to combat cancer.Cancer Nanotheranostics is comprehensive in that it discusses all aspects of cancer nanotechnology. Because of the vast amount of information, it was decided to split this material into two volumes. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy, including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials and nano-antibodies. In the second volume, we discuss the nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nano-erythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, the safety of nano-biomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics.

Nanomaterials and Their Applications

Author : Zishan Husain Khan
Publisher : Springer
ISBN 13 : 9811062145
Total Pages : 328 pages
Book Rating : 4.8/5 (11 download)

DOWNLOAD NOW!

Book Synopsis Nanomaterials and Their Applications by : Zishan Husain Khan

Download or read book Nanomaterials and Their Applications written by Zishan Husain Khan and published by Springer. This book was released on 2017-10-20 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the latest advances in the field of nanomaterials and their applications, and provides a comprehensive overview of the state-of-the-art of research in this rapidly developing field. The book comprises chapters exploring various aspects of nanomaterials. Given the depth and breadth of coverage, the book offers a valuable guide for researchers and students working in the area of nanomaterials.

Engineering Technologies and Clinical Translation

Author : Mansoor M. Amiji
Publisher : Academic Press
ISBN 13 : 0323909507
Total Pages : 526 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Engineering Technologies and Clinical Translation by : Mansoor M. Amiji

Download or read book Engineering Technologies and Clinical Translation written by Mansoor M. Amiji and published by Academic Press. This book was released on 2021-08-25 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Explores engineering technologies and their clinical translation in a comprehensive way - Presents forecasting on the future of nanotechnology and drug delivery for IO - Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side

The Drug Development Paradigm in Oncology

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309457971
Total Pages : 145 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!

Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.

Gold Nanoparticles in Biomedical Applications

Author : Lev Dykman
Publisher : CRC Press
ISBN 13 : 1351360477
Total Pages : 365 pages
Book Rating : 4.3/5 (513 download)

DOWNLOAD NOW!

Book Synopsis Gold Nanoparticles in Biomedical Applications by : Lev Dykman

Download or read book Gold Nanoparticles in Biomedical Applications written by Lev Dykman and published by CRC Press. This book was released on 2017-12-12 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses fabrication of functionalized gold nanoparticles (GNPs) and multifunctional nanocomposites, their optical properties, and applications in biological studies. This is the very first book of its kind to comprehensively discuss published data on in vitro and in vivo biodistribution, toxicity, and uptake of GNP by mammalian cells providing a systematization of data over the GNP types and parameters, their surface functionalization, animal and cell models. As distinct from other related books, Gold Nanoparticles in Biomedical Applications discusses the immunological properties of GNPs and summarizes their applications as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. Although the potential of GNPs in nanobiotechnology has been recognized for the past decade, new insights into the unique properties of multifunctional nanostructures have recently emerged. With these developments in mind, this book unites ground breaking experimental data with a discussion of hybrid nanoparticle systems that combine different nanomaterials to create multifunctional structures. These novel hybrids constitute the material basis of theranostics, bringing together the advanced properties of functionalized GNPs and composites into a single multifunctional nanostructure with simultaneous diagnostic and therapeutic functions. Such nanohybrids can be physically and chemically tailored for a particular organ, disease, and patient thus making personalized medicine available.

The Elsevier Guide to Oncology Drugs & Regimens

Author : Elsevier
Publisher :
ISBN 13 : 9781416044222
Total Pages : 543 pages
Book Rating : 4.0/5 (442 download)

DOWNLOAD NOW!

Book Synopsis The Elsevier Guide to Oncology Drugs & Regimens by : Elsevier

Download or read book The Elsevier Guide to Oncology Drugs & Regimens written by Elsevier and published by . This book was released on 2006 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Premier edition on PDA gives busy oncology practitioners fast access to the most current information on commonly prescribed oncology drugs and regimens-and the supportive therapies needed to manage the patient's disease and drug side effects. Full-length monographs, organized alphabetically, for more than 150 generic oncology drugs including 40 commonly used supportive-care drugs The latest FDA-approved indications-plus the most common off-label uses (with dosages) When and how to modify dosages based on patient condition and response FDA "black-box" warnings and common and life-threatening adverse reactions Interactions with other drugs, diagnostic tests, foods, and herbs Step-by-step drug preparation and administration protocols Special section on more than 180 common chemotherapy regimens used in major cancer centers, organized by cancer-type, plus supportive therapy necessitated by each regimen