Drug Analysis

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Handbook of Forensic Drug Analysis

Author : Fred Smith
Publisher : Elsevier
ISBN 13 : 0080472893
Total Pages : 585 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Handbook of Forensic Drug Analysis by : Fred Smith

Download or read book Handbook of Forensic Drug Analysis written by Fred Smith and published by Elsevier. This book was released on 2004-12-31 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Forensic Drug Analysis is a comprehensive chemical and analytic reference for the forensic analysis of illicit drugs. With chapters written by leading researchers in the field, the book provides in-depth, up-to-date methods and results of forensic drug analyses. This Handbook discusses various forms of the drug as well as the origin and nature of samples. It explains how to perform various tests, the use of best practices, and the analysis of results. Numerous forensic and chemical analytic techniques are covered including immunoassay, gas chromatography, and mass spectrometry. Topics range from the use of immunoassay technologies for drugs-of-abuse testing, to methods of forensic analysis for cannabis, hallucinogens, cocaine, opioids, and amphetamine. The book also looks at synthetic methods and law enforcement concerns regarding the manufacture of illicit drugs, with an emphasis on clandestine methamphetamine production. This Handbook should serve as a widely used reference for forensic scientists, toxicologists, pharmacologists, drug companies, and professionals working in toxicology testing labs, libraries, and poison control centers. It may also be used by chemists, physicians and those in legal and regulatory professions, and students of graduate courses in forensic science. Contributed to by leading scientists from around the world The only analysis book dedicated to illicit drugs of abuse Comprehensive coverage of sampling methods and various forms of analysis

Plant Drug Analysis

Author : Sabine Bladt
Publisher : Springer Science & Business Media
ISBN 13 : 3662023989
Total Pages : 314 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Plant Drug Analysis by : Sabine Bladt

Download or read book Plant Drug Analysis written by Sabine Bladt and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Drug Analysis has proven an invaluable and unique aid for all those involved with drug production and analysis, including pharmacists, chemical and pharmaceutical researchers and technicians, drug importers and exporters, governmental chemical control agencies, and health authorities. From the reviews of the German Edition: "The reviewer would like to recommend this excellent book to all chromatographers, as he considers it highly relevant to the solution of numerous problems. Its main purpose is the demonstration of thin-layer chromatograms of the usual commercial drugs as an aid in testing for identity and purity. ... 165 colour plates, each showing 6 chromatograms and all of superb quality photographs ..." (Journal of Chromatography)

LC-MS in Drug Analysis

Author : Loralie J. Langman
Publisher : Humana Press
ISBN 13 : 9781617799334
Total Pages : 0 pages
Book Rating : 4.7/5 (993 download)

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Book Synopsis LC-MS in Drug Analysis by : Loralie J. Langman

Download or read book LC-MS in Drug Analysis written by Loralie J. Langman and published by Humana Press. This book was released on 2012-07-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.

Analysis of Drug Impurities

Author : Richard J. Smith
Publisher : John Wiley & Sons
ISBN 13 : 0470994223
Total Pages : 288 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Analysis of Drug Impurities by : Richard J. Smith

Download or read book Analysis of Drug Impurities written by Richard J. Smith and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods. Written for both practicing and student analytical chemists, Analysis of Drug Impurities provides a detailed overview of the challenges and the techniques available to permit accurate identification and quantification of drug impurities.

Thin Layer Chromatography in Drug Analysis

Author : Lukasz Komsta
Publisher : CRC Press
ISBN 13 : 1466507152
Total Pages : 1070 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Thin Layer Chromatography in Drug Analysis by : Lukasz Komsta

Download or read book Thin Layer Chromatography in Drug Analysis written by Lukasz Komsta and published by CRC Press. This book was released on 2013-12-20 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separation and analysis of chiral substances. The text addresses the newest advances in TLC instrumentation, two-dimensional TLC, quantification by slit scanning densitometry and image analysis, statistical processing of data, and various detection and identification methods. It also describes the use of TLC for solving a key issue in the drug market—the presence of substandard and counterfeit pharmaceutical products. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups. Each chapter contains an introduction about the structures and medicinal actions of the described substances and a literature review of their TLC analysis. A useful resource for chromatographers, pharmacists, analytical chemists, students, and R&D, clinical, and forensic laboratories, this book can be utilized as a manual, reference, and teaching source.

The Analysis of Controlled Substances

Author : Michael D. Cole
Publisher : John Wiley & Sons
ISBN 13 : 0470864559
Total Pages : 216 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis The Analysis of Controlled Substances by : Michael D. Cole

Download or read book The Analysis of Controlled Substances written by Michael D. Cole and published by John Wiley & Sons. This book was released on 2003-07-25 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting new developments in sampling and drug profiling, this book also provides practical information on how to carry out analysis, what the results mean and how they can be used as court evidence and for drugs intelligence purposes. * Includes case-studies with full data and spectra, helping readers to identify substances * Accessibly organized by class of compound * Contains an up-to-date list of the newest drugs

Methods of Behavior Analysis in Neuroscience

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Hair Analysis in Clinical and Forensic Toxicology

Author : Pascal Kintz
Publisher : Academic Press
ISBN 13 : 0128017104
Total Pages : 391 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Hair Analysis in Clinical and Forensic Toxicology by : Pascal Kintz

Download or read book Hair Analysis in Clinical and Forensic Toxicology written by Pascal Kintz and published by Academic Press. This book was released on 2015-06-25 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair. Unites an international team of leading experts to provide an update on the cutting-edge advances in the toxicological analysis of hair Demonstrates toxicological techniques relating to a variety of scenarios and exposure types Ideal resource for the further study of the psychoactive substances, drug-facilitated crimes, ecotoxicology, analytical toxicology, occupational toxicology, toxicity testing, and forensic toxicology Includes detailed instructions for the collection, preparation, and handling of hair, and how to best interpret results

The Analysis Of Drugs Of Abuse: An Instruction Manual

Author : M D Cole
Publisher : CRC Press
ISBN 13 : 0203014324
Total Pages : 186 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis The Analysis Of Drugs Of Abuse: An Instruction Manual by : M D Cole

Download or read book The Analysis Of Drugs Of Abuse: An Instruction Manual written by M D Cole and published by CRC Press. This book was released on 1994-11-30 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a self-teaching reference text for forensic chemistry laboratories and law enforcement agencies world-wide. The text includes sections on the importance of physical examinations of drugs and their wrappings; and the use of gas and high-performance chromatography.

Pharmaceutical Drug Analysis

Author : Ashutosh Kar
Publisher : New Age International
ISBN 13 : 9788122416749
Total Pages : 566 pages
Book Rating : 4.4/5 (167 download)

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Book Synopsis Pharmaceutical Drug Analysis by : Ashutosh Kar

Download or read book Pharmaceutical Drug Analysis written by Ashutosh Kar and published by New Age International. This book was released on 2005 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Synergism and Dose-Effect Data Analysis

Author : Ronald J. Tallarida
Publisher : CRC Press
ISBN 13 : 1420036106
Total Pages : 268 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Drug Synergism and Dose-Effect Data Analysis by : Ronald J. Tallarida

Download or read book Drug Synergism and Dose-Effect Data Analysis written by Ronald J. Tallarida and published by CRC Press. This book was released on 2000-07-21 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.

Drug Safety Data

Author : Michael J. Klepper
Publisher : Jones & Bartlett Learning
ISBN 13 : 0763769126
Total Pages : 332 pages
Book Rating : 4.7/5 (637 download)

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Book Synopsis Drug Safety Data by : Michael J. Klepper

Download or read book Drug Safety Data written by Michael J. Klepper and published by Jones & Bartlett Learning. This book was released on 2011 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk provides pharmaceutical scientists, researchers and technicians with an accessible, practical framework for the analysis, summary and interpretation of drug safety data. The only guide of its kind, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk is an invaluable reference for premarketing risk assessment. This unique resource enhances the ability of pharmaceutical professionalsùthose with and without clinical trainingùto determine the risk of a drug or biologic ahead of its release, thereby reducing unnecessary jeopardy to the patient. Authors Dr. Michael Klepper and Dr. Barton Cobert, who together bring decades of pharmaceutical research and drug safety expertise, discuss how quality planning, safety training and data standardization result in significant cost, time and resource savings. Through illustrative, step-by-step instruction, Drug Safety Data: How to Analyze, Summarize and Interpret to Determine Risk provides the definitive guide to drug safety data analysis and reporting. Key features include: Step-by-step instruction on how to analyze, summarize and interpret safety data for mandatory governmental safety reports Pragmatic tipsàand mistakes to avoid Simple explanations of what safety data are collected, and what the data mean Practical approaches to determining a drug effect and understanding its clinical significance Guidance for determining risk throughout the lifecycle of a drug, biologic or nutraceutical Examples of user-friendly data displays that enhance safety signal identification Ways to improve data quality and reduce the time, resources and costs involved in mandatory safety reporting Relevant material for the required training of drug safety/pharmacovigilance professionals SPECIAL FEATURE: Actual examples of an Integrated Analysis of Safety (IAS) -used in the preparation of the Integrated Summary of Safety (ISS) and the Summary of Clinical Safety (SCS) reports -, and the Periodic Safety Update Report (PSUR)

An Economic Analysis of a Drug-selling Gang's Finances

Author : Steven D. Levitt
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis An Economic Analysis of a Drug-selling Gang's Finances by : Steven D. Levitt

Download or read book An Economic Analysis of a Drug-selling Gang's Finances written by Steven D. Levitt and published by . This book was released on 1998 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: We analyze a unique data set detailing the financial activities of a drug-selling street gang on a monthly basis over a four-year period in the recent past. The data, originally compiled by the gang leader to aid in managing the organization, contain detailed information on both the sources of revenues (e.g. drug sales, extortion) and expenditrues (e.g. costs of drugs sold, weapons, tribute to the central gang organization, wages paid to various levels of the gang). Street-level drug dealing appears to be less lucrative than is generally though. We estimate the average wage in the organization to rise from roughly $6 per hour to $11 per hour over the time period studied. The distribution of wages, however, is extremely skewed. Gang leaders earn far more than they could in the legitimate sector, but the actual street-level dealers appear to earn less than the minimum wage throughout most of our sample, in spite of the substantial risks associated with such activities (the annual violent death rate in our sample is 0.07), There is some evidence consistent both with compensating differentials and efficiency wages. The markup on drugs suggests that the gang has substantial local market power. Gang wars appear to have an important strategic component: violence on another gang's turf shifts demand away from that area. The gang we observe responds to such attacks by pricing below marginal cost, suggesting either economic punishment for the rival gang or the presence of switching for users that makes market share maintenance valuable. We investigate a range of alternative methods for estimating the willingness of gang members to accept risks of death, all of which suggest that the implicit value that gang members place on their own lives is very low.

Instrumental Data for Drug Analysis, Third Edition - 6 Volume Set

Author : Terry Mills, III
Publisher : CRC Press
ISBN 13 : 9780849319747
Total Pages : 842 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Instrumental Data for Drug Analysis, Third Edition - 6 Volume Set by : Terry Mills, III

Download or read book Instrumental Data for Drug Analysis, Third Edition - 6 Volume Set written by Terry Mills, III and published by CRC Press. This book was released on 2005-08-30 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finding current, detailed information on the analysis of drug-related compounds is challenging at best. While almost everyone engaged in the study of these compounds has accumulated a vast variety of data over time, a single-source, comprehensive review of that data would be an invaluable resource to have. Instrumental Data for Drug Analysis (IDDA), Third Edition is that resource, presenting the latest information on these compounds in a thorough, straightforward format. What's new in the Third Edition: Presents FT-Raman Spectra tables Includes information and analysis relating to 125 new drugs, including Zoloft, Claritin, Ambien, and the latest generation of narcotics Organizes information on each drug in a simple, streamlined format

Drug-like Properties: Concepts, Structure Design and Methods

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di

Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Workplace Drug Testing

Author : Alain G. Verstraete
Publisher : Pharmaceutical Press
ISBN 13 : 0853696942
Total Pages : 461 pages
Book Rating : 4.8/5 (536 download)

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Book Synopsis Workplace Drug Testing by : Alain G. Verstraete

Download or read book Workplace Drug Testing written by Alain G. Verstraete and published by Pharmaceutical Press. This book was released on 2011 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text provides clear explanations of the effects of drugs on human performance and the need for workplace drug testing. It provides essential information on the regulatory and legal frameworks around the world, how to set policies and coverage of all aspects of drug analysis and the associated interpretation of results.Contents include:* epidemiology of drug use in the working population* the evidence base and guidelines for workplace drug testing* legal, regulatory aspects and policies for drugs and alcohol* urine and alternative sample collection process* analytical techniques and specimen adulteration.Case studies of successful programmes are also included to illustrate the principles discussed.Written by internationally acknowledged experts this informative book will be essential reading for anyone interested in workplace drug testing or setting up such a system including clinical and forensic toxicologists, occupational health physicians, nurses, human resources, drug counselling and treatment providers, analytical chemists and lawyers.Alain Verstraete is Professor at the Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium and Department Head of the Toxicology Laboratory of the Laboratory of Clinical Biology, Ghent University Hospital, Ghent, Belgium.

Drug Identification and Testing in the Juvenile Justice System

Author : Ann H. Crowe
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Drug Identification and Testing in the Juvenile Justice System by : Ann H. Crowe

Download or read book Drug Identification and Testing in the Juvenile Justice System written by Ann H. Crowe and published by . This book was released on 1998 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: