Downstream Processing

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Handbook of Downstream Processing

Author : E. Goldberg
Publisher : Springer Science & Business Media
ISBN 13 : 9400915632
Total Pages : 745 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Handbook of Downstream Processing by : E. Goldberg

Download or read book Handbook of Downstream Processing written by E. Goldberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Protein Downstream Processing

Author : Nikolaos E. Labrou
Publisher : Humana
ISBN 13 : 9781493960408
Total Pages : 0 pages
Book Rating : 4.9/5 (64 download)

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Book Synopsis Protein Downstream Processing by : Nikolaos E. Labrou

Download or read book Protein Downstream Processing written by Nikolaos E. Labrou and published by Humana. This book was released on 2016-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are the most diverse group of biologically important substances. With the recent technological advances in the genomics area and the efforts in proteomics research, the rate of discovery for new proteins with unknown structure and function has increased. These proteins generated from genomic approaches present enormous opportunities for research and industrial application. Protein Downstream Processing: Design, Development and Application of High and Low-Resolution Methods is a compilation of chapters within the exciting area of protein purification designed to give the laboratory worker the information needed to design and implement a successful purification strategy. It presents reliable and robust protocols in a concise form, emphasizing the critical aspects on practical problems and questions encountered at the lab bench. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Protein Downstream Processing: Design, Development and Application of High and Low-Resolution Methods will be an ideal source of scientific information to advanced students, junior researchers, and scientists involved in health sciences, cellular and molecular biology, biochemistry, and biotechnology and other related areas in both academia and industry.

Downstream Processing in Biotechnology

Author : Venko N. Beschkov
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311057411X
Total Pages : 177 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Downstream Processing in Biotechnology by : Venko N. Beschkov

Download or read book Downstream Processing in Biotechnology written by Venko N. Beschkov and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-06-21 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.

Downstream Processing of Proteins

Author : Mohamed A. Desai
Publisher : Springer Science & Business Media
ISBN 13 : 1592590276
Total Pages : 233 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Downstream Processing of Proteins by : Mohamed A. Desai

Download or read book Downstream Processing of Proteins written by Mohamed A. Desai and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable effort and time is allocated to introducing cell culture and fermentation technology to undergraduate students in academia, generally through a range of courses in industrial biotechnology and related disciplines. Similarly, a large number of textbooks are available to describe the appli- tions of these technologies in industry. However, there has been a general lack of appreciation of the significant developments in downstream processing and isolation technology, the need for which is largely driven by the stringent re- latory requirements for purity and quality of injectable biopharmaceuticals. This is particularly reflected by the general absence of coverage of this s- ject in many biotechnology and related courses in educational institutions. For a considerable while I have felt that there is increasing need for an introductory text to various aspects of downstream processing, particularly with respect to the needs of the biopharmaceutical and biotechnology ind- try. Although there are numerous texts that cover various aspects of protein purification techniques in isolation, there is a need for a work that covers the broad range of isolation technology in an industrial setting. It is anticipated that Downstream Processing of Proteins: Methods and Protocols will play a small part in filling this gap and thus prove a useful contribution to the field. It is also designed to encourage educational strategists to broaden the coverage of these topics in industrial biotechnology courses by including accounts of this important and rapidly developing element of the industrial process.

Bioprocess Engineering

Author : Pau Loke Show
Publisher : CRC Press
ISBN 13 : 0429882521
Total Pages : 210 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Bioprocess Engineering by : Pau Loke Show

Download or read book Bioprocess Engineering written by Pau Loke Show and published by CRC Press. This book was released on 2019-05-24 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students.

Biopharmaceutical Processing

Author : Gunter Jagschies
Publisher : Elsevier
ISBN 13 : 0128125527
Total Pages : 1310 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biopharmaceutical Processing by : Gunter Jagschies

Download or read book Biopharmaceutical Processing written by Gunter Jagschies and published by Elsevier. This book was released on 2018-01-18 with total page 1310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. - Offers a comprehensive, go-to reference for daily work decisions - Covers both upstream and downstream processes - Includes case studies that emphasize financial outcomes - Presents summaries, decision grids, graphs and overviews for quick reference

Downstream Processing of Natural Products

Author : M. S. Verrall
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Downstream Processing of Natural Products by : M. S. Verrall

Download or read book Downstream Processing of Natural Products written by M. S. Verrall and published by John Wiley & Sons. This book was released on 1996-08-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products, broadly defined as high value chemical entities derived from plants or microbial sources, have been known and exploited for many years. In recent years, as the need for higher potency and predictability of such products has increased, more sophisticated concentration and isolation procedures have been developed. With the passage of time, such procedures have been rationalized in terms of scientific principles but, in general, theory has followed behind practice, leading at any given time to an absence from the literature of methods which are truly state of the art. Downstream Processing of Natural Products: A Practical Handbook is a highly practical manual which addresses this issue, and guides researchers and industrial workers through the many potential pitfalls of natural product isolation. The contributors to this volume, all of whom have wide practical experience in this field, present state-of-the-art techniques and observations. The three main stages of natural product purification are covered, namely product release, capture, and purification, and both proteins and secondary metabolites are covered. There is special mention of the requirements of the regulatory authorities with respect to Good Manufacturing Practice, and practical guidance is given on scale-up procedures and process scale instrumentation. Downstream Processing of Natural Products: A Practical Handbook will provide essential practical guidance to all those involved in natural product isolation. This includes academic and industrial researchers, postgraduate students and technicians working in the biotechnology field.

Bioseparations Downstream Processing for Biotechnology

Author : Paul A. Belter
Publisher : Wiley-Interscience
ISBN 13 : 9780471121138
Total Pages : 0 pages
Book Rating : 4.1/5 (211 download)

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Book Synopsis Bioseparations Downstream Processing for Biotechnology by : Paul A. Belter

Download or read book Bioseparations Downstream Processing for Biotechnology written by Paul A. Belter and published by Wiley-Interscience. This book was released on 1994-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a concise introduction to the separation and purification of biochemicals. Bridges two scientific cultures, providing an introduction to bioseparations for scientists with no background in engineering and for engineers with little grounding in biology. The authors supplement the ideas by simple worked examples, making the techniques of bioseparations easy to learn. Discusses removal of insolubles, product isolation, purification and polishing.

Process Scale Purification of Antibodies

Author : Uwe Gottschalk
Publisher : John Wiley & Sons
ISBN 13 : 1119126932
Total Pages : 849 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Process Scale Purification of Antibodies by : Uwe Gottschalk

Download or read book Process Scale Purification of Antibodies written by Uwe Gottschalk and published by John Wiley & Sons. This book was released on 2017-03-07 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing

Single-Use Technology in Biopharmaceutical Manufacture

Author : Regine Eibl
Publisher : John Wiley & Sons
ISBN 13 : 1119477786
Total Pages : 367 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Single-Use Technology in Biopharmaceutical Manufacture by : Regine Eibl

Download or read book Single-Use Technology in Biopharmaceutical Manufacture written by Regine Eibl and published by John Wiley & Sons. This book was released on 2019-07-18 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative guide to the principles, characteristics, engineering aspects, economics, and applications of disposables in the manufacture of biopharmaceuticals The revised and updated second edition of Single-Use Technology in Biopharmaceutical Manufacture offers a comprehensive examination of the most-commonly used disposables in the manufacture of biopharmaceuticals. The authors—noted experts on the topic—provide the essential information on the principles, characteristics, engineering aspects, economics, and applications. This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells. This important book: • Contains an updated and end-to-end view of the development and manufacturing of single-use biologics • Helps in the identification of appropriate disposables and relevant vendors • Offers illustrative case studies that examine manufacturing, quality assurance, and environmental influences • Includes updated coverage on cross-functional/transversal dependencies, significant improvements made by suppliers, and the successful application of the single-use technologies Written for biopharmaceutical manufacturers, process developers, and biological and chemical engineers, Single-Use Technology in Biopharmaceutical Manufacture, 2nd Edition provides the information needed for professionals to come to an easier decision for or against disposable alternatives and to choose the appropriate system.

Natural Gas Processing from Midstream to Downstream

Author : Nimir O. Elbashir
Publisher : John Wiley & Sons
ISBN 13 : 1119269636
Total Pages : 584 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Natural Gas Processing from Midstream to Downstream by : Nimir O. Elbashir

Download or read book Natural Gas Processing from Midstream to Downstream written by Nimir O. Elbashir and published by John Wiley & Sons. This book was released on 2018-11-26 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the current status and challenges for natural gas and shale gas production, treatment and monetization technologies Natural Gas Processing from Midstream to Downstream presents an international perspective on the production and monetization of shale gas and natural gas. The authors review techno-economic assessments of the midstream and downstream natural gas processing technologies. Comprehensive in scope, the text offers insight into the current status and the challenges facing the advancement of the midstream natural gas treatments. Treatments covered include gas sweeting processes, sulfur recovery units, gas dehydration and natural gas pipeline transportation. The authors highlight the downstream processes including physical treatment and chemical conversion of both direct and indirect conversion. The book also contains an important overview of natural gas monetization processes and the potential for shale gas to play a role in the future of the energy market, specifically for the production of ultra-clean fuels and value-added chemicals. This vital resource: Provides fundamental chemical engineering aspects of natural gas technologies Covers topics related to upstream, midstream and downstream natural gas treatment and processing Contains well-integrated coverage of several technologies and processes for treatment and production of natural gas Highlights the economic factors and risks facing the monetization technologies Discusses supply chain, environmental and safety issues associated with the emerging shale gas industry Identifies future trends in educational and research opportunities, directions and emerging opportunities in natural gas monetization Includes contributions from leading researchers in academia and industry Written for Industrial scientists, academic researchers and government agencies working on developing and sustaining state-of-the-art technologies in gas and fuels production and processing, Natural Gas Processing from Midstream to Downstream provides a broad overview of the current status and challenges for natural gas production, treatment and monetization technologies.

Downstream Processing and Bioseparation

Author : Jean-François Hamel
Publisher : Washington, D.C. : American Chemical Society
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Downstream Processing and Bioseparation by : Jean-François Hamel

Download or read book Downstream Processing and Bioseparation written by Jean-François Hamel and published by Washington, D.C. : American Chemical Society. This book was released on 1990 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume examines the state of the art of several important separation processes as they relate to biotechnology. Focusing on isolation and purification of downstream processing, it presents recent research results of several promising techniques. Its 15 chapters cover extraction and membrane processing, processes using biospecific interaction with proteins, and novel isolation and purification processes. Many of the chapters contain data that have not been published before. This volume presents the spectrum of current thinking and activities on bioseparation, specifically of large molecules such as proteins and polysaccharides.

Downstream Process Technology: A New Horizon In Biotechnology

Author : Krishna Kant Prasad
Publisher : PHI Learning Pvt. Ltd.
ISBN 13 : 812034040X
Total Pages : 374 pages
Book Rating : 4.1/5 (23 download)

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Book Synopsis Downstream Process Technology: A New Horizon In Biotechnology by : Krishna Kant Prasad

Download or read book Downstream Process Technology: A New Horizon In Biotechnology written by Krishna Kant Prasad and published by PHI Learning Pvt. Ltd.. This book was released on 2010-01-30 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, biochemical process industry demands fast and economic processes for the partitioning and purification of biomolecules that give high yield and high purity of the product. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification. The aim of this comprehensive text is to provide an insightful overview of the whole aspects of downstream processing for biochemical product recovery. Intended for undergraduate and postgraduate students of biotechnology and chemical engineering, this self-contained text includes the chapters based on the recent developments in the industry and academics. It covers the importance of the downstream processing in terms of its relevancy to modern days ever-changing consumer needs, process design criteria relevance to set objectives, and physicochemical factors that help to formulate the strategy to develop a configuration among the raw material, methodology and instruments. This overview is followed by different downstream processing steps. The text concludes with the discussion on stabilization of the product to improve the shelf life of the product. Key Features Includes detailed biological, mathematical, chemical and physical aspects of downstream processing. Distinguishes downstream processing from analytical bioseparation. Contains numerous illustrations and solved problems.

Biochemical Engineering and Biotechnology

Author : Ghasem Najafpour
Publisher : Elsevier
ISBN 13 : 0444633774
Total Pages : 669 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Biochemical Engineering and Biotechnology by : Ghasem Najafpour

Download or read book Biochemical Engineering and Biotechnology written by Ghasem Najafpour and published by Elsevier. This book was released on 2015-02-24 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Engineering and Biotechnology, 2nd Edition, outlines the principles of biochemical processes and explains their use in the manufacturing of every day products. The author uses a diirect approach that should be very useful for students in following the concepts and practical applications. This book is unique in having many solved problems, case studies, examples and demonstrations of detailed experiments, with simple design equations and required calculations. - Covers major concepts of biochemical engineering and biotechnology, including applications in bioprocesses, fermentation technologies, enzymatic processes, and membrane separations, amongst others - Accessible to chemical engineering students who need to both learn, and apply, biological knowledge in engineering principals - Includes solved problems, examples, and demonstrations of detailed experiments with simple design equations and all required calculations - Offers many graphs that present actual experimental data, figures, and tables, along with explanations

Protein Chromatography

Author : Giorgio Carta
Publisher : John Wiley & Sons
ISBN 13 : 352734666X
Total Pages : 440 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Protein Chromatography by : Giorgio Carta

Download or read book Protein Chromatography written by Giorgio Carta and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.

UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS

Author : R. Puvanakrishnan
Publisher : MJP Publisher
ISBN 13 :
Total Pages : 242 pages
Book Rating : 4./5 ( download)

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Book Synopsis UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS by : R. Puvanakrishnan

Download or read book UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS written by R. Puvanakrishnan and published by MJP Publisher. This book was released on 2019-06-20 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF.

Downstream Industrial Biotechnology

Author : Michael C. Flickinger
Publisher : John Wiley & Sons
ISBN 13 : 111861898X
Total Pages : 884 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Downstream Industrial Biotechnology by : Michael C. Flickinger

Download or read book Downstream Industrial Biotechnology written by Michael C. Flickinger and published by John Wiley & Sons. This book was released on 2013-07-17 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.