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Dopaminergic Neuron Transplantation In The Weaver Mouse Model Of Parkinsons Disease
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Book Synopsis Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease by : Lazaros C. Triarhou
Download or read book Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease written by Lazaros C. Triarhou and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.
Book Synopsis Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease by : Lazaros Constantinos Triarhou
Download or read book Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease written by Lazaros Constantinos Triarhou and published by . This book was released on 2002-01-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is the result of 15 years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse, a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons."--V.
Book Synopsis Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease by : Lazaros Triarhou
Download or read book Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease written by Lazaros Triarhou and published by Springer. This book was released on with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Doctoral Dissertation [1987] by : Lazaros C. Triarhou
Download or read book Doctoral Dissertation [1987] written by Lazaros C. Triarhou and published by Createspace Independent Publishing Platform. This book was released on 2016-02-13 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Striatal dopamine (DA) deficiency has been recognized as one of the phenotypic expressions of the mutant gene in homozygous weaver mice. The present study has been aimed at (i) characterizing the deficit of the mesostriatal pathway in the weaver mutant in relation to the number of DA neurons in the ventral mesencephalon and to the synaptology of DA containing nerve terminals in the striatum, and (ii) attempting to reconstruct the anatomical deficit by grafting ventral mesencephalic anlagen to the weaver striatum. Experimental procedures included dissection of embryonic brain, intracerebral grafting, light and electron microscopic immunocytochemistry, and quantitative morphometry. The results show that the weaver mutant mouse is characterized by a spontaneous loss of DA neurons in all mesencephalic DA cell groups. The available anatomical evidence suggests that the mesostriatal DA projection does not reach full development and further regresses with age. Despite the naturally occurring degenerative process, the striatum of weaver mutants is receptive to reinnervation by DA afferent fibers originating in grafts from normal donor embryos. The synaptic investment of striatal cellular domains approximately resembles that seen under normal circumstances. This investigation is relevant to the understanding of (i) pathogenetic mechanisms associated with the mesostriatal DA deficiency found in familial Parkinson's disease, and (ii) modalities of therapeutic intervention in abiotrophic diseases of the brain.
Book Synopsis Transplantation of Mouse Embryonic Stem Cell-Derived Dopaminergic Neurons in a Unilateral 6-Hydroxydopamine Lesion Rat Model of Parkinson’s Disease by : Keneuoe Hycianth Thinyane
Download or read book Transplantation of Mouse Embryonic Stem Cell-Derived Dopaminergic Neurons in a Unilateral 6-Hydroxydopamine Lesion Rat Model of Parkinson’s Disease written by Keneuoe Hycianth Thinyane and published by . This book was released on 2004 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra by : Giuseppe di Giovanni
Download or read book Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra written by Giuseppe di Giovanni and published by Springer Science & Business Media. This book was released on 2009-09-02 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scientists in their fields, explore the life cycle of dopaminergic neurons from their birth to death, the cause of Parkinson's disease, the second most common and disabling condition in the elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is symptomatic rather than preventive. The mechanisms by which alterations cause neuronal death, new therapeutic approaches and the latest evidence of a possible de novo neurogenesis in the SNc are reviewed and singled out in different chapters. This book bridges basic science and clinical practice and will prepare the reader for the next few years, which will surely be eventful in terms of the progress of dopamine research.
Book Synopsis Transplantation of Fetal Dopamine Neurons in an Animal Model of Parkinson's Disease by : Craig Gilmour Van Horne
Download or read book Transplantation of Fetal Dopamine Neurons in an Animal Model of Parkinson's Disease written by Craig Gilmour Van Horne and published by . This book was released on 1992 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Differential Susceptibility of Dopamine Neuronal Populations in a Mouse Model of Parkinson's Disease by : Bahareh Behrouz
Download or read book Characterization of the Differential Susceptibility of Dopamine Neuronal Populations in a Mouse Model of Parkinson's Disease written by Bahareh Behrouz and published by . This book was released on 2008 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transplantation of Mouse Embryonic Stem Cell-derived Dopaminergic Neurons in a Unilateral 6-hydroxydopamine Lesion Rat Model of Parkinson's Disease by : Keneuoe Hycianth Thinyane
Download or read book Transplantation of Mouse Embryonic Stem Cell-derived Dopaminergic Neurons in a Unilateral 6-hydroxydopamine Lesion Rat Model of Parkinson's Disease written by Keneuoe Hycianth Thinyane and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microtransplantation of Nigral Dopamine Neurons in a Rat Model of Parkinson's Disease by : Guido Nikkhah
Download or read book Microtransplantation of Nigral Dopamine Neurons in a Rat Model of Parkinson's Disease written by Guido Nikkhah and published by . This book was released on 1994 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Dopaminergic Neurons from Neural Stem Cells and Transplantation Into a Neonatal and Adult Animal Model of Parkinson's Disease by : Torben Scholz
Download or read book Development of Dopaminergic Neurons from Neural Stem Cells and Transplantation Into a Neonatal and Adult Animal Model of Parkinson's Disease written by Torben Scholz and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Guidance of Dopaminergic Cells Transplanted in a Mouse Model of Parkinson's Disease by : Joanna Kalaani
Download or read book Molecular Guidance of Dopaminergic Cells Transplanted in a Mouse Model of Parkinson's Disease written by Joanna Kalaani and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is characterised by the degeneration of the dopaminergic nigrostriatal pathway. Cell therapy using intranigral transplantation of foetal ventral mesencephalon (VM) cells in a mouse model of PD results in anatomical and functional reconstruction of the pathway. This suggests a role for axon guidance molecules (GMs) in reconnecting transplanted cells to their striatal target. To test this hypothesis, we studied the expression of axon GMs in the intact adult brain, on cells used for transplantation and in a mouse model of PD after cell therapy. In the intact brain, we showed that GMs as semaphorin7A (Sema7A) and Sema3A and their corresponding receptors, plexinC1 and neuropilin1, retain an expression at the protein level, therefore showing a possible role for these guidance cues in the adult brain. Moreover, using microarray, we studied GM receptor expression profiles in two types of cells used for transplantation and exhibiting different functional ameliorations. Robo2, neuropilin1, neuropilin2, EphA5 and DCC receptors showed differential expression between the two cellular populations, indicating their possible contribution to the different functional outcomes observed. In the lesioned mouse brain, we observed, using RT-qPCR, variations of mRNA expression of these axon GMs after intranigral transplantation of foetal VM derived cells, thus suggesting the implication of Sema3A, Sema3F, and Sema7A in the reconstruction of the pathway. Overall, this work highlights particular importance of semaphorins in the nigrostriatal pathway reconstruction. Integrating these cues in transplantation procedures can possibly optimize cell therapy for PD patients.
Book Synopsis Electrophysiological Characterization of Surviving Dopaminergic Neurons in a Mouse Model of Parkinson's Disease by : Alexander Prinz
Download or read book Electrophysiological Characterization of Surviving Dopaminergic Neurons in a Mouse Model of Parkinson's Disease written by Alexander Prinz and published by . This book was released on 2013 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dopamine Handbook by : Leslie L. Iversen
Download or read book Dopamine Handbook written by Leslie L. Iversen and published by . This book was released on 2010 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.
Book Synopsis Transplantation of Mesenchymal Stem Cell-derived Dopaminergic Neuronal-like Cells Into the 6-hydroxydopamine Rat Model of Parkinson's Disease by : Gabrielle P. Shall
Download or read book Transplantation of Mesenchymal Stem Cell-derived Dopaminergic Neuronal-like Cells Into the 6-hydroxydopamine Rat Model of Parkinson's Disease written by Gabrielle P. Shall and published by . This book was released on 2018 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Definition of the Mesostriatal Dopamine Deficit in the Weaver Mutant Mouse and Reconstruction of the Damaged Pathway by Means of Neural Transplantation by : Lazaros Constantinos Triarhou
Download or read book Definition of the Mesostriatal Dopamine Deficit in the Weaver Mutant Mouse and Reconstruction of the Damaged Pathway by Means of Neural Transplantation written by Lazaros Constantinos Triarhou and published by . This book was released on 1987 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Towards a transplantation therapy for Parkinson's disease by : Patrik Brundin
Download or read book Towards a transplantation therapy for Parkinson's disease written by Patrik Brundin and published by . This book was released on 1988 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Doctoral Dissertation [1987] PDF Online Free](https://books.google.com/books/content/images/frontcover/Vi6PjwEACAAJ?fife=w200-h370)
