Dna Damage And Chromosomal Instability

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DNA Damage and Chromosomal Instability

Author :
Publisher : Elsevier
ISBN 13 : 0443188998
Total Pages : 350 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis DNA Damage and Chromosomal Instability by :

Download or read book DNA Damage and Chromosomal Instability written by and published by Elsevier. This book was released on 2024-02-13 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Updated release includes the latest information on the DNA Damage and Chromosomal Instability

New Research on Genomic Instability

Author : Eleanor J. Gloscow
Publisher : Nova Publishers
ISBN 13 : 9781600213205
Total Pages : 312 pages
Book Rating : 4.2/5 (132 download)

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Book Synopsis New Research on Genomic Instability by : Eleanor J. Gloscow

Download or read book New Research on Genomic Instability written by Eleanor J. Gloscow and published by Nova Publishers. This book was released on 2007 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many cancer biologists now believe that genomic instability not only initiates carcinogenesis, but also allows the tumour cell to become metastatic and evade drug toxicity. The loss of stability of the genome is becoming accepted as one of the most important aspects of carcinogenesis. One of the hallmarks of the cancer cell is the inherent instability of its genome. This book presents important research in this exciting field.

Chromosomal Instability and Aging

Author : Fuki Hisama
Publisher : CRC Press
ISBN 13 : 0824708563
Total Pages : 598 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Chromosomal Instability and Aging by : Fuki Hisama

Download or read book Chromosomal Instability and Aging written by Fuki Hisama and published by CRC Press. This book was released on 2003-01-29 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.

Genome Stability and Human Diseases

Author : Heinz-Peter Nasheuer
Publisher : Springer Science & Business Media
ISBN 13 : 9048134714
Total Pages : 346 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Genome Stability and Human Diseases by : Heinz-Peter Nasheuer

Download or read book Genome Stability and Human Diseases written by Heinz-Peter Nasheuer and published by Springer Science & Business Media. This book was released on 2009-12-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Chromosomal Instability and Aging

Author : Fuki Hisama
Publisher : CRC Press
ISBN 13 : 9781135546656
Total Pages : 600 pages
Book Rating : 4.5/5 (466 download)

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Book Synopsis Chromosomal Instability and Aging by : Fuki Hisama

Download or read book Chromosomal Instability and Aging written by Fuki Hisama and published by CRC Press. This book was released on 2003-01-29 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.

Genome Stability

Author : Igor Kovalchuk
Publisher : Academic Press
ISBN 13 : 0323856802
Total Pages : 762 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Chromosomal Instability in Cancer Cells

Author : B. Michael Ghadimi
Publisher : Springer
ISBN 13 : 331920291X
Total Pages : 228 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Chromosomal Instability in Cancer Cells by : B. Michael Ghadimi

Download or read book Chromosomal Instability in Cancer Cells written by B. Michael Ghadimi and published by Springer. This book was released on 2015-09-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Dna Repair, Genetic Instability, And Cancer

Author : Qingyi Wei
Publisher : World Scientific
ISBN 13 : 9814477117
Total Pages : 374 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Dna Repair, Genetic Instability, And Cancer by : Qingyi Wei

Download or read book Dna Repair, Genetic Instability, And Cancer written by Qingyi Wei and published by World Scientific. This book was released on 2007-01-08 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.

DNA Damage, Genome Stability and Human Disease

Author : Yuejin Hua
Publisher : Frontiers Media SA
ISBN 13 : 288974194X
Total Pages : 154 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis DNA Damage, Genome Stability and Human Disease by : Yuejin Hua

Download or read book DNA Damage, Genome Stability and Human Disease written by Yuejin Hua and published by Frontiers Media SA. This book was released on 2022-01-27 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genome Instability in Cancer Development

Author : Erich A. Nigg
Publisher : Springer Science & Business Media
ISBN 13 : 1402037643
Total Pages : 509 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Genome Instability in Cancer Development by : Erich A. Nigg

Download or read book Genome Instability in Cancer Development written by Erich A. Nigg and published by Springer Science & Business Media. This book was released on 2006-01-14 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.

DNA Damage Responses in Nijmegen Breakage Syndrome

Author : Vikky Yamazaki
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis DNA Damage Responses in Nijmegen Breakage Syndrome by : Vikky Yamazaki

Download or read book DNA Damage Responses in Nijmegen Breakage Syndrome written by Vikky Yamazaki and published by . This book was released on 1999 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cytogenomics

Author : Thomas Liehr
Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

The DNA Damage Response: Implications on Cancer Formation and Treatment

Author : Kum Kum Khanna
Publisher : Springer Science & Business Media
ISBN 13 : 9048125618
Total Pages : 450 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis The DNA Damage Response: Implications on Cancer Formation and Treatment by : Kum Kum Khanna

Download or read book The DNA Damage Response: Implications on Cancer Formation and Treatment written by Kum Kum Khanna and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Diagnostic Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128229934
Total Pages : 846 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Diagnostic Molecular Pathology by : William B. Coleman

Download or read book Diagnostic Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2023-10-27 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

The Micronucleus Assay in Toxicology

Author : Siegfried Knasmüller
Publisher : Royal Society of Chemistry
ISBN 13 : 1788018494
Total Pages : 684 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis The Micronucleus Assay in Toxicology by : Siegfried Knasmüller

Download or read book The Micronucleus Assay in Toxicology written by Siegfried Knasmüller and published by Royal Society of Chemistry. This book was released on 2019-07-18 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods which are currently used for the analyses of micronuclei in different types of cells in human in vivo biomonitoring studies, routine in vivo tests with rodents, in vitro studies with human and mammalian cells, environmental monitoring with invertebrates and vertebrates such as molluscs, fish and, also, in plant bioassays. Moreover, this book also focuses on the use of the micronucleus technique in other research areas, including the detection of DNA damage caused by important groups of genotoxic carcinogens (heavy metals, industrial chemicals, cytotoxic drugs, pesticides, ionising radiation, etc.) as well as study designs, statistical analyses, international regulatory guidelines, and the development of automated scoring devices for this assay. This book will serve as both, a reference and a guide to students, and investigators in biomedical, biochemical and pharmaceutical sciences interested in gaining a better understanding of the biology of micronuclei and their application in measuring DNA damage caused by natural or man-made genotoxins.

DNA Repair and Human Disease

Author : Adayabalam Balajee
Publisher : Springer Science & Business Media
ISBN 13 : 0387368027
Total Pages : 161 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis DNA Repair and Human Disease by : Adayabalam Balajee

Download or read book DNA Repair and Human Disease written by Adayabalam Balajee and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.