DNA and Chromatin Damage Caused by Radiation

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Publisher : Academic Press
ISBN 13 : 1483282279
Total Pages : 520 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis DNA and Chromatin Damage Caused by Radiation by : John T. Lett

Download or read book DNA and Chromatin Damage Caused by Radiation written by John T. Lett and published by Academic Press. This book was released on 2013-10-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.

Relative Radiation Sensitivities of Human Organ Systems

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Publisher :
ISBN 13 : 9780120354146
Total Pages : 348 pages
Book Rating : 4.3/5 (541 download)

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Book Synopsis Relative Radiation Sensitivities of Human Organ Systems by : John Lett

Download or read book Relative Radiation Sensitivities of Human Organ Systems written by John Lett and published by . This book was released on 1990 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emph ...

Molecular Determinants of Radiation Response

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 144198044X
Total Pages : 282 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Molecular Determinants of Radiation Response by : Theodore L. DeWeese

Download or read book Molecular Determinants of Radiation Response written by Theodore L. DeWeese and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Ionizing Radiation Damage to DNA

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Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Ionizing Radiation Damage to DNA by : Radiation Research Society (U.S.)

Download or read book Ionizing Radiation Damage to DNA written by Radiation Research Society (U.S.) and published by . This book was released on 1990-09-13 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprised of a series of short papers, dedicated exclusively to the molecular aspects of ionizing radiation-induced damage and its subsequent biological processing. Representing a scientific cross-section, with contributions by major researchers in the field, it examines new and innovative methodologies for detecting and quantifying the broad spectrum of DNA damage, spotlights the use of recombinant DNA technologies for introducing unique model lesions into DNA, and assesses their mutagenic potential.

The Early Effects of Radiation on DNA

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Publisher : Springer Science & Business Media
ISBN 13 : 3642751482
Total Pages : 437 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis The Early Effects of Radiation on DNA by : E.M. Fielden

Download or read book The Early Effects of Radiation on DNA written by E.M. Fielden and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the biological effects of ionising radiation closely followed the identification of such radiation. The realisation that DNA is the site of genetic infonnation in cells subsequently focussed attention on DNA as an important target in the lethal and mutagenic effects of ionising radiation. Thus radiation effects upon DNA became an important area for fundamental scientific studies by radiation biologists, chemists and physicists. To a first approximation, the concerns of the three disciplines can be divided by time scales: the physical process of energy deposition from photon or charged 16 12 particle and subsequent relaxation (-10- to 10- secs), followed by chemical 12 2 reactions (- 10- to 10 secs), and fmally, the expression of biological effect (minutes to years). Thus, the concept of 'early processes' conveys different ideas to different scientists, although they are all interrelated. To attempt to describe in any detail all these processes is a mammoth task which is not made easier by the different conventions and experimental approaches of the three disciplines. However, the recent advances in all these scientific areas seemed, to the organisers at least, to offer the opportunity to stimulate more active interaction between physicists, chemists and biologists. With this in mind, a multi-disciplinary workshop was organised, which brought together some fifty scientists to present their own specialist interests and, through extensive discussion, explore which problems are of high priority and require input from the different disciplines to resolve them.

Mechanisms of DNA Damage and Repair

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Publisher : Springer Science & Business Media
ISBN 13 : 1461594626
Total Pages : 567 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Mechanisms of DNA Damage and Repair by : Michael G. Simic

Download or read book Mechanisms of DNA Damage and Repair written by Michael G. Simic and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

Radiation Damage in DNA

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Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Radiation Damage in DNA by : Alfred F. Fuciarelli

Download or read book Radiation Damage in DNA written by Alfred F. Fuciarelli and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Determinants of Radiation Response

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Author :
Publisher : Springer
ISBN 13 : 9781441980458
Total Pages : 276 pages
Book Rating : 4.9/5 (84 download)

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Book Synopsis Molecular Determinants of Radiation Response by : Theodore L. DeWeese

Download or read book Molecular Determinants of Radiation Response written by Theodore L. DeWeese and published by Springer. This book was released on 2011-06-08 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Determinants of Radiation Response includes chapters by expert authors who detail the present understanding of key DNA damage response pathways and proteins. The chapters include comprehensive discussions on where and how specific alterations in function of these pathways and proteins result in substantive modifications of cellular response to DNA injury. Given the importance of therapies that induce DNA injury in the management of human disease, this book is timely and relevant for basic and translational researchers, as well as clinicians alike.

Free-Radical and Radiation-Induced Damage to DNA

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Author :
Publisher : CRC Press
ISBN 13 : 9783718648740
Total Pages : 138 pages
Book Rating : 4.6/5 (487 download)

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Book Synopsis Free-Radical and Radiation-Induced Damage to DNA by : D. Schulte-Frohlinde

Download or read book Free-Radical and Radiation-Induced Damage to DNA written by D. Schulte-Frohlinde and published by CRC Press. This book was released on 1989 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in DNA Damage and Repair

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Publisher : Springer Science & Business Media
ISBN 13 : 1461548659
Total Pages : 502 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Advances in DNA Damage and Repair by : Miral Dizdaroglu

Download or read book Advances in DNA Damage and Repair written by Miral Dizdaroglu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.

Basic Clinical Radiobiology

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Publisher : CRC Press
ISBN 13 : 0429955405
Total Pages : 361 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Basic Clinical Radiobiology by : Michael C. Joiner

Download or read book Basic Clinical Radiobiology written by Michael C. Joiner and published by CRC Press. This book was released on 2018-08-28 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Builds on success and reputation of previous editions Draws on the considerable teaching experience of an international author team, most notably the US and European Editors The gold-standard European text for training, adopted by ESTRO as a course book, as a text for the Royal College of Radiologists' radiobiology exam and by courses in the US Highly illustrated with new, 2 colour illustrations Clear and concise style, appropriate for trainees and also practising radiation oncologists requiring a ready reference to the subject Includes new chapters on stem cells, tissue response and the meeting point of meeting point of radiotherapy, radiobiology and physics

Understanding Radiation Biology

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Publisher : CRC Press
ISBN 13 : 1000733548
Total Pages : 253 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Understanding Radiation Biology by : Kenneth Chadwick

Download or read book Understanding Radiation Biology written by Kenneth Chadwick and published by CRC Press. This book was released on 2019-11-15 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose–effect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography. Features Presents a comprehensive insight into radiation action on living matter Contains important implications for radiological protection and regulations Provides analytical methods for applications in radiotherapy

Advances in DNA Damage and Repair

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Publisher : Springer Science & Business Media
ISBN 13 : 9780306460425
Total Pages : 528 pages
Book Rating : 4.4/5 (64 download)

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Book Synopsis Advances in DNA Damage and Repair by : Miral Dizdaroglu

Download or read book Advances in DNA Damage and Repair written by Miral Dizdaroglu and published by Springer Science & Business Media. This book was released on 1999-02-28 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.

X-rays, Gamma-rays

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Publisher :
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis X-rays, Gamma-rays by : United States. National Aeronautics and Space Administration

Download or read book X-rays, Gamma-rays written by United States. National Aeronautics and Space Administration and published by . This book was released on 1977 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radiation Damage in Biomolecular Systems

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Publisher : Springer Science & Business Media
ISBN 13 : 9400725639
Total Pages : 508 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Radiation Damage in Biomolecular Systems by : Gustavo García Gómez-Tejedor

Download or read book Radiation Damage in Biomolecular Systems written by Gustavo García Gómez-Tejedor and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can induce molecular fragmentation via dissociative processes such as internal excitation and electron attachment. This prompted collaborative projects between different research groups from European countries together with other specialists from Canada, the USA and Australia. This book summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems. An extensive Part I deals with recent experimental and theoretical findings on radiation induced damage at the molecular level. It includes many contributions on electron and positron collisions with biologically relevant molecules. X-ray and ion interactions are also covered. Part II addresses different approaches to radiation damage modelling. In Part III biomedical aspects of radiation effects are treated on different scales. After the physics-oriented focus of the previous parts, there is a gradual transition to biology and medicine with the increasing size of the object studied. Finally, Part IV is dedicated to current trends and novel techniques in radiation reserach and the applications hence arising. It includes new developments in radiotherapy and related cancer therapies, as well as technical optimizations of accelerators and totally new equipment designs, giving a glimpse of the near future of radiation-based medical treatments.

Life Sciences and Radiation

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540204787
Total Pages : 306 pages
Book Rating : 4.2/5 (47 download)

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Book Synopsis Life Sciences and Radiation by : Jürgen Kiefer

Download or read book Life Sciences and Radiation written by Jürgen Kiefer and published by Springer Science & Business Media. This book was released on 2004-02-20 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains the proceedings of an international workshop held in Giessen in October 2002 that explored the potential of radiation research in the life sciences. The contributions demonstrate that the development of molecular biology and cell biology is intimately linked with the application of radiation methods. It is shown that the study of the cell cycle and of intercellular communication, as well as recent achievements in radiation therapy and the understanding of carcinogenic processes are not possible without radiation research. Repair of genetic damage cannot be studied without the analysis of radiation induced damage and its modification. The book thus details the great importance of radiation research in the whole field of life sciences and constitutes not only an important source book for radiation scientists but also an introduction in the field for the nonspecialist interested in the state of the art in radiation research.

Health Risks from Exposure to Low Levels of Ionizing Radiation

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Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.