Discovery Techniques

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Advances in Drug Discovery Techniques

Author : Alan L. Harvey
Publisher : CRC Press
ISBN 13 : 9780471975090
Total Pages : 232 pages
Book Rating : 4.9/5 (75 download)

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Book Synopsis Advances in Drug Discovery Techniques by : Alan L. Harvey

Download or read book Advances in Drug Discovery Techniques written by Alan L. Harvey and published by CRC Press. This book was released on 1998-08-15 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.

Continuous Discovery Habits

Author : Teresa Torres
Publisher : Product Talk LLC
ISBN 13 : 1736633317
Total Pages : 201 pages
Book Rating : 4.7/5 (366 download)

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Book Synopsis Continuous Discovery Habits by : Teresa Torres

Download or read book Continuous Discovery Habits written by Teresa Torres and published by Product Talk LLC. This book was released on 2021-05-19 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: "If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.

The Other Side of Innovation

Author : Vijay Govindarajan
Publisher : Harvard Business Press
ISBN 13 : 1422162303
Total Pages : 241 pages
Book Rating : 4.4/5 (221 download)

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Book Synopsis The Other Side of Innovation by : Vijay Govindarajan

Download or read book The Other Side of Innovation written by Vijay Govindarajan and published by Harvard Business Press. This book was released on 2010-09-02 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: In their first book, Ten Rules for Strategic Innovators, the authors provided a better model for executing disruptive innovation. They laid out a three-part plan for launching high-risk/high-reward innovation efforts: (1) borrow assets from the existing firms, (2) unlearn and unload certain processes and systems that do not serve the new entity, and (3) learn and build all new capabilities and skills. In their study of the Ten Rules in action, Govindarajan and Trimble observed many other kinds of innovation that were less risky but still critical to the company's ongoing success. In case after case, senior executives expected leaders of innovation initiatives to grapple with forces of resistence, namely incentives to keep doing what the company has always done--rather than develop new competence and knowledge. But where to begin? In this book, the authors argue that the most successful everyday innovators break down the process into six manageable steps: 1. Divide the labor 2. Assemble the dedicated team 3. Manage the partnership 4. Formalize the experiment 5. Break down the hypothesis 6. Seek the truth. The Other Side of Innovation codifies this staged approach in a variety of contexts. It delivers a proven step-by-step guide to executing (launching, managing, and measuring) more modest but necessary innovations within large firms without disrupting their bread-and-butter business.

EMPOWERED

Author : Marty Cagan
Publisher : John Wiley & Sons
ISBN 13 : 1119691257
Total Pages : 435 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis EMPOWERED by : Marty Cagan

Download or read book EMPOWERED written by Marty Cagan and published by John Wiley & Sons. This book was released on 2020-12-03 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Great teams are comprised of ordinary people that are empowered and inspired. They are empowered to solve hard problems in ways their customers love yet work for their business. They are inspired with ideas and techniques for quickly evaluating those ideas to discover solutions that work: they are valuable, usable, feasible and viable. This book is about the idea and reality of "achieving extraordinary results from ordinary people". Empowered is the companion to Inspired. It addresses the other half of the problem of building tech products?how to get the absolute best work from your product teams. However, the book's message applies much more broadly than just to product teams. Inspired was aimed at product managers. Empowered is aimed at all levels of technology-powered organizations: founders and CEO's, leaders of product, technology and design, and the countless product managers, product designers and engineers that comprise the teams. This book will not just inspire companies to empower their employees but will teach them how. This book will help readers achieve the benefits of truly empowered teams"--

Data Mining Methods for Knowledge Discovery

Author : Krzysztof J. Cios
Publisher : Springer Science & Business Media
ISBN 13 : 1461555892
Total Pages : 508 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Data Mining Methods for Knowledge Discovery by : Krzysztof J. Cios

Download or read book Data Mining Methods for Knowledge Discovery written by Krzysztof J. Cios and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Mining Methods for Knowledge Discovery provides an introduction to the data mining methods that are frequently used in the process of knowledge discovery. This book first elaborates on the fundamentals of each of the data mining methods: rough sets, Bayesian analysis, fuzzy sets, genetic algorithms, machine learning, neural networks, and preprocessing techniques. The book then goes on to thoroughly discuss these methods in the setting of the overall process of knowledge discovery. Numerous illustrative examples and experimental findings are also included. Each chapter comes with an extensive bibliography. Data Mining Methods for Knowledge Discovery is intended for senior undergraduate and graduate students, as well as a broad audience of professionals in computer and information sciences, medical informatics, and business information systems.

Target Discovery and Validation

Author : Alleyn T. Plowright
Publisher : John Wiley & Sons
ISBN 13 : 3527345299
Total Pages : 396 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Target Discovery and Validation by : Alleyn T. Plowright

Download or read book Target Discovery and Validation written by Alleyn T. Plowright and published by John Wiley & Sons. This book was released on 2020-02-18 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Knowledge Discovery Process and Methods to Enhance Organizational Performance

Author : Kweku-Muata Osei-Bryson
Publisher : CRC Press
ISBN 13 : 1482212382
Total Pages : 398 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Knowledge Discovery Process and Methods to Enhance Organizational Performance by : Kweku-Muata Osei-Bryson

Download or read book Knowledge Discovery Process and Methods to Enhance Organizational Performance written by Kweku-Muata Osei-Bryson and published by CRC Press. This book was released on 2015-03-16 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the terms "data mining" and "knowledge discovery and data mining" (KDDM) are sometimes used interchangeably, data mining is actually just one step in the KDDM process. Data mining is the process of extracting useful information from data, while KDDM is the coordinated process of understanding the business and mining the data in order to identify previously unknown patterns. Knowledge Discovery Process and Methods to Enhance Organizational Performance explains the knowledge discovery and data mining (KDDM) process in a manner that makes it easy for readers to implement. Sharing the insights of international KDDM experts, it details powerful strategies, models, and techniques for managing the full cycle of knowledge discovery projects. The book supplies a process-centric view of how to implement successful data mining projects through the use of the KDDM process. It discusses the implications of data mining including security, privacy, ethical and legal considerations. Provides an introduction to KDDM, including the various models adopted in academia and industry Details critical success factors for KDDM projects as well as the impact of poor quality data or inaccessibility to data on KDDM projects Proposes the use of hybrid approaches that couple data mining with other analytic techniques (e.g., data envelopment analysis, cluster analysis, and neural networks) to derive greater value and utility Demonstrates the applicability of the KDDM process beyond analytics Shares experiences of implementing and applying various stages of the KDDM process in organizations The book includes case study examples of KDDM applications in business and government. After reading this book, you will understand the critical success factors required to develop robust data mining objectives that are in alignment with your organization’s strategic business objectives.

High Performance Discovery In Time Series

Author : New York University
Publisher : Springer Science & Business Media
ISBN 13 : 1475740468
Total Pages : 195 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis High Performance Discovery In Time Series by : New York University

Download or read book High Performance Discovery In Time Series written by New York University and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph is a technical survey of concepts and techniques for describing and analyzing large-scale time-series data streams. Some topics covered are algorithms for query by humming, gamma-ray burst detection, pairs trading, and density detection. Included are self-contained descriptions of wavelets, fast Fourier transforms, and sketches as they apply to time-series analysis. Detailed applications are built on a solid scientific basis.

Advances in Data Mining: Applications and Theoretical Aspects

Author : Petra Perner
Publisher : Springer Science & Business Media
ISBN 13 : 3642143997
Total Pages : 667 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Advances in Data Mining: Applications and Theoretical Aspects by : Petra Perner

Download or read book Advances in Data Mining: Applications and Theoretical Aspects written by Petra Perner and published by Springer Science & Business Media. This book was released on 2010-07-05 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: These are the proceedings of the tenth event of the Industrial Conference on Data Mining ICDM held in Berlin (www.data-mining-forum.de). For this edition the Program Committee received 175 submissions. After the pe- review process, we accepted 49 high-quality papers for oral presentation that are included in this book. The topics range from theoretical aspects of data mining to app- cations of data mining such as on multimedia data, in marketing, finance and telec- munication, in medicine and agriculture, and in process control, industry and society. Extended versions of selected papers will appear in the international journal Trans- tions on Machine Learning and Data Mining (www.ibai-publishing.org/journal/mldm). Ten papers were selected for poster presentations and are published in the ICDM Poster Proceeding Volume by ibai-publishing (www.ibai-publishing.org). In conjunction with ICDM four workshops were held on special hot applicati- oriented topics in data mining: Data Mining in Marketing DMM, Data Mining in LifeScience DMLS, the Workshop on Case-Based Reasoning for Multimedia Data CBR-MD, and the Workshop on Data Mining in Agriculture DMA. The Workshop on Data Mining in Agriculture ran for the first time this year. All workshop papers will be published in the workshop proceedings by ibai-publishing (www.ibai-publishing.org). Selected papers of CBR-MD will be published in a special issue of the international journal Transactions on Case-Based Reasoning (www.ibai-publishing.org/journal/cbr).

Privacy-Aware Knowledge Discovery

Author : Francesco Bonchi
Publisher : CRC Press
ISBN 13 : 1439803668
Total Pages : 527 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Privacy-Aware Knowledge Discovery by : Francesco Bonchi

Download or read book Privacy-Aware Knowledge Discovery written by Francesco Bonchi and published by CRC Press. This book was released on 2010-12-02 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering research at the frontier of this field, Privacy-Aware Knowledge Discovery: Novel Applications and New Techniques presents state-of-the-art privacy-preserving data mining techniques for application domains, such as medicine and social networks, that face the increasing heterogeneity and complexity of new forms of data. Renowned authorities

Explorations in Automatic Thesaurus Discovery

Author : Gregory Grefenstette
Publisher : Springer Science & Business Media
ISBN 13 : 0792394682
Total Pages : 324 pages
Book Rating : 4.7/5 (923 download)

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Book Synopsis Explorations in Automatic Thesaurus Discovery by : Gregory Grefenstette

Download or read book Explorations in Automatic Thesaurus Discovery written by Gregory Grefenstette and published by Springer Science & Business Media. This book was released on 1994-07-31 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explorations in Automatic Thesaurus Discovery presents an automated method for creating a first-draft thesaurus from raw text. It describes natural processing steps of tokenization, surface syntactic analysis, and syntactic attribute extraction. From these attributes, word and term similarity is calculated and a thesaurus is created showing important common terms and their relation to each other, common verb--noun pairings, common expressions, and word family members. The techniques are tested on twenty different corpora ranging from baseball newsgroups, assassination archives, medical X-ray reports, abstracts on AIDS, to encyclopedia articles on animals, even on the text of the book itself. The corpora range from 40,000 to 6 million characters of text, and results are presented for each in the Appendix. The methods described in the book have undergone extensive evaluation. Their time and space complexity are shown to be modest. The results are shown to converge to a stable state as the corpus grows. The similarities calculated are compared to those produced by psychological testing. A method of evaluation using Artificial Synonyms is tested. Gold Standards evaluation show that techniques significantly outperform non-linguistic-based techniques for the most important words in corpora. Explorations in Automatic Thesaurus Discovery includes applications to the fields of information retrieval using established testbeds, existing thesaural enrichment, semantic analysis. Also included are applications showing how to create, implement, and test a first-draft thesaurus.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1437 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1437 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Drug Discovery Strategies and Methods

Author : Alexandros Makriyannis
Publisher : CRC Press
ISBN 13 : 082475767X
Total Pages : 317 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Drug Discovery Strategies and Methods by : Alexandros Makriyannis

Download or read book Drug Discovery Strategies and Methods written by Alexandros Makriyannis and published by CRC Press. This book was released on 2003-11-04 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.

Biophysical Techniques in Drug Discovery

Author : Angeles Canales
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012860
Total Pages : 336 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Biophysical Techniques in Drug Discovery by : Angeles Canales

Download or read book Biophysical Techniques in Drug Discovery written by Angeles Canales and published by Royal Society of Chemistry. This book was released on 2017-11-14 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

Knowledge Discovery in Bioinformatics

Author : Xiaohua Hu
Publisher : John Wiley & Sons
ISBN 13 : 9780470124635
Total Pages : 400 pages
Book Rating : 4.1/5 (246 download)

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Book Synopsis Knowledge Discovery in Bioinformatics by : Xiaohua Hu

Download or read book Knowledge Discovery in Bioinformatics written by Xiaohua Hu and published by John Wiley & Sons. This book was released on 2007-06-11 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this edited book is to bring together the ideas and findings of data mining researchers and bioinformaticians by discussing cutting-edge research topics such as, gene expressions, protein/RNA structure prediction, phylogenetics, sequence and structural motifs, genomics and proteomics, gene findings, drug design, RNAi and microRNA analysis, text mining in bioinformatics, modelling of biochemical pathways, biomedical ontologies, system biology and pathways, and biological database management.

Modern Methods of Drug Discovery

Author : Alexander Hillisch
Publisher : Springer Science & Business Media
ISBN 13 : 9783764360818
Total Pages : 314 pages
Book Rating : 4.3/5 (68 download)

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Book Synopsis Modern Methods of Drug Discovery by : Alexander Hillisch

Download or read book Modern Methods of Drug Discovery written by Alexander Hillisch and published by Springer Science & Business Media. This book was released on 2002-12-11 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Discovery in Canadian Common Law

Author : Todd L. Archibald
Publisher :
ISBN 13 : 9780433492405
Total Pages : 241 pages
Book Rating : 4.4/5 (924 download)

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Book Synopsis Discovery in Canadian Common Law by : Todd L. Archibald

Download or read book Discovery in Canadian Common Law written by Todd L. Archibald and published by . This book was released on 2017-07 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Discovery is a central element of civil litigation--it is a mechanism in civil litigation to prepare both parties to a lawsuit to know the case that they have to meet so they can prepare for trial or resolve their disputes by settlement. The book covers the principles of and approaches to discovery, and gives practical advice on the techniques and tactics to be deployed, and ethical issues. As well, the book serves as a "how-to" quick manual on conducting discovery in all common law jurisdictions in Canada (i.e., all provinces except Quebec) and explains and updates the discussion in light of current e-discovery practices."--