Developmental Toxicity Of Organophosphate Based Flame Retardants

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Developmental Toxicity of Organophosphate-based Flame Retardants

Author : Sean P. McGee
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (88 download)

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Book Synopsis Developmental Toxicity of Organophosphate-based Flame Retardants by : Sean P. McGee

Download or read book Developmental Toxicity of Organophosphate-based Flame Retardants written by Sean P. McGee and published by . This book was released on 2012 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: The commercial polybrominated diphenyl ether (PBDE) mixture known as PentaBDE was once the primary flame retardant (FR) used in the US to comply with California's Technical Bulletin 117 (TB117) - a mandated flammability standard for polyurethane foam within upholstered furniture and baby products. In 2004, due to concerns about persistence, bioaccumulation, and toxicity, PentaBDE was voluntarily phased out, prompting an industry-wide shift toward the use of alternative flame retardant formulations containing at least one of the two major classes of organophosphate-based flame retardants (OPFRs) - chlorinated phosphate esters (CPEs) and aryl phosphate esters (APEs). Due to rapid adoption as PentaBDE replacements, organophosphate-based flame retardants (OPFRs) have been detected at concentrations comparable to and, in some cases, higher than total PBDE concentrations in household dust, suggesting that chronic human exposure to these alternative flame retardants following leaching from treated products is common within the United States. Despite the need for a better understanding of the potential developmental effects of OPFRs (since infants and children tend to (1) ingest more house dust than adults due to crawling and mouthing behaviors and (2) be exposed up to five times the acceptable daily OPFR intake level due to use in residential furniture), most studies to date have focused on the genotoxicity or neurotoxicity of OPFRs within adult animals. Using zebrafish as an animal model, the objective of these studies was to begin uncovering the mechanisms of developmental toxicity for OPFRs commonly detected within indoor environments. Our results demonstrate that the two major classes of OPFRs - CPEs and APEs - exhibit distinct mechanisms of toxicity during zebrafish embryogenesis. Specifically, exposure to the high-production volume CPE tris(1,3- dichloro-2-propyl) phosphate (TDCPP) delayed zygotic genome remethylation during early embryogenesis, while exposure to triphenyl phosphate (TPP) and monoisopropylated triaryl phosphate (Mono-ITP) - two APEs that account for 49% of Firemaster 550, a major PentaBDE replacement - resulted in severe cardiac abnormalities during early vertebrate development. Overall, these results are the first to show early developmental toxicity of widely used and detected OPFRs.

A Class Approach to Hazard Assessment of Organohalogen Flame Retardants

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309491215
Total Pages : 103 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis A Class Approach to Hazard Assessment of Organohalogen Flame Retardants by : National Academies of Sciences, Engineering, and Medicine

Download or read book A Class Approach to Hazard Assessment of Organohalogen Flame Retardants written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-07-19 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 1970s, flame retardants began to be added to synthetic materials to meet strict flammability standards. Over the years, diverse flame retardants have been manufactured and used in various products. Some flame retardants have migrated out of the products, and this has led to widespread human exposure and environmental contamination. There also is mounting evidence that many flame retardants are associated with adverse human health effects. As a result, some flame retardants have been banned, restricted, or voluntarily phased out of production and use. This publication develops a scientifically based scoping plan to assess additive, nonpolymeric organohalogen flame retardants as a class for potential chronic health hazards under the Federal Hazardous Substances Act, including cancer, birth defects, and gene mutations.

Screening-level Hazard Assessment of Human and Environmental Health Endpoints of Halogenated and Organophosphate Flame Retardants

Download Screening-level Hazard Assessment of Human and Environmental Health Endpoints of Halogenated and Organophosphate Flame Retardants PDF Online Free

Author : Seth Rojello Fernández
Publisher :
ISBN 13 : 9781392170205
Total Pages : 119 pages
Book Rating : 4.1/5 (72 download)

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Book Synopsis Screening-level Hazard Assessment of Human and Environmental Health Endpoints of Halogenated and Organophosphate Flame Retardants by : Seth Rojello Fernández

Download or read book Screening-level Hazard Assessment of Human and Environmental Health Endpoints of Halogenated and Organophosphate Flame Retardants written by Seth Rojello Fernández and published by . This book was released on 2019 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organohalogen flame retardants are extensively used in both industrial and consumer products but now are being phased out of circulation by both state governments and the United States Federal government. Organophosphate flame retardants have been chosen as the replacement for the halogenated flame retardants. However, relatively little is known about the potential hazard of these class of chemicals to cause adverse health and environmental effects. To address this, we conducted a health and environmental hazard screening of 90 halogenated and 97 organophosphate flame retardants based on the GreenScreen® or Quick Chemical Assessment Tool (QCAT©) methodologies. Priority consideration was given to human health hazards including carcinogenicity (including mutagenicity and genetic toxicity), reproductive or developmental toxicity, endocrine disruption, and acute mammalian toxicity. Environmental hazards given priority consideration included acute aquatic toxicity, persistence, and bioaccumulation. Using publicly available information, each hazard category was assigned a concern level (very-low, low, moderate, high, or very high) based on pre-defined numerical ranges, such as no-observed adverse effect levels and hazard classification schemes from authoritative sources, when available. Where empirical data were not identified, quantitative structure-activity relationship (QSAR) models were relied upon to predict hazard potential. After assigning concern levels for each priority health effect, each chemical received a score, similar to a report card (A, B, C, or F). The majority of the screened chemicals received an F grade due to empirical data suggesting high hazard, QSAR model predictions, and/or excessive data gaps. Acute Mammalian Toxicity was the most prominent potential health hazard identified based on empirical data. The most prevalent data gap was found in both reproductive toxicity and endocrine disruption endpoints due to the lack of identified empirical data or computer models able to predict this hazard. This study highlights the limited toxicity information available for these widely used chemical classes and indicates that more testing and oversight is critically needed to identify safer alternatives for fire prevention.

Toxicology of Organophosphate and Carbamate Compounds

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0080543103
Total Pages : 781 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Toxicology of Organophosphate and Carbamate Compounds by : Ramesh C Gupta

Download or read book Toxicology of Organophosphate and Carbamate Compounds written by Ramesh C Gupta and published by Academic Press. This book was released on 2011-04-28 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

The Non-halogenated Flame Retardant Handbook

Author : Alexander B. Morgan
Publisher : John Wiley & Sons
ISBN 13 : 1118939204
Total Pages : 314 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis The Non-halogenated Flame Retardant Handbook by : Alexander B. Morgan

Download or read book The Non-halogenated Flame Retardant Handbook written by Alexander B. Morgan and published by John Wiley & Sons. This book was released on 2014-04-07 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-stop, practical handbook containing all of the current commercial non-halogenated flame retardant technologies as well as experimental systems near commercialization In response to the emphasis on replacing halogenated flame retardants with alternate technologies, this handbook focuses on existing non-halogenated flame retardants and the experimental close-to-production systems that are available today. The Non-Halogenated Flame Retardant Handbook starts with an overview of the regulations and customer perceptions driving non-halogenated flame retardant selections over older halogenated technologies. It then moves on to cover the known major classes of non-halogenated flame retardants, before concluding with the current niche-performing technologies and untried commercial contenders of the future. The Non-Halogenated Flame Retardant Handbook: Takes a practical approach to addressing the narrow subject of non-halogenated flame retardancy—placing more emphasis on flame retardant selection for specific plastics, practical considerations in flame retardant material design, and the various technologies’ strengths and limits Focuses on the proper use of non-halogenated flame retardants, rather than the mechanics of how they work Discusses important future trends in flame retardancy Features sections written by industrial and chemical experts who know how to apply the technology to polymers for fire safety needs

Toxicological Risks of Selected Flame-Retardant Chemicals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171938
Total Pages : 534 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Risks of Selected Flame-Retardant Chemicals by : National Research Council

Download or read book Toxicological Risks of Selected Flame-Retardant Chemicals written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Polymer Green Flame Retardants

Author : Constantine D. Papaspyrides
Publisher : Newnes
ISBN 13 : 0444538097
Total Pages : 943 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Polymer Green Flame Retardants by : Constantine D. Papaspyrides

Download or read book Polymer Green Flame Retardants written by Constantine D. Papaspyrides and published by Newnes. This book was released on 2014-08-14 with total page 943 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer Green Flame Retardants covers key issues regarding the response of polymers during fire, the mechanisms of their flame retardation, the regulations imposed on their use, and the health hazards arising from their combustion. Presenting the latest research developments, the book focuses in particular on nanocomposites, believed to be the most promising approach for producing physically superior materials with low flammability and ecological impact. The fire properties of nanocomposites of various matrixes and fillers are discussed, the toxicological characteristics of these materials are analyzed, addressing also their environmental sustainability. Edited by distinguished scientists, including an array of international industry and academia experts, this book will appeal to chemical, mechanical, environmental, material and process engineers, upper-level undergraduate and graduate students in these disciplines, and generally to researchers developing commercially attractive and environmentally friendly fire-proof products. Provides recent findings on the manufacture of environmentally sustainable flame retardant polymeric materials Covers legislation and regulations concerning flame retarded polymeric material use Includes tables containing the fire properties of the most common polymeric materials

Green Toxicology

Author : Alexandra Maertens
Publisher : Royal Society of Chemistry
ISBN 13 : 1839164409
Total Pages : 225 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Green Toxicology by : Alexandra Maertens

Download or read book Green Toxicology written by Alexandra Maertens and published by Royal Society of Chemistry. This book was released on 2022-02-01 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Marine Ecotoxicology

Author : Julián Blasco
Publisher : Academic Press
ISBN 13 : 012803372X
Total Pages : 334 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Marine Ecotoxicology by : Julián Blasco

Download or read book Marine Ecotoxicology written by Julián Blasco and published by Academic Press. This book was released on 2016-08-05 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Ecotoxicology: Current Knowledge and Future Issues is the first unified resource to cover issues related to contamination, responses, and testing techniques of saltwater from a toxicological perspective. With its unprecedented focus on marine environments and logical chapter progression, this book is useful to graduate students, ecotoxicologists, risk assessors, and regulators involved or interested in marine waters. As human interaction with these environments increases, understanding of the pollutants and toxins introduced into the oceans becomes ever more critical, and this book builds a foundation of knowledge to assist scientists in studying, monitoring, and making decisions that affect both marine environments and human health. A team of world renowned experts provide detailed analyses of the most common contaminants in marine environments and explain the design and purpose of toxicity testing methods, while exploring the future of ecotoxicology studies in relation to the world’s oceans. As the threat of increasing pollution in marine environments becomes an ever more tangible reality, Marine Ecotoxicology offers insights and guidance to mitigate that threat. Provides practical tools and methods for assessing and monitoring the accumulation and effects of contaminants in marine environments Unites world renowned experts in marine ecotoxicology to deliver thorough and diverse perspectives Builds the foundation required for risk assessors and regulators to adequately assess and monitor the impact of pollution in marine environments Offers helpful insights and guidance to graduate students, ecotoxicologists, risk assessors, and regulators interested in mitigating threats to marine waters

Systems Biology in Toxicology and Environmental Health

Author : Rebecca Fry
Publisher : Academic Press
ISBN 13 : 0128015683
Total Pages : 285 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Systems Biology in Toxicology and Environmental Health by : Rebecca Fry

Download or read book Systems Biology in Toxicology and Environmental Health written by Rebecca Fry and published by Academic Press. This book was released on 2015-06-11 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

Fire Retardancy of Polymeric Materials

Author : Charles A. Wilkie
Publisher : CRC Press
ISBN 13 : 1040035256
Total Pages : 800 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Fire Retardancy of Polymeric Materials by : Charles A. Wilkie

Download or read book Fire Retardancy of Polymeric Materials written by Charles A. Wilkie and published by CRC Press. This book was released on 2024-07-29 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of Fire Retardancy of Polymeric Materials provides a single source for all aspects of this highly challenging field of applied research. This authoritative book covers design and non-fire requirements that drive how these materials are fire protected. Detailed study and consideration of chemistry, physics, materials science, economic issues and fire safety science is necessary to address considerations of mechanical, thermal, environmental, and end-use requirements on top of fire protection means that the field requires. This thoroughly revised new edition continues to offer comprehensive coverage of the scientific approach for those developing fire safe materials. It covers new topics such as bio-based materials, regulatory issues, recycling, newer flame retardant chemical classes, and more details on how to flame retard materials for specific market applications. Written by a team of experts, this book covers the fundamentals of polymer burning and combustion and how to apply fire protection or flame-retardant chemistries to specific material classes and applications. The book is written for material scientists and fire safety scientists who seek to develop new fire safe materials or understand why materials burn in our modern environment. Features Connects fundamentals of material flammability to practical fire safety needs Covers current fire safety requirements and regulations affecting flame retardant selection Provides information on chemical structure-property relationships for flame retardancy Provides practical guidance on how to design fire safe materials for specific fire risk scenarios The new edition is expanded to 32 chapters and all chapters are updated and revised with the newest information

Indoor Environment

Author : Lidia Morawska
Publisher : John Wiley & Sons
ISBN 13 : 3527609202
Total Pages : 467 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Indoor Environment by : Lidia Morawska

Download or read book Indoor Environment written by Lidia Morawska and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the fundamentals of air-borne particles and settled dust in the indoor environment, this handy reference investigates: * relevant definitions and terminology, * characteristics, * sources, * sampling techniques and instrumentation, * exposure assessment, * monitoring methods. The result is a useful and comprehensive overview for chemists, physicists and biologists, postgraduate students, medical practitioners, occupational health professionals, building owners and managers, building, construction and air-conditioning engineers, architects, environmental lawyers, government and regulatory professionals.

Flame Retardant Polymer Nanocomposites

Author : Alexander B. Morgan
Publisher : John Wiley & Sons
ISBN 13 : 0470109025
Total Pages : 451 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Flame Retardant Polymer Nanocomposites by : Alexander B. Morgan

Download or read book Flame Retardant Polymer Nanocomposites written by Alexander B. Morgan and published by John Wiley & Sons. This book was released on 2007-04-06 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flame Retardant Polymer Nanocomposites takes a comprehensive look at polymer nanocomposites for flame retardancy applications and includes nanocomposite fundamentals (theory, design, synthesis, characterization) as well as polymer flammability fundamentals with emphasis on how nanocomposites affect flammability. The book has practical examples from literature, patents, and existing commercial products. Readers can design new work based upon the material in the book or use it as a handy reference for interpreting existing work and results.

Flame-Retardant Polymeric Materials

Author : Eli Pearce
Publisher : Springer Science & Business Media
ISBN 13 : 1468421484
Total Pages : 463 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Flame-Retardant Polymeric Materials by : Eli Pearce

Download or read book Flame-Retardant Polymeric Materials written by Eli Pearce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flammability has been recognized as an increasingly important social and scientific problem. Fire statistics in the United States (Report of the National Commission on Fire Prevention and Control. "America Burning:' 1973) emphasized the vast devastation to life and property--12.000 lives lost annually due to fire. and these deaths are usually caused by inhaling smoke or toxic gases: 300.000 fire injuries: 11.4 billion dollars in fire cost at which 2.7 billion dollars is related to property loss: a billion dollars to burn injury treatment: and 3.3 billion dollars in productivity loss. It is obvious that much human and economic misery can be attributed to fire situations. In relation to this. polymer flammability has been recognized as an in creasingly important social and scientific problem. The development of flame-retardant polymeric materials is a current example where the initia tive for major scientific and technological developments is motivated by sociological pressure and legislation. This is part of the important trend toward a safer environment and sets a pattern for future example. Flame retardancy deals with our basic everyday life situations-housing. work areas. transportation. clothing and so forth-the "macroenvironment" capsule within which "homosapiens" live. As a result. flame-retardant polymers are now emerging as a specific class of materials leading to new and diversified scientific and technological ventures.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264067396
Total Pages : 26 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study written by OECD and published by OECD Publishing. This book was released on 2007-10-15 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...

Emergency Response Guidebook

Author : U.S. Department of Transportation
Publisher : Simon and Schuster
ISBN 13 : 1626363765
Total Pages : 400 pages
Book Rating : 4.6/5 (263 download)

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Book Synopsis Emergency Response Guidebook by : U.S. Department of Transportation

Download or read book Emergency Response Guidebook written by U.S. Department of Transportation and published by Simon and Schuster. This book was released on 2013-06-03 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.

Toxicants in Food Packaging and Household Plastics

Author : Suzanne M. Snedeker
Publisher : Springer
ISBN 13 : 1447165004
Total Pages : 311 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Toxicants in Food Packaging and Household Plastics by : Suzanne M. Snedeker

Download or read book Toxicants in Food Packaging and Household Plastics written by Suzanne M. Snedeker and published by Springer. This book was released on 2014-08-13 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a comprehensive resource on toxicants that can be released from food packaging materials and household plastics. Chapters include sources and levels of chemical exposure, known and suspected health effects and the identification of data gaps with recommendations for further research. In addition, regulatory approaches and risk assessment challenges in the United States and Europe are discussed. Chapters cover both the more widely known chemicals that can migrate from food packaging (bisphenol A, perfluorinated chemicals), and household plastics (lead, phthalates, brominated flame retardants), as well as chemicals that are just entering use in food packaging (nanomaterials in polymer food packaging) and chemicals recently identified as migrating from food packaging to food stuffs (phthalates, benzophenones, antimony, methylnaphthalene and the alkylphenols nonylphenol and octylphenol). Chapters on phthalates and brominated flame retardants discuss challenges that arise with the use of replacement chemicals. The health effect sections of chapters have drawn on a wide variety of toxicological endpoints and recommend approaches to better assess toxicological risks in vulnerable human populations. Reflecting the global nature of our food supply and household consumer goods, contributions have been drawn from international experts. A wide range of scientists will find this book to be useful, including toxicologists, environmental health scientists, food scientists, and regulators.