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Development Of Spectral Domain Optical Coherence Tomography For Pharmaceutical And Medical Application
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Book Synopsis Development of Spectral Domain Optical Coherence Tomography for Pharmaceutical and Medical Application by : Yue Dong
Download or read book Development of Spectral Domain Optical Coherence Tomography for Pharmaceutical and Medical Application written by Yue Dong and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Spectral Domain Optical Coherence Tomography in Macular Diseases by : Carsten H. Meyer
Download or read book Spectral Domain Optical Coherence Tomography in Macular Diseases written by Carsten H. Meyer and published by Springer. This book was released on 2016-11-21 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to build concepts and create a solid foundation in the field of optical coherence tomography (OCT) for the general ophthalmologists as well as for the resident trainees and fellows. The chapters are written by leading international authorities in a style comprehensible to a broad audience. Numerous clinical pictures and SD-OCT scans help elucidate various clinical entities.OCT is the optical analog of ultrasound imaging and has emerged as a powerful imaging technique that enables non-invasive, in-vivo, high-resolution, cross-sectional imaging in retinal tissue. A new generation spectral domain optical coherence tomography (SD-OCT) technology has now been developed, representing a quantum leap in resolution and speed, achieving in vivo optical biopsy. i.e. the visualization of tissue architectural morphology in situ and in real time. This book encompasses the role of SD-OCT in both medical and surgical macular disorders. The book is meant coherent and comprehensive for both vitreoretinal specialists as well as general ophthalmologists.
Book Synopsis Guide to Interpreting Spectral Domain Optical Coherence Tomography by : Lumbroso Bruno
Download or read book Guide to Interpreting Spectral Domain Optical Coherence Tomography written by Lumbroso Bruno and published by JP Medical Ltd. This book was released on 2011-09 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides ophthalmologists through the interpretation of Optical Coherence Tomography (OCT) images. The first phase of analysis subdivides each image into its smallest components. The second phase combines these fine details to allow diagnosis and identification of appropriate treatment. Written by leading European experts, this manual features detailed schematic illustrations as well as actual scans, and offers information on the technical and clinical uses in the study of glaucoma and on three dimensional images.
Book Synopsis Development and Application of Optical Coherence Tomography (OCT) by : Michael Pircher
Download or read book Development and Application of Optical Coherence Tomography (OCT) written by Michael Pircher and published by MDPI. This book was released on 2018-03-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Development and Application of Optical Coherence Tomography (OCT)" that was published in Applied Sciences
Book Synopsis Spectral Domain Optical Coherence Tomography: A Practical Guide by : Dacosta Shaun
Download or read book Spectral Domain Optical Coherence Tomography: A Practical Guide written by Dacosta Shaun and published by JP Medical Ltd. This book was released on 2011-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Spectral Domain OCT is a practical guide to the investigation and diagnosis of retinal disease using the Topcon machine. Beginning with an overview of OCT, the book provides a step by step approach to image capture, analysis and interpretation. With the help of numerous case studies, OCT patterns in different types of retinal disease are presented as both 2D and 3D images. In addition, Spectral Domain OCT highlights features of the new Topcon 2000 machine with an enhanced speed of 27,000 A scans/second, improved software algorithms and extra facilities for anterior segment imaging.
Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Book Synopsis Optical Coherence Tomography and Its Non-medical Applications by : Michael Wang
Download or read book Optical Coherence Tomography and Its Non-medical Applications written by Michael Wang and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhancing security in biometric applications. OCT can also be used for the evaluation of fastener flushness for improving aerodynamic performance of high-speed aircraft. More and more OCT non-medical applications are emerging. In this book, we present some recent advancements in OCT technology and non-medical applications.
Book Synopsis Optical Coherence Tomography by : Rui Bernardes
Download or read book Optical Coherence Tomography written by Rui Bernardes and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.
Book Synopsis Spectral-domain Optical Coherence Tomography Imaging of the Eye by : Anand Vinekar
Download or read book Spectral-domain Optical Coherence Tomography Imaging of the Eye written by Anand Vinekar and published by Elsevier Health Sciences. This book was released on 2012-10-30 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectral-domain Optical Coherence Tomography Imaging of the Eye is the first case-based atlas in its class: Covering over 120 clinical entities from the anterior to the posterior segment of the eye, from the most common to the rarest conditions Over 1000 descriptive high-resolution OCT images with clinical correlation Case report format for 'easy reading’ Over 100 Internationally reputed contributors Separate sections on Cornea, Lens, Glaucoma, Retina, Pediatric Retina, and Uvea
Book Synopsis Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography by : Yan Wang
Download or read book Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography written by Yan Wang and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1 describes the construction and characterization of a multi-functional SD-OCT system at 1300nm. The axial resolution, lateral resolution, imaging depth, signal sensitivity drop-off, spectrometer efficiency, phase noise, system noise, polarization noise, computation of phase retardation, optic axis and diattenuation were characterized. Multiple samples were imaged to demonstrate each imaging facet (intensity, polarization and flow) of the system.
Book Synopsis Development of Spectral Domain Optical Coherence Tomography for in Vivo Functional Imaging of Biological Tissues by : Lin An
Download or read book Development of Spectral Domain Optical Coherence Tomography for in Vivo Functional Imaging of Biological Tissues written by Lin An and published by . This book was released on 2013 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography is a rapidly developing optical imaging modality capable of noninvasively providing depth resolved information of biological tissue at micrometer scale. Since its first report in 1991, it has made tremendous progress leading to successful applications in a number of fields, such as ophthalmology, gastroenterology, dermatology, dentistry, dermatology, cardiology, etc. According to [1], there are more than 15,000 OCT units that had been put into service in ophthalmic clinic by 2009, which represented approximately $1 billion market. The total amount paid by Medicare for OCT scans has increased from $1 billion per year in 2001 to $7 billion per year by 2008. The market size has kept growing in recent years. Reported in [2] by IBISWorld (an American research company), the OCT has achieved an annual growth rate of 27.4% since 2007. In 2012, the revenue is expected to be $478.4 million, which is 24.7% larger than last year. Despite the massive success, there are still several technical issues that need to be addressed, which could help the OCT technology to deliver even better imaging quality. In this thesis, we described several OCT technologies that can be used to double the imaging depth, realize functional vasculature imaging of biological tissue and increase the imaging speed of OCT system. Aim 1: Use of a scanner to introduce spatial frequency modulation to OCT spectral interferograms for in vivo full-range Fourier-domain optical coherence tomography. A novel method was developed that could easily introduce a modulation frequency onto the X-direction (i.e., B-scan) of the FDOCT scanning system, enabling full-range Fourier-domain Optical Coherence Tomography (frFDOCT). Compared to the conventional FDOCT system, the newly developed frFDOCT system can provide increased system sensitivity and deeper imaging depth. The previous technology that can achieve frFDOCT either needed multiple steps for data capturing, which is time consuming, or required additional components which increased the system's complexity. The newly developed method generates a modulation spatial frequency in the spectral interferogram by simply offsetting the probe beam at the X-scanner. In this way, the frFDOCT could be easily realized through applying a Hilbert transformation. Aim 2: Using optical micro-angiography to achieve in vivo volumetric imaging of vascular perfusion within human retina and choroids. Optical Micro-Angiography (OMAG) is a functional extension of FDOCT technology. It can achieve visualization of vasculature network of biological tissue. In order to apply the OMAG method to image vasculature map of human retina and choroid, a phase compensation algorithm was developed, which could minimize the motion artifacts generated by the movements of human eye and head. The original scanning protocol of OMAG method could only achieve ~2 mm x 2 mm scanning area on the retina, which is relatively small for clinical applications. To achieve large field of view of vasculature visualization of retina and choroid, multiple small areas of retina were sequentially scanned. After being processed, all the vasculature maps coming from small areas were stitched together to produce a vasculature map of the whole retina and choroid, which is comparable to Fluorescein Angiography. Aim 3: Developing ultrahigh sensitive optical micro-angiography to achieve micro vasculature imaging of biological tissue. Though the OMAG has been successfully applied for visualizing vasculature networks of different biological tissue, there are several problems that need to be solved, such as lower flow sensitivity, longer imaging time and so on. To improve the vasculature image quality, we developed ultrahigh sensitive OMAG (UHS-OMAG). Unlike conventional OMAG, UHS-OMAG applied the OMAG algorithm onto the slow direction of FDOCT scan (Y-direction). Because the time interval between adjacent B-frames is much longer than that between adjacent A-lines, UHS-OMAG can achieve much higher flow sensitivity compared to the conventional OMAG. In addition, the UHS-OMAG usually employed high frame rate (typically 300 frames per second) to achieve 3D scan, it cost much less time to finish one 3D scan compared to the traditional OMAG. However, when it was applied to visualize vasculature map of human tissue, the motion artifacts caused by the inevitable movements is still the biggest challenge. Based on the phase difference calculated from two adjacent B-frames, a new phase compensation algorithm was developed. The UHS-OMAG system was then applied onto human retina and skin to produce detailed micro vasculature networks. Aim 4: Developing ultrahigh speed Spectral Domain OCT system through sequentially controlling two high speed line scan CMOS cameras. Since the report of OCT technology, the imaging speed is always the hot topic along its development path. Though one branch of FDOCT technology, swept source OCT, can run at several megahertz, SSOCT is still not approved by FDA for human eye imaging. The development of spectral domain OCT is more attractive from a commercialization perspective. Two identical high speed line cameras were employed to build two home build high speed spectrometers. Through sequentially controlling the reading time period of two cameras, the imaging speed of the whole system could reach twice higher than the single camera system. The newly built 800 nm SDOCT system which can work at 500,000 Hz A-lines capturing speed was then used to achieve in vivo 3D imaging in both high speed and large field of view mode. In addition, through combining with the OMAG algorithm, the newly developed system is capable of providing detailed micro-vasculature imaging of human retina and optic nerve head.
Book Synopsis SWEPT SOURCE OPTICAL COHERENCE by : Luoqin Yu
Download or read book SWEPT SOURCE OPTICAL COHERENCE written by Luoqin Yu and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Swept Source Optical Coherence Tomography System Development for Bioimaging Applications" by Luoqin, Yu, 俞罗琴, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Optical coherence tomography (OCT) is an imaging modality with strengths in high-resolution, label-free, and noninvasive, which strategically fills the gap between ultrasound and microscopy and is superior for some biomedical applications. Swept source OCT (SS-OCT) improves system simplicity and sensitivity compared to previous versions of time domain OCT (TD-OCT) because of a static reference mirror and has faster imaging speed compared to spectral domain OCT (SD-OCT) because of a single photodetector and the availability of high-repetition-rate broadband lasers. Furthermore, functional spectroscopic OCT (SOCT) analyzes materials according to their specific optical properties at different wavelengths. Thus, by utilizing an ultra-wide band OCT and analyzing the sub-band images, it provides us a spectroscopic way to recognize materials. These kinds of newly developed OCT systems are quite promising in clinical bioimaging applications. One of the most commonly used swept sources in SS-OCT systems is the Fourier domain mode-locked (FDML) laser. It has a narrow instantaneous linewidth that improves imaging range, a broad sweeping range that renders high resolution, fast building up time that enables fast scanning, and a proper output power. However, traditional FDML lasers have limited sweeping range because of a limited amplification window of the gain medium that is usually unable to achieve an ultra-wide wavelength range. It hinders its way in spectroscopic imaging applications. Nevertheless, multi-band illumination can break through the bandwidth limitation of single-band SOCT. Consequently, developing swept sources with various output wavelength ranges is of high interest. The FDML lasers with output at 1.0 m range are most suitable in water-rich tissues where water dispersion and absorption are minimized. Thus, 1.0 m FDML laser cavities are firstly proposed with different amplification schemes to compare their performances. Dual-and tri-band SS-OCT systems for SOCT application are further investigated for contrast enhancement and differentiation of materials, such as lipid and porcine artery. Not only the output wavelength ranges of swept sources are of big concern, the swept speed is another bottleneck yet to be surpassed, especially for endoscopic applications. As the mechanical inertia of FDML lasers will limit the fundamental A-scan rate to hundreds of kilohertz, an ultrafast mode-locked laser together with inertia-free optical time-stretch mechanism is a promising alternative for SS-OCT endoscopic application. It has long imaging range and allows an A-scan rate up to more than ten megahertz. We further demonstrated this kind of amplified optical time-stretch (AOT) OCT with extensional application by endoscopic imaging. In summary, the goal of this thesis is to develop and extend SS-OCT systems in different aspects for various bioimaging applications. The SS-OCT systems with different advantages are proposed for spectroscopic and endoscopic imaging. Subjects: Imaging systems in medicine Optical coherence tomography
Book Synopsis A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications by : Mengyang Liu
Download or read book A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications written by Mengyang Liu and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) has been widely used in biomedical imaging ever since its introduction. However, the application of OCT for biometrics is relatively new. This thesis demonstrates the feasibility of applying a spectral domain optical coherence tomography (SD-OCT) system to fingertip biometric information retrieval. The results show that SD-OCT is capable of retrieving Level 3 fingertip information. Combined with traditional Level 1 and 2 fingerprint information, which can also be easily acquired by SD-OCT, the proposed application shows potential for ultra-secure scenarios. Photoacoustic microscopy (PAM) is another imaging modality gaining considerable interest in the past decade. Different than OCT, it employs ultrasound detection for optically induced thermal expansion in tissue. Bovine articulate cartilage samples are imaged with a single wavelength PAM system using India ink as a contrast agent. The same samples were also imaged with SD-OCT. Image analysis shows that PAM produces excellent contrast between intact and fibrillated regions in cartilage while SD-OCT visualizes topological changes with fine spatial resolution. A spectroscopic PAM system is also developed using a tunable source based on supercontinuum generation in a photonic crystal fiber. Imaging experiments of tissue phantoms demonstrate the ability to differentiate various chromophores with unique absorption characteristics. Another spectroscopic PAM system is currently being developed, where the tunable source is based on stimulated Raman scattering. This new system is being studied and some preliminary results are given to demonstrate its advantages over the supercontinuum approach.
Book Synopsis Selected Topics in Optical Coherence Tomography by : Gangjun Liu
Download or read book Selected Topics in Optical Coherence Tomography written by Gangjun Liu and published by IntechOpen. This book was released on 2012-02-08 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book.
Book Synopsis Ultrahigh-resolution, Deep-penetration Spectral-domain Optical Coherence Tomography by : Liane Sarah Bel Bernstein
Download or read book Ultrahigh-resolution, Deep-penetration Spectral-domain Optical Coherence Tomography written by Liane Sarah Bel Bernstein and published by . This book was released on 2018 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a label-free optical imaging modality that allows non-invasive in-depth visualization of microscopic structures in samples. With a typical resolution of 10-15 [mu]m and a penetration of up to a few mm, OCT is widely used for medical diagnoses in fields such as ophthalmology and cardiology. However, the more common diagnostic tool in the microscopic regime of medical imaging is histology, an invasive technique requiring tissue biopsy. Its resolution can be as small as 0.2 [mu]m, allowing the visualization of subcellular structures. To help bridge this gap between OCT and histology, ultrahigh-resolution OCT systems have been developed, with resolutions on the order of 1 [mu]m. Yet their application remains limited, since they employ shorter-wavelength sources, reducing penetration in tissue. We have designed and built a spectral-domain ultrahigh-resolution, deep-penetration OCT system centered at 1290 nm with axial and lateral resolutions of 2 and 5 [mu]m, respectively. To our knowledge, this is the best axial resolution obtained for a highspeed OCT system centered this deeply in the infrared. We demonstrate imaging of the cardiac conduction system, which could eventually be used for intraoperative identification of conducting tissue. In addition, we show images of the corneo-scleral angle, which could help properly diagnose primary angle-closure glaucoma. Other potential applications are also discussed.
Book Synopsis Spectral Domain Optical Coherence Tomography: A Practical Guide by : Dacosta Shaun, Rajendran Babu, Janakiraman P
Download or read book Spectral Domain Optical Coherence Tomography: A Practical Guide written by Dacosta Shaun, Rajendran Babu, Janakiraman P and published by JAYPEE BROTHERS PUBLISHERS. This book was released on with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Optical Coherence Tomography by : Mark E. Brezinski
Download or read book Optical Coherence Tomography written by Mark E. Brezinski and published by Elsevier. This book was released on 2006-08-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. - Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. - Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.
