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Development Of Novel Formulations Of Bioactive Glass Based Calcium Phosphate Cement For Bone Grafting
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Book Synopsis Development of Novel Formulations of Bioactive Glass Based Calcium Phosphate Cement for Bone Grafting by : Alessia D'Onofrio
Download or read book Development of Novel Formulations of Bioactive Glass Based Calcium Phosphate Cement for Bone Grafting written by Alessia D'Onofrio and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Calcium Phosphate Biomaterials by : Besim Ben-Nissan
Download or read book Advances in Calcium Phosphate Biomaterials written by Besim Ben-Nissan and published by Springer Science & Business. This book was released on 2014-04-17 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Book Synopsis Developments and Applications of Calcium Phosphate Bone Cements by : Changsheng Liu
Download or read book Developments and Applications of Calcium Phosphate Bone Cements written by Changsheng Liu and published by Springer. This book was released on 2017-10-20 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Book Synopsis Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery by : Chengtie Wu
Download or read book Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery written by Chengtie Wu and published by CRC Press. This book was released on 2013-03-22 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioceramics play an important role in repairing and regenerating defective or damaged bone. Annually, more than 500,000 bone graft procedures are performed in the United States and approximately 2.2 million are conducted worldwide. Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery reviews the latest advances in the field of bioceramics. The book summarizes innovative concepts, bioceramic design, and methods for material synthesis and drug delivery. Offering guidance for biomedical engineering researchers and material scientists, the book explores: Novel mesoporous bioactive glasses and silicate-based ceramics for bone regeneration and drug delivery Bioactive silicate ceramics, including their mechanical properties, interaction with bone-forming cells, and in vivo osteogenesis and angiogenesis Silica nanospheres with a core-shell structure and their specific properties for controllable drug delivery The 3D-printing technique to prepare advanced bioceramic scaffolds for bone tissue engineering applications—including the preparation, mechanical strength, and biological properties of 3D-printed porous scaffolds of calcium phosphate cement and silicate bioceramics Biomimetic preparation and controllable crystal growth and biomineralization of bioceramics Inorganic and organic composite materials and their unique biological, electrical, and mechanical properties that enable the design of excellent bone regeneration and gene delivery systems A comprehensive survey of the research progress of bioceramics and their applications in bone repair and regeneration, this volume is designed to enhance study and career development for those in this field and to facilitate further research and opportunities for new solutions.
Book Synopsis Development of a Novel In-vivo Setting Bone Graft Substitute from Bioactive Glass by : Niall William Kent
Download or read book Development of a Novel In-vivo Setting Bone Graft Substitute from Bioactive Glass written by Niall William Kent and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advanced Synthesis and Medical Applications of Calcium Phosphates by : S.S. Nanda
Download or read book Advanced Synthesis and Medical Applications of Calcium Phosphates written by S.S. Nanda and published by CRC Press. This book was released on 2024-05-15 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium phosphate materials are used in many medical and dental applications. Advanced Synthesis and Medical Applications of Calcium Phosphates covers the structure, chemistry, synthesis, and properties of both natural and synthetic calcium-based biomaterials and details a variety of medical applications. Depicts the latest advances in using calcium phosphates in bone regeneration and tissue engineering Includes the latest generation of regenerative biomaterials with an integrated perspective combining both research and clinical issues Provides an understanding of the clinical targets and requirements for regenerative medicine Detailing fundamentals through applications, this book helps biomaterials researchers to better understand the clinical targets and requirements for use of these materials for optimal synthesis and development.
Book Synopsis Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates by : Michael R. Mucalo
Download or read book Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates written by Michael R. Mucalo and published by MDPI. This book was released on 2020-12-15 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into the use of calcium phosphates in the development and clinical application of biomedical materials has been a significantly diverse activity conducted by a wide range of scientists, engineers, and medical practitioners, among others. The field of research in this area can, hence, be truly defined as interdisciplinary, and much interesting work leading to imaginative and innovative solutions for the improvement of health outcomes continues to be generated. It has been the intention of this Special Issue to summarise a number of current topical research advances in this area, as well as to review the important area of calcium phosphate-based biomaterials, namely, composites of hydroxyapatite with carbon-based materials. The scientific papers contained in this Special Issue report on advances in the areas of dental-based materials science, bone cements, use of biomaterials created from natural sources, influences of added agents such as adipose stem cells and statins on bioactivity as well as surface influences on electrical potential of biomaterials and uses of glow discharge methods to remove impurities from biomaterial surfaces.
Book Synopsis Development of a Novel Dual Paste Injectable Calcium Phosphate Cement for Bone Void Filling by : Aoife Culliton
Download or read book Development of a Novel Dual Paste Injectable Calcium Phosphate Cement for Bone Void Filling written by Aoife Culliton and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Calcium Orthophosphates by : Sergey V. Dorozhkin
Download or read book Calcium Orthophosphates written by Sergey V. Dorozhkin and published by CRC Press. This book was released on 2012-06-04 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Book Synopsis Bone Tissue Engineering by : Jeffrey O. Hollinger
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Book Synopsis Octacalcium Phosphate Biomaterials by : Gerard Insley
Download or read book Octacalcium Phosphate Biomaterials written by Gerard Insley and published by Woodhead Publishing. This book was released on 2019-11-20 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration
Book Synopsis Bioactive Materials for Bone Regeneration by : Jiang Chang
Download or read book Bioactive Materials for Bone Regeneration written by Jiang Chang and published by Academic Press. This book was released on 2020-02-28 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments
Book Synopsis Optimising Calcium Phosphate Cement Formulations to Widen Clinical Applications by : Sarika Patel
Download or read book Optimising Calcium Phosphate Cement Formulations to Widen Clinical Applications written by Sarika Patel and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The demand for reconstructive orthopaedic implants continues expanding at a reasonable pace as the incidence of fracture injuries and infectious diseases rises. There has been an increase in the clinical need for more effective synthetic bone graft materials due to the drawbacks of autogenous grafts. Since the 1980?s calcium phosphate cements (CPC?s) have attracted a great deal of interest due to their chemical similarities to natural bone; chemical, physical and mechanical characteristics have been investigated and manipulated to maximise osteoconductivity and osteointegration of these CPC?s since the start of their commercialisation. Here in this thesis, a series of investigation are complied to demonstrate novel and inventive approaches to expand the application of CPC?s: (1) limiting the liquid phase in the setting reaction of a brushite cement to produce monetite (dehydrated brushite) based cement, with increased solubility to overcome the problems faced by long term stability of hydroxyapatite (HA) cements; (2) manipulating the cement formulation to produce a cement that can set on a change in temperature, upon implantation, increasing handling time during surgeries; (3) incorporating therapeutic molecules to eliminate secondary surgeries following infectious diseases; (4) to enhance osteointegration of CPC?s by synchronising the degradation to natural bone formation. Results exhibit compressive strength appropriate for the application of cranioplasty; long term ageing studies demonstrates that the novel cement formulations do not hydrolyse to HA, eliminating the risk of catastrophic brittle failure that is commonly associated with CPC?s.
Download or read book Orthopaedic Bone Cements written by S Deb and published by Elsevier. This book was released on 2008-10-16 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone cements are widely used in orthopaedic applications to anchor implants to existing bone, reconstruct bone and deliver bioactive agents to the body. With an increasing number of bone cements available, it is vital that the correct material is selected for specific clinical procedures. Orthopaedic bone cements reviews the most recent research in this field. Part one discusses the current uses of orthopaedic bone cements with chapters on such topics as hip replacements, verteboplasty and wear particles and osteolysis. Part two reviews materials and types of cement such as acrylic, polymethylmethacrylate and calcium phosphate cements. Chapters in Part three address the mechanical properties of bone cements such as fracture toughness and dynamic creep. The final section examines methods to enhance the properties of bone cements with coverage of themes such as antibiotic loaded bone cements and bioactive cements. With its eminent editor and multidisciplinary team of international contributors, Orthopaedic bone cements is an invaluable reference for materials scientists, medical researchers and all those involved in the development of bone cements for orthopaedic applications and joint replacement. Provides a review of recent research focussing on improving the mechanical and biological performance of bone cements Discusses the current applications of bone cements particularly in hip replacement, verteboplasty and wear particles Reviews types of materials and acrylic, polymethlymethacrylate and calcium phosphate as types of cements
Book Synopsis Development and Characterization of Bioactive Bone Cements for the Treatment of Vertebral Compression Fractures by : Shant Aghyarian
Download or read book Development and Characterization of Bioactive Bone Cements for the Treatment of Vertebral Compression Fractures written by Shant Aghyarian and published by . This book was released on 2016 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of commercially available powder-liquid acrylic bone cements in vertebral compression fracture augmentation can lead to procedural complications. These limitations of these cements are the source of complications with such techniques. A premixed cement system was developed as an alternative material for spinal procedures to overcome limitations such as poor handling and pseudoplasticity, and bioinertness of the powder-liquid cements. Spinal augmentation procedures such as vertebroplasty require high viscosity cements that can be injected through small cannulas. The cement must also be able to interdigitate and osseointegrate with the surrounding trabecular bone in order to provide desirable fixation. Premixed acrylic-calcium phosphate composite formulations were prepared through customizing the handling properties of the cement. Furthermore, bioactivity was introduced through calcium phosphate phase addition. The goal of this study was to develop composite cements tailored for use in vertebroplasty. Cement properties were characterized and the formulations were tested in vertebroplasty models. Cell and animal studies were performed to analyze the osseointegrative ability of the cements. In summary, novel premixed composite formulations were successfully developed, demonstrating desirable characteristics for use in vertebral augmentation.
Book Synopsis Development of Novel High Strength Composite Calcium Phosphate Cement for Orthopedic Applications by : S M Mahmudul Hassan
Download or read book Development of Novel High Strength Composite Calcium Phosphate Cement for Orthopedic Applications written by S M Mahmudul Hassan and published by . This book was released on 2018 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis, Characterisation and Performance of Calcium Phosphate Bone Graft Substitutes by : Zeeshan Sheikh
Download or read book Synthesis, Characterisation and Performance of Calcium Phosphate Bone Graft Substitutes written by Zeeshan Sheikh and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Synthetic bone graft substitutes are frequently used to fill defects with significant bone loss to prevent fibrous tissue ingrowth and loss of function. Bone grafts are often used to augment deficient alveolar ridges allowing placement of dental implants subsequent to prior bone loss. Although autografts, allografts and xenografts have been used and researched extensively, they have inherent limitations. To overcome these, synthetic alternatives, such as calcium phosphate cement-based biomaterials are being developed. Brushite and monetite are acidic calcium phosphates having similar chemical composition. However, their in vivo behavior differs in terms of resorption and bone response. Although brushite and monetite have been shown to resorb faster in vivo than hydroxyapatite (HA), a significant reduction in the rate of resorption occurs following phase conversion of brushite to insoluble HA. As such differences between bone grafts are attributed to material composition even though physical properties such as surface area and porosity invariably differ. This thesis focuses on determining the factors and mechanisms that makes these chemically similar materials behave differently in vivo. We produced brushite cement grafts and converted them to two types of monetite by using wet (autoclaving) and dry heat (under vacuum) dehydration which resulted in materials with differing physicochemical properties. These grafts were then aged in vitro using bovine serum and phosphate buffered saline (PBS) solutions, implanted subcutaneously, in femoral condyles and onlay grafted on calvaria. The dissolution, resorption and bone formation potential of these dicalcium phosphate cement grafts was assessed and compared. Also, we developed a new alkali ion (sodium and potassium) substituted calcium phosphate cement, reinforced with silica and set using phytic acid. The set cement blocks were aged in PBS solutions and their in vitro dissolution and degradation along with other physico-chemical properties was assessed.Results presented in this Ph.D thesis discuss and shed light on the fundamental yet not understood questions regarding the relative contributions from chemico- vs physico-biomaterial properties in graft resorption and bone regeneration. This will allow in future the preparation of improved calcium phosphate-based bone substitute grafts with potential to achieve higher clinical efficiency. " --
