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Development Of New Methods For The Synthesis Of Indolines And Quinolizidines
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Book Synopsis Development of New Methods for the Synthesis of Indolines and Quinolizidines by : Hui Li
Download or read book Development of New Methods for the Synthesis of Indolines and Quinolizidines written by Hui Li and published by . This book was released on 2015 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt: I. (3 + 2) Cycloaddition reactions of oxyallyl cationic intermediates with indoles Cyclopenta-and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 +2) cycloaddition reactions of 3-substituted indoles with [alpha]-haloketones to access those scaffolds. Significant diastereo-and regiochemical control were observed. The reactions were found to proceed via an O-bound intermediate. Kinetic studies of the cycloaddition reactions and DFT calculations (B3LYP-D3/6-311++G**/MeOH) on cyclization mechanisms involving the 2-hydroxyallyl cation and its deprotonated oxyallyl cation have been performed. Both oxyallyl cationic intermediates were predicted to be viable reactive species. The synthetic potential of these reactions were demonstrated in the concise syntheses of structural cores of vincorine, isocorymine, and aspidophylline A. II. Vinylogous Mukaiyama-Michael reactions of Dihydropyridinones 2,3-Dihydro-4-pyridinones are versatile building blocks in constructing nitrogen-containing heterocyclic compounds. We have developed In(III)-catalyzed vinylogous Mukaiyama-Michael (vM-Michael) addition of O-silyl vinylketene acetals to dihydropyridinones. The reactions featured the employment of supersilyl groups to control the [alpha]-vs-[gamma] regioselectivity when [gamma]-substituted O-silyl vinylketene acetals were used. These transformations can allow easy access to quinolizidine-based alkaloids. This potential was demonstrated by formal synthesis of deoxynupharidine, lasubine I and II, as well as construction of the structural core of hupermine A. III. Discovery of the first known apoptotic monomeric nuphar analogs and enantioselective formal syntheses of 11 nuphar alkaloids (+)-6-Hydroxythiobinupharidine induces apoptosis of U937 human leukemia cells in a speed faster than any known small organic molecules. In order to obtain useful SAR information, we have designed and synthesized a stereochemically diverse collection of monomeric nuphar analogs bearing C6 hemiaminal hydroxyl groups. We have also achieved the concise enantioselective formal syntheses of eight dimeric and three monomeric nuphar alkaloids. The above syntheses involved the development of highly enantioselective chiral phosphoric acid-catalyzed vinylogous Mukaiyama-Mannich (vM-Mannich) reactions. The vM-Mannich reactions employed the supersilyl groups as a key element in controlling regio-, enantio- and diastereoselectivity. Biological evaluation of the monomeric nuphar quinolizidines identified analogs that are even more potent than the parent natural product (+)-6-Hydroxythiobinupharidine.
Book Synopsis Development of New Methods for the Synthesis of Annulated Quinones and Quinoid Compounds by : Sven Claessens
Download or read book Development of New Methods for the Synthesis of Annulated Quinones and Quinoid Compounds written by Sven Claessens and published by . This book was released on 2007 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Application of New Methods to the Synthesis of Constrained Proline Derivatives, (+)-serratezomine A, and Hapalindoles A, G, I, and K by : Aroop Chandra
Download or read book The Application of New Methods to the Synthesis of Constrained Proline Derivatives, (+)-serratezomine A, and Hapalindoles A, G, I, and K written by Aroop Chandra and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Hans-Joachim Knoelker Publisher :Springer Science & Business Media ISBN 13 :3642255280 Total Pages :268 pages Book Rating :4.6/5 (422 download)
Book Synopsis Alkaloid Synthesis by : Hans-Joachim Knoelker
Download or read book Alkaloid Synthesis written by Hans-Joachim Knoelker and published by Springer Science & Business Media. This book was released on 2012-01-13 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Book Synopsis Rhodium Catalysis by : Carmen Claver
Download or read book Rhodium Catalysis written by Carmen Claver and published by Springer. This book was released on 2017-12-15 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbrev iated as Top Organomet Chem and cited as a journal.
Download or read book Ecocatalysis written by Claude Grison and published by Elsevier. This book was released on 2015-08-19 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reconquest of biodiversity; remediation of degraded and anthropic areas, prevention of environmental health risks; eco-innovation; Green industry ... The current French ambitions are closely related to an interdisciplinary approach to scientific ecology, all of which participate in the expected industrial renewal.Ecocatalysis explores the unusual combination of phytotechnologies adapted to pollution, ecological rehabilitation of polluted sites and enhancement of these processes through innovative green chemistry, all of which contribute to the development of scientific priorities; economic, ecological innovation and current environmental, of biomass conversion and transition from fossil fuels to renewable.
Book Synopsis Recent Advances in Natural Products Analysis by : Seyed Mohammad Nabavi
Download or read book Recent Advances in Natural Products Analysis written by Seyed Mohammad Nabavi and published by Elsevier. This book was released on 2020-03-07 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group
Book Synopsis Green Organic Reactions by : Gopinathan Anilkumar
Download or read book Green Organic Reactions written by Gopinathan Anilkumar and published by Springer Nature. This book was released on 2021-03-27 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents important developments and applications of green chemistry, especially in the field of organic chemistry. The chapters give a brief account of green organic reactions in water, green organic reactions using microwave and in solvent-free conditions. In depth discussions on the green aspects of ionic liquids, flow reactions, and recoverable catalysts are provided in this book. An exclusive chapter devoted to green Lewis acid is also included. The potential of supercritical fluids as green solvents in various areas of organic reactions is explained as well. This book will be a valuable reference for beginners as well as advanced researchers interested in green organic chemistry.
Book Synopsis Catalytic Cascade Reactions by : Peng-Fei Xu
Download or read book Catalytic Cascade Reactions written by Peng-Fei Xu and published by John Wiley & Sons. This book was released on 2013-11-11 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.
Book Synopsis Asymmetric Domino Reactions by : Hélène Pellissier
Download or read book Asymmetric Domino Reactions written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2013 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accessible references for researchers and industrialists in this exciting field, covering both developments and applications of catalysis.
Download or read book Book of Abstracts written by and published by . This book was released on 2000 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nitroarenes written by Paul C. Howard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.
Book Synopsis Comprehensive Natural Products III by :
Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience
Book Synopsis Indole Ring Synthesis by : Gordon W. Gribble
Download or read book Indole Ring Synthesis written by Gordon W. Gribble and published by John Wiley & Sons. This book was released on 2016-08-08 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
Book Synopsis Isocyanide-based Multicomponent Reactions by : Jonathan G. Rudick
Download or read book Isocyanide-based Multicomponent Reactions written by Jonathan G. Rudick and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Transition Metal-Catalyzed Carbene Transformations by : Jianbo Wang
Download or read book Transition Metal-Catalyzed Carbene Transformations written by Jianbo Wang and published by John Wiley & Sons. This book was released on 2021-12-20 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an up-to-date overview of the rapidly growing field of carbene transformations Carbene transformations have had an enormous impact on catalysis and organometallic chemistry. With the growth of transition metal-catalyzed carbene transformations in recent decades, carbene transformations are today an important compound class in organic synthesis as well as in the pharmaceutical and agrochemical industries. Edited by leading experts in the field, Transition Metal-Catalyzed Carbene Transformations is a thorough summary of the most recent advances in the rapidly expanding research area. This authoritative volume covers different reaction types such as ring forming reactions and rearrangement reactions, details their conditions and properties, and provides readers with accurate information on a wide range of carbene reactions. Twelve in-depth chapters address topics including carbene C-H bond insertion in alkane functionalization, the application of engineered enzymes in asymmetric carbene transfer, progress in transition-metal-catalyzed cross-coupling using carbene precursors, and more. Throughout the text, the authors highlight novel catalytic systems, transformations, and applications of transition-metal-catalyzed carbene transfer. Highlights the dynamic nature of the field of transition-metal-catalyzed carbene transformations Summarizes the catalytic radical approach for selective carbene cyclopropanation, high enantioselectivity in X-H insertions, and bio-inspired carbene transformations Introduces chiral N,N'-dioxide and chiral guanidine-based catalysts and different transformations with gold catalysis Discusses approaches in cycloaddition reactions with metal carbenes and polymerization with carbene transformations Outlines multicomponent reactions through gem-difunctionalization and transition-metal-catalyzed cross-coupling using carbene precursors Transition Metal-Catalyzed Carbene Transformations is essential reading for all chemists involved in organometallics, including organic and inorganic chemists, catalytic chemists, and chemists working in industry.
Book Synopsis Oxidative Cross-Coupling Reactions by : Aiwen Lei
Download or read book Oxidative Cross-Coupling Reactions written by Aiwen Lei and published by John Wiley & Sons. This book was released on 2016-08-12 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first handbook on this emerging field provides a comprehensive overview of transition metal-catalyzed coupling reactions in the presence of an oxidant. Following an introduction to the general concept and mechanism of this reaction class, the team of authors presents chapters on C-C cross-coupling reactions using organometallic partners, C-Heteroatom bond forming reactions via oxidative couplings, and C-H couplings via C-H activation. The text also covers such groundbreaking topics as recent achievements in the fields of C-C and C-X bond formation reactions as well as C-H activation involving oxidative couplings. With its novel and concise approach towards important building blocks in organic chemistry and its focus on synthetic applications, this handbook is of great interest to all synthetic chemists in academia and industry alike.
