Development Of A Multi Channel Visible Light Optical Coherence Tomography Platform For Investigating Fibrotic Disease Using Optical Scattering

Download Development Of A Multi Channel Visible Light Optical Coherence Tomography Platform For Investigating Fibrotic Disease Using Optical Scattering full books in PDF, epub, and Kindle. Read online Development Of A Multi Channel Visible Light Optical Coherence Tomography Platform For Investigating Fibrotic Disease Using Optical Scattering ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Development of a Multi-channel Visible-light Optical Coherence Tomography Platform for Investigating Fibrotic Disease Using Optical Scattering

Author : Ryan Niemeier
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (124 download)

DOWNLOAD NOW!

Book Synopsis Development of a Multi-channel Visible-light Optical Coherence Tomography Platform for Investigating Fibrotic Disease Using Optical Scattering by : Ryan Niemeier

Download or read book Development of a Multi-channel Visible-light Optical Coherence Tomography Platform for Investigating Fibrotic Disease Using Optical Scattering written by Ryan Niemeier and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging and microscopy provide multi-dimensional information in both the laboratory and clinical settings. Novel imaging methods have leveraged several contrast sources in order to provide both qualitative and quantitative metrics. Optical coherence tomography (OCT) is a volumetric, micro-scale imaging modality which draws intrinsic contrast from the optical scattering of tissue. Visible-light OCT (VIS-OCT) increases the scattering contrast and is ideal for imaging thin layers of tissue with subtle changes to the optical scattering. The work contained in this dissertation is a modification of VIS-OCT to utilize simultaneous acquisition of multiple channels. Multi-channel VIS-OCT is capable of noise reduction, polarization sensitivity, and quantifying tissue optical scattering. The multi-channel system was used in several imaging applications with relevance to translational medical care and bench-top research. The system was used to image the optical scattering changes in esophageal tissue before and after microwave ablation. Measurements of optical scattering helped to identify the boundaries of the ablation which can provide valuable information both during treatment and for microwave and radiofrequency ablation antenna design. By adding polarization channels, multi-channel VIS-OCT was capable of measuring birefringence in a mouse model of pulmonary fibrosis which is being used to test novel therapeutics for lung disease. Finally, a variation of this OCT system was developed to be used in a multi-modal system which combines and co-registers several other imaging modalities and is well-suited to study fibrosis in glaucoma and cancer. The sensitivity of this VIS-OCT system to optical scattering and polarization effects make it a valuable tool with which to study fibrosis. This dissertation describes the framework of this platform and several utilities which in future work will incorporate a lens-free probe for cost-effective in vivo imaging and other bench-top variations will enable higher resolution imaging capable of capturing dynamic processes in live cells.

Optical Coherence Tomography

Author : Wolfgang Drexler
Publisher : Springer Science & Business Media
ISBN 13 : 3540775501
Total Pages : 1346 pages
Book Rating : 4.5/5 (47 download)

DOWNLOAD NOW!

Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler

Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.

SWEPT SOURCE OPTICAL COHERENCE

Author : Luoqin Yu
Publisher : Open Dissertation Press
ISBN 13 : 9781361012970
Total Pages : 100 pages
Book Rating : 4.0/5 (129 download)

DOWNLOAD NOW!

Book Synopsis SWEPT SOURCE OPTICAL COHERENCE by : Luoqin Yu

Download or read book SWEPT SOURCE OPTICAL COHERENCE written by Luoqin Yu and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Swept Source Optical Coherence Tomography System Development for Bioimaging Applications" by Luoqin, Yu, 俞罗琴, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Optical coherence tomography (OCT) is an imaging modality with strengths in high-resolution, label-free, and noninvasive, which strategically fills the gap between ultrasound and microscopy and is superior for some biomedical applications. Swept source OCT (SS-OCT) improves system simplicity and sensitivity compared to previous versions of time domain OCT (TD-OCT) because of a static reference mirror and has faster imaging speed compared to spectral domain OCT (SD-OCT) because of a single photodetector and the availability of high-repetition-rate broadband lasers. Furthermore, functional spectroscopic OCT (SOCT) analyzes materials according to their specific optical properties at different wavelengths. Thus, by utilizing an ultra-wide band OCT and analyzing the sub-band images, it provides us a spectroscopic way to recognize materials. These kinds of newly developed OCT systems are quite promising in clinical bioimaging applications. One of the most commonly used swept sources in SS-OCT systems is the Fourier domain mode-locked (FDML) laser. It has a narrow instantaneous linewidth that improves imaging range, a broad sweeping range that renders high resolution, fast building up time that enables fast scanning, and a proper output power. However, traditional FDML lasers have limited sweeping range because of a limited amplification window of the gain medium that is usually unable to achieve an ultra-wide wavelength range. It hinders its way in spectroscopic imaging applications. Nevertheless, multi-band illumination can break through the bandwidth limitation of single-band SOCT. Consequently, developing swept sources with various output wavelength ranges is of high interest. The FDML lasers with output at 1.0 m range are most suitable in water-rich tissues where water dispersion and absorption are minimized. Thus, 1.0 m FDML laser cavities are firstly proposed with different amplification schemes to compare their performances. Dual-and tri-band SS-OCT systems for SOCT application are further investigated for contrast enhancement and differentiation of materials, such as lipid and porcine artery. Not only the output wavelength ranges of swept sources are of big concern, the swept speed is another bottleneck yet to be surpassed, especially for endoscopic applications. As the mechanical inertia of FDML lasers will limit the fundamental A-scan rate to hundreds of kilohertz, an ultrafast mode-locked laser together with inertia-free optical time-stretch mechanism is a promising alternative for SS-OCT endoscopic application. It has long imaging range and allows an A-scan rate up to more than ten megahertz. We further demonstrated this kind of amplified optical time-stretch (AOT) OCT with extensional application by endoscopic imaging. In summary, the goal of this thesis is to develop and extend SS-OCT systems in different aspects for various bioimaging applications. The SS-OCT systems with different advantages are proposed for spectroscopic and endoscopic imaging. Subjects: Imaging systems in medicine Optical coherence tomography

Advanced Biophotonics

Author : Ruikang K. Wang
Publisher : Taylor & Francis
ISBN 13 : 1439895821
Total Pages : 726 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!

Book Synopsis Advanced Biophotonics by : Ruikang K. Wang

Download or read book Advanced Biophotonics written by Ruikang K. Wang and published by Taylor & Francis. This book was released on 2016-04-19 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics: Tissue Optical Sectioning presents contemporary methods and

Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography

Author : Yan Wang
Publisher :
ISBN 13 : 9781303293115
Total Pages : 172 pages
Book Rating : 4.2/5 (931 download)

DOWNLOAD NOW!

Book Synopsis Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography by : Yan Wang

Download or read book Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography written by Yan Wang and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1 describes the construction and characterization of a multi-functional SD-OCT system at 1300nm. The axial resolution, lateral resolution, imaging depth, signal sensitivity drop-off, spectrometer efficiency, phase noise, system noise, polarization noise, computation of phase retardation, optic axis and diattenuation were characterized. Multiple samples were imaged to demonstrate each imaging facet (intensity, polarization and flow) of the system.

Biomedical Optical Imaging Technologies

Author : Rongguang Liang
Publisher : Springer Science & Business Media
ISBN 13 : 3642283918
Total Pages : 391 pages
Book Rating : 4.6/5 (422 download)

DOWNLOAD NOW!

Book Synopsis Biomedical Optical Imaging Technologies by : Rongguang Liang

Download or read book Biomedical Optical Imaging Technologies written by Rongguang Liang and published by Springer Science & Business Media. This book was released on 2012-09-21 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.

Optical Coherence Tomography and Its Non-medical Applications

Author : Michael Wang
Publisher : BoD – Books on Demand
ISBN 13 : 1789842611
Total Pages : 226 pages
Book Rating : 4.7/5 (898 download)

DOWNLOAD NOW!

Book Synopsis Optical Coherence Tomography and Its Non-medical Applications by : Michael Wang

Download or read book Optical Coherence Tomography and Its Non-medical Applications written by Michael Wang and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhancing security in biometric applications. OCT can also be used for the evaluation of fastener flushness for improving aerodynamic performance of high-speed aircraft. More and more OCT non-medical applications are emerging. In this book, we present some recent advancements in OCT technology and non-medical applications.

Multi-scale Optical Coherence Tomography Imaging

Author : Michael Christopher Oliveira
Publisher :
ISBN 13 : 9781321320367
Total Pages : 103 pages
Book Rating : 4.3/5 (23 download)

DOWNLOAD NOW!

Book Synopsis Multi-scale Optical Coherence Tomography Imaging by : Michael Christopher Oliveira

Download or read book Multi-scale Optical Coherence Tomography Imaging written by Michael Christopher Oliveira and published by . This book was released on 2014 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: An optical modality capable of quantitative, label-free, high-speed and high-resolution imaging across spatiotemporal scales coupled with sophisticated software for image reconstruction and quantitative analyses would be of great utility to scientists and engineers in the medical and life sciences fields. Currently, a combination of optical imaging techniques and software packages are needed to address the list of capabilities described previously. Optical coherence tomography is an optical imaging technique based on low coherence interferometry capable of measuring light backscattered from the sample at micrometer-level resolutions over millimeter-level penetration depths in biological tissue. Phase-sensitive extensions of OCT enable the functional assessment of biological tissue samples as well as the structural examination of samples down to the single-cell level. This dissertation describes the development and application of high-speed real-time multi-functional spectral-domain OCT (MF-SD-OCT) for structural and functional examination of biological samples across spatiotemporal scales. A discussion of the development of a GPU-accelerated high-speed MF-SD-OCT imaging system accompanied by demonstrations of the performance enhancements due to the GPU are presented initially. Next, the development of MF-SD-OCT-based quantitative methods for the structural and functional assessment and characterization and classification of biological tissue samples is discussed. The utility of these methods is demonstrated through structural, functional and optical characterization and classification of peripheral nerve and muscle tissue. The dissertation concludes with a discussion of the improvements made to spectral-domain optical coherence phase microscopy (SD-OCPM) to enable dynamic live cell imaging and the application of dynamic live cell SD-OCPM for morphological visualization of cheek epithelial cells and examination of functionally stimulated morphological changes in neurons. The work described in this dissertation demonstrates the versatility of OCT imaging technology to perform quantitative, label-free, high-speed and high-resolution imaging across spatiotemporal scales, enabling the examination of native dynamic tissue and cellular physiology.

Tissue Optics

Author : Valeriĭ Viktorovich Tuchin
Publisher : SPIE-International Society for Optical Engineering
ISBN 13 :
Total Pages : 394 pages
Book Rating : 4.:/5 (318 download)

DOWNLOAD NOW!

Book Synopsis Tissue Optics by : Valeriĭ Viktorovich Tuchin

Download or read book Tissue Optics written by Valeriĭ Viktorovich Tuchin and published by SPIE-International Society for Optical Engineering. This book was released on 2000 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This tutorial text explores light-scattering techniques developed for studies of tissues and optical cell ensembles. It discusses results of theoretical and experimental investigations into photon transport in tissues and describes methods for solving direct and inverse scattering problems involving different types of tissues and fluids (opaque vs transparent).

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV

Author : James G. Fujimoto
Publisher : SPIE-International Society for Optical Engineering
ISBN 13 : 9780819484260
Total Pages : 480 pages
Book Rating : 4.4/5 (842 download)

DOWNLOAD NOW!

Book Synopsis Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV by : James G. Fujimoto

Download or read book Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV written by James G. Fujimoto and published by SPIE-International Society for Optical Engineering. This book was released on 2011 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes Proceedings Vol. 7821

Development of Advanced Label-Free Optical Bioimaging Technologies

Author : JINGJIANG. XU
Publisher :
ISBN 13 : 9781361347706
Total Pages : pages
Book Rating : 4.3/5 (477 download)

DOWNLOAD NOW!

Book Synopsis Development of Advanced Label-Free Optical Bioimaging Technologies by : JINGJIANG. XU

Download or read book Development of Advanced Label-Free Optical Bioimaging Technologies written by JINGJIANG. XU and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Development of Advanced Label-free Optical Bioimaging Technologies" by Jingjiang, Xu, 许景江, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Today label-free bioimaging has been leading to widespread and fast-growing applications, which demands for a more efficient way to keep up such momentum. To this end, the research in this thesis will study the techniques of efficiency improvement for advanced label-free bioimaging, including the time efficiency, cost efficiency and information efficiency. Optical coherence tomography (OCT) is one of the most valuable label-free bioimaging modalities to provide noninvasive cross-sectional assessment of biological tissue. In many occasions, these applications demand for three dimensional (3D) imaging at video-rate in order to perform real-time diagnoses, which can be overcome by MHz-OCT. Here we demonstrate inertia-free all-optical ultrahigh-speed swept-source optical coherence tomography (OCT) based on amplified optical time-stretch (AOT). More importantly, the key significance of AOT-OCT is its broadband amplification stage, which greatly enhances the detection sensitivity compared with the prior attempts to employ optical time-stretch to OCT. We report an AOT-OCT system which is operated at an A-scan rate of multi-megahertz with high sensitivity (>80 dB) and perform time-stretch-based OCT of biological tissue in vivo. Moreover, using a more stable and coherent mode-locked fiber laser, we can achieve better performance without the compromise of averaging for supercontinuum-generation-based AOT-OCT system. It represents a major step forward in utilizing AOT as an alternative for achieving practical time-efficient OCT imaging at multi-MHz speed. For the further development of this ultrahigh-speed OCT, we present a theoretical analysis of the AOT-OCT system. The spectral resolution, coherence length and sensitivity of AOT-OCT system have been discussed in detail. By theoretical model of the noise sources based on Raman amplifier, we also quantify how the input signal, amplifier gain, A-scan rate affect the sensitivity of AOT-OCT imaging. These simulation results are expected to be valuable for optimizing the design of AOT-OCT. We also investigate in cost-effective implementation to realize efficient optical time-stretch process based on dispersive fiber. We explore and demonstrate the feasibility of using the standard telecommunication single-mode fibers as few-mode fibers (FMFs) for optical time-stretch confocal microscopy in the 1m range. It can provide sufficiently high dispersion-to-loss ratios for practical time-stretch imaging at 1 m, without the needs for high-cost specialty 1 m single mode fiber. In addition, Coherent anti-Stokes Raman scattering (CARS) microscopy is another attractive efficient tool for label-free biochemical-specific imaging, which can bypass laborious steps of preparing and staining in routine standard histopathology. Here we further explore ultrabroadband hyperspectral multiplex (HM-CARS) to perform chemoselective histological imaging with efficient information in fingerprint region. In order to unravel the congested CARS spectra, we employ phase-retrieval algorithm based on Kramers-Kronig (KK) transform and principal component analysis (PCA) to display the key cellular structures with components distribution. All these research efforts are aiming at improving the efficiency, from theory to implementation, for label-free bioimaging technology such as OCT and CARS. These schemes demonstrate great potential to realize powerful label-free bioimaging

Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy

Download Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy PDF Online Free

Author : Sebina Shrestha
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (96 download)

DOWNLOAD NOW!

Book Synopsis Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy by : Sebina Shrestha

Download or read book Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy written by Sebina Shrestha and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Both morphological and biochemical changes occur in a diseased tissue. As a result, tissue optical response changes with the progression of disease. A single optical imaging modality can assess either morphological or biochemical changes. In order to investigate the development of a disease in detail, both of these characteristics need to be probed simultaneously. Therefore, researchers have been interested in combining different imaging modalities that can provide complementary, morphological and biochemical images. This dissertation focuses on the development of dual-modality systems that incorporate Optical coherence Tomography (OCT) and Fluorescence Lifetime Imaging Microscopy (FLIM) for simultaneous characterization of tissue morphology and its biochemistry. In the first phase of the research, we combined spectral-domain OCT with FLIM that is designed for endogenous emission acquisition. The operating wavelength for OCT and FLIM were 830nm and 355nm, respectively. The maximum field of view (FOV) was 4mmx4mm. The combined system was used to image hamster cheek pouch model for oral cancer in vivo and postmortem human coronary arteries with atherosclerotic plaques ex vivo. Their morphological and endogenous emission images correlation was studied. The evaluation was equivalent to their histopathological analysis. In the second phase of this research, we built a bench-top prototype that comprised of swept source OCT (SSOCT) and a FLIM system with the capability to characterize endogenous and exogenous emissions simultaneously. The swept laser had a sweep rate of 50 kHz and the center wavelength was at 1310nm. FLIM utilized lasers with wavelengths 355nm and 532nm to excite endogenous and exogenous fluorophores, respectively. The maximum FOV was 16mmx16mm. With this system, OCT-FLIM images of a Watanabe rabbit aorta, which was non-specifically tagged with Alexa Fluor 532, were acquired ex-vivo. The results appraised the ability of the system to simultaneously probe the sample's structure, its endogenous emission and the exogenous fluorescence of the dye tagged to it. We hypothesize that the OCT-FLIM imaging tool adds a potential to study the activities of important non-fluorescing molecules in an artery while relating the analysis to its morphology and biochemistry. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/155617

OCT Angiography in Retinal and Macular Diseases

Author : F. Bandello
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318058300
Total Pages : 198 pages
Book Rating : 4.3/5 (18 download)

DOWNLOAD NOW!

Book Synopsis OCT Angiography in Retinal and Macular Diseases by : F. Bandello

Download or read book OCT Angiography in Retinal and Macular Diseases written by F. Bandello and published by Karger Medical and Scientific Publishers. This book was released on 2016-03-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: In only a short period of time, the innovative procedure of OCT angiography has become an essential macula imaging technique. Now that it is routinely used in clinical practice, the investigation of retinal and choroidal circulation is non-invasive, which significantly changes the professional’s approach to patients. In this volume, retina specialists and renowned experts share their experience with OCT angiography. They have included numerous color images and presented current ideas to form a base for further research and discussion. This book provides retina specialists, ophthalmologists, and researchers with a first glance at original research and clinical reports on this new methodology.

Investigation of a Fibre-optic Fizeau Interferometer Configuration and Coherent Fibre-optic Imaging Bundles for Optical Coherence Tomography

Download Investigation of a Fibre-optic Fizeau Interferometer Configuration and Coherent Fibre-optic Imaging Bundles for Optical Coherence Tomography PDF Online Free

Author : Georgios Sarantavgas
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (656 download)

DOWNLOAD NOW!

Book Synopsis Investigation of a Fibre-optic Fizeau Interferometer Configuration and Coherent Fibre-optic Imaging Bundles for Optical Coherence Tomography by : Georgios Sarantavgas

Download or read book Investigation of a Fibre-optic Fizeau Interferometer Configuration and Coherent Fibre-optic Imaging Bundles for Optical Coherence Tomography written by Georgios Sarantavgas and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently several medical imaging techniques are in operation in clinicalenvironments that help the doctors to diagnose diseases before proceeding totreatment. This research investigated and implemented configurations for a medicalimaging technique called Optical Coherence Tomography (OCT). The Michelson interferometer has been the principal configuration for OCT systems. For endoscopic OCT applications though such a configuration is susceptible topolarisation induced signal fading due to environmental changes within the samplearm, like fibre bending and temperature fluctuations. The development and testing ofa Fizeau interferometer based OCT system demonstrate the elimination of thispolarisation induced signal fading as the sample and reference arm of theinterferometer experience the same environmental changes. The Fizeau interferometeris formed between the end of the fibre and the sample itself. A secondary processinginterferometer is used in this configuration, to compensate the path difference inherentto the Fizeau configuration. Longitudinal resolution is about 19 m in air, and lateralresolution about 23 m. A signal-to-noise ratio of about 80 dB was achieved with thissystem and several sets of image data were collected from laboratory and biologicalsamples. An OCT system based on a Fizeau interferometer incorporating a coherent fibreimaging bundle was also investigated. Fibres in the bundle are accessed sequentiallyby a beam focused onto the input face of the bundle, allowing 2D information to beacquired using point detection. Incorporating a fibre optic imaging bundle in Fizeaubased interferometer OCT allows mechanical scanning parts to be removed from thesample arm, resulting in a passive probe. Such a configuration can form a compact, robust and?downlead insensitive? OCT system and is a strong candidate for in vivoapplications. The performance of leached and wound coherent fibre optic bundles wasaccessed and an analysis is presented. The longitudinal resolution of the systemdeveloped was about 10 m in air, and lateral resolution about 9 m. This thesisdemonstrates several sets of image data that were collected from various samplesusing a Fizeau interferometer based OCT incorporating coherent imaging bundles. 2Dimage data captured by such a configuration are presented and reported for the firsttime in this thesis.

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

Author : Joseph A. Izatt
Publisher :
ISBN 13 : 9780819488565
Total Pages : 466 pages
Book Rating : 4.4/5 (885 download)

DOWNLOAD NOW!

Book Synopsis Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI by : Joseph A. Izatt

Download or read book Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI written by Joseph A. Izatt and published by . This book was released on 2012 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes Proceedings Vol. 7821

Development and Investigation of Devices for Ultrahigh Speed Gastrointestinal Optical Coherence Tomography Imaging

Author : Kaicheng Liang
Publisher :
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.:/5 (15 download)

DOWNLOAD NOW!

Book Synopsis Development and Investigation of Devices for Ultrahigh Speed Gastrointestinal Optical Coherence Tomography Imaging by : Kaicheng Liang

Download or read book Development and Investigation of Devices for Ultrahigh Speed Gastrointestinal Optical Coherence Tomography Imaging written by Kaicheng Liang and published by . This book was released on 2018 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diseases of the gastrointestinal (GI) tract are typically diagnosed by random biopsy of tissue, which samples only a small area and often misses focal neoplasias. Existing endoscopic visualization tools including white light endoscopy, narrowband imaging and confocal laser endomicroscopy have enabled in vivo assessment to guide biopsies, but suffer from technical limitations and have demonstrated suboptimal sensitivity and specificity to neoplasia. Optical Coherence Tomography (OCT) can generate in vivo, 3-dimensional microscopic imaging. Recent efforts in ultrahigh-speed OCT systems for endoscopic applications have shown promise, but devices had limited fields of view and imprecise beam scanning mechanisms, limiting image quality and coverage. This thesis develops a wide range of new fiber optic devices that substantially extend OCT capabilities in the GI tract, either by greatly increasing field of view for wide field mapping of entire luminal organs, or achieving high precision 2-D beam scanning with compact actuators for in vivo microscopy. Piezoelectrically actuated fiber scanning devices enable forward viewing for focal inspection, while micromotor actuators combined with pneumatic or piezoelectric mechanisms enclosed in tethered capsules generate side viewing over large areas. The work also advances the emerging paradigm of gastrointestinal screening without use of sedation, which promises to lower costs of screening and improve access for a broader population. Design, fabrication and benchtop evaluation of devices, as well as pre-clinical and clinical imaging protocols are reported. Results from validation studies in living swine, and human patients in collaboration with the Veterans Affairs Boston Healthcare System are discussed. The thesis work demonstrates new imaging modalities for in vivo detection and diagnosis of GI pathology that could have important applications in disease screening, surveillance, and therapeutic procedures.

Translational Multimodality Optical Imaging

Author : Fred S. Azar
Publisher : Artech House Publishers
ISBN 13 : 9781596933071
Total Pages : 386 pages
Book Rating : 4.9/5 (33 download)

DOWNLOAD NOW!

Book Synopsis Translational Multimodality Optical Imaging by : Fred S. Azar

Download or read book Translational Multimodality Optical Imaging written by Fred S. Azar and published by Artech House Publishers. This book was released on 2008 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast-emerging optical imaging and data fusion techniques are creating a huge buzz as potentially powerful tools for cancer detection and other important clinical applications. Heres the first comprehensive resource on multimodal optical imaging. This unique book gives biomedical researchers the full details on in-vivo microscopy, optical coherence tomography, endoscopy, and diffuse optical techniques. It explains how these tools can be integrated with other modalities to capture and apply biological information in significant new ways. Written by pioneers in the field, this milestone work discusses each of the optical imaging techniques in depth and describes the integration of the techniques with other modalities like MRI, X-Ray imaging, and PET imaging. The volume also covers photodynamic therapy and molecular imaging, and reviews clinical studies in optical imaging and other issues. DVD Included! Contains full-color images and videos that support key topics covered in the book.