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Development Integration And Simulation Of Multiscale Mathematical Models Of Physiological Processes A Software Engineering Perspective
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Book Synopsis Development, Integration and Simulation of Multiscale Mathematical Models of Physiological Processes: A Software Engineering Perspective by : E. Zeynep Erson
Download or read book Development, Integration and Simulation of Multiscale Mathematical Models of Physiological Processes: A Software Engineering Perspective written by E. Zeynep Erson and published by . This book was released on 2011 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of systems biology, modeling of physiological models started to adopt more integrative approaches instead of reductionist methods. In order to understand the complex system, which is human body, multiscale physiological models must be integrated and analyzed as a whole. However modeling and simulation of multiscale physiological processes deal with the challenges such as high coupling within and among scales. In order to deal with such challenges in a systematic way, there is a significant need for information technology solutions together with related analytical and computational tools that will facilitate integration of models and simulations of complex biological systems. The idea of functional modularity and structural modularity presented in this thesis helps to cope with the highly complex and coupled nature of the physiological processes in the software level. Functional modularity is proposed through the use of information flow, which aims to separate the information and the flow of information in physiological processes. Ontology based design approaches are suggested for representing the anatomical and structural information of physiological processes, in order to achieve structural modularity. In this thesis, we also present a software framework which is built on the principles of structural and functional modularity. Physiological Model Simulation, Integration and Modeling Framework (Phy-SIM) is an information technology framework to facilitate development, integration and simulation of large-scale highly-integrated models of human physiology. Ultimate aim of Phy-SIM is to enhance the physiological model development processes; but more importantly to accelerate the development, analysis and testing of integration approaches for multiscale and multilevel physiological models.
Book Synopsis Modelling Methodology for Physiology and Medicine by : Ewart Carson
Download or read book Modelling Methodology for Physiology and Medicine written by Ewart Carson and published by Newnes. This book was released on 2013-12-05 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems
Book Synopsis Multiscale Modeling of the Skeletal System by : Marco Viceconti
Download or read book Multiscale Modeling of the Skeletal System written by Marco Viceconti and published by Cambridge University Press. This book was released on 2011-12-15 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative approaches to biomedical research promise to advance our understanding of the human body and physiopathology of diseases. In this book, the author focuses on the skeletal system, demonstrating how multiscale modeling can determine the relationship between bone mechanics and disease. Introductory chapters explain the concept of integrative research, what a model is, predictive modeling, and the computational methods used throughout the book. Starting with whole body anatomy, physiology and modeling, subsequent chapters scale down from bone and tissue levels to the cellular level, where the modeling of mechanobiological processes is addressed. Finally, the principles are applied to address truly complex, multiscale interactions. Special attention is given to real-world clinical applications: one in pediatric skeletal oncology and one on the prediction of fracture risks in osteoporotic patients. This book has wide interdisciplinary appeal and is a valuable resource for researchers in mechanical and biomedical engineering, quantitative physiology and computational biology.
Book Synopsis Multiscale Modeling of Developmental Systems by :
Download or read book Multiscale Modeling of Developmental Systems written by and published by Academic Press. This book was released on 2007-12-18 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation. This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds. * Articles written by leading exponents in the field * Provides techniques to address multiscale modeling * Coverage includes a wide spectrum of modeling approaches * Includes descriptions of the most recent advances in the field
Book Synopsis Introduction to Modeling in Physiology and Medicine by : Claudio Cobelli
Download or read book Introduction to Modeling in Physiology and Medicine written by Claudio Cobelli and published by Academic Press. This book was released on 2019-08-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials. Covers the underlying principles of good quantitative modeling methodology, with applied biomedical engineering and bioscience examples to ensure relevance to students, current research and clinical practice Includes modeling data, modeling systems, linear and non-linear systems, model identification, parametric and non-parametric models, and model validation Presents clear, step-by-step working plus examples and extensive case studies that relate concepts to real world applications Provides end-of-chapter exercises and assignments to reinforce learning
Book Synopsis Applied Mathematical Models in Human Physiology by : Johnny T. Ottesen
Download or read book Applied Mathematical Models in Human Physiology written by Johnny T. Ottesen and published by SIAM. This book was released on 2004-02-01 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors discuss models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation. This is the only book available that analyzes up-to-date models of the physiological system at several levels of detail; both simple 'real-time' models that can be directly used in larger systems, and more detailed 'reference' models that show the underlying physiological mechanisms and provide parameters for and validation of simpler models. The book also covers two-dimensional modeling of the fluid dynamics in the heart and its ability to pump, and includes a discussion of modeling wave-propagation throughout the systemic arteries.
Author :Abdelghani Bellouquid Publisher :Springer Science & Business Media ISBN 13 :0817645039 Total Pages :194 pages Book Rating :4.8/5 (176 download)
Book Synopsis Mathematical Modeling of Complex Biological Systems by : Abdelghani Bellouquid
Download or read book Mathematical Modeling of Complex Biological Systems written by Abdelghani Bellouquid and published by Springer Science & Business Media. This book was released on 2007-10-10 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the evolution of several socio-biological systems using mathematical kinetic theory. Specifically, it deals with modeling and simulations of biological systems whose dynamics follow the rules of mechanics as well as rules governed by their own ability to organize movement and biological functions. It proposes a new biological model focused on the analysis of competition between cells of an aggressive host and cells of a corresponding immune system. Proposed models are related to the generalized Boltzmann equation. The book may be used for advanced graduate courses and seminars in biological systems modeling.
Book Synopsis Mathematical and Computer Modeling of Physiological Systems by : Vincent C. Rideout
Download or read book Mathematical and Computer Modeling of Physiological Systems written by Vincent C. Rideout and published by . This book was released on 1991 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modelling, Simulation and Software Concepts for Scientific-Technological Problems by : Ernst Stephan
Download or read book Modelling, Simulation and Software Concepts for Scientific-Technological Problems written by Ernst Stephan and published by Springer Science & Business Media. This book was released on 2011-04-28 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book includes different contributions that cover interdisciplinary research in the areas of · Error controlled numerical methods, efficient algorithms and software development · Elastic and in elastic deformation processes · Models with multiscales and multi-physics “High Performance” adaptive numerical methods using finite elements (FEM) and boundary elements (BEM) are described as well as efficient solvers for linear systems and corresponding software components for non-linear, coupled field equations of various branches of mechanics, electromagnetics, and geosciences.
Book Synopsis Multiscale Cancer Modeling by : Thomas S. Deisboeck
Download or read book Multiscale Cancer Modeling written by Thomas S. Deisboeck and published by CRC Press. This book was released on 2010-12-08 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat
Book Synopsis Integrated Multi-scale Mathematical Models for Biologics Process Development by : António Carlos Martins de Jesus Lima Grilo
Download or read book Integrated Multi-scale Mathematical Models for Biologics Process Development written by António Carlos Martins de Jesus Lima Grilo and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic by : Julius Guccione
Download or read book Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic written by Julius Guccione and published by Frontiers Media SA. This book was released on 2020-01-13 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Mathematics and Mechanics of Biological Growth by : Alain Goriely
Download or read book The Mathematics and Mechanics of Biological Growth written by Alain Goriely and published by Springer. This book was released on 2017-05-29 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph presents a general mathematical theory for biological growth. It provides both a conceptual and a technical foundation for the understanding and analysis of problems arising in biology and physiology. The theory and methods are illustrated on a wide range of examples and applications. A process of extreme complexity, growth plays a fundamental role in many biological processes and is considered to be the hallmark of life itself. Its description has been one of the fundamental problems of life sciences, but until recently, it has not attracted much attention from mathematicians, physicists, and engineers. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form. The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics. Accordingly, the discussion proceeds in order of complexity and the book is divided into five parts. First, a general introduction on the problem of growth from a historical perspective is given. Then, basic concepts are introduced within the context of growth in filamentary structures. These ideas are then generalized to surfaces and membranes and eventually to the general case of volumetric growth. The book concludes with a discussion of open problems and outstanding challenges. Thoughtfully written and richly illustrated to be accessible to readers of varying interests and background, the text will appeal to life scientists, biophysicists, biomedical engineers, and applied mathematicians alike.
Book Synopsis The Emerging Discipline of Quantitative Systems Pharmacology by : Tarek A. Leil
Download or read book The Emerging Discipline of Quantitative Systems Pharmacology written by Tarek A. Leil and published by Frontiers Media SA. This book was released on 2015-09-07 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.
Download or read book Mechanobiology written by Glen L. Niebur and published by Elsevier. This book was released on 2019-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena
Book Synopsis Mathematics and 21st Century Biology by : National Research Council
Download or read book Mathematics and 21st Century Biology written by National Research Council and published by National Academies Press. This book was released on 2005-07-16 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exponentially increasing amounts of biological data along with comparable advances in computing power are making possible the construction of quantitative, predictive biological systems models. This development could revolutionize those biology-based fields of science. To assist this transformation, the U.S. Department of Energy asked the National Research Council to recommend mathematical research activities to enable more effective use of the large amounts of existing genomic information and the structural and functional genomic information being created. The resulting study is a broad, scientifically based view of the opportunities lying at the mathematical science and biology interface. The book provides a review of past successes, an examination of opportunities at the various levels of biological systemsâ€" from molecules to ecosystemsâ€"an analysis of cross-cutting themes, and a set of recommendations to advance the mathematics-biology connection that are applicable to all agencies funding research in this area.
Book Synopsis Multiscale Modelling and Simulation by : Sabine Attinger
Download or read book Multiscale Modelling and Simulation written by Sabine Attinger and published by Springer Science & Business Media. This book was released on 2004-07-12 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In August 2003, ETHZ Computational Laboratory (CoLab), together with the Swiss Center for Scientific Computing in Manno and the Università della Svizzera Italiana (USI), organized the Summer School in "Multiscale Modelling and Simulation" in Lugano, Switzerland. This summer school brought together experts in different disciplines to exchange ideas on how to link methodologies on different scales. Relevant examples of practical interest include: structural analysis of materials, flow through porous media, turbulent transport in high Reynolds number flows, large-scale molecular dynamic simulations, ab-initio physics and chemistry, and a multitude of others. Though multiple scale models are not new, the topic has recently taken on a new sense of urgency. A number of hybrid approaches are now created in which ideas coming from distinct disciplines or modelling approaches are unified to produce new and computationally efficient techniques.
