Design Synthesis And Formulation Of Bioactive Based Polymers

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Design, Synthesis, and Formulation of Bioactive-based Polymers

Author : Nicholas David Stebbins
Publisher :
ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.:/5 (936 download)

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Book Synopsis Design, Synthesis, and Formulation of Bioactive-based Polymers by : Nicholas David Stebbins

Download or read book Design, Synthesis, and Formulation of Bioactive-based Polymers written by Nicholas David Stebbins and published by . This book was released on 2015 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradable, bioactive-based polymers have been successfully employed as sustained bioactive delivery systems. This dissertation describes bioactives that have been chemically incorporated into novel, biodegradable polymers via covalent bonds for controlled, sustained, and tunable release properties. Bioactives are released from polymers via hydrolytic degradation. The polymers described herein utilize alternative synthetic methods and a wide array of bioactives, including antibiotics, antioxidants, antimicrobials, and anti-inflammatory drugs. One goal is to focus on naturally-occurring bioactives that are generally regarded as safe (GRAS) by the FDA. First, poly(anhydride-amides) comprised of ampicillin were synthesized and formulated as coatings. Polymer adhesion onto medical-grade stainless steel surfaces was assessed and in vitro release characterized. Cytocompatibility and antibacterial activity elucidated polymer safety and efficacy for potential in vivo use. These localized delivery systems could mediate the issues caused by implant surgery. Second, poly(anhydride-esters) comprised solely of naturally-occurring phenols and EDTA were synthesized and physicochemical properties determined. Bioactive release was ascertained, in addition to antioxidant activity and activity against Gram-positive and Gram-negative bacteria. These polymers can act as potential preservatives, increasing cosmetic and food product shelf life through antioxidant and antimicrobial pathways. Third, through environmentally sustainable (i.e, green) methods, polyesters with pendant anti-inflammatory groups and a sugar-based backbone were prepared with minimal solvent use, enzymatic catalysis, and biorenewable reactants and reagents. Three comonomers of varying hydrophobicity were tested to elucidate changes in polymer thermal properties and bioactive release rate. Fourth, poly(anhydride-esters) with a mannitol backbone and multiple bioactive groups per repeat unit were developed as the first linear, biodegradable polymers with high bioactive loading (~70%) using a polyol. In vitro ibuprofen release was quantified and an anti-inflammatory assay determined that bioactive retained activity upon polymer degradation. Alteration of polyol, bioactive class, and other facets leads to highly tunable polymer properties. Last, to combat bacterial spoilage and oxidation, poly(anhydride-esters) containing natural antimicrobials were designed for food applications. Bioactive released from polymer exhibited radical scavenging ability and antibacterial activity. Furthermore, polymers were blended with current food packaging materials (e.g., polyethylene) and molded into films for active food packaging that contains a higher percentage of biodegradable content.

Design, Synthesis, and Fabrication of Biodegradable, Bioactive-based Polymers for Controlled Release Applications

Author : Michelle Aimee Ouimet
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (87 download)

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Book Synopsis Design, Synthesis, and Fabrication of Biodegradable, Bioactive-based Polymers for Controlled Release Applications by : Michelle Aimee Ouimet

Download or read book Design, Synthesis, and Fabrication of Biodegradable, Bioactive-based Polymers for Controlled Release Applications written by Michelle Aimee Ouimet and published by . This book was released on 2013 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hydrogels

Author : Thakur Raghu Raj Singh
Publisher : CRC Press
ISBN 13 : 1351648276
Total Pages : 289 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Hydrogels by : Thakur Raghu Raj Singh

Download or read book Hydrogels written by Thakur Raghu Raj Singh and published by CRC Press. This book was released on 2018-02-28 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

Smart Polymeric Nano-Constructs in Drug Delivery

Author : Suresh P Vyas
Publisher : Academic Press
ISBN 13 : 0323913997
Total Pages : 626 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Smart Polymeric Nano-Constructs in Drug Delivery by : Suresh P Vyas

Download or read book Smart Polymeric Nano-Constructs in Drug Delivery written by Suresh P Vyas and published by Academic Press. This book was released on 2022-11-12 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications

Hybrid Nanomaterials

Author : Weibo Cai
Publisher : CRC Press
ISBN 13 : 1498720943
Total Pages : 451 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Hybrid Nanomaterials by : Weibo Cai

Download or read book Hybrid Nanomaterials written by Weibo Cai and published by CRC Press. This book was released on 2017-05-25 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

Biopolymer-Based Formulations

Author : Kunal Pal
Publisher : Elsevier
ISBN 13 : 0128168986
Total Pages : 966 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biopolymer-Based Formulations by : Kunal Pal

Download or read book Biopolymer-Based Formulations written by Kunal Pal and published by Elsevier. This book was released on 2020-01-18 with total page 966 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymer-Based Formulations: Biomedical and Food Applications presents the latest advances in the synthesis and characterization of advanced biopolymeric formulations and their state-of-the-art applications across biomedicine and food science. Sections cover the fundamentals, applications, future trends, environmental, ethical and medical considerations, and biopolymeric architectures that are organized in nano, micro and macro scales. The final section of the book focuses on novel applications and recent developments. This book is an essential resource for researchers, scientists and advanced students in biopolymer science, polymer science, polymer chemistry, polymer composites, plastics engineering, biomaterials, materials science, biomedical engineering, and more. It will also be of interest to R&D professionals, scientists and engineers across the plastics, food, biomedical and pharmaceutical industries. Provides in-depth coverage of methods for the characterization of the physical properties of biopolymeric architectures Supports a range of novel applications, including scaffolds, implant coatings, drug delivery, and nutraceutical encapsulation systems Includes the use of experimental data and mathematical modeling, thus enabling the reader to analyze and compare the properties of different polymeric gels

Design, Synthesis And Applications Of Polymer Biomaterials

Author : Frankie Costanza
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (927 download)

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Book Synopsis Design, Synthesis And Applications Of Polymer Biomaterials by : Frankie Costanza

Download or read book Design, Synthesis And Applications Of Polymer Biomaterials written by Frankie Costanza and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of antibiotic resistant bacteria has prompted the research into novel kinds of antibacterial small molecules and polymers. Nature has solved this issue with the use of cationic antimicrobial peptides, which act as nonspecific antibiotics against invading species. Herein, we have tried to mimic this general mechanism in a biocompatible and biodegradable polymer micelle based on the polymerization of naturally occurring amino acids lysine and phenylalanine linked to a PEG tether. This amphiphilic structure allows for the spontaneous collapse into stable nanoparticles in solution, which contains a hydrophilic outer layer and a hydrophobic core. Our polymers have shown activity against clinically relevant strains including Methicillin Resistant S. epidermidis, B. subtilis, K. pneumoniae, and P. aeruginosa. To further the application of our biopolymers, we have used them as drug delivery vehicles as well. First, we have used an anionic analogue based on glutamic acid to encapsulate a super hydrophobic drug Tanshinone IIA, and use it against a hepatoma bearing mouse model. Second, we have used a cationic analogue to form a complex with miRNA-139 and use it against a hepatoma bearing mouse model as well. In both cases, our PEG poly(amino acids)s have shown promising efficacy in drastically reducing the tumor size compared to the control only. Taken together, our results show that our nanoparticles have the potential to be versatile biomaterials as antibacterials as well as drug delivery vehicles in vivo.

Biodegradable Polymers as Drug Delivery Systems

Author : Mark Chasin
Publisher : CRC Press
ISBN 13 : 9780824783440
Total Pages : 368 pages
Book Rating : 4.7/5 (834 download)

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Book Synopsis Biodegradable Polymers as Drug Delivery Systems by : Mark Chasin

Download or read book Biodegradable Polymers as Drug Delivery Systems written by Mark Chasin and published by CRC Press. This book was released on 1990-08-31 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the properties, synthesis, and formulations of a number of well studied polymers increasingly being used in site-specific or systematic administration of pharmaceutical agents. For each of the polymers, discusses the background; chemistry and synthesis; the formulation of microcapsules, solv

Biomedical Nanomaterials

Author : Rostyslav S. Stoika
Publisher : Springer
ISBN 13 : 9783030762377
Total Pages : 0 pages
Book Rating : 4.7/5 (623 download)

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Book Synopsis Biomedical Nanomaterials by : Rostyslav S. Stoika

Download or read book Biomedical Nanomaterials written by Rostyslav S. Stoika and published by Springer. This book was released on 2022-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book characterizes how to design and synthesize nanomaterials of an organic and mineral nature. The book also discusses the visualization of developed nanomaterials and their bio-applications, as well as describes the biomedical effects and environmental impact of nanomaterials. This is an ideal book for students studying biomedicine or the life sciences, as well as researchers and professionals in medicine, environmental protection, biotechnology, agriculture, and the food industry. More specifically, this book addresses the important nanomaterials and nanobiotechnologies that are used in those fields in biomedicine and life sciences.

Sequence-Controlled Polymers

Author : Jean-François Lutz
Publisher : John Wiley & Sons
ISBN 13 : 3527342370
Total Pages : 532 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Sequence-Controlled Polymers by : Jean-François Lutz

Download or read book Sequence-Controlled Polymers written by Jean-François Lutz and published by John Wiley & Sons. This book was released on 2018-04-09 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a leading authority in the field, the first book on this important and emerging topic provides an overview of the latest trends in sequence-controlled polymers. Following a brief introduction, the book goes on to discuss various synthetic approaches to sequence-controlled polymers, including template polymerization, genetic engineering and solid-phase chemistry. Moreover, monomer sequence regulation in classical polymerization techniques such as step-growth polymerization, living ionic polymerizations and controlled radical polymerizations are explained, before concluding with a look at the future for sequence-controlled polymers. With its unique coverage of this interdisciplinary field, the text will prove invaluable to polymer and environmental chemists, as well as biochemists and bioengineers.

Drug Delivery Systems in Cancer Therapy

Author : Dennis M. Brown
Publisher : Springer Science & Business Media
ISBN 13 : 1592594271
Total Pages : 438 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Drug Delivery Systems in Cancer Therapy by : Dennis M. Brown

Download or read book Drug Delivery Systems in Cancer Therapy written by Dennis M. Brown and published by Springer Science & Business Media. This book was released on 2003-09-08 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Biological Activities of Polymers

Author : Charles E. Carraher (Jr.)
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Biological Activities of Polymers by : Charles E. Carraher (Jr.)

Download or read book Biological Activities of Polymers written by Charles E. Carraher (Jr.) and published by . This book was released on 1982 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a symposium sponsored by the Division of Organic Coatings and Plastics Chemistry at the 181st meeting of the American Chemical Society, Atlanta, Ga., Mar. 30-31, 1981.

The Design, Synthetic Strategies and Biocompatibility of Polymer Scaffolds for Biomedical Application

Author : Shunsheng Cao
Publisher : Bentham Science Publishers
ISBN 13 : 160805876X
Total Pages : 355 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis The Design, Synthetic Strategies and Biocompatibility of Polymer Scaffolds for Biomedical Application by : Shunsheng Cao

Download or read book The Design, Synthetic Strategies and Biocompatibility of Polymer Scaffolds for Biomedical Application written by Shunsheng Cao and published by Bentham Science Publishers. This book was released on 2014-10-13 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Biomaterials: The Design, Synthetic Strategies and Biocompatibility of Polymer Scaffolds for Biomedical Application, Volume 1 highlights the importance of biomaterials and their interaction with biological system. The need for the development of biomaterials as scaffold for tissue regeneration is driven by the increasing demands for materials that mimic functions of extracellular matrices of body tissues. This eBook covers the latest challenges on the biocompatibility of scaffold overtime after implantation and discusses the requirement of innovative technologies and strategies for the development of materials with long-lasting scaffold and biocompatibility functions. The contents of this eBook include chapters on cell-scaffold interactions in three dimensions, nanocrystalline diamond films for biomedical applications, bioceramics-design, synthesis and biological applications, polyester biomaterials for regenerative medicine, nanomaterials for skin regeneration and many more. This book is a valuable resource for MSc and PhD students , academic personnel and researchers seeking updated and critically important information on biomaterials and biomedical applications.

Functional Biomaterials Design, Synthesis and Applications

Author : Manjie Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832552196
Total Pages : 154 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Functional Biomaterials Design, Synthesis and Applications by : Manjie Zhang

Download or read book Functional Biomaterials Design, Synthesis and Applications written by Manjie Zhang and published by Frontiers Media SA. This book was released on 2024-08-21 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early diagnosis of cancer is still a major challenge in cancer therapy. In recent years, the development of multifunctional nanomaterials has provided a new diagnosis and treatment platform to combat cancer. Polymer-inorganic nanomaterials with novel structures such as bowl-shaped/Janus/core-shell have drawn much attention owing to their diversity in composition or asymmetry in structure. More importantly, imparting unique optical, electrical, and magnetic properties to these nanocomposites can further extend their function repertoire. However, to fulfill this vision, fundamental understandings regarding strategies of precise synthesis, mechanisms of structure formation, in vivo synergistic effects in bioapplications, and biosafety of these materials are needed. Besides, nanomaterials with novel structures are well positioned for imaging-guided cancer theranostic. On one hand, nanomaterials themselves are suitable for imaging because of their intrinsic properties such as fluorescent or magnetic properties. On the other hand, nanomaterials can serve as functional platforms that integrate various therapeutic modalities including photothermal therapy, chemodynamic/ion-interference therapy, photodynamic therapy, and cuproptosis to efficiently kill cancer cells. This Research Topic aims at collecting works about synthesis, and biomedical applications of polymer/mesoporous inorganic nanomaterials, especially in the aspect of novel synthetic approaches for fabricating nanomaterials with unique structures. Additionally, we hope that in-depth research articles on this topic can provide insights into the mechanism of nanomaterials acting in cancer diagnosis and therapy. These include the mechanisms of customized drug load/release and synergistic effects in theranostics of these materials. Meanwhile, elucidations of key proteins’ roles in cancer development are also anticipated. Lastly, we hope that this topic can brew new ideas for the adaption of nanomaterials as platforms that allow for multimodal therapeutic modalities. The current Research Topic centers on the design, precise synthesis, and biomedical applications of nanomaterials. It aims to cover novel and promising research trends in nanomaterials with different morphology for cancer theranostics. Manuscripts from the following aspects, but not limited to, are welcomed: • Tailoring of asymmetrically structured (bowl-shaped, Janus, Yin Yang-like) polymer-inorganic nanomaterials; • Inorganic functional nanocrystals and functionalized mesoporous nanomaterials; • Design and synthesis of functional biomaterials, including lipids, polymers, and 2D materials • Non-viral DNA/mRNA delivery or drug/molecular inhibitor delivery; • Synthesizing biomaterials with novel nanostructures such as bowl-shaped, core-shell, spherical, Janus, and quantum dots; • Conquering drug resistance issues, tumor metastasis, and recurrence, as well as designing combination nanomedicines; • Dissecting the role of menin in prostate cancer and breast cancer: crosstalk between menin and AR signaling; • Multi-stimulus-responsive drug release and biological molecules.

Bioactive Surfaces

Author : Hans G. Börner
Publisher : Springer Science & Business Media
ISBN 13 : 3642201547
Total Pages : 232 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Bioactive Surfaces by : Hans G. Börner

Download or read book Bioactive Surfaces written by Hans G. Börner and published by Springer Science & Business Media. This book was released on 2011-06-01 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erik Wischerhoff, Nezha Badi, André Laschewsky and Jean-François Lutz Smart Polymer Surfaces: Concepts and Applications in Biosciences; S. Petersen, M. Gattermayer and M. Biesalski Hold on at the Right Spot: Bioactive Surfaces for the Design of Live-Cell Micropatterns; Julien Polleux Interfacing Cell Surface Receptors to Hybrid Nanopatterned Surfaces: A Molecular Approach for Dissecting the Adhesion Machinery; Abigail Pulsipher and Muhammad N. Yousaf Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology; D. Volodkin, A. Skirtach and H. Möhwald LbL Films as Reservoirs for Bioactive Molecules; R. Gentsch and H. G. Börner Designing Three-Dimensional Materials at the Interface to Biology; Joerg C. Tiller Antimicrobial Surfaces;

Polymeric Drug Delivery Systems

Author : Glen S. Kwon
Publisher : CRC Press
ISBN 13 : 9780824725327
Total Pages : 680 pages
Book Rating : 4.7/5 (253 download)

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Book Synopsis Polymeric Drug Delivery Systems by : Glen S. Kwon

Download or read book Polymeric Drug Delivery Systems written by Glen S. Kwon and published by CRC Press. This book was released on 2005-04-12 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Polymeric Gene Delivery Systems

Author : Yiyun Cheng
Publisher : Springer
ISBN 13 : 3319778668
Total Pages : 361 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Polymeric Gene Delivery Systems by : Yiyun Cheng

Download or read book Polymeric Gene Delivery Systems written by Yiyun Cheng and published by Springer. This book was released on 2018-09-04 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.