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Design Synthesis And Biological Evaluation Of 1213 Cycloalkl Epothilones
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Book Synopsis Design, Synthesis, and Biological Evaluation of 12,13-cycloalkl Epothilones by : Kenji Namoto
Download or read book Design, Synthesis, and Biological Evaluation of 12,13-cycloalkl Epothilones written by Kenji Namoto and published by . This book was released on 2002 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: An array of new epothilone analogues, namely 12,13-cycloalkyl epothilones, were prepared through chemical synthesis and subsequently evaluated with in vitro tubulin polymerization assays and cytotoxicity assays against a panel of cancer cell lines. Guided by the careful analysis of the existing SARs of epothilones, the synthetic targets were selected, the synthetic plans and strategies were formulated, and the actual syntheses were executed. Based on well-established stereochemical transformations combined with highly convergent approach, the synthetic effort culminated in a variety of stereochemically well-defined potent 12,13-cycloalkylepothilone analogues, the biological investigation of which clarified some important problems in the existing SARs such as the role of C12,13-epoxide and the potency enhancing effect of C12 methyl group. In addition, the most potent epothilone analogues identified in this study are being further evaluated towards clinical studies because of their potentially suitable pharmacological profiles.
Book Synopsis Organic Synthesis Using Biocatalysis by : Animesh Goswami
Download or read book Organic Synthesis Using Biocatalysis written by Animesh Goswami and published by Academic Press. This book was released on 2015-09-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. - Provides a concise background of the application of biocatalysis for the synthesis of organic compounds - Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more - Contains detailed, separate chapters that describe the application of biocatalysis
Download or read book Index Medicus written by and published by . This book was released on 2001-12 with total page 2106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Book Synopsis Treatment and Management of Obesity by : George A. Bray
Download or read book Treatment and Management of Obesity written by George A. Bray and published by HarperCollins Publishers. This book was released on 1974 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
