Design And Development Of Colon Targeted Drug Delivery System

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Design and Development of Colon Targeted Drug Delivery System

Author : Mukesh R. Patel
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783847309765
Total Pages : 96 pages
Book Rating : 4.3/5 (97 download)

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Book Synopsis Design and Development of Colon Targeted Drug Delivery System by : Mukesh R. Patel

Download or read book Design and Development of Colon Targeted Drug Delivery System written by Mukesh R. Patel and published by LAP Lambert Academic Publishing. This book was released on 2012-06 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: The oral administration is the most convenient and commonly used method for drug delivery. Traditionally, solid oral dosage forms have been designed to release their drug load in the upper region of the gastrointestinal tract, where conditions are more suited to drug dissolutions and absorptions. Recently, greater emphasis has been placed on controlling site of drug release from oral formulations for the purposes of improving patient compliance and treatment efficiency . Many protein and peptide drugs like insulin cannot be administered through the oral route because of their degradation by the digestive enzymes of the stomach and the small intestine. Colon-specific drug delivery systems offer several potential therapeutic advantages.The opportunity to reduce adverse effects in the treatment of colonic diseases like, ulcerative colitis, colorectal cancer, Chorn s diseases and amoebiasis by topical application of drugs, active at the mucosal level The elucidation of the mode of action of some nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac (metabolized in the colon to the active moiety, sulindac sulfide) that were found to interfere with the proliferation of co

Design of Controlled Release Drug Delivery Systems

Author : Xiaoling Li
Publisher : McGraw Hill Professional
ISBN 13 : 0071588833
Total Pages : 453 pages
Book Rating : 4.0/5 (715 download)

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Book Synopsis Design of Controlled Release Drug Delivery Systems by : Xiaoling Li

Download or read book Design of Controlled Release Drug Delivery Systems written by Xiaoling Li and published by McGraw Hill Professional. This book was released on 2005-11-24 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

The Development of Novel Colon Targeted Drug Delivery Systems

Author : Zuzana Hlaskova
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Book Synopsis The Development of Novel Colon Targeted Drug Delivery Systems by : Zuzana Hlaskova

Download or read book The Development of Novel Colon Targeted Drug Delivery Systems written by Zuzana Hlaskova and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design and Evaluation of Colon Specific Drug Delivery System

Author : Nirav Patel
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783844394825
Total Pages : 288 pages
Book Rating : 4.3/5 (948 download)

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Book Synopsis Design and Evaluation of Colon Specific Drug Delivery System by : Nirav Patel

Download or read book Design and Evaluation of Colon Specific Drug Delivery System written by Nirav Patel and published by LAP Lambert Academic Publishing. This book was released on 2011 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn s diseases, ulcerative colitis, irritable bowl syndrome but also for the potential it holds for the systemic delivery of proteins and therapeutic peptides. Targeted drug delivery to the colon would therefore, ensure direct treatment at the disease site and, consequently, lower dosing and reducing systemic side effects. The most critical challenge in such drug delivery approach is to preserve the formulation during its passage through the stomach and about first six meters of small intestine. In the present investigations, two drugs mesalamine and budesonide was selected for ulcerative colitis in colon. An attempt was made to prepare formulations which could not release the drug into stomach for up to 2 h. which is residence time for it, also it could not release the drug into small intestine up to 3 h. which is residence time for it and could release the drug up to 24 h to 3 days which is residence time for colon. These attempts formulate the colon targeted controlled release dosage form for ulcerative colitis.

A Digital Twin of the Human Colon for the Design and Optimisation of Colon-targeted Drug Delivery Systems

Author : Michael Schûtt
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis A Digital Twin of the Human Colon for the Design and Optimisation of Colon-targeted Drug Delivery Systems by : Michael Schûtt

Download or read book A Digital Twin of the Human Colon for the Design and Optimisation of Colon-targeted Drug Delivery Systems written by Michael Schûtt and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This note is part of Quality testing.

Design and Development of a Rupturable Drug Delivery System for Delivering Drug to the Distal Gastrointestinal Tract-colon

Author : Rahmat M. Talukder
Publisher :
ISBN 13 :
Total Pages : 618 pages
Book Rating : 4.:/5 (852 download)

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Book Synopsis Design and Development of a Rupturable Drug Delivery System for Delivering Drug to the Distal Gastrointestinal Tract-colon by : Rahmat M. Talukder

Download or read book Design and Development of a Rupturable Drug Delivery System for Delivering Drug to the Distal Gastrointestinal Tract-colon written by Rahmat M. Talukder and published by . This book was released on 2005 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advanced Drug Delivery Systems for Colonic Disorders

Author : Harish Dureja
Publisher : Elsevier
ISBN 13 : 0443140456
Total Pages : 463 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Advanced Drug Delivery Systems for Colonic Disorders by : Harish Dureja

Download or read book Advanced Drug Delivery Systems for Colonic Disorders written by Harish Dureja and published by Elsevier. This book was released on 2023-11-04 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems for Colonic Disorders present the current state of the art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency. Chapters are written in a way that allows the audience to not only become familiar with the most recent advancement in the field, but to better understand them by referring to various illustrations, figures, and informative tables. The contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the current status of clinical trials in the area. Advanced Drug Delivery Systems for Colonic Disorders is the perfect resources for researchers in pharma, biomaterials, and nutrition to familiarize themselves with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications. - Covers recent perspectives and challenges towards the treatment of colonic disorders - Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of colonic disorders - Discusses drug delivery strategies to manage inflammatory bowel disease (chronic inflammation in the digestive tract), ulcerative colitis (inflammation and ulcers in colon), Crohn's disease, Colonic polyps, Shigellosis, Colon Bleeding or Hemorrhage, Diverticulosis and colon cancer

Advanced Drug Delivery Systems in the Management of Cancer

Author : Kamal Dua
Publisher : Elsevier
ISBN 13 : 0323900798
Total Pages : 572 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua

Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Oral Controlled Release Formulation Design and Drug Delivery

Author : Hong Wen
Publisher : John Wiley & Sons
ISBN 13 : 1118060326
Total Pages : 571 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Oral Controlled Release Formulation Design and Drug Delivery by : Hong Wen

Download or read book Oral Controlled Release Formulation Design and Drug Delivery written by Hong Wen and published by John Wiley & Sons. This book was released on 2011-01-14 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Chitosan in Drug Delivery

Author : Md Saquib Hasnain
Publisher : Academic Press
ISBN 13 : 0128193379
Total Pages : 557 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chitosan in Drug Delivery by : Md Saquib Hasnain

Download or read book Chitosan in Drug Delivery written by Md Saquib Hasnain and published by Academic Press. This book was released on 2021-10-26 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan

Nanocarriers Based Colon Targeting

Author : Lalit Kumar
Publisher : Academic Press
ISBN 13 : 9780443248061
Total Pages : 0 pages
Book Rating : 4.2/5 (48 download)

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Book Synopsis Nanocarriers Based Colon Targeting by : Lalit Kumar

Download or read book Nanocarriers Based Colon Targeting written by Lalit Kumar and published by Academic Press. This book was released on 2025-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a ground-breaking exploration of nanotechnology's potential in revolutionizing drug delivery for colon-related ailments. Nowadays, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, poses significant medical challenges. Conventional methods to deliver drugs to this system proves difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology, to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, the book delves into cutting-edge topics such as gold nanoparticles, supramagnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, "Nanocarriers Based Colon Targeting" is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy to this organ system. Toxicologists, material scientists, research physicians and regulators can also benefit from the case studies developed by expert authors.

Development of Anti-EpCAM Targeted Drug Delivery Systems for Treatment of Colon Cancer

Author : 侯宗緯
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (899 download)

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Book Synopsis Development of Anti-EpCAM Targeted Drug Delivery Systems for Treatment of Colon Cancer by : 侯宗緯

Download or read book Development of Anti-EpCAM Targeted Drug Delivery Systems for Treatment of Colon Cancer written by 侯宗緯 and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Development of a Biorelevant Dynamic Model of Human Proximal Colon

Author : Konstantinos Stamatopoulos
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (118 download)

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Book Synopsis Development of a Biorelevant Dynamic Model of Human Proximal Colon by : Konstantinos Stamatopoulos

Download or read book Development of a Biorelevant Dynamic Model of Human Proximal Colon written by Konstantinos Stamatopoulos and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design and Development of Novel Nanocarriers for Targeted Drug Delivery

Author : Mhd Anas Tomeh
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (127 download)

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Book Synopsis Design and Development of Novel Nanocarriers for Targeted Drug Delivery by : Mhd Anas Tomeh

Download or read book Design and Development of Novel Nanocarriers for Targeted Drug Delivery written by Mhd Anas Tomeh and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Swellable Core Tablet

Author : Chirag Patel
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783847342045
Total Pages : 160 pages
Book Rating : 4.3/5 (42 download)

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Book Synopsis Swellable Core Tablet by : Chirag Patel

Download or read book Swellable Core Tablet written by Chirag Patel and published by LAP Lambert Academic Publishing. This book was released on 2014-02 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel drug delivery systems (NDDS) have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Delivery of drugs directly to targeted sites of action provides several advantages over non-specific delivery of drugs. Oral colon targeted drug delivery system is one of that NDDS which directly deliver a drug in to the colon for local treatment of a variety of colonic diseases as well as systemic absorption of proteins and peptides. The Metronidazole is the drug of choice in the treatment of the diseases like Amoebiasis, Giardiasis, Trichomonosis and Bacterial Vaginosis. The aim of the present research was to design, development and optimization of swellable rupturable system taking account of local action of the Metronidazole drug in the lower gastrointestinal tract to kill the bacteria in the disease conditions like Amoebiasis, Giardiasis and Trichomonosis.

The Design of Drug Delivery Systems for the Colon

Author : Janine Lesley Bragger
Publisher :
ISBN 13 :
Total Pages : 237 pages
Book Rating : 4.:/5 (596 download)

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Book Synopsis The Design of Drug Delivery Systems for the Colon by : Janine Lesley Bragger

Download or read book The Design of Drug Delivery Systems for the Colon written by Janine Lesley Bragger and published by . This book was released on 1995 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications

Author : Neeraj Mishra
Publisher : Springer
ISBN 13 : 9789819969166
Total Pages : 0 pages
Book Rating : 4.9/5 (691 download)

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Book Synopsis Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications by : Neeraj Mishra

Download or read book Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications written by Neeraj Mishra and published by Springer. This book was released on 2023-12-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.