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Design And Development Of A Heart Cut Two Dimensional Capillary Electrophoresis System With Mass Spectrometric Detection Using A Mechanical Valve As Interface
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Book Synopsis Design and Development of a Heart-cut Two-dimensional Capillary Electrophoresis System with Mass Spectrometric Detection Using a Mechanical Valve as Interface by : Felix Jonas Kohl
Download or read book Design and Development of a Heart-cut Two-dimensional Capillary Electrophoresis System with Mass Spectrometric Detection Using a Mechanical Valve as Interface written by Felix Jonas Kohl and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Application of Two-dimensional Separation Systems Coupled to Mass Spectrometry Incorporating Capillary Electrophoresis by : Kevin Jooß
Download or read book Development and Application of Two-dimensional Separation Systems Coupled to Mass Spectrometry Incorporating Capillary Electrophoresis written by Kevin Jooß and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Interfaces for Capillary Electrophoresis with Inductively Coupled Plasma Mass Spectrometric Detection and Supercritical Fluid Extraction of Metal-based Species from Environmental Samples by : Peter Wesley Kirlew
Download or read book Development of Interfaces for Capillary Electrophoresis with Inductively Coupled Plasma Mass Spectrometric Detection and Supercritical Fluid Extraction of Metal-based Species from Environmental Samples written by Peter Wesley Kirlew and published by . This book was released on 1997 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Application of Two-dimensional Capillary Electrophoresis for Online Mass Spectrometry of CE(SDS)-separated Proteins by : Jennifer Römer
Download or read book Development and Application of Two-dimensional Capillary Electrophoresis for Online Mass Spectrometry of CE(SDS)-separated Proteins written by Jennifer Römer and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Capillary Electrophoresis - Mass Spectrometry for Proteomics and Metabolomics by : Rawi Ramautar
Download or read book Capillary Electrophoresis - Mass Spectrometry for Proteomics and Metabolomics written by Rawi Ramautar and published by John Wiley & Sons. This book was released on 2022-10-03 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics A powerful and essential resource for researchers with an interest in CE-MS In Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications, a team of distinguished researchers delivers a comprehensive overview of bioanalytical capillary electrophoresis coupled to mass spectrometry (CE-MS). The book explains foundational principles, technology as well the strategies and techniques used in data analysis for metabolic and proteomic studies. It also provides a global overview of recent developments and advances for improving CE-MS sensitivity and reproducibility. An essential handbook for everyone performing metabolomic and proteomic analysis, the information provided here will assist researchers in tapping into the full potential of this technique to answer biological and clinical questions. Readers will also find: A thorough introduction to the principles of capillary electrophoresis, including its fundamentals, CE separation modes, capillary coatings, and the fundamentals of mass spectrometry In-depth examinations of technological developments in capillary electrophoresis, including sample preparation, online preconcentration, detection sensitivity, and metabolic coverage Comprehensive discussions of metabolomic studies, including their biomedical and clinical applications Recent advances in proteomics, including top-down and bottom-up approaches Perfect for analytical and clinical chemists, Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications will also earn a place in the libraries of biochemists, molecular biologists, and other molecular life scientists.
Book Synopsis Two-dimensional Capillary-based Electrophoretic Separation Coupled to Mass Spectrometry by a Mechanical Valve by :
Download or read book Two-dimensional Capillary-based Electrophoretic Separation Coupled to Mass Spectrometry by a Mechanical Valve written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Capillary Electrophoresis - Mass Spectrometry (CE-MS) by : Gerhardus de Jong
Download or read book Capillary Electrophoresis - Mass Spectrometry (CE-MS) written by Gerhardus de Jong and published by John Wiley & Sons. This book was released on 2016-06-16 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph offers the reader a complete overview on both principles and applications of CE-MS. Starting with an introductory chapter on detection in CE, also related and more specialized techniques such as electrophoretic and chromatographic preconcentration are discussed. A special emphasis is put on CE-MS interfaces, which are described in detail. In a separate chapter, attention is paid to sheath-liquid interfacing. The developments and possibilities of microchip CE-MS are also described. Applications to all relevant areas are discussed in distinct chapters, each written by experts in the respective fields. Besides applications in pharmaceutical analysis and bioanalysis, recent implementations in food science, forensic analysis, analysis of intact proteins, metabolomics and proteomics are highlighted. MS is a perfectly appropriate detection system for CE, as efficient separation is coupled to sensitive and selection detection. Moreover, MS can provide structure information on the separated compounds. CE-MS has now been developed into a strong hyphenated system complementary to LC-MS. This monograph is an unique source of knowledge for everyone dealing with and interested in CE-MS.
Book Synopsis Capillary Electrophoresis–Mass Spectrometry for Metabolomics by : Rawi Ramautar
Download or read book Capillary Electrophoresis–Mass Spectrometry for Metabolomics written by Rawi Ramautar and published by Royal Society of Chemistry. This book was released on 2018-07-12 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis–mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In this book, the unique features of CE-MS for metabolomics studies are highlighted including CE separation modes, capillary coatings and practical aspects of CE-MS coupling alongside a comprehensive overview of recent technological developments and applications. CE-MS can be considered a relatively new technique in the field of metabolomics and it is therefore important to inform the scientific community about the possibilities of advanced CE-MS approaches for metabolomics studies. This book outlines the potential of this technique for researchers working in metabolomics, bioanalytics and biomarker analysis.
Book Synopsis Selectivity Enhancement in Capillary Electrophoresis - Development of a Two-dimensional Separation and a Dual Detection System by : Andrea Beutner
Download or read book Selectivity Enhancement in Capillary Electrophoresis - Development of a Two-dimensional Separation and a Dual Detection System written by Andrea Beutner and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Capillary Electrophoresis and Mass Spectrometry Methods in Protein Analysis by : Lin Liu
Download or read book Development of Capillary Electrophoresis and Mass Spectrometry Methods in Protein Analysis written by Lin Liu and published by . This book was released on 1999 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Capillary Electrophoresis-Mass Spectrometry by : James Q. Xia
Download or read book Capillary Electrophoresis-Mass Spectrometry written by James Q. Xia and published by Springer. This book was released on 2018-06-28 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest developments in capillary electrophoresis-mass spectrometry for the analysis of therapeutic proteins. The application of capillary electrophoresis-mass spectrometry (CE-MS) coupling technology in the analysis of recombinant therapeutic proteins is detailed thoroughly. Specific topics include recent developments in coupling capillary electrophoresis with mass spectrometry for the quality control of monoclonal antibody therapeutics, top-down analysis of monoclonal antibody using the CE-MS platform, and detection of host cell protein impurities. Comprehensive characterization of antibody-drug conjugates (ADCs) by coupling capillary electrophoresis with mass spectrometry is also covered. This is an ideal book for scientists in the life science and biopharmaceutical industry who are working on characterizing the PTMs of monoclonal antibodies, as well as graduate students and researchers in the separation science and biological mass spectrometry fields.
Book Synopsis Interfacing and Detection Aspects of Two-dimensional Microcolumn Liquid Chromatography-capillary Electrophoresis by : Thomas F. Hooker
Download or read book Interfacing and Detection Aspects of Two-dimensional Microcolumn Liquid Chromatography-capillary Electrophoresis written by Thomas F. Hooker and published by . This book was released on 1997 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Capillary Electrophoresis-Mass Spectrometry by : Christian Neusüß
Download or read book Capillary Electrophoresis-Mass Spectrometry written by Christian Neusüß and published by Humana. This book was released on 2023-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details aspects and applications of interfacing capillary electrophoresis (CE) with mass spectrometry (MS). Chapters guide readers through approaches based on different types of CE-MS interfaces such as (nano)sheath liquid, porous tip, and liquid junction, as well as various capillary coatings, and a broad range of applications including several top-down and bottom-up proteomic approaches. Additionally, a list of analyte targets was provided consisting of amphetamines, antibiotics, carbohydrates (including glycosaminoglycans and glycopeptides), enantiomers, extracellular matrix metabolites, monoclonal antibodies, and nanoparticles, and therefore covers numerous fields of applications such as pharmaceutical, biomedical, food, agrochemical, and environmental analysis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Capillary Electrophoresis-Mass Spectrometry: Methods and Protocols aims to provide highly valuable information for both beginners and experts in the field be it students, technical staff, and scientists.
Book Synopsis An Automated Comprehensive Ultrasensitive Two-dimensional Capillary Electrophoresis System for Proteomic Analysis by : David A. Michels
Download or read book An Automated Comprehensive Ultrasensitive Two-dimensional Capillary Electrophoresis System for Proteomic Analysis written by David A. Michels and published by . This book was released on 2004 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Independent Parallel Capillary Array Separations for Rapid Second Dimension Sampling in On-Line Two-Dimensional Capillary Electrophoresis of Complex Biological Samples by : John D. Chin
Download or read book Independent Parallel Capillary Array Separations for Rapid Second Dimension Sampling in On-Line Two-Dimensional Capillary Electrophoresis of Complex Biological Samples written by John D. Chin and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological samples remain challenging in proteomic separations due to their complexity and large concentration dynamic range. Improvements to separation power are needed to interrogate proteomes more deeply and facilitate the advancement of biomarker discovery for personalized medicine. Current online multidimensional separations require compromise; long analysis times if the second dimension (2nd-D) must be regenerated between injections, or reduced separation efficiency if the 2nd-D is operated rapidly. Using an array of capillaries as the 2nd-D, operated in parallel, allows fast sampling of the first dimension (1st-D). This relaxes the constraints on the 2nd-D separation, allowing it to operate at optimal separation conditions that would otherwise be sacrificed for speed. This configuration allows total separation times to approximately equal to the 1st-D separation time. We have developed a novel interface that enables continuous sampling of a 1st-D separation by a 2nd-D capillary array for rapid, high peak capacity two dimensional (2D) separations, based upon automated precision positioning of capillaries. Within a laminar flow regime, a capillary electrophoresis (CE) 1st-D separation was coupled to an array of eight independent CE 2nd-D separations. The instrument terminus provides laser induced fluorescence detection via a sheath flow cuvette. Effluent transfer efficiency, from the 1st-D to the 2nd-D, and detection was optimized using visible and fluorescent dye tracers. To that end, this dissertation will discuss characterization of interface and detector parameters, including: inter capillary transverse alignment accuracy, injection distance, injection time, hydrodynamic flow rate, density considerations, inter and intra capillary differences, signal crosstalk and laser intensity. Separation performance will further be demonstrated using model protein and serum digestates. Each dimension of the 2D instrument will be operated as a one dimensional (1D) instrument to compare against an optimized commercial 1D CE instrument. These results will be used to evaluate the quality of the separations operated in on-line 2D capillary electrophoresis-to-capillary array electrophoresis (CE×CAE) mode. A novel application of the CE×CAE design will be discussed in the spirit of resolving the long standing challenge of migration time reproducibility in CE separations.
Book Synopsis Design and Applications of an Improved Capillary Electrophoresis - Electrospray Ionization - Mass Spectrometry Interface by : Xuefei Zhong
Download or read book Design and Applications of an Improved Capillary Electrophoresis - Electrospray Ionization - Mass Spectrometry Interface written by Xuefei Zhong and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book V2D written by Andrea Renata Laine and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
