Dermatokinetics Of Therapeutic Agents

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Dermatokinetics of Therapeutic Agents

Author : S. Narasimha Murthy
Publisher : CRC Press
ISBN 13 : 143980477X
Total Pages : 222 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Dermatokinetics of Therapeutic Agents by : S. Narasimha Murthy

Download or read book Dermatokinetics of Therapeutic Agents written by S. Narasimha Murthy and published by CRC Press. This book was released on 2011-04-15 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents. Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents Drug Delivery Approaches to Modulate Dermatokinetics of Drugs Conventional Methods of Cutaneous Drug Sampling Cutaneous Microdialysis Sampling Substrates by Skin Permeabilization Spectroscopic Techniques in Dermatokinetics Studies Regulatory Perspective of Dermatokinetic Studies

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Oral Drug Absorption

Author : Jennifer B. Dressman
Publisher : CRC Press
ISBN 13 : 1420077341
Total Pages : 432 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Oral Drug Absorption by : Jennifer B. Dressman

Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

Author : Michael W. Jann
Publisher : Springer
ISBN 13 : 3319278835
Total Pages : 597 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents by : Michael W. Jann

Download or read book Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents written by Michael W. Jann and published by Springer. This book was released on 2016-03-02 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.

Drug Delivery Approaches

Author : Bret Berner
Publisher : John Wiley & Sons
ISBN 13 : 1119772737
Total Pages : 466 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Drug Delivery Approaches by : Bret Berner

Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Introduction to Pharmacokinetics and Pharmacodynamics

Author : Thomas N. Tozer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781751490
Total Pages : 342 pages
Book Rating : 4.7/5 (514 download)

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Book Synopsis Introduction to Pharmacokinetics and Pharmacodynamics by : Thomas N. Tozer

Download or read book Introduction to Pharmacokinetics and Pharmacodynamics written by Thomas N. Tozer and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

A Textbook of Clinical Pharmacology and Therapeutics, 5Ed

Author : James Ritter
Publisher : CRC Press
ISBN 13 : 1444113003
Total Pages : 480 pages
Book Rating : 4.4/5 (441 download)

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Book Synopsis A Textbook of Clinical Pharmacology and Therapeutics, 5Ed by : James Ritter

Download or read book A Textbook of Clinical Pharmacology and Therapeutics, 5Ed written by James Ritter and published by CRC Press. This book was released on 2008-04-25 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding.Fully revised throughout and extensively illust

Handbook of Pharmaceutical Salts Properties, Selection, and Use

Author : P. Heinrich Stahl
Publisher : John Wiley & Sons
ISBN 13 : 9783906390581
Total Pages : 392 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Handbook of Pharmaceutical Salts Properties, Selection, and Use by : P. Heinrich Stahl

Download or read book Handbook of Pharmaceutical Salts Properties, Selection, and Use written by P. Heinrich Stahl and published by John Wiley & Sons. This book was released on 2008-08-04 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive up-to-date guide and information source is an instructive companion for all scientists involved in research and development of drugs and, in particular, of pharmaceutical dosage forms. The editors have taken care to address every conceivable aspect of the preparation of pharmaceutical salts and present the necessary theoretical foundations as well as a wealth of detailed practical experience in the choice of pharmaceutically active salts. Altogether, the contributions reflect the multidisciplinary nature of the science involved in selection of suitable salt forms for new drug products.

Individualized Drug Therapy for Patients

Author : Roger W Jelliffe
Publisher : Academic Press
ISBN 13 : 0128033495
Total Pages : 435 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Individualized Drug Therapy for Patients by : Roger W Jelliffe

Download or read book Individualized Drug Therapy for Patients written by Roger W Jelliffe and published by Academic Press. This book was released on 2016-11-15 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. 2018 PROSE Awards - Honorable Mention, Clinical Medicine: Association of American Publishers Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Pharmacokinetics and Adverse Effects of Drugs

Author : Ntambwe Malangu
Publisher : BoD – Books on Demand
ISBN 13 : 1789231388
Total Pages : 164 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Pharmacokinetics and Adverse Effects of Drugs by : Ntambwe Malangu

Download or read book Pharmacokinetics and Adverse Effects of Drugs written by Ntambwe Malangu and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

Author : Avraham Yacobi
Publisher : Springer
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development by : Avraham Yacobi

Download or read book Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development written by Avraham Yacobi and published by Springer. This book was released on 1993-02-28 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991

Study Guide to Accompany Drug Therapy in Nursing

Author : Diane S. Aschenbrenner
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781777438
Total Pages : 360 pages
Book Rating : 4.7/5 (774 download)

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Book Synopsis Study Guide to Accompany Drug Therapy in Nursing by : Diane S. Aschenbrenner

Download or read book Study Guide to Accompany Drug Therapy in Nursing written by Diane S. Aschenbrenner and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The perfect companion to Drug Therapy in Nursing, Second Edition, this invaluable study partner delivers guidance on individual patient management from a nurse-as-caregiver perspective, helping you build essential knowledge and develop sound practice skills. Knowledge-building features include Top Ten Things to Know lists, key terms, multiple-choice questions, case studies, and critical thinking challenges. A "Just the Facts" feature helps deepen your understanding of essential drugs, their actions, indications, contraindications, and cautions. A "Patients Please" feature helps you put the needs of the patient first, with facts on core patient variables.

Rational Therapeutics for Infants and Children

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309183642
Total Pages : 135 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rational Therapeutics for Infants and Children by : Institute of Medicine

Download or read book Rational Therapeutics for Infants and Children written by Institute of Medicine and published by National Academies Press. This book was released on 2000-04-07 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be convened to conduct a dialogue and exchange information related to the development of drugs, biologics, and medical devices. Members have expertise in clinical medicine, pediatrics, clinical pharmacology, health policy, health insurance, industrial management, and product development; and they represent interests that address all facets of public policy issues. From time to time, the Roundtable requests that a workshop be conducted for the purpose of exploring a specific topic in detail and obtaining the views of additional experts. The first workshop for the Roundtable was held on April 14 and 15, 1998, and was entitled Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making. The summary on that workshop is available from IOM. This workshop summary covers the second workshop, which was held on May 24 and 25, 1999, and which was aimed at facilitating the development and proper use of drugs, biologics, and medical devices for infants and children. It explores the scientific underpinnings and clinical needs, as well as the regulatory, legal, and ethical issues, raised by this area of research and development.

Therapeutic Systems

Author : Klaus Heilmann
Publisher :
ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Therapeutic Systems by : Klaus Heilmann

Download or read book Therapeutic Systems written by Klaus Heilmann and published by . This book was released on 1978 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Therapeutic Drugs

Author : Colin T. Dollery
Publisher :
ISBN 13 : 9780443051487
Total Pages : 1000 pages
Book Rating : 4.0/5 (514 download)

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Book Synopsis Therapeutic Drugs by : Colin T. Dollery

Download or read book Therapeutic Drugs written by Colin T. Dollery and published by . This book was released on 1999 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized alphabetically by generic drug name. Each entry includes the chemistry, pharmacology, toxicology, clinical pharmacology, pharmacokinetics, concentration-effect relationship, metabolism, pharmaceutics,genomics, therapeutic use, adverse reactions, high risk groups, drug interactions, and clinical trials and evidence-based medicine.

Pharmacokinetics and Pharmacodynamics of Biotech Drugs

Author : Bernd Meibohm
Publisher : John Wiley & Sons
ISBN 13 : 3527609520
Total Pages : 426 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Pharmacokinetics and Pharmacodynamics of Biotech Drugs by : Bernd Meibohm

Download or read book Pharmacokinetics and Pharmacodynamics of Biotech Drugs written by Bernd Meibohm and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first ever coverage of the pharmacokinetic and pharmacodynamic characteristics of biopharmaceuticals meets the need for a comprehensive book in this field. It spans all topics from lead identification right up to final-stage clinical trials. Following an introduction to the role of PK and PD in the development of biotech drugs, the book goes on to cover the basics, including the pharmacokinetics of peptides, monoclonal antibodies, antisense oligonucleotides, as well as viral and non-viral gene delivery vectors. The second section discusses such challenges and opportunities as pulmonary delivery of proteins and peptides, and the delivery of oligonucleotides. The final section considers the integration of PK and PD concepts into the biotech drug development plan, taking as case studies the preclinical and clinical drug development of tasidotin, as well as the examples of cetuximab and pegfilgrastim. The result is vital reading for all pharmaceutical researchers.

Drug Transporters

Author : Martin F. Fromm
Publisher : Springer Science & Business Media
ISBN 13 : 3642145418
Total Pages : 457 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Drug Transporters by : Martin F. Fromm

Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.