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Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cole M. Haynes
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (569 download)
Download or read book Degradation of Misfolded Proteins from the Endoplasmic Reticulum written by Cole M. Haynes and published by . This book was released on 2003 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 9780128186671
Total Pages : 0 pages
Book Rating : 4.1/5 (866 download)
Download or read book Ubiquitin-dependent Protein Degradation written by and published by Academic Press. This book was released on 2019-03-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more.
Author : Sabrina R. Caldwell
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (569 download)
Download or read book Misfolded Protein Degradation Requires ER-Golgi Transport and the Novel Cargo Receptor, Erv29 written by Sabrina R. Caldwell and published by . This book was released on 2003 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sofia Banchenko
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (973 download)
Download or read book Structural Basis of Endoplasmic Reticulum-associated Degradation of Misfolded Proteins (ERAD) written by Sofia Banchenko and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rocco John Casagrande
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (492 download)
Download or read book Protein Degradation from the Endoplasmic Reticulum in Yeast written by Rocco John Casagrande and published by . This book was released on 2001 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marina Ramirez-Alvarado
Publisher : John Wiley & Sons
ISBN 13 : 1118031814
Total Pages : 1311 pages
Book Rating : 4.1/5 (18 download)
Download or read book Protein Misfolding Diseases written by Marina Ramirez-Alvarado and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 1311 pages. Available in PDF, EPUB and Kindle. Book excerpt: An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
Author : Matthew M. LaVail
Publisher : Springer Science & Business Media
ISBN 13 : 1461406315
Total Pages : 867 pages
Book Rating : 4.4/5 (614 download)
Download or read book Retinal Degenerative Diseases written by Matthew M. LaVail and published by Springer Science & Business Media. This book was released on 2011-12-21 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
Author : Emmanuel Wiertz
Publisher : Springer Science & Business Media
ISBN 13 : 3540280073
Total Pages : 180 pages
Book Rating : 4.5/5 (42 download)
Download or read book Dislocation and Degradation of Proteins from the Endoplasmic Reticulum written by Emmanuel Wiertz and published by Springer Science & Business Media. This book was released on 2006-02-04 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). This area is of immediate medical relevance and has blossomed, to no small extent, because of the study of molecules central to the function of the immune system [immunogl- ulins, T cell receptors, major histocompatibility complex (MHC)-encoded products]. Similarly, the clever strategies used by bacteria or viruses to gain a foothold in the host and ensure their continued survival have uncovered altogether new cell biological principles. It is therefore ?tting that a special volume be devoted to the interplay between pathways of protein degradation in the ER and a wide variety of pathogens. The concept of quality control emerged with the appreciation that, in the case of multimeric glycoproteins, any unpaired glycoprotein subunit had great dif?culties leaving its site of synthesis—the ER—and was destroyed instead. Free immunoglobulin heavy chains were probably the earliest documented example of this kind, and were long known to cause pathology when their accumulation went unchecked. Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made. The T cell receptor for antigen, long considered the paradigm of this mode of degradation, led the way in these early explorations.
Author : Brandan E. Crum
Publisher :
ISBN 13 :
Total Pages : 78 pages
Book Rating : 4.:/5 (921 download)
Download or read book The Analysis of Biomedically Important Proteins Involved in Endoplasmic Reticulum Associated Protein Degradation written by Brandan E. Crum and published by . This book was released on 2005 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Endoplasmic Reticulum Associated Protein Degradation (ERAD) is a process that requires retrotranslocation of aberrant proteins from the endoplasmic reticulum (ER) lumen to the cytosol where proteasomal degradation of these aberrant proteins occurs. When ERAD is saturated, misfolded proteins are trafficked to the vacuole via the biosynthetic pathway and/or autophagy. Studies to examine the mutant fibrinogen subunits, gamma Aguadilla and gamma Brescia, as substrates of ERAD were initiated in wild-type Saccharomyces cerevisiae. Colony-blot immunoassay results demonstrate that both Aguadilla and Brescia mutant gamma proteins are degraded within the cell. In studying the degradation of these mutant gamma proteins, we tested the hypothesis that ERAD becomes saturated at elevated levels of gamma expression and that excess mutant gamma protein was then targeted to autophagy, and alternative quality control pathway. It was found that over-expression of mutant gamma led to vacuole-dependent degradation and that autophagy was required for delivery of the aggregated form of excess mutant gamma to the vacuole. Together, these findings indicate that both mutant gamma fibrinogens, Aguadilla and Brescia, are ERAD substrates and further that autophagy acts in the clearance of the aggregated gamma."--Abstract.
Author : Peter Bross
Publisher : Springer Science & Business Media
ISBN 13 : 1592593941
Total Pages : 317 pages
Book Rating : 4.5/5 (925 download)
Download or read book Protein Misfolding and Disease written by Peter Bross and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer’s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes.
Author : Peter Zwickl
Publisher : Springer Science & Business Media
ISBN 13 : 364259414X
Total Pages : 222 pages
Book Rating : 4.6/5 (425 download)
Download or read book The Proteasome — Ubiquitin Protein Degradation Pathway written by Peter Zwickl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.
Author : Roberto Pérez Torrado
Publisher :
ISBN 13 : 9781071617328
Total Pages : 332 pages
Book Rating : 4.6/5 (173 download)
Download or read book The Unfolded Protein Response written by Roberto Pérez Torrado and published by . This book was released on 2022 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : R. John Mayer
Publisher : John Wiley & Sons
ISBN 13 : 3527620303
Total Pages : 258 pages
Book Rating : 4.5/5 (276 download)
Download or read book The Ubiquitin-Proteasome System and Disease written by R. John Mayer and published by John Wiley & Sons. This book was released on 2008-06-25 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research. From the contents: * Ubiquitin and cancer * Ubiquitin and liver cancer * Muscle atrophy * Aggresomes and human disease * Parkin and neurodegeneration * Chronic neurodegenerative diseases * Parkinson's disease * Ubiquitin and viruses * Druggability of the ubiquitin-proteasome system Required reading for molecular and cell biologists, as well as physiologists with an interest in the topic.
Author : Margit Pavelka
Publisher : Springer Science & Business Media
ISBN 13 : 3211993908
Total Pages : 366 pages
Book Rating : 4.2/5 (119 download)
Download or read book Functional Ultrastructure written by Margit Pavelka and published by Springer Science & Business Media. This book was released on 2010-07-16 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.
Author : Ethan Joseph Greenblatt
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (775 download)
Download or read book Derlin-1 is a Rhomboid Pseudoprotease Required for the Dislocation of Misfolded Proteins from the Endoplasmic Reticulum written by Ethan Joseph Greenblatt and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The degradation of misfolded secretory proteins is ultimately mediated by the ubiquitin-proteasome system in the cytoplasm, therefore endoplasmic reticulum-associated degradation (ERAD) substrates must be dislocated across the ER membrane through a process driven by the AAA ATPase p97/VCP. Derlins recruit p97/VCP and have been proposed to be part of the dislocation machinery. Here we report that Derlins are inactive members of the rhomboid family of intramembrane proteases and bind p97/VCP through C-terminal SHP boxes. Human Derlin-1 harboring mutations within the rhomboid domain stabilized mutant [alpha]-1 antitrypsin (NHK) at the cytosolic face of the ER membrane without disrupting the p97/VCP interaction. We propose that substrate interaction and p97/VCP recruitment are separate functions that are essential for dislocation and can be assigned respectively to the rhomboid domain and the C terminus of Derlin-1. These data suggest that intramembrane proteolysis and protein dislocation share unexpected mechanistic features.
Author : Claudio Hetz
Publisher : Bentham Science Publishers
ISBN 13 : 1608050130
Total Pages : 156 pages
Book Rating : 4.6/5 (8 download)
Download or read book Protein Misfolding Disorders written by Claudio Hetz and published by Bentham Science Publishers. This book was released on 2009 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This book gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context. -- Publisher.
