Dancing Protein Clouds Intrinsically Disordered Proteins In The Norm And Pathology

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Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Author :
Publisher : Academic Press
ISBN 13 : 0323853005
Total Pages : 438 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C by :

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C written by and published by Academic Press. This book was released on 2021-10-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology

Author : Vladimir Uversky
Publisher : Academic Press
ISBN 13 : 012816851X
Total Pages : 426 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology by : Vladimir Uversky

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology written by Vladimir Uversky and published by Academic Press. This book was released on 2019-09-15 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Author :
Publisher : Academic Press
ISBN 13 : 9780128168516
Total Pages : 0 pages
Book Rating : 4.1/5 (685 download)

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Book Synopsis Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A by :

Download or read book Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A written by and published by Academic Press. This book was released on 2019-09-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Author :
Publisher : Academic Press
ISBN 13 : 9780323852999
Total Pages : 0 pages
Book Rating : 4.8/5 (529 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C by :

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C written by and published by Academic Press. This book was released on 2021-10-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128226048
Total Pages : 406 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B by :

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B written by and published by Academic Press. This book was released on 2020-08-19 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. - Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases - Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided - Includes contributions from recognized experts in the field

Structure and Intrinsic Disorder in Enzymology

Author : Munishwar Nath Gupta
Publisher : Elsevier
ISBN 13 : 0323995349
Total Pages : 529 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Structure and Intrinsic Disorder in Enzymology by : Munishwar Nath Gupta

Download or read book Structure and Intrinsic Disorder in Enzymology written by Munishwar Nath Gupta and published by Elsevier. This book was released on 2022-11-17 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. - Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins - Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study - Features chapter contributions from international leaders in the field

Intrinsically Disordered Proteins

Author :
Publisher : Academic Press
ISBN 13 : 0128156503
Total Pages : 756 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Intrinsically Disordered Proteins by :

Download or read book Intrinsically Disordered Proteins written by and published by Academic Press. This book was released on 2018-11-21 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins, Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock, and more. - Breadth of experimental approaches and systems that will be covered - The expertise of the contributors writing the articles

Intrinsically Disordered Proteins

Author : Vladimir N. Uversky
Publisher : Springer
ISBN 13 : 3319089218
Total Pages : 73 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Intrinsically Disordered Proteins by : Vladimir N. Uversky

Download or read book Intrinsically Disordered Proteins written by Vladimir N. Uversky and published by Springer. This book was released on 2014-08-05 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Structure and Function of Intrinsically Disordered Proteins

Author : Peter Tompa
Publisher : CRC Press
ISBN 13 : 1420078933
Total Pages : 362 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Structure and Function of Intrinsically Disordered Proteins by : Peter Tompa

Download or read book Structure and Function of Intrinsically Disordered Proteins written by Peter Tompa and published by CRC Press. This book was released on 2009-11-18 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev

Intrinsically Disordered Proteins

Author : Nicola Salvi
Publisher : Academic Press
ISBN 13 : 0128167327
Total Pages : 358 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Intrinsically Disordered Proteins by : Nicola Salvi

Download or read book Intrinsically Disordered Proteins written by Nicola Salvi and published by Academic Press. This book was released on 2019-06-14 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs. - Provides in-depth discussion of fundamental IDP and IDR dynamics, function, and binding, with mechanistic insight to support new drug development - Describes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targets - Features chapter contributions from international experts in IDP and IDR biochemical function and methods of study

Intrinsically Disordered Proteins (IDPs)

Author : Violet Weber
Publisher : Nova Science Publishers
ISBN 13 : 9781634844079
Total Pages : 0 pages
Book Rating : 4.8/5 (44 download)

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Book Synopsis Intrinsically Disordered Proteins (IDPs) by : Violet Weber

Download or read book Intrinsically Disordered Proteins (IDPs) written by Violet Weber and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an important role in cellular regulation, signaling and control in health and disease. However, the unusual biophysics of these proteins makes structural characterisation of IDPs and their complexes not only challenging but often resulting in opposite conclusions. This book studies the structural characterisation and future directions of IDPs. Chapter One focuses on the DNA-binding IDPs and how intrinsic disorder affects their function. Chapter Two discusses the use of a computer atomistic simulation for the structural analysis of IDPs. The final chapter, Chapter Three, examines two long-standing contradictions concerning dimerisation and membrane-binding activities of IDPs; provides an explanation of these discrepancies; and demonstrates how the resolution of these critical issues in the field results in the expanded understanding of cell function with multiple applications in biology and medicine.

The Emperor of All Maladies

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
ISBN 13 : 1439170916
Total Pages : 624 pages
Book Rating : 4.4/5 (391 download)

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Book Synopsis The Emperor of All Maladies by : Siddhartha Mukherjee

Download or read book The Emperor of All Maladies written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2011-08-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Health of People, Health of Planet and Our Responsibility

Author : Wael Al-Delaimy
Publisher : Springer Nature
ISBN 13 : 3030311252
Total Pages : 417 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Health of People, Health of Planet and Our Responsibility by : Wael Al-Delaimy

Download or read book Health of People, Health of Planet and Our Responsibility written by Wael Al-Delaimy and published by Springer Nature. This book was released on 2020-05-13 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book not only describes the challenges of climate disruption, but also presents solutions. The challenges described include air pollution, climate change, extreme weather, and related health impacts that range from heat stress, vector-borne diseases, food and water insecurity and chronic diseases to malnutrition and mental well-being. The influence of humans on climate change has been established through extensive published evidence and reports. However, the connections between climate change, the health of the planet and the impact on human health have not received the same level of attention. Therefore, the global focus on the public health impacts of climate change is a relatively recent area of interest. This focus is timely since scientists have concluded that changes in climate have led to new weather extremes such as floods, storms, heat waves, droughts and fires, in turn leading to more than 600,000 deaths and the displacement of nearly 4 billion people in the last 20 years. Previous work on the health impacts of climate change was limited mostly to epidemiologic approaches and outcomes and focused less on multidisciplinary, multi-faceted collaborations between physical scientists, public health researchers and policy makers. Further, there was little attention paid to faith-based and ethical approaches to the problem. The solutions and actions we explore in this book engage diverse sectors of civil society, faith leadership, and political leadership, all oriented by ethics, advocacy, and policy with a special focus on poor and vulnerable populations. The book highlights areas we think will resonate broadly with the public, faith leaders, researchers and students across disciplines including the humanities, and policy makers.

The Hostage Brain

Author : Bruce S. McEwen
Publisher : Rockefeller Univ. Press
ISBN 13 : 9780874700565
Total Pages : 336 pages
Book Rating : 4.7/5 (5 download)

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Book Synopsis The Hostage Brain by : Bruce S. McEwen

Download or read book The Hostage Brain written by Bruce S. McEwen and published by Rockefeller Univ. Press. This book was released on 1994 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

For the Love of Enzymes

Author : Arthur Kornberg
Publisher : Harvard University Press
ISBN 13 : 9780674307766
Total Pages : 356 pages
Book Rating : 4.3/5 (77 download)

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Book Synopsis For the Love of Enzymes by : Arthur Kornberg

Download or read book For the Love of Enzymes written by Arthur Kornberg and published by Harvard University Press. This book was released on 1991 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the American Medical Writers' Association Book Award, this volume describes, with observations on the process of scientific research, the author's successive research problems, the challenges they presented and the ultimate accomplishments thatresulted.

Public Health Response to Biological and Chemical Weapons

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241546158
Total Pages : 365 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Public Health Response to Biological and Chemical Weapons by : World Health Organization

Download or read book Public Health Response to Biological and Chemical Weapons written by World Health Organization and published by World Health Organization. This book was released on 2004-01-21 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of this publication which focuses on the public health aspects of the possible deliberate use of biological or chemical agents. Issues discussed include: the key principles for public health planning, risk assessment, hazard identification and evaluation, risk management strategies, and response planning as part of existing national emergency plans, disease surveillance and early warning systems, the national and international legal framework, and international sources of assistance. Technical annexes cover a range of issues including chemical agents, toxins, biological agents, principles of protection, precautions against the sabotage of drinking water, food and other products, information resources and the affiliation of WHO Member States to the international treaties on biological and chemical weapons.

Innovations in Biomedical Engineering

Author : Marek Gzik
Publisher : Springer Nature
ISBN 13 : 3030991121
Total Pages : 341 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Innovations in Biomedical Engineering by : Marek Gzik

Download or read book Innovations in Biomedical Engineering written by Marek Gzik and published by Springer Nature. This book was released on 2022-05-31 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest developments in the field of biomedical engineering and includes practical solutions and strictly scientific considerations. The development of new methods of treatment, advanced diagnostics or personalized rehabilitation requires close cooperation of experts from many fields, including, among others, medicine, biotechnology and finally biomedical engineering. The latter, combining many fields of science, such as computer science, materials science, biomechanics, electronics not only enables the development and production of modern medical equipment, but also participates in the development of new directions and methods of treatment. The presented monograph is a collection of scientific papers on the use of engineering methods in medicine. The topics of the work include both practical solutions and strictly scientific considerations expanding knowledge about the functioning of the human body. We believe that the presented works will have an impact on the development of the field of science, which is biomedical engineering, constituting a contribution to the discussion on the directions of development of cooperation between doctors, physiotherapists and engineers. We would also like to thank all the people who contributed to the creation of this monograph—both the authors of all the works and those involved in technical works.