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Cytokines In Severe Sepsis And Septic Shock
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Book Synopsis Cytokines in Severe Sepsis and Septic Shock by : H. Redl
Download or read book Cytokines in Severe Sepsis and Septic Shock written by H. Redl and published by Springer. This book was released on 2013-03-11 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.
Book Synopsis Cytokines in Severe Sepsis and Septic Shock by : Heinz Redl
Download or read book Cytokines in Severe Sepsis and Septic Shock written by Heinz Redl and published by Birkhauser. This book was released on 1998-01-01 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Shock, Sepsis, and Organ Failure by : Günther Schlag
Download or read book Shock, Sepsis, and Organ Failure written by Günther Schlag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the result of the 3rd Wiggers Bernard Conference. The Wiggers Bernard Conferences, named after two great physiologists of the past, are biannual gatherings of the leaders in the field of shock. The meetings focus on specific areas of interest, where a lot of new informations is available, but needs to be focused. There are informal presentations during which the seminarian can be intenupted in order to clarify a pat1icular point; formal discussions follow each presentation; these are followed by infOlmal gatherings in which these discussion continue in a very relaxed environment. The 1992 meeting took place in Obermayerhofen, a small but charming castle in the soft green hills of Eastern Styria in the South-Eastern part of Austria. The castle was built in 1130, restored and turned into a hotel in 1977. The renaissance court yard and the generous and exclusive decors make it one of the most beautiful castles in Austria. The frank beauty and hospitality of this area acted as a catalyst to crystalize the thoughts of this interdisciplinary group of scientists as they discussed new findings in the cytokine area.
Book Synopsis Continuous Renal Replacement Therapy by : John A. Kellum
Download or read book Continuous Renal Replacement Therapy written by John A. Kellum and published by Oxford University Press. This book was released on 2016 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance for the management of critically ill patients with acute renal failure, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice.
Book Synopsis Evolving Concepts in Sepsis and Septic Shock by : Peter Q. Eichacker
Download or read book Evolving Concepts in Sepsis and Septic Shock written by Peter Q. Eichacker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.
Book Synopsis Pathology of Septic Shock by : Ernst T. Rietschel
Download or read book Pathology of Septic Shock written by Ernst T. Rietschel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.
Book Synopsis Infectious Process and Sepsis by : Vincenzo Neri
Download or read book Infectious Process and Sepsis written by Vincenzo Neri and published by . This book was released on 2020 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis is a very complex clinical condition that can be considered the central point of the infectious process: the arrival point in the evolution of a localized septic outbreak that has caused a systemic inflammatory reaction. In the clinical setting two important questions regarding the transition from local inflammation, with beneficial effect, to systemic inflammatory disease, with deleterious results, remain unanswered. First, why does the transition from local to systemic disease only occur in some subjects? Second, how long does this transition take? This book attempts to answer these questions. Chapters cover such topics as surgical infections, microbiota therapy in sepsis, cytokines for host immune response, and the role of serum amyloid A in the acute phase of sepsis.
Book Synopsis Infectious Process and Sepsis by : Vincenzo Neri
Download or read book Infectious Process and Sepsis written by Vincenzo Neri and published by BoD – Books on Demand. This book was released on 2020-07-15 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis is a very complex clinical condition that can be considered the central point of the infectious process: the arrival point in the evolution of a localized septic outbreak that has caused a systemic inflammatory reaction. In the clinical setting two important questions regarding the transition from local inflammation, with beneficial effect, to systemic inflammatory disease, with deleterious results, remain unanswered. First, why does the transition from local to systemic disease only occur in some subjects? Second, how long does this transition take? This book attempts to answer these questions. Chapters cover such topics as surgical infections, microbiota therapy in sepsis, cytokines for host immune response, and the role of serum amyloid A in the acute phase of sepsis.
Book Synopsis Sepsis - Pro-Inflammatory and Anti-Inflammatory Responses by : H. Herwald
Download or read book Sepsis - Pro-Inflammatory and Anti-Inflammatory Responses written by H. Herwald and published by Karger Medical and Scientific Publishers. This book was released on 2011-05-31 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis is a serious condition that is associated with high mortality despite advanced modern medical treatment. Recent years have witnessed novel paradigms describing host responses in sepsis. In particular, the delicate balance between pro- and anti-inflammatory reactions has been subject to intense research. This volume in the book series ‘Contributions to Microbiology’ presents the state of the art in this rapidly expanding field of research. Leading international experts have contributed with reviews on the most relevant topics in the field such as clinical aspects, pathways of sepsis and pro- and anti-inflammatory mechanisms as well as their regulation. The book will be a valuable source of up-to-date information for clinicians, microbiologists, immunologists, and students with an interest in the complex regulation of host responses during microbial sepsis.
Book Synopsis Septic Shock by : George H. Sakorafas
Download or read book Septic Shock written by George H. Sakorafas and published by Nova Publishers. This book was released on 2005 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis is one of the most frequent complications in the surgical patient and one of the leading causes of mortality in intensive care units. During the past two decades, a great deal has been learned about surgical bacteriology, antibiotic prophylaxis, supportive management, and the host response to microbial invasion. Sepsis can be caused by infection with gram-negative bacteria, gram-positive bacteria, fungi (and particularly Candida), or viruses. Sepsis may also occur in the absence of detectable bacterial invasion, and in these cases, microbial toxins, particularly gram-negative bacterial endotoxin (lipopolysaccharide, LPS), and endogenous cytokine production have been implicated as initiators and mediators. Although activation of the immune system during microbial invasion is generally protective, septic shock develops in a significant number of patients as a consequence of a poorly regulated immune response to the offending organism. Sepsis can be presented with a spectrum of severity. Septic shock represents the most severe form of host response to infection. The aim of this monograph is to summarise the currently available data regarding epidemiology, pathogenesis, and optimal management of septic shock, with a particular emphasis on the role of source control in sepsis. Emerging therapies for septic shock are also discussed.
Book Synopsis Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma by : Lukas Martin
Download or read book Translational Insights into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma written by Lukas Martin and published by Frontiers Media SA. This book was released on 2020-12-15 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Sepsis written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-02-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological approaches to therapy for early and late sepsis Includes detailed discussion of the various physiological systems implicated in sepsis Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.
Book Synopsis The Sepsis Text by : Jean-Louis Vincent
Download or read book The Sepsis Text written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.
Book Synopsis Sepsis—Advances in Research and Treatment: 2013 Edition by :
Download or read book Sepsis—Advances in Research and Treatment: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis—Advances in Research and Treatment / 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Septic Shock in a concise format. The editors have built Sepsis—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Septic Shock in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sepsis—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Shock, Sepsis, and Organ Failure by : Günther Schlag
Download or read book Shock, Sepsis, and Organ Failure written by Günther Schlag and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.
Book Synopsis Sepsis and Non-infectious Systemic Inflammation by : Jean-Marc Cavaillon
Download or read book Sepsis and Non-infectious Systemic Inflammation written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2008-11-24 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing definitions, clinical features and epidemiology, this handbook and reference adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, it is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.
Book Synopsis Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery by : E. Abraham
Download or read book Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery written by E. Abraham and published by Springer Science & Business Media. This book was released on 2007-08-27 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.
