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Cytokine Bioassays
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Book Synopsis Cytokine Bioassays by : Ivana Vancurova
Download or read book Cytokine Bioassays written by Ivana Vancurova and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are pleiotropic regulatory proteins involved in essentially all biological processes and associated with a wide variety of diseases, including inflammatory disorders as well as many types of cancer and leukemia. Knowledge about the quantitative and qualitative nature of cytokine production is critical in the understanding of normal and pathological processes. The cytokine detection in biological and clinical samples faces many challenges including their low abundance, the need to distinguish between active and latent cytokine forms, and the need to measure multiple cytokines in a single assay. This volume will provide a comprehensive collection of classic and cutting-edge methodologies that are currently used to analyze and quantify cytokines and their biological activities in complex biological and clinical samples. The chapters are divided into four main categories. The first group focuses on the immunodetection of released cytokines in tissue culture supernatants, plasma, serum and whole blood samples by immunoassays. These immunoassays measure the total concentrations of released cytokines regardless of their biological activity and include ELISA, flow cytometry, ELISPOT and the antibody-based proximity ligation. The second group will focus on the analysis of biologically active cytokines by bioassays using neutralizing antibodies, chemotaxis assay, cytokine-induced cell degranulation assay, cell proliferation and differentiation, cytokine-induced cytokine production and the radioreceptor cytokine assay. The third group focuses on the analysis of intracellular cytokines by flow cytometry, western blotting and fluorescence and confocal microscopy. In addition, this category includes protocols for quantitative analysis of cytokine gene expression by real time RT-PCR and analysis of the cytokine promoter occupancy by chromatin immunoprecipitation. The fourth group focuses on the recently developed multiplex arrays that can measure multiple cytokines in the same sample at the same time. This group includes quantification of multiple cytokines using cytometric bead arrays, ELISPOT assays, proteomics cytokine evaluation, multiplexed proximity ligation assays for high-throughput cytokine analysis and finally, cytokine gene expression analysis by gene arrays. The protocols will be written by experienced basic and clinical researchers with hands-on knowledge of the described protocols. By covering a broad variety of methods used in cytokine detection and analysis, this book will be of interest not only to biochemists, molecular biologists and immunologists but also to physician-scientists working in the field of cytokine research.
Book Synopsis Cytokine Cell Biology by : Fran Balkwill
Download or read book Cytokine Cell Biology written by Fran Balkwill and published by OUP Oxford. This book was released on 2000-11-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokine Cellular Biology focuses on cell biology techniques for studying cytokines, cytokine receptors, and cytokine driven processes. Assays for human B cell responses, leucocyte migration, haematopoietic growth factors, macrophage activation by cytokines, RIA, IRMA, and ELISA assays, and quantitative biological assays for cytokines are all covered in detail. There are also updated chapters on studying cytokine regulation of endothelial cells; the measurement of proliferative, cytostatic, and cytolytic activity of cytokines; and the development of antibodies to cytokines. In addition there is a new chapter on the use of flow ctyometry and intracellular fluorescent staining. Written by experts in the field, Cytokine Molecular Biology and Cytokine Cellular Biology form a comprehensive and essential guide to cytokine research.
Download or read book Cytokines written by Frances R. Balkwill and published by Oxford University Press, USA. This book was released on 1991 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a catalogue of techniques that are applicable to cytokine research. The book selects a number of biological models and outlines the ways of assaying cykotine activity in these systems. Also covered is cykotine production at the level of messenger RNA and protein.
Book Synopsis Cytokine Effector Functions in Tissues by : Maria Foti
Download or read book Cytokine Effector Functions in Tissues written by Maria Foti and published by Academic Press. This book was released on 2017-07-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types. Categorizes the cytokines based primarily on tissue and target cells Emphasizes different roles and outcomes observed during innate and adaptive response Represents a rapid guide to cytokines in health and disease in tissue and organ context Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
Book Synopsis Cytokine Molecular Biology by : Fran Balkwill
Download or read book Cytokine Molecular Biology written by Fran Balkwill and published by OUP Oxford. This book was released on 2000-11-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokine Molecular Biology concentrates on molecular biology techniques for the study of cytokines, cytokine receptors, and cytokine driven processes. Updated topics from the previous edition are: the cloning and expressing cytokine genes;; the detection of cytokine mRNA; receptor binding studies; the PC-specific phosphslipase C and sphingomylinases. In addition, new topics covered are the purification, sequencing, and synthesis of cytokines; studying cytokine gene polymorphisms; the use of proteomics in cytokine research; and the Jak/STAT and MAPK signalling pathways. Written by experts in the field, Cytokine Molecular Biology and Cytokine Cellular Biology form a comprehensive and essential guide to cytokine research.
Download or read book Cytokine Protocols written by Marc De Ley and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of biochemical, cellular, and molecular techniques for unraveling and quantifying the events occurring between the initial contact of a cytokine at the membrane receptor and the eventual activation of gene transcription. The techniques used include the generation of transfectants, the immunohistochemical detection of cytokines in tissue sections, and optimized staining for cytoplasmic detection. Highlights include RT-PCR of small amounts of mRNA, in situ hybridization, biosensor analysis, measurement of biological activities and standardization, immunohistochemical and single-cell detection, and receptor isolation, characterization, and crystallization. Enjoy a quick and smooth introduction to the key methods used in cytokine research Use readily reproducible techniques that ensure successful experimental results Employ antisense-RNA, RT-PCR of small amounts of mRNA, and in situ hybridization.
Book Synopsis The Cytokines of the Immune System by : Zlatko Dembic
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Author :Nicos Nicola Publisher :Sambrook and Tooze Publication at Oxford University Press ISBN 13 : Total Pages :292 pages Book Rating :4.3/5 (91 download)
Book Synopsis Guidebook to Cytokines and Their Receptors by : Nicos Nicola
Download or read book Guidebook to Cytokines and Their Receptors written by Nicos Nicola and published by Sambrook and Tooze Publication at Oxford University Press. This book was released on 1994 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of cytokines and related growth factors has increased dramatically in recent years to several dozen. This text provides a succinct reference manual for all known cytokines, growth factors, interleukins and lymphokines as well as their receptors.
Book Synopsis The Cytokine Handbook, Two-Volume Set by : Angus W. Thomson
Download or read book The Cytokine Handbook, Two-Volume Set written by Angus W. Thomson and published by Elsevier. This book was released on 2003-04-22 with total page 1510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics. Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures
Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine
Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Book Synopsis The Molecular Biology of Cytokines by : Anthony Meager
Download or read book The Molecular Biology of Cytokines written by Anthony Meager and published by . This book was released on 1998-08-21 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Series Editors Keith James, University of Edinburgh Medical School, UK Alan Morris, University of Warwick, UK This series is designed to bridge the gap between pure research in the biomedical sciences and its practical application in clinical medicine. The objective is to promote the understanding of the molecular basis of human physiology and disease, and new techniques for diagnosis and treatment. Primarily intended for graduate students of medicine, the books will also be of use to molecular biologists, biochemists, physiologists, pharmacologists and biotechnologists, as well as medical practitioners and technicians who seek to update their knowledge. The Molecular Biology of Cytokines Tony Meager National Institute for Biological Standards, Potters Bar, UK The Molecular Biology of Cytokines draws together the underlying themes and principles into one indispensable volume. Topics include: Molecular characteristics of cytokines and receptors Gene activation and cytokine production In vitro and in vivo properties Pathology, and Clinical applications This book will be an invaluable source of information for immunologists, haematologists and molecular biologists.
Book Synopsis Molecular and Cellular Biology of Cytokines by : Joost J. Oppenheim
Download or read book Molecular and Cellular Biology of Cytokines written by Joost J. Oppenheim and published by . This book was released on 1990 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are regulatory polypeptides synthesized by a variety of cells in response to injury, inflammation or infection and which act on different tissues by changing gene expression and cellular metabolism. This book provides the results from recent in vitro studies of the structure and function of various cytokines. It offers an up-to-date overview of the latest advances in cytokine research, including research developments dealing with colony stimulating factors, interferons and growth and differentiation factors - as well as classical hormones such as insulin, neurokinin, somatomedin and parathormones. Several newly identified cytokine receptor structures are also discussed, as are certain activities of the recently discovered 8,000-10,000 m.w. cytokine family.
Book Synopsis The Cytokine Handbook by : Angus W. Thomson
Download or read book The Cytokine Handbook written by Angus W. Thomson and published by Gulf Professional Publishing. This book was released on 2003 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Expanded to two volumes, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems.
Download or read book Cytokine Biology written by Fran Balkwill and published by Oxford University Press, USA. This book was released on 2003-05-15 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This set comprises the two paperback volumes of Cytokine Cell Biology and Cytokine Molecular Biology. The study of cytokines is central to biomedical research as they are involved in regulating development, tissue repair, haemopoiesis, inflammation, and the immune response. The field has grown so much in the past 5 years that the third edition has expanded into two volumes, one concentrating on molecular biology and the other on cellular biology.
Book Synopsis Biological Characterization and Assay of Cytokines and Growth Factors by : Fred Brown
Download or read book Biological Characterization and Assay of Cytokines and Growth Factors written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 1999 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines and growth factors have vast therapeutic potentials for a wide range of diseases. Many have been cloned and produced, using recombinant DNA technology, by the biopharmaceutical industry. Of these, several have proved to be extremely successful biological medicines with increasing numbers undergoing clinical trials. One aspect of the successful development of these proteins as therapeutics is assuring quality control. This can mainly be achieved through thorough characterization of the product, both biologically and physico-chemically. In this book, leading scientists from industry, research and regulatory agencies present papers on the various methods currently available for analyzing cytokines and growth factors, including novel, developing technology. A particular focus on bioassays provides a unique and comprehensive coverage of their relevance, design, execution and analysis during product development and manufacture. This volume should be read by all those working on protein therapeutics, as many of the principles described generally apply to any biological product. Scientists working in industry and regulatory authorities will find it a useful reference for drug development and licensing.
Book Synopsis Cytokines and Cytokine Receptors by : Constantin A. Bona
Download or read book Cytokines and Cytokine Receptors written by Constantin A. Bona and published by CRC Press. This book was released on 2003-09-02 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Book Synopsis Cytokines in Animal Health and Disease by : Michael J. Myers
Download or read book Cytokines in Animal Health and Disease written by Michael J. Myers and published by CRC Press. This book was released on 2020-08-26 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work offers comprehensive, up-to-date coverage of cytokine biology in veterinary and agricultural species, describing the role of cytokines in physiological and pathological processes. It addresses recent advances and new information on the function of cytokines in reproduction, detoxification of xenobiotics, growth modulation and other areas, and discusses the approaches to and pitfalls of studying cytokines in animals.
