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Curcumin In Health And Disease
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Book Synopsis Curcumin in Health and Disease by : Beatrice E. Bachmeier
Download or read book Curcumin in Health and Disease written by Beatrice E. Bachmeier and published by MDPI. This book was released on 2019-10-11 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.
Book Synopsis The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by : Bharat B. Aggarwal
Download or read book The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease written by Bharat B. Aggarwal and published by Springer Science & Business Media. This book was released on 2007-08-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.
Book Synopsis The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by : Bharat B. Aggarwal
Download or read book The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease written by Bharat B. Aggarwal and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.
Book Synopsis Curcumin in Health and Disease by : Beatrice Bachmeier
Download or read book Curcumin in Health and Disease written by Beatrice Bachmeier and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin's antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs' therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.
Book Synopsis Turmeric and Curcumin for Neurodegenerative Diseases by : Magisetty Obulesu
Download or read book Turmeric and Curcumin for Neurodegenerative Diseases written by Magisetty Obulesu and published by Academic Press. This book was released on 2021-01-26 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference. Summarizes the therapeutic efficacy of turmeric and curcumin for neurodegenerative diseases Includes effects on Alzheimer’s, Parkinson’s and liver diseases Focuses on different types of drug delivery systems and their challenges Examines novel nanotechnological therapeutics and biomaterial design strategies
Book Synopsis Herbal Drugs: Ethnomedicine to Modern Medicine by : Kishan Gopal Ramawat
Download or read book Herbal Drugs: Ethnomedicine to Modern Medicine written by Kishan Gopal Ramawat and published by Springer Science & Business Media. This book was released on 2008-11-25 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable progress has been made in our healthcare system, in particular with respect to sensitive diagnostic tools, reagents and very effective and precise drugs. On the other hand, high-throughput screening technology can screen vast numbers of compounds against an array of targets in a very short time, and leads thus - tained can be further explored. In developing countries, the exploding population exerts pressure not only on natural resources but also on the human population - self, whose members strive to become successful and advance in society. This leads to increased blood pressure, anxiety, obesity-associated lipid disorders, cardiov- cular diseases and diabetes. Most of these diseases result in disturbed family life, including sexual behaviour. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the Third World and terminal patients in the West. Herbal drugs, in addition to being cost effective and easily accessible, have been used since time immemorial and have passed the test of time without having any side effects. The multitarget effects of herbs (holistic approaches) are the fun- mental basis of their utilization. This approach is already used in traditional systems of medicine like Ayurveda, which has become more popular in the West in recent years. However, the integration of modern science with traditional uses of herbal drugs is of the utmost importance if ones wishes to use ancient knowledge for the betterment of humanity.
Book Synopsis Curcumin and Its Role in Health and Disease by : Kathryn Woltjer
Download or read book Curcumin and Its Role in Health and Disease written by Kathryn Woltjer and published by . This book was released on 2023-03-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains eight chapters discussing curcumin and its role in health and disease. Chapter One evaluates curcumin's role in cancer prevention. Chapter Two reviews curcumin's function as a natural systemic disease modulator. Chapter Three looks at the effects of curcumin supplantation and exercise training on Alzheimer's disease and age-associated cognitive decline. Chapter Four focuses on the antiviral effects of curcumin, with a special emphasis on COVID-19. Chapter Five examines green extraction techniques for curcumin, synthetic approaches, as well as its anti-inflammatory, anti-oxidant, and anti-neoplastic effects. Chapter Six reviews the possible effects of immune responses to the preventive combined effects of exercise training and curcumin supplementation in chronic disease. Chapter Seven is a mini review of the essential therapeutic effects of curcumin. The eighth and final chapter examines the promises and challenges of curcumin in medical research.
Book Synopsis Curcumin: Nature's Answer to Cancer and Other Chronic Diseases by : Ajay Goel Ph D
Download or read book Curcumin: Nature's Answer to Cancer and Other Chronic Diseases written by Ajay Goel Ph D and published by Take Charge Books. This book was released on 2016-03-02 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Curcumin is the answer to cancer and chronic health problems Have you: Been diagnosed with cancer? Had cancer and "recovered" only to fear its recurrence? Had a friend or loved one with cancer? Been diagnosed with diabetes or pre-diabetes? Struggled with your weight? Been depressed? Worried about your memory? Had high blood pressure, high triglycerides, high cholesterol or other signs of heart disease? Had joint pain or arthritis? Had digestive disorders like inflammatory or irritable bowel, chronic constipation or diarrhea or Crohn's disease? Curcumin offers the solution you need to prevent and even reverse these diseases to create a lifetime of vibrant health. Dr. Ajay Goel has spent more than 20 years researching the most effective natural means of combatting cancer and other chronic diseases."
Book Synopsis Nutrition and Wound Healing by : Joseph A. Molnar MD PhD FACS
Download or read book Nutrition and Wound Healing written by Joseph A. Molnar MD PhD FACS and published by CRC Press. This book was released on 2006-10-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: With mounting evidence regarding the role of poor nutrition in the development of chronic diseases such as heart disease and diabetes, it is no secret that appropriate nutrition is crucial to optimal health. Achieving the correct balance of elements provides the body with the ability to adapt to a shifting and often hazardous environment. Never is
Book Synopsis Turmeric for Health by : Britt Brandon
Download or read book Turmeric for Health written by Britt Brandon and published by Simon and Schuster. This book was released on 2016-09-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the power of turmeric! For centuries, turmeric, the spice that gives curry its yellow color and its distinctive warm and earthy flavor, has been used in eastern medicine traditions as an anti-inflammatory and pain-relieving remedy. Now, new medical studies are confirming this wisdom--and adding to it. Turmeric contains powerful antioxidants, which can help combat chronic life-threatening diseases, including heart disease, certain types of cancer, arthritis, Parkinson's disease, and Alzheimer's disease. It's also an all-natural remedy for common ailments and an effective health and beauty aid. Turmeric for Health provides 100 all-natural solutions that help: Soothe digestive upset Relieve daily aches and pains and reduce inflammation Improve metabolic function and weight loss Promote healthy skin, hair, and nails With Turmeric for Health, you'll discover all the benefits that this simple spice can bring--without dangerous chemicals or costly procedures.
Book Synopsis Drug-Induced Liver Disease by : Neil Kaplowitz
Download or read book Drug-Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.
Book Synopsis Curcumin and Neurodegenerative Diseases by : Mahendra Rai
Download or read book Curcumin and Neurodegenerative Diseases written by Mahendra Rai and published by Springer. This book was released on 2024-03-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the potential benefits of turmeric, and specifically curcumin, in the treatment and prevention of neurodegenerative diseases. The book covers various aspects of turmeric, including its traditional use in Ayurveda and Chinese medicine, secondary metabolites, curcuminoids, and sesquiterpenoids found in turmeric, as well as the use of nano curcumin in neurodegenerative diseases. It discusses the different ways in which turmeric can be used to treat neurodegenerative diseases, including as a therapy for brain diseases, curcumin-induced neuroprotection in cerebral ischemia, and neural stem cell therapy in combination with curcumin. It also discusses the role of nano curcumin in neurodegenerative diseases, including its potential use in the treatment of Alzheimer's disease. The book provides the scientific evidence behind the use of turmeric and its compounds in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Overall, this book is an invaluable resource for researchers and healthcare professionals interested in exploring the potential benefits of turmeric and curcumin in the treatment and prevention of neurodegenerative diseases.
Book Synopsis Curcuma Longa and Its Health Effects. Volume 2 by : Noboru Motohashi
Download or read book Curcuma Longa and Its Health Effects. Volume 2 written by Noboru Motohashi and published by . This book was released on 2020-07-30 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Curcumin, which is contained in turmeric in India and surrounding areas, has been widely used for colorants such as curry for thousands of years. Recent studies of curcuminn have reported that curcumin is effective in preventing and treating lifestyle-related diseases such as hypertension, diabetes, dementia, liver disease, heart failure and eye strain. This volume contains the following contents: In Chapter 1, curcumin, also known as diferuloylmethane is a primary and essential constituent of turmeric (Curcuma longa) rhizomes with numerous biological activities. Curcumin was established to benefit in the treatment of inflammatory conditions, metabolic syndrome, pain as well as in controlling inflammatory and degenerative eye conditions including cancers. In addition, curcumin aided in the control of ailments associated with kidneys. These numerous therapeutic benefits of curcumin supplementation were accredited to its potent anti-inflammatory and antioxidant effects. Some of these activities by curcumin were attributed through its interference with aberrant cellular signaling pathways that resulted in many diseases such as cancer, arthritis and other inflammatory diseases. In recent times curcumin is available in multiple formulations including capsules, cosmetics, energy drinks, ointments, soaps and tablets. Curcumin was approved by the US Food and Drug Administration (FDA) as "Generally Recognized As Safe" (GRAS) and curcumin excellent tolerability and safety were established through clinical trials, even at relative high doses. Since 4000 years, turmeric has been used to treat a variety of ailments. Turmeric is used in religious ceremonies as well as textile dyeing owing to its vibrant orange color. In Ayurveda and Chinese traditional medicine (CTM), turmeric is often expended as anti-inflammatory agent in the treatment of digestive and liver ailments, skin diseases including wounds. Turmeric has been consumed in different forms in various countries due to curcumin beneficial effects. In USA, turmeric is used in mustard sauce, cheese, butter, and chips, as a preservative and a coloring agent. In Chapter 2, Curcuma longa L. belongs to the ginger family. It is widely cultivated and distributed in South and Southeast Asia. Besides gastronomic uses, Curcuma is one of the main plants used throughout the folklore medicine such as Ayurveda, Unani, Siddha, and Chinese medicine. To date, traditional medicinal treatments have been increasing worldwide to treat common diseases. Therefore, this chapter focused on the curcuma ́s essential oil beneficial properties. The antifungal and antibacterial activities of curcuma ́s essential oil are highly important due to become natural methods to prevent food deterioration and extend shelf life caused by Aspergillus, Fusarium or Colletotrichum genus. Moreover, Curcuma ́s essential oil exhibits antimicrobial activities against pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger that cause diverse infections in humankind. According to these properties, Curcuma ́s essential oil may be an ecofriendly alternative to produce antimicrobial and anti-fungicides agents with important industrial applications. Chapter 3, flavanones are one of the most diverse and widespread group belongs to the subclass of flavanoids. They contain hydroxyl and methoxy groups and occupy a prominent position in the plant kingdom due to the wide variety of multi-directional pharmacological properties. The discovery of vital molecules by isolation and synthesis of natural products from medicinal plants has always been a challenge in the field of natural products chemistry. Syzygium samarangense is a famous plant belongs to the family Myrtaceae and widely cultivated and grown thought out India for their edible fruits. Then, here, one of the family Myrtaceae contains diarylheptanoids (curcuminoids). Then, Chapter 3 reviews the isolation and semisynthesis of typical biocomponents other than diarylheptanoids (curcuminoids) for Syzygium samarangense (water apple. wax apple), a family Myrtaceae. The fruit pulp and leaves of water apple is a rich source of phenols, flavonoids, triterpenoids, chalcones, tannins, and several antioxidant compounds and as a result, it is believed to have great potential health benefits and is used in traditional medicine to cure diabetes. Syzygium samarangense was reported to posses antidiabetic activity, antihyperglycemic activity, spasmolytic, antioxidant, and immunomodulatory activity. Basing on the excellent pharmacological properties of Syzygium samarangense, we have selected the stem bark of Syzygium samarangense, extracted with different organic solvents, subjected to acid hydrolysis and then purified by using preparative HPLC. 7-Hydroxy flavanone was isolated and then subjected to semi synthesis by using different substituted isoxazoles and cinnamic acid. The present chapter discusses the isolation of 7-hydroxy flavanone from the stem bark of Syzygium samarangense and also explored the facile synthesis of 7-hydroxyflavanone with isoxazoles and cinnamic acids.
Download or read book Turmeric written by P. N. Ravindran and published by CRC Press. This book was released on 2007-03-01 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the last 6000 years turmeric has been used in Ayurvedic medicine to alleviate pain, balance digestion, purify body and mind, clear skin diseases, expel phlegm, and invigorate the blood. Nowadays, this plant has acquired great importance with its anti-aging, anti-cancer, anti-Altzheimer, antioxidant, and a variety of other medicinal properties.
Download or read book Curcumin written by Jun Sasaki and published by Nova Science Publishers. This book was released on 2012-05-01 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Curcumin is a natural product found in the rhizome of Curcuma longa. Ongoing research and clinical trials prove this natural phenolic compound to possess diverse pharmacological potency and is effective as an antioxidant, anti-inflammatory, antimicrobial/antiviral property and is also being considered as a cancer chemo-preventive agent. Topics discussed in this book include the implications of curcumin treatment of central nervous system disease; phosphorylase kinase inhibition in skin disease; PEGylated curcumin; the potential role of curcumin as a chemotherapeutic drug and the pharmaceutical implications of curcumin in the development of drugs for cystic fibrosis pharmacotherapy.
Download or read book Curcumin written by Daniel Loïc Pouliquen and published by . This book was released on 2014-01-01 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examples of plant-derived pharmaceuticals that have become the focus of continuous and exponential research and development interest have, to date, been somewhat scarce. After a long period, the last two decades have been characterized by a 100-fold increase in the number of scientific articles published annually that are of relevance to the use of curcumin in biomedicine. Today, the already-wide spectrum of potential clinical applications of this natural drug and its synthetic derivatives continues to grow, including chemoprevention and the treatment of cancers, inflammatory and immune diseases, diabetes, bacterial and viral infections, parasitosis, and cardiovascular and neurodegenerative diseases. Over the last two decades, numerous findings have confirmed the safety of curcumin, both in preclinical and clinical studies. Its physicochemical properties, low bioavailability and rapid metabolism have, however, somewhat limited its potential therapeutic applications. To overcome these limitations, the last few years have seen an impressive development of research on analogs, prodrugs and nanostructured systems, a number of which are already demonstrating improved properties compared with the parent structure. In parallel, new administration routes have been explored, and additional pharmacological properties have been documented, leading in particular to promising prospects for pain management.
Book Synopsis Studies on Biomarkers and New Targets in Aging Research in Iran by : Paul C. Guest
Download or read book Studies on Biomarkers and New Targets in Aging Research in Iran written by Paul C. Guest and published by Springer. This book was released on 2021-06-20 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today it is the center of many world issues due to its economic, religious and political importance. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications and the country of Iran has spearheaded this progress. Much of the research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human healthspan. This book provides a comprehensive overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. Hundreds of studies have now been published describing the health benefits of this spice. The importance of this research is exemplified by poor data regarding health and longevity as only 0.08% of the population in Iran consists of individuals over 90 years of age. This is approximately 10 times lower than the percentage of this same age group in the United Kingdom and the United States of America and almost 20 times lower than that in Japan. This book presents a series of reviews and meta-studies describing research which has resulted in identification potential new biomarkers and drug targets for age-related disorders. All of the studies have focussed on the testing of curcumin and related products, which have already shown some promising leads in age-related conditions such as heart-disease, diabetes, cognitive impairment and cancer. The authors in this series come from different centers and cities of Iran, including Mashhad, Tehran, Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters feature collaborations with other countries of the Middle East and throughout the world, including Brazil, Italy, Mexico, Oman, Poland, Switzerland, the United Kingdom and the United States of America. This underscores the emergence of the Middle East into this arena of research. The book will be of high interest to scientific and clinical researchers in the subject of aging and age-related disease, and to physicians and pharmaceutical company scientists since it gives insights into the latest strategies, biomarkers and targets involved in the mechanism of action of curcumin to promote healthy aging. It will also provide important information on disease mechanisms related to age-related disorders, as each chapter will be presented in the context of specific chronic diseases.
