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Crosstalk Between The Aryl Hydrocarbon And Estrogen Receptor Signaling Pathways In Human Breast Cancer Cells
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Book Synopsis Crosstalk Between the Aryl Hydrocarbon and Estrogen Receptor Signaling Pathways in Human Breast Cancer Cells by : Weili Wang
Download or read book Crosstalk Between the Aryl Hydrocarbon and Estrogen Receptor Signaling Pathways in Human Breast Cancer Cells written by Weili Wang and published by . This book was released on 1998 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aryl Hydrocarbon and Estrogen Receptor Alpha Crosstalk in Human Breast and Endometrial Cancer Cell Lines by : Mark Thomas Wormke
Download or read book Aryl Hydrocarbon and Estrogen Receptor Alpha Crosstalk in Human Breast and Endometrial Cancer Cell Lines written by Mark Thomas Wormke and published by . This book was released on 2002 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Molecular Toxicology by : Jason Matthews
Download or read book Advances in Molecular Toxicology written by Jason Matthews and published by Elsevier Inc. Chapters. This book was released on 2013-08-12 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aryl hydrocarbon receptor (AHR) and estrogen receptors (ERs) are ligand-activated transcription factors and members of the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) and nuclear receptor (NR) superfamilies, respectively. The bHLH-PAS and NRs regulate many vital physiological processes including metabolism, circadian rhythm, differentiation, development, and reproduction. However, both receptor families are also associated with numerous human diseases. Reciprocal crosstalk between AHR and ERs is proposed to both positively and negatively impact human health. ERs are the most important targets in the treatment of breast cancer. The AHR, which is activated by many environmental pollutants, natural/dietary compounds, and endogenous substances, is a negative regulator of ER function. The role of ERα in AHR signaling is less clear as it is known to exhibit cell-type and promoter-specific differences. In this chapter, we will highlight the current understanding of AHR and ER crosstalk and toxicity.
Book Synopsis Cross-talk Between Hormone-regulated Transcription Factors, STAT5b and ER, and Xenochemical Receptors, PPAR and AhR by : Jonathan M. Shipley
Download or read book Cross-talk Between Hormone-regulated Transcription Factors, STAT5b and ER, and Xenochemical Receptors, PPAR and AhR written by Jonathan M. Shipley and published by . This book was released on 2005 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Nuclear receptors are ligand-inducible transcription factors that bind to DNA-response elements of target genes as monomers, homodimers, or as heterodimers with the retinoid X receptor. Two members of the nuclear receptor superfamily are peroxisome proliferator activated receptors (PPAR) and the estrogen receptor (ER). JAK-STAT signaling is activated by multiple cytokines and hormones, including growth hormone (GH), and leads to the translocation of dimerized STAT proteins to the nucleus where they activate transcription of target genes. Previous studies have demonstrated that STAT5b can inhibit PPAR-regulated transcription. Herein this inhibitory cross-talk is shown to be mutual, and that GH-induced, STAT5b-regulated, luciferase reporter gene transcription is inhibited up to 80% by ligand-activated PPAR. Mechanistic studies characterize aspects of PPAR/STAT5b cross-talk, including the effect of PPAR on STAT5b protein levels and DNA-binding activity, as well as the role of specific PPAR protein domains. A PPAR-activated Renilla luciferase reporter plasmid was constructed and used in combination with a STAT5b firefly luciferase reporter to show that in cells co-stimulated with GH and a PPAR agonist, STAT5b inhibition of PPAR-regulated transcription occurs simultaneous with PPAR inhibition of STAT5b-regulated transcription. Another example of cross-talk involving a nuclear receptor is aryl hydrocarbon receptor (AhR) inhibition of ER-regulated transcription. Recent studies have demonstrated a pro-estrogenic action of the AhR that proceeds via the formation of an (AhR-Arnt)-ER complex, which binds to estrogen response elements (EREs) and stimulates transcription of ER target genes. Activation by the AhR ligand, 3-methylcholanthrene (3MC), of an ER-regulated luciferase reporter and ER target genes in the breast cancer cell line MCF-7 is demonstrated. ER reporter activity is additionally activated by 3MC in the AhR-positive mouse hepatoma 5L cell line and its AhR-negative variant BP8. The ability of 3MC to activate ER-regulated transcription in the absence of AhR suggests that this AhR ligand may activate ER directly, instead of, or in addition to, the AhR-dependent mechanism proposed. Together, these studies elucidate mechanisms through which the xenochemical receptors PPAR and AhR may respectively exert crosstalk with hormone-activated signaling pathways involving STAT5b and ER.
Book Synopsis Crosstalk Between IGF-1 and Estrogen Receptor Non-genomic Signaling Pathway in Breast Cancer by : Ali Choucair
Download or read book Crosstalk Between IGF-1 and Estrogen Receptor Non-genomic Signaling Pathway in Breast Cancer written by Ali Choucair and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a major health problem currently affecting 1 out of 5 women. Seventy percent of breast cancers are hormone-dependent, and are treated by hormonal therapies targeting estrogen receptor and consequently the inhibition of its pro-tumorigenic effects. In parallel to the genomic estrogen signaling, non-genomic signaling has been described, where ERa recruits Src kinase and PI3K at the plasma membrane and thus activates downstream phosphorylation cascades like AKT, which in turn leads to survival and proliferation of cancer cells. Our team has found that estrogen-induced methylation of arginine 260 of ERa is a prerequisite for the formation of this non-genomic complex, regulating cell proliferation. In 2012, we have shown that this pathway is activated in aggressive breast tumors representing a new potential target for breast cancer therapy. Crosstalk between estrogen and growth factors signaling involving phosphorylation has been largely described. For this reason, we investigated if ERa R260 methylation could be involved in this crosstalk. Among several growth factors, we found that IGF-1 was the only one able to induce methylation of ERa in an estrogen-independent manner. Similarly to estrogen, IGF-1 induces a rapid and transient methylation of ERa by the Protein Arginine Methyltransferase (PRMT1) concomitant with the formation of ERa/Src/PI3K complex. Using several approaches, we found significant results showing that PRMT1 probably via ERa methylation plays a crucial role in IGF-1 signaling. Interestingly, we have recently found also that receptor tyrosine kinase IGF-1R phosphorylates the DNA binding domain (DBD) of ERa that could modulate the latter downstream signaling. In line with these results, we found on TMAs of a cohort of 440 breast tumors that IGF-1 expression is correlated with ERa non-genomic signaling. These results report new insight into estrogen and IGF-1 interference, which open new perspectives of combining therapies targeting the two pathways.
Book Synopsis Alterations in Estrogen Receptor Signaling Pathways in Breast Cancer Cells with Acquired Antiestrogen Resistance by : Lei Chen
Download or read book Alterations in Estrogen Receptor Signaling Pathways in Breast Cancer Cells with Acquired Antiestrogen Resistance written by Lei Chen and published by . This book was released on 2005 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogen and Aryl Hydrocarbon Receptor Signaling by : Elin Swedenborg
Download or read book Estrogen and Aryl Hydrocarbon Receptor Signaling written by Elin Swedenborg and published by . This book was released on 2009 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Activation of Estrogen Receptor Alpha, Aryl Hydrocarbon Receptor, and Nuclear Factor Erythroid-2 Like 2 in Human Breast Cancer Cells by : Raymond Ho Fai Lo
Download or read book Activation of Estrogen Receptor Alpha, Aryl Hydrocarbon Receptor, and Nuclear Factor Erythroid-2 Like 2 in Human Breast Cancer Cells written by Raymond Ho Fai Lo and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Aryl Hydrocarbon Receptor and Estrogen Receptor Action in Breast Cancer Cells by : Jeong Eun Lee
Download or read book Mechanisms of Aryl Hydrocarbon Receptor and Estrogen Receptor Action in Breast Cancer Cells written by Jeong Eun Lee and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In MCF7 and T47D cells cotreated with 1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) plus 0.1-10 uM 3̕,4̕ -dimethoxy flavone (DMF), there was a concentration-dependent decrease in the TCDD-induced ethoxyresorufin O-deethylase (EROD) activity. Gel mobility shift assays showed that 3̕,4̕ -DMF inhibited TCDD-induced aryl hydrocarbon receptor (AhR) transformation in rat liver cytosol and blocked TCDD-induced formation of the nuclear AhR complex in MCF7 and T47D cells. The antiestrogenic activity of TCDD in estrogen-induced transactivation assays in MCF7 cells was reversed by 3̕,4̕ -DMF, confirming the AhR antagonist activity of this compound in breast cancer cells. Cotreatment of T47D and MCF7 cells with TCDD and 10 uM resveratrol inhibited induction of CYP1A1 mRNA and EROD activity. Resveratrol did not inhibit TCDD-induced AhR transformation and reporter gene activity. Actinomycin D chase experiments in T47D cells showed that the mechanism of inhibition of CYP1A1 mRNA and EROD activity is due to an increased rate of CYP1A1 mRNA degradation, suggesting that resveratrol inhibits CYP1A1 via an AhR-independent post-transcriptional pathway. Vitamin D receptor-interacting protein 150 (DRIP150) coactivated estrogen receptor [alpha] (ER [alpha])-mediated transactivation and the response was AF2-dependent in ZR75 breast cancer cells. C-and N-terminal NR-boxes (amino acids 1186-1182 and 73-69, respectively) were not necessary for coactivation of ER [alpha]. Analysis of DRIP150 deletion mutants identified a 23 amino acid sequence (811-789) required for coactivation. The 23 amino acid contained two regions at amino acids 789-794 and 795-804 which resembled [alpha] -helical motifs identified in Lanuguinosa lipase/histamine N-methyl transferase and hepatocyte nuclear factor 1, respectively. A squelching assay using specific point mutations within each [alpha] -helix showed that the NIFSEVRVYN (795-804) region was the critical sequence required for the coactivator activity of DRIP150.
Book Synopsis Characterization of Transcriptional Cross-talk Between the Estrogen Receptor and Retinoic Acid Receptor in Human Breast Cancer Cells by : Caroline Rousseau
Download or read book Characterization of Transcriptional Cross-talk Between the Estrogen Receptor and Retinoic Acid Receptor in Human Breast Cancer Cells written by Caroline Rousseau and published by . This book was released on 2004 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Retinoids are derivatives of vitamin A with demonstrated therapeutic potential for the treatment of breast cancer. The efficacy of retinoids in vitro and in vivo correlates with the expression of the estrogen receptor alpha (ERalpha). The role of ERalpha in mediating RA-induced sensitivity is not understood and is further complicated by the recent discovery of ERalpha. This dissertation explores the transcriptional, as well as proliferative, response to RA in human breast cancer cells expressing ERbeta or ERbeta. First, ER-negative breast cancer cells were stably transduced with ERalpha-deletion mutants using retroviral technology. We compared the effect of the ERalpha wild-type, ERalpha-deletion mutants or the parental ER-negative cells on transcriptional activity from the RARbeta2 promoter, a gene regulated by retinoids and potentially involved in retinoid-mediated growth inhibition. We observed that expression of ERalpha suppressed basal expression of the RA-responsive gene RARbeta2, while allowing it to be strongly induced by RA. Repression of basal RARbeta2 transcription was confirmed by transient expression of a reporter plasmid containing the RARbeta2 minimal promoter. We further determined that RARbeta2 induction required the N-terminal AF-1 containing region of ERalpha, including the DNA-binding domain, but was independent of the C-terminal ligand-binding domain. The effect of ERalpha was specific for RAR-mediated transcription and did not alter transcription from vitamin D or thyroid hormone response elements. Moreover, the cross-talk between ERalpha and RAR was not mediated by sequestration of a number of common co-regulators. To characterize the growth and transcription effect of ERbeta on retinoid-mediated pathways, we generated stable transfectants using this isoform. Significant RA-mediated growth inhibition was observed in the ERbeta-positive cells and not in the parental ER-negative cells. Furthermore, RA altered ERbeta-me" --
Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini
Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Book Synopsis Hormonally Active Agents in the Environment by : National Research Council
Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Book Synopsis Current Trends in Cancer Management by : Liliana Streba
Download or read book Current Trends in Cancer Management written by Liliana Streba and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques.
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2692 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bioactive Compounds and Cancer by : John A. Milner
Download or read book Bioactive Compounds and Cancer written by John A. Milner and published by Springer Science & Business Media. This book was released on 2010-06-25 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of the wealth of new information generated by the scientific community during the last decade on the role of nutrition on cancer risk, this book provides a forum for presentation and discussion of recent scientific data and highlights a set of dietary recommendations. Bioactive Compounds and Cancer presents chapters that highlight laboratory and clinical findings on how selected nutrients function as signaling molecules and, as such, influence cellular behavior and cancer predisposition. This important compendium focuses on understanding the role of nutrition in cancer biology, the molecular action of bioactive food components and xenobiotics on cancer risk, the role of dietary components in cancer prevention and/or treatment, and nutrition education with the most up to date dietary recommendations that may reduce cancer risk. This volume will be of interest to specialized health professionals, clinicians, nurses, basic and clinical researchers, graduate students, and health officials of public and private organizations.
Book Synopsis Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics by : Pandurangan, Ashok Kumar
Download or read book Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics written by Pandurangan, Ashok Kumar and published by IGI Global. This book was released on 2022-03-18 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.
Book Synopsis Translational Immunotherapy of Brain Tumors by : John H. Sampson
Download or read book Translational Immunotherapy of Brain Tumors written by John H. Sampson and published by Academic Press. This book was released on 2017-02-06 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors
