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Copper Zinc Superoxide Dismutase And Amyotrophic Lateral Sclerosis
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Book Synopsis Copper, Zinc Superoxide Dismutase and Amyotrophic Lateral Sclerosis by : Cami K. Bruns
Download or read book Copper, Zinc Superoxide Dismutase and Amyotrophic Lateral Sclerosis written by Cami K. Bruns and published by . This book was released on 2006 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mutant Copper-zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis by : Fujian Zhang
Download or read book Mutant Copper-zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis written by Fujian Zhang and published by . This book was released on 2005 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper, Zinc Superoxide Dismutase and Mitochondria by : Hibiki Kawamata Fujita
Download or read book Copper, Zinc Superoxide Dismutase and Mitochondria written by Hibiki Kawamata Fujita and published by . This book was released on 2008 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biophysical Studies of Human Copper-zinc Superoxide Dismutase and Mutants Associated with the Nuerodegenerative Disease Amyotrophic Lateral Sclerosis by : Peter Anthony Doucette
Download or read book Biophysical Studies of Human Copper-zinc Superoxide Dismutase and Mutants Associated with the Nuerodegenerative Disease Amyotrophic Lateral Sclerosis written by Peter Anthony Doucette and published by . This book was released on 2004 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Elucidating the Role of Mutant Human Copper-zinc Superoxide Dismutase Aggregates and Metal Ions in a Mouse Model of Amyotrophic Lateral Sclerosis by : Herman Louis Lelie
Download or read book Elucidating the Role of Mutant Human Copper-zinc Superoxide Dismutase Aggregates and Metal Ions in a Mouse Model of Amyotrophic Lateral Sclerosis written by Herman Louis Lelie and published by . This book was released on 2010 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Thermal Stability, Catalytic Activity and Spectroscopic Properties of Amyotrophic Lateral Sclerosis-associated Copper-zinc Superoxide Dismutases by : Jorge Abelardo Rodriguez
Download or read book Thermal Stability, Catalytic Activity and Spectroscopic Properties of Amyotrophic Lateral Sclerosis-associated Copper-zinc Superoxide Dismutases written by Jorge Abelardo Rodriguez and published by . This book was released on 2004 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biophysical Studies of Human Copper-zinc Superoxide Dismutases by : Kevin N. Malek
Download or read book Biophysical Studies of Human Copper-zinc Superoxide Dismutases written by Kevin N. Malek and published by . This book was released on 2002 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper, Zinc Superoxide Dismutase Misfolding in Amyotrophic Lateral Sclerosis by : Rishi Rakhit
Download or read book Copper, Zinc Superoxide Dismutase Misfolding in Amyotrophic Lateral Sclerosis written by Rishi Rakhit and published by . This book was released on 2009 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration resulting in progressive paralysis and death. The only known cause of typical ALS is mutations in SOD1; these predominantly missense mutations produce a toxic gain-of-function in the enzyme Cu/Zn superoxide dismutase (SOD1). The prevailing hypotheses regarding the mechanism of toxicity were (a) oxidative damage from aberrant SOD1 redox chemistry, and (b) misfolding of the mutant protein. The goal of this thesis was to investigate the molecular mechanisms of the mutant SOD1 (mSOD1) misfolding and toxicity.To interrogate the in vivo misfolding pathway of SOD1, we used its high-resolution structure to create an antibody that reacts with monomer/misfolded SOD1 but not the native dimer. Upon verifying the reactivity of this antibody, we showed that monomer/misfolded SOD1 is found in a human case of familial ALS and in transgenic animal models of ALS. Misfolded SOD1 is found primarily in affected cells, motor neurons. Misfolded SOD1 is also initially absent, but appears prior to symptom onset. These observations together suggest a causal role for SOD1 misfolding through a monomeric intermediate in ALS pathogenesis.Because oxidation of SOD1 primarily affected the metal-binding His residues, we hypothesized that oxidation of wild-type, holo-SOD1 should lead to aggregation. Increasing the concentration of wild-type SOD1 in oxidation reactions produced aggregates similar to those observed earlier. Both wild-type and mSOD1 aggregation kinetics revealed an initial decrease in particle size rather than a monotonic increase using dynamic light scattering. This was consistent with the conversion of SOD1, normally an obligate homodimer, into monomers prior to aggregation. This observation was confirmed using analyatical ultracentrifugation. The common aggregation pathway for wild-type and mSOD1 suggested a mechanism for sporadic ALS caused by SOD1 misfolding.We proposed that oxidative damage to SOD1 itself could cause its misfolding and aggregation. To investigate this hypothesis, we subjected purified SOD1 in vitro to metal catalyzed oxidation. Oxidation of SOD1 produced aggregates reminiscent of those observed in ALS pathology. Aggregation propensity of zinc-deficient SOD1 and several mSOD1s known to have lower zinc-binding affinity was proportional to partial unfolding. Oxidation of SOD1 caused conversion of several His residues to 2-oxo-histidine.
Book Synopsis Gain of Toxic Properties of Amyotrophic Lateral Sclerosis-causing Copper/zinc Superoxide Dismutase Variants by : Qi Wang
Download or read book Gain of Toxic Properties of Amyotrophic Lateral Sclerosis-causing Copper/zinc Superoxide Dismutase Variants written by Qi Wang and published by . This book was released on 2010 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper-zinc Superoxide Dismutase and Amyotrophic Lateral Sclerosis by : Bryan Francis Shaw
Download or read book Copper-zinc Superoxide Dismutase and Amyotrophic Lateral Sclerosis written by Bryan Francis Shaw and published by . This book was released on 2005 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper-zinc Superoxide Dismutase and Its Copper Chaperone by : Haining Zhu
Download or read book Copper-zinc Superoxide Dismutase and Its Copper Chaperone written by Haining Zhu and published by . This book was released on 2000 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper-zinc Superoxide Dismutase and Its Copper Chaperone by : Jennifer Erin Stine Elam
Download or read book Copper-zinc Superoxide Dismutase and Its Copper Chaperone written by Jennifer Erin Stine Elam and published by . This book was released on 2004 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biochemical and Biophysical Studies of Human Copper Zinc Superoxide Dismutase by : Hongbin Liu
Download or read book Biochemical and Biophysical Studies of Human Copper Zinc Superoxide Dismutase written by Hongbin Liu and published by . This book was released on 2000 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Dynamics Investigation of the Effect of Familial Amyotrophic Lateral Sclerosis Related Metal Ion Loss on Copper, Zinc Superoxide Dismutase by : Andreas Martin Eggenschwiler
Download or read book Molecular Dynamics Investigation of the Effect of Familial Amyotrophic Lateral Sclerosis Related Metal Ion Loss on Copper, Zinc Superoxide Dismutase written by Andreas Martin Eggenschwiler and published by . This book was released on 2000 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stability and Aggregation of Amyotrophic Lateral Sclerosis-associated Mutant Copper, Zinc Superoxide Dismutases [microform] by : Peter Basile Stathopulos
Download or read book Stability and Aggregation of Amyotrophic Lateral Sclerosis-associated Mutant Copper, Zinc Superoxide Dismutases [microform] written by Peter Basile Stathopulos and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2005 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oxidants in Biology by : Giuseppe Valacchi
Download or read book Oxidants in Biology written by Giuseppe Valacchi and published by Springer Science & Business Media. This book was released on 2008-06-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing. Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.
Book Synopsis Amyotrophic Lateral Sclerosis by : Martin Henrik Maurer
Download or read book Amyotrophic Lateral Sclerosis written by Martin Henrik Maurer and published by IntechOpen. This book was released on 2012-01-20 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research.