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Contemporary Topics In Molecular Immunology Vol 8
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Book Synopsis Contemporary Topics in Molecular Immunology by : F. P. Inman
Download or read book Contemporary Topics in Molecular Immunology written by F. P. Inman and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included in this volume is a broad range of topics. Immunology is such a diverse field that many of the subspecialties overlap, and one finds it convenient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at the molecular level often provides an explanation of phenomena observed at other levels. Myelin basic protein holds the interest of immunologists because it is impli cated in the induction of the autoimmune disease called experimental allergie encephalomyelitis (EAE). Although much biochemical and immunological information about this protein has been uncovered, it is not understood how such an inaccessible self-antigen can serve as the focal point in the central ner vous system for myelin basic protein-specific EAE-inducing T cells. Day dis cusses the problem by first reviewing the sequences of the proteins from several species and the antigenicity of the proteins and peptides derived from them. The reader is then led into a thorough discussion of the immunological relation ships that do and do not influence development of the encephalitis. From this discussion, the author promulgates the bystander model as the best overall mechanism to explain why different fragments of the highly conserved protein are needed by various species to give rise to the same type of localized central nervous system disease.
Book Synopsis Contemporary Topics in Molecular Immunology by : Gordon Ada
Download or read book Contemporary Topics in Molecular Immunology written by Gordon Ada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of volumes devoted to molecular immunology will contain, for the most part, articles which attempt to explain immunological phenomena in terms of the behavior and properties of particular molecules. Many of the articles in this volume do this. At the same time, there are many instances-and this is particularly so in the case of immunology-where phenomena must first be described and interpreted in terms of the properties and behavior of cells. Most of us would hope that in due course a fuller understanding will be forthcoming. This volume starts off with such a contribution. Perhaps the most fascinat ing problem in immunology is how diversity is generated. There are two broad proposals: (1) that complete information exists ab initio (the germ-line theory), and (2) that there is initially a limited amount of information, and diversity is generated by somatic mutation. The issue is unresolved, but Cunningham has taken many of the data which have previously been used to support the germ-line theory and shows that the interpretations are not always clear-cut and can frequently be used to support another possibility-that new specificities may arise after stimulation of appropriate cells by antigens. And he has produced experimental evidence to support this notion. On the other hand, there can be little doubt that to a considerable degree the specificity of the immune response is determined by the selection by antigen of cells with receptors of appropriate specificity. This is essentially a surface phenomenon.
Book Synopsis Contemporary Topics in Molecular Immunology by : R. A. Reisfeld
Download or read book Contemporary Topics in Molecular Immunology written by R. A. Reisfeld and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider able information has accumulated as the result of the efforts of many investigators, but the conclusions from the various laboratories have not been summarized recently in a comprehensible manner. One such situation has to do with work on IgD. An up-to-date report on this immunoglobulin was included in Volume 10f this series, but since that time there has been considerable progress in the deter mination of its structure and function. In the present volume Leslie and Martin have reviewed the accomplishments of recent years and the problems remaining to be solved. New information regarding the concentration of IgD in body fluids in normal and disease states is presented. Studies of the ontogeny of surface IgD in animals are described, and the fmdings imply that it may be important in the primary immune response. The role of IgD on lymphocyte surfaces is thoroughly discussed especially in terms of stimulating or suppressive combinations of signals delivered to the lymphocyte by agents which bind or alter the surface rt:ceptors. The authors conclude by proposing a model for plasma-cell differentiation which accounts fo~ the existence of triple Ig-bearing cells, many IgM-IgD-bearing cells, and the low percentage of cells bearing a single isotype. Sometimes the serum of an individual contains abnormally large amounts of two distinct, homogeneous populations of immunoglobulins.
Book Synopsis Contemporary Topics in Molecular Immunology by : F. Inman
Download or read book Contemporary Topics in Molecular Immunology written by F. Inman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: recipients and acceptance of allografts can be made. The authors have the experi ence and ability to bridge the entire field of transplantation and their article encompasses both clinical and immunochemical data in this area. Their data show clearly that matches for the DR antigens are more important than those at the ABC loci in determination of graft survival. Additional relevant factors, in cluding autoimmunity and other B-cell antigens, are discussed and correlated with graft survival. The authors also present pathology data concerning the distribution of HLA-DR antigens in various tissues. These data indicate a fruitful area for future investigations on the chemical aspects of the various antigens encoded within the human MHC. Do changes in the structure of lymphocyte surface glycoproteins, especially changes in their carbohydrate portions, occur during normal lymphoid differen tiation? Information about this question is limited, and pertinent data are avail able for only a few proteins. Three of the proteins are major glycoprotein con stituents of rodent thymocyte membranes: the Thy-! antigen, a glycosylated leukocyte sialoglycoprotein called W3/13, and a high-molecular-weight glycopro tein known as the leukocyte-common antigen. In his contribution, Pink thor oughly characterizes these glycoproteins and discusses the evidence that the structures change when a thymocyte differentiates into a mature, peripheral T cell. A comparison is drawn between lymphocyte glycoprotein changes and those that occur during red blood cell differentiation. The reader will find Pink's discourse informative and provocative. Mast cells, basophils, and related tumor lines bind IgE with very high affinity.
Book Synopsis Contemporary Topics in Molecular Immunology by : H. Eisen
Download or read book Contemporary Topics in Molecular Immunology written by H. Eisen and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunochemistry, recently rechristened molecular immunology, has been pre occupied throughout its long history with the structure and function of antibodies and the specificity of antibody-antigen reactions. With the recent X-ray diffrac of several crystallized immunoglobulin (Ig) fragments and a whole tion analyses Ig molecule, the three-dimensional structure of antibodies and their ligand combining sites has been realized, marking the concluding stages of a phase of immunological research that can be traced back at least 75 years. At the same time chemically minded immunologists have been moving in new directions. A substantial beginning in one direction has been made with the purification of messenger RNAs (mRNAs) for Ig chains. Hybridization of these RNAs (or their DNA copies made with the enzyme reverse transcriptase) to cell DNA is beginning to provide convincing estimates of the number of germ-line Ig genes. And some hybridization studies have already yielded suggestive evidence for translocation of V and C genes from separate to contiguous positions in DNA isolated from cells at different stages of differentiation. Moreover, in vitro trans lation of Ig mRNAs has revealed a remarkably hydrophobic stretch of about 20 amino acids at the N-terminus of the nascent Ig chain. This extra piece is absent in the Ig extracted from or secreted by plasma cells, presumably because it is rapidly cleaved from the "preimmunoglobulin" chain within the cell, but the extra piece probably plays a key role in directing the synthesis of prelg to the cell's secretory pathway.
Book Synopsis Cellular and Molecular Immunology by : Abul K. Abbas
Download or read book Cellular and Molecular Immunology written by Abul K. Abbas and published by W B Saunders Company. This book was released on 2005 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 5th Edition of this comprehensive title continues the tradition of delivering an accessible, engaging, and current introduction to this essential subject. The authors describe the principles of basic and applied immunology in a concise, straightforward manner, while incorporating the most up-to-date information. Over 400 illustrations help readers quickly and easily grasp key concepts. The entire text has been revised and includes new information about the organization of lymphoid organs and the mechanisms of innate immunity. (Midwest).
Book Synopsis Contemporary Topics in Molecular Immunology by : R. Porter
Download or read book Contemporary Topics in Molecular Immunology written by R. Porter and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The distinction between molecular immunology and immunobiology is neces sarily arbitrary. The most rapid progress is usually made in the blurred area between the two, when the chemist is aware of the full significance of the biological problems, and the biologist is alert to the contribution that a knowl edge of molecular structure can be made to their solution. The range of scientific disciplines able to contribute to research in immunology, which this approach brings, is reflected in the present volume. Protein chemists worked out the arrangement of the polypeptide chains and the amino acid sequences of antibodies and X-ray crystallographers the three dimensional structure, but more precise definition of the amino acid side chain positions in the combining site is required for an understanding of the subtleties of antibody specificity. That this can be achieved with physical techniques such as nuclear magnetic resonance has been shown by R. A. Dwek, and in his chapter he summarizes these results with a minimum of technical detail. The immune response has been shown to be dependent on complex cellular interactions and further progress will be facilitated by investigation of the molecular basis of these interactions. This necessitates study of the structure and organization of the molecules in the surfaces of lymphocytes and other cells.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Contemporary Topics in Immunobiology by : John J. Marchalonis
Download or read book Contemporary Topics in Immunobiology written by John J. Marchalonis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The problem that virtually all cells have in discriminating between "self" and "non-self" molecules and cells has been considered at great length in immuno biology. However, cells that clearly are incapable of carrying out mammalian type immune functions can exhibit exquisite specificity in their capacity to discriminate among syngeneic, allogeneic, and xenogeneic cells. In this volume of Contemporary Topics in Immunobiology we have chosen to consider the general problem of self/non-self discrimination as it is manifest in recognition reactions of plants and invertebrates and in the evolutionary development of the immune response of vertebrates. A broad, many-faceted approach is taken toward fundamental issues in immunobiology in order to develop innovative concepts of receptor function as well as to delineate traditional views. The capacity of plants to discriminate between self and non-self is addressed in Chapter 1 by R. B. Knox and Adrienne E. Clarke. These authors provide examples of cell-cell recognition in plants that parallel those occurring in in vertebrates and vertebrates. In general, tolerance (acceptance) of grafts is re stricted to plants within closely related genera. Recognition is mediated by callus cells, which proliferate at wound surfaces in higher plants, and there is a correlation between cell and tissue type and antigenic markers detectable with the use of mammalian antibodies. Certain flowering plants exhibit precise discrimination in fertilization, when pollen must be from the same species, but fertilization occurs only if the pollen is genetically non-self.
Book Synopsis Contemporary Topics in Immunobiology by : Noel Warner
Download or read book Contemporary Topics in Immunobiology written by Noel Warner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this current volume of Contemporary Topics in Immunobiology we have chosen to continue with the multiple-theme approach that was developed in Volumes 1, 3, and 5 of this series. Immunobiology still shows little sign of decreasing its active growth rate, but rather is continuing to broaden its range of interests and applications, particularly as new techniques and methods are adapted from other fields of medical research. This present volume reflects both several of the more classical areas of immunology now addressed in the light of contemporary immunology, and several newer directions that have been taken in other fields. The general subject of T-cell heterogeneity and functions of T-cell subpop ulations is addressed in Chapters 1 and 2. The potential role of genes of the major histocompatibility complex in controlling the immune functions of T lymphocytes still remains a major unresolved issue in immunogenetics, and the current status of this problem is excellently reviewed by J. F. A. P. Miller. The further elucidation of functional subpopulations of human T lymphocytes has been particularly hampered by the lack of available markers for character izing and isolating such sUbpopulations. A major step in this direction has been made by L. Moretta, M. Ferrarini, and M. D. Cooper, who review their ex perience with Fc-receptor-bearing human T-Iymphocyte populations.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Good Serials Department by : Peter Gellatly
Download or read book The Good Serials Department written by Peter Gellatly and published by Routledge. This book was released on 2019-12-06 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 1990, examines in detail 12 serials departments, both large and small, that experts have selected as representative examples of notable serials departments. The departments have in common a general reputation in the serials field as being good operations, in the sense of providing optimum services to their users despite the challenges of current-day problems in financial planning and collection re-evaluation and shaping. The examples offered serve mainly to suggest what works well in the serials operation today. Despite the lack of space devoted to the good serials department or the often crisis-oriented approach to serials problems that is occasionally emphasized in the literature, the ‘good serials operation’ undeniably exists and always has. Certain serials departments receive the utmost praise from librarian colleagues and faculty/student users alike. This authoritative volume shows that good serials librarianship remains what it has always been - a means of providing serials and the information in them to an ever-widening audience of readers and researchers. Economic changes may alter the pattern of serials department services, but they do not alter the real and ultimate goals of the serials department.
Download or read book Books in Print Supplement written by and published by . This book was released on 1994 with total page 1852 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endotoxin written by H. Friedman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the proceedings of the International Symposium on Bacterial Endotoxins held in Japan. May 11-14. 1988 and sponsored by the International Endotoxin Society and the International Society for Immuno pharmacology. Speakers and participants of this symposium provided new information concerning fundamental and clinical aspects of endotoxin research conducted over the last half decade or so. Advances have been made in understanding the structure and nature of endotoxin molecules and their effects on a wide variety of both cellular and subcellular aspects, of immunity. metabolism and physiology. both in vivo and in vitro. Endotoxins are constituents of gram negative bacteria. Since their original discovery in the nineteenth century. many laboratories studied their chemical composition. their physico- and immunochemica1 properties. as well as their pharmacological and physiological effects on the host. Much is now known about the chemical structure of the endotoxins. There is also a grow ing body of information concerning the multiple effects of endotoxins on the host including immune mechanisms. Some effects have been found to be benefi cial to the host and endotoxins are being used more frequently to induce important mediators of immunity as well as increasing resistance against infections by many microorganisms as well as inhibiting growth of tumors in experimental animal models and in man.
Book Synopsis The Publishers' Trade List Annual by :
Download or read book The Publishers' Trade List Annual written by and published by . This book was released on 1985 with total page 2200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunology and Epidemiology by : Geoffrey W. Hoffmann
Download or read book Immunology and Epidemiology written by Geoffrey W. Hoffmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: In February 1985 a small international meeting of scientists took place at the recreation resort of the Polish Academy of Sci ences in Mogilany, near Cracow, Poland. The initiative for holding the workshop came from a working meeting on mathematical immunology and related topics at the International Institute for Applied Sys tems Analysis in Laxenburg, Austria, in November 1983. In addition to representatives of IIASA, delegates of the IIASA National Member Organizations (NMO) of Czechoslovakia, Italy, and the soviet Union took part in that working meeting. The participants came to the conclusion that IIASA could play an important role in facilitating the development of research in this field. The first step that they recommended to I IASA was to organize a workshop on mathematical immunology. The purpose of the workshop was to review the progress that has been made in applying mathematics to problems in immunology and to explore ways in which further progress might be achieved, especially by more efficient interactions between scientists working in mathematical and experimental immunology. Some National Member Organizations contributed to the success of the workshop by nominat ing further participants working in this or related fields. For instance, thanks to a suggestion of the British NMO, the meeting also included analyses of the interactions between the immune state of a population and epidemiological phenomena. There were 33 participants at Mogilany from 11 countries, namely Canada, Czechoslovakia, Federal Republic of Germany, Hungary, Japan, Netherlands, Poland, Sweden, united Kingdom, USA, and USSR.
Book Synopsis Macrophage Biology and Activation by : Stephen W. Russell
Download or read book Macrophage Biology and Activation written by Stephen W. Russell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amazing world of the mononuclear phagocytes keeps expanding at a truly awesome pace. As a result, maintaining currency with the latest developments and controversies that pertain to this cell type is increasingly difficult. The aspects covered in this volume have been selected to provide an overview of subject areas that either have recently become much better understood or hold the promise of new levels of understanding as they are developed in the future. The scope of topics ranges from how these cells develop, through the means that are used to regulate them, to the roles that they have in different tissues and in a variety of infectious diseases.
