Connective Methodologies For Natural Product Synthesis

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Connective Methodologies for Natural Product Synthesis

Author : Qunying Dai
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.:/5 (441 download)

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Book Synopsis Connective Methodologies for Natural Product Synthesis by : Qunying Dai

Download or read book Connective Methodologies for Natural Product Synthesis written by Qunying Dai and published by . This book was released on 2000 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic synthesis is one of the most challenging fields of chemistry while natural product synthesis is the most appealing field of organic synthesis. The purpose of this research was to develop efficient synthesis of natural products or molecules that mimic natural products with biological activities beneficial to human beings. The first chapter covered a direct synthesis approach to a potential anticoccidial compound. It was achieved by electrophilic substitution of 2,3,4-thibromobut-2-en-4-olide to 1,4-dimethoxynaphthalene as the key step. Following ceric ammonium nitrate oxidation got the desired 2-(3,4-dibromo-5-oxo-2,5-dihydrofuran-2-yl)-1,4-naphthoquinone. In the second chapter, we developed a new methodology of forming two new carbon-carbon bond using [(phenyisulfonyl)-methylene]dilithium. A number of 1,4 and, 5-dicarbonyl compounds reacted with the sulfonyl-stabilized dianion and led to the corresponding fused bicyclic compounds. This new route promises to open up an entirely new approach to the total synthesis of glycinoeclapin A. The third chapter covered the study toward the total synthesis of eleutherobin. We developed a direct synthetic approach to the skeleton of eleutherobin from a commercial available keton, 6-methyl-5-hepen-2-one. It was achieved in six steps. This pathway can enable medicinal researchers to synthesize diverse analogs of eleutherobin.

Efficiency in Natural Product Total Synthesis

Author : Pei-Qiang Huang
Publisher : John Wiley & Sons
ISBN 13 : 1118605403
Total Pages : 512 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Efficiency in Natural Product Total Synthesis by : Pei-Qiang Huang

Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang and published by John Wiley & Sons. This book was released on 2018-10-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Natural Product Synthesis I

Author :
Publisher :
ISBN 13 :
Total Pages : 239 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Natural Product Synthesis I by :

Download or read book Natural Product Synthesis I written by and published by . This book was released on 2005 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products

Author : Sasadhar Majhi
Publisher : World Scientific
ISBN 13 : 9811268703
Total Pages : 469 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products by : Sasadhar Majhi

Download or read book Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products written by Sasadhar Majhi and published by World Scientific. This book was released on 2023-04-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.

Total Synthesis of Natural Products

Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3642340652
Total Pages : 292 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Total Synthesis of Natural Products by : Jie Jack Li

Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

From Biosynthesis to Total Synthesis

Author : Alexandros L. Zografos
Publisher : John Wiley & Sons
ISBN 13 : 1118751736
Total Pages : 585 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis From Biosynthesis to Total Synthesis by : Alexandros L. Zografos

Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field

Metathesis in Natural Product Synthesis

Author : Janine Cossy
Publisher : John Wiley & Sons
ISBN 13 : 3527642080
Total Pages : 413 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Metathesis in Natural Product Synthesis by : Janine Cossy

Download or read book Metathesis in Natural Product Synthesis written by Janine Cossy and published by John Wiley & Sons. This book was released on 2011-09-22 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.

Natural Product Synthesis II

Author : U. Beifuss
Publisher : Springer Science & Business Media
ISBN 13 : 9783540211242
Total Pages : 284 pages
Book Rating : 4.2/5 (112 download)

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Book Synopsis Natural Product Synthesis II by : U. Beifuss

Download or read book Natural Product Synthesis II written by U. Beifuss and published by Springer Science & Business Media. This book was released on 2005-02-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: T. Heckrodt and J. Mulzer: Marine Natural Products from Pseudopterogorgia Elisabethae: Structures, Biosynthesis, Pharmacology and Total Synthesis .-M. Kalesse: Recent Advances in Vinylogous Aldol Reactions and their Applications in Natural Product Synthesis .- U. Beifuss and M. Tietze: Methanophenazine and Other Biologically Active Phenazines .-H.-J. Knoelker: Occurrence, Biological Activity, and Convergent Organometallic Synthesis of Carbazole Alkaloids .-U. Nubbemeyer: Recent Advances in Charge Accelerated Aza-Claisen Rearrangements.- P. Metz: Synthetic Studies on the Pamamycin Macrodiolides

Analytical Techniques for Natural Product Research

Author : Satyanshu Kumar
Publisher : CABI
ISBN 13 : 1780644736
Total Pages : 206 pages
Book Rating : 4.7/5 (86 download)

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Book Synopsis Analytical Techniques for Natural Product Research by : Satyanshu Kumar

Download or read book Analytical Techniques for Natural Product Research written by Satyanshu Kumar and published by CABI. This book was released on 2015-12-15 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are important source of lead molecules for drug discovery. These lead molecules serve as starting materials for laboratory synthesis of drug as well a model for production of biologically active compounds. Phytochemical processing of raw plant materials is essentially required to optimize the concentration of known constituents and also to maintain their activities. Extraction techniques and analytical techniques have played critical roles in phytochemical processing of raw materials. Extraction technologies from conventional extraction to green extraction as well as analytical techniques from single technique to hyphenated/coupled techniques most frequently used in phytochemistry laboratories are covered in the book.

Molecular Rearrangements in Organic Synthesis

Author : Christian M. Rojas
Publisher : John Wiley & Sons
ISBN 13 : 1118939891
Total Pages : 774 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Molecular Rearrangements in Organic Synthesis by : Christian M. Rojas

Download or read book Molecular Rearrangements in Organic Synthesis written by Christian M. Rojas and published by John Wiley & Sons. This book was released on 2015-10-01 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for practitioners of organic synthesis, this book helps chemists understand and take advantage of rearrangement reactions to enhance the synthesis of useful chemical compounds. Provides ready access to the genesis, mechanisms, and synthetic utility of rearrangement reactions Emphasizes strategic synthetic planning and implementation Covers 20 different rearrangement reactions Includes applications for synthesizing compounds useful as natural products, medicinal compounds, functional materials, and physical organic chemistry

The Way of Synthesis

Author : Tomas Hudlicky
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 1032 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis The Way of Synthesis by : Tomas Hudlicky

Download or read book The Way of Synthesis written by Tomas Hudlicky and published by Wiley-VCH. This book was released on 2007-09-04 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)

Asymmetric Synthesis of Natural Products

Author : Ari M. P. Koskinen
Publisher : John Wiley & Sons
ISBN 13 : 1119707021
Total Pages : 388 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Asymmetric Synthesis of Natural Products by : Ari M. P. Koskinen

Download or read book Asymmetric Synthesis of Natural Products written by Ari M. P. Koskinen and published by John Wiley & Sons. This book was released on 2022-11-30 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric Synthesis of Natural Products Fully updated learning resource covering the concept of using natural product chemistry for strategies in asymmetric synthesis The third edition of Asymmetric Synthesis of Natural Products introduces students to the rapidly growing field of natural products in organic chemistry, discussing the practical, mainly pharmacological, importance of selected compounds and emphasizing the target-oriented approach of organic synthesis which is key in industrial strategies. To aid in reader comprehension, the text includes key references and an Index of Compounds. The textbook is based on two lecture courses (Asymmetric Synthesis & Asymmetric Synthesis of Natural Products), which the author has delivered more than 50 times over the past 20 years in Finland, the UK, Italy, and Greece. This third edition is fully updated from the earlier versions (published by Wiley in 1993 and 2012). The importance of natural products as truly renewable raw materials in sustainable chemistry and circular economy is illustrated through applications of e.g. organocatalysis, organometallic catalysis, and biocatalysis. The contents consist of traditional text supplemented with illustrations (such as chemical drawings and structural formulae). Three dimensional aspects are also discussed with the use of 3D renderings of structures for both reaction mechanisms (molecular modeling) and crystallographic data. Sample topics covered in the textbook include: The foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions Sustainable development, the circular economy, and use of renewable raw materials that have become prominent in many fields of science and technology Various natural product classes, including carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, and polyketides The properties of these natural product classes, including their structures, biosynthesis, and interrelationships, as well as examples of asymmetric syntheses and the practical value of these compounds Asymmetric Synthesis of Natural Products is a comprehensive, authoritative, and up-to-date learning resource on the subject for advanced level undergraduate or early-stage graduate students. It is also useful for specialists already working in synthesis who wish to learn about asymmetric synthesis.

Natural Product Synthesis II

Author : Johann H. Mulzer
Publisher : Springer
ISBN 13 : 9783642059322
Total Pages : 270 pages
Book Rating : 4.0/5 (593 download)

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Book Synopsis Natural Product Synthesis II by : Johann H. Mulzer

Download or read book Natural Product Synthesis II written by Johann H. Mulzer and published by Springer. This book was released on 2010-10-19 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Development of Novel Synthetic Methodologies and Their Application to Natural Product Synthesis

Author : David A. Gerstenhaber
Publisher :
ISBN 13 : 9781124782195
Total Pages : pages
Book Rating : 4.7/5 (821 download)

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Book Synopsis The Development of Novel Synthetic Methodologies and Their Application to Natural Product Synthesis by : David A. Gerstenhaber

Download or read book The Development of Novel Synthetic Methodologies and Their Application to Natural Product Synthesis written by David A. Gerstenhaber and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Total Synthesis of Natural Products, Volume 6

Author : John ApSimon
Publisher : John Wiley & Sons
ISBN 13 : 0470129573
Total Pages : 306 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis The Total Synthesis of Natural Products, Volume 6 by : John ApSimon

Download or read book The Total Synthesis of Natural Products, Volume 6 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sixth volume of The Total Synthesis of Natural Products continues editor John ApSimon's exploration of one of the most promising areas for the future development of organic chemistry: synthesis. ApSimon has compiled the first definitive reference source of successful synthetic approaches to a wide variety of natural products. This new volume considers the total synthesis of triterpenes, carbohydrates, aromatic steroids, pyrrole pigments and genes first reported during the period from 1972 through 1982 in this series. The Total Synthesis of Natural Products, Volume Six forms an integral part of the invaluable working reference begun in Volumes One through Five, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.

Classics in Total Synthesis

Author : K. C. Nicolaou
Publisher : John Wiley & Sons
ISBN 13 : 3527292314
Total Pages : 826 pages
Book Rating : 4.5/5 (272 download)

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Book Synopsis Classics in Total Synthesis by : K. C. Nicolaou

Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

The Chemical Synthesis of Natural Products

Author : Karl Hale
Publisher : Burns & Oates
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Chemical Synthesis of Natural Products by : Karl Hale

Download or read book The Chemical Synthesis of Natural Products written by Karl Hale and published by Burns & Oates. This book was released on 2000 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a chemist, you may be called on to generate any number of products efficiently and quickly. A well-equipped, shrewd chemist will be prepared to accomplish this goal under any circumstance. The Chemical Synthesis of Natural Products helps you become this chemist - the master of major, recent developments who uses the progress of the past decade to their advantage. Each of the chapters concentrates on the synthesis of a particular product: complex carbohydrates, cyclitols, polyethers, terpenes, aromatic heterocycles, carboaromatics, cyclic peptides, and others. This product-driven presentation from expert authors offers a practical introduction to the latest advanced methods. The final section is an invaluable glossary for the synthetic chemist. This list of terms concisely defines key reactions, reagents, and synthetic methods. It includes oxidation and reduction, the stereoselective creation of carbon-carbon double bonds, and strategies for joining together large molecules. The glossary also describes useful methods for introducing asymmetric stereocenters by employing chiral auxiliaries and chiral reagents in a catalytic and stoichiometric manner. With all of the accessible information it holds, The Chemical Synthesis of Natural Products is an ideally structured introduction to the newest trends and major issues in the discipline. Its sweeping overview, concise glossary, and accessible list of supplementary readings make an indispensable reference to which you will turn time and again.