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Computational Biomechanics For Ventricle Arterial Dysfunction And Remodeling In Heart Failure
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Book Synopsis Computational Biomechanics for Ventricle-arterial Dysfunction and Remodeling in Heart Failure by :
Download or read book Computational Biomechanics for Ventricle-arterial Dysfunction and Remodeling in Heart Failure written by and published by Frontiers Media SA. This book was released on 2021-08-24 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational biomechanics for ventricle-arterial dysfunction and remodeling in heart failure, volume II by : Yunlong Huo
Download or read book Computational biomechanics for ventricle-arterial dysfunction and remodeling in heart failure, volume II written by Yunlong Huo and published by Frontiers Media SA. This book was released on 2023-01-09 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Cardiovascular Mechanics by : Julius M. Guccione
Download or read book Computational Cardiovascular Mechanics written by Julius M. Guccione and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Cardiovascular Mechanics provides a cohesive guide to creating mathematical models for the mechanics of diseased hearts to simulate the effects of current treatments for heart failure. Clearly organized in a two part structure, this volume discusses various areas of computational modeling of cardiovascular mechanics (finite element modeling of ventricular mechanics, fluid dynamics) in addition to a description an analysis of the current applications used (solid FE modeling, CFD). Edited by experts in the field, researchers involved with biomedical and mechanical engineering will find Computational Cardiovascular Mechanics a valuable reference.
Book Synopsis Computational Biomechanics of the Heart and Vasculature with Potential Clinical and Surgical Applications by : Dalin Tang
Download or read book Computational Biomechanics of the Heart and Vasculature with Potential Clinical and Surgical Applications written by Dalin Tang and published by Frontiers Media SA. This book was released on 2022-05-03 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomechanical Systems Technology by : Cornelius T. Leondes
Download or read book Biomechanical Systems Technology written by Cornelius T. Leondes and published by World Scientific. This book was released on 2007 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of rapid developments in computer technology and computational techniques, advances in a wide spectrum of technologies, coupled with cross-disciplinary pursuits between technology and its application to human body processes, the field of biomechanics continues to evolve. Many areas of significant progress include dynamics of musculoskeletal systems, mechanics of hard and soft tissues, mechanics of bone remodeling, mechanics of blood and air flow, flow-prosthesis interfaces, mechanics of impact, dynamics of man-machine interaction, and more. Thus, the great breadth and significance of the field in the international scene require a well integrated set of volumes to provide a complete coverage of the exciting subject of biomechanical systems technology. World-renowned contributors tackle the latest technologies in an in-depth and readable manner. . Sample Chapter(s). Chapter 1: A Simulation Study of Hemodynamic Benefits and Optimal Control of Axial Flow Pump-Based Left Ventricular Assist. Contents: Techniques in Visualization and Evaluation of the In Vivo Microcirculation (S Ichioka); Analyzing Cardiac Biomechanics by Heart Sound (A Voss et al.); Numerical and Experimental Techniques for the Study of Biomechanics in the Arterial System (T P O''Brien et al.); and many other papers. Readership: Academics, researchers and postgraduate students in anatomy, cardiology, orthopaedic, biomechanics and surgery.
Book Synopsis Biomechanical Analyses of Ventricular and Vascular Function in Disease Models by : Mark J. Golob
Download or read book Biomechanical Analyses of Ventricular and Vascular Function in Disease Models written by Mark J. Golob and published by . This book was released on 2017 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease (CVD) is a leading cause of death worldwide. Clinically, CVD includes a wide range of pathologies that result in structural remodeling and functional adaptations in cardiovascular tissues, leading to heart failure and ultimately death if left untreated. Using an engineering approach, cardiovascular performance in CVD can be evaluated by measuring vascular and ventricular function, which are coupled in healthy states and uncoupled in disease. Limiting assessment only to vascular or ventricular tissues hinders the ability to understand the global cardiovascular consequences of CVD. The work in this dissertation focuses on the characterization of cardiovascular biomechanics in healthy conditions and several disease states. Stiffening of large proximal arteries impairs conduit and damping function, is associated with hypertension and aging, and serves as a prognostic indicator for CVD. Here, arterial stiffness was evaluated using experimental testing measurements and constitutive modeling analyses in small and large animal models. The data show that mitochondria DNA mutations lead to the development of hypertension and age-related arterial stiffening. I also report that stiffening can be differentiated into strain-induced and remodeling-induced modalities in a chronic model of pulmonary hypertension. Increased loading on the ventricle due to hypertension or arterial stiffening leads to ventricular hypertrophy and a reduced coupling efficiency with the vasculature. Here, ventricular function and ventricular-vascular coupling were evaluated using a pressure-volume technique. The data show that limiting collagen turnover via intrinsic resistance to degradation results in beneficial effects for the right ventricle in pulmonary arterial hypertension. I also demonstrate that left and right ventricular function are preserved despite disruption of collagen synthesis. The biomechanical assessment of vascular and ventricular function used here via cardiac catheterization, ex vivo mechanical testing, echocardiography, and histological staining can be used as a framework for future studies independent of species or diseases. Characterizing the individual mechanical adaptations in the heart and arteries in response to a stimulus, e.g. pressure in hypertensive conditions, and relating these changes between vascular and ventricular tissues can lead to i) understanding disease development processes, ii) identifying indices that can have prognostic value for CVD patients, and iii) developing novel disease treatments.
Book Synopsis Clinical Application of Computational Mechanics to the Cardiovascular System by : T. Yamaguchi
Download or read book Clinical Application of Computational Mechanics to the Cardiovascular System written by T. Yamaguchi and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular diseases, particularly atherosclerosis, are the most frequent and critical underlying fatal disorders in the industrialized world. Cardiovascular deaths are the leading cause of death in the Western world. Although cancer or malignant neoplasms recently have topped the list of causes of deaths in Japan, cardiovascular and cerebrovascular diseases bring about more deaths than cancer if they are reclassified into a unified category of diseases of the vascular system. The National Cardiovascular Center was established by the Ministry of Health and Welfare of Japan to combat cardiovascular and cerebrovascular diseases. Since the Center was opened, we have continued to support basic and clinical sturlies of cardiovascular and cerebrovascular diseases within as weil as outside the Center. Clinical studies that we have supported in modern diagnostic and therapeutic measures against cardio- and cerebrovascular diseases have made remarkable advances in recent years, especially in medical imaging technology including CT and MRI, and in interventional measures including balloon angioplasty and other catheter-based treatments. We are proud of the significant improvement in the overall survival rate and the quality of life of patients suffering from vascular disorders. However, there are still many essential difficulties remaining in the diagnosis and treatment of vascular disorders. Such difficulties necessitate further fundamental studies not only from the practical aspect but also from the integrated perspectives of medicine, biology, and engineering.
Book Synopsis Computational Cardiology by : Frank B. Sachse
Download or read book Computational Cardiology written by Frank B. Sachse and published by Springer Science & Business Media. This book was released on 2004-04-15 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to computer-based modeling in cardiology, by taking an educational point of view, and by summarizing knowledge from several, commonly considered delimited areas of cardiac research in a consistent way. First, the foundations and numerical techniques from mathematics are provided, with a particular focus on the finite element and finite differences methods. Then, the theory of electric fields and continuum mechanics is introduced with respect to numerical calculations in anisotropic biological media. In addition to the presentation of digital image processing techniques, the following chapters deal with particular aspects of cardiac modeling: cardiac anatomy, cardiac electro physiology, cardiac mechanics, modeling of cardiac electro mechanics. This book was written for researchers in modeling and cardiology, for clinical cardiologists, and for advanced students.
Book Synopsis Biomechanics of Soft Tissue in Cardiovascular Systems by : Gerhard A. Holzapfel
Download or read book Biomechanics of Soft Tissue in Cardiovascular Systems written by Gerhard A. Holzapfel and published by Springer. This book was released on 2014-05-04 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is written by leading experts in the field presenting an up-to-date view of the subject matter in a didactically sound manner. It presents a review of the current knowledge of the behaviour of soft tissues in the cardiovascular system under mechanical loads, and the importance of constitutive laws in understanding the underlying mechanics is highlighted. Cells are also described together with arteries, tendons and ligaments, heart, and other biological tissues of current research interest in biomechanics. This includes experimental, continuum mechanical and computational perspectives, with the emphasis on nonlinear behaviour, and the simulation of mechanical procedures such as balloon angioplasty.
Book Synopsis Computational Modeling of Cardiac Mechanics by : Ce Xi
Download or read book Computational Modeling of Cardiac Mechanics written by Ce Xi and published by . This book was released on 2019 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart diseases, which approximately account for 31% of all human mortality every year, are the leading cause of death worldwide. Computational cardiac models have gained increasing popularity and become an indispensable and powerful tool in elucidating the pathological process of different heart diseases. They can be used to estimate important physiological and clinically relevant quantities that are difficult to directly measure in experiments. The broad goals of this thesis were to develop 1) a microstructure-based constitutive model of the heart and 2) patient-specific computational models that would ultimately help medical scientists to diagnose and treat heart diseases.Heart diseases such as heart failure with preserved ejection fraction (HFpEF) are characterized by abnormalities of ventricular function that can be attributed to, changes in geometry, impaired myocyte (LV) relaxation, cardiac fibrosis and myocyte passive stiffening. Understanding how LV filling is affected by each of the many microstructural pathological features in heart diseases is very important and may help in the development of appropriate treatments. To address this need, we have developed and validated a microstructure-based computational model of the myocardium to investigate the role of tissue constituents and their ultrastructure in affecting the heart function. The model predicted that the LV filling function is sensitive to the collagen ultrastructure and the load taken up by the tissue constituents varies depending on the LV transmural location. This finding may have implications in the development of new pharmaceutical treatments targeting individual cardiac tissue constituents to normalize LV filling function in HFpEF.Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by elevated pulmonary artery pressure (PAP) and pulmonary artery vascular resistance, with limited survival rate and can affect patients of all ages. The increased pressure or afterload in the right ventricle (RV) can result in pathological changes in RV mechanics, which are currently not well-understood. To fill this void, we have developed patient-specific computational models to investigate effects of PAH on ventricular mechanics. Specifically, we have quantified regional ventricular myofiber stress, myofiber strain, contractility, and passive tissue stiffness in PAH patients, and compare them to those found in age- and gender-matched normal controls. Our results showed that RV longitudinal, circumferential and radial strain were depressed in PAH patients compared with controls; RV passive stiffness increased progressively with the degree of remodeling as indexed by the RV and LV end-diastolic volume ratio (RVEDV/LVEDV); Peak contractility of the RV was found to be strongly correlated, and had an inverse relationship with RVEDV/LVEDV. These results provide the mechanical basis of using RVEDV/LVEDV as a clinical index for delineating disease severity and estimating RVFW contractility in PAH patients.
Book Synopsis Cardiovascular Biomechanics by : Peter R. Hoskins
Download or read book Cardiovascular Biomechanics written by Peter R. Hoskins and published by Springer. This book was released on 2017-02-16 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.
Book Synopsis Women in Heart Failure and Transplantation by : Maya Ignaszewski
Download or read book Women in Heart Failure and Transplantation written by Maya Ignaszewski and published by Frontiers Media SA. This book was released on 2023-03-01 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pulmonary Hypertension in the Modern Era: Science and Clinical Practice, Volume II by : Harm Jan Bogaard
Download or read book Pulmonary Hypertension in the Modern Era: Science and Clinical Practice, Volume II written by Harm Jan Bogaard and published by Frontiers Media SA. This book was released on 2023-03-09 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Development and Disease written by and published by Elsevier. This book was released on 2024-04-02 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Heart Development Disease
Book Synopsis Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic by : Julius Guccione
Download or read book Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic written by Julius Guccione and published by Frontiers Media SA. This book was released on 2020-01-13 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Reduced Order Models for the Biomechanics of Living Organs by : Francisco Chinesta
Download or read book Reduced Order Models for the Biomechanics of Living Organs written by Francisco Chinesta and published by Elsevier. This book was released on 2023-05-25 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reduced Order Models for the Biomechanics of Living Organs, a new volume in the Biomechanics of Living Organisms series, provides a comprehensive overview of the state-of-the-art in biomechanical computations using reduced order models, along with a deeper understanding of the associated reduction algorithms that will face students, researchers, clinicians and industrial partners in the future. The book gathers perspectives from key opinion scientists who describe and detail their approaches, methodologies and findings. It is the first to synthesize complementary advances in Biomechanical modelling of living organs using reduced order techniques in the design of medical devices and clinical interventions, including surgical procedures. This book provides an opportunity for students, researchers, clinicians and engineers to study the main topics related to biomechanics and reduced models in a single reference, with this volume summarizing all biomechanical aspects of each living organ in one comprehensive reference. Introduces the fundamental aspects of reduced order models Presents the main computational studies in the field of solid and fluid biomechanical modeling of living organs Explores the use of reduced order models in the fields of biomechanical electrophysiology, tissue growth and prosthetic designs
Book Synopsis Encyclopedia of Computational Mechanics by : Erwin Stein
Download or read book Encyclopedia of Computational Mechanics written by Erwin Stein and published by . This book was released on 2004 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Computational Mechanics provides a comprehensive collection of knowledge about the theory and practice of computational mechanics.
