Author : Ayman F. El-Kattan
Publisher : John Wiley & Sons
ISBN 13 : 1118916697
Total Pages : 452 pages
Book Rating : 4.1/5 (189 download)
Book Synopsis Oral Bioavailability Assessment by : Ayman F. El-Kattan
Download or read book Oral Bioavailability Assessment written by Ayman F. El-Kattan and published by John Wiley & Sons. This book was released on 2017-06-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development