Combinatorial Libraries

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Combinatorial Library

Author : Lisa B. English
Publisher : Springer Science & Business Media
ISBN 13 : 1592592856
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Library by : Lisa B. English

Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

Combinatorial Synthesis of Natural Product-Based Libraries

Author : Armen M. Boldi
Publisher : CRC Press
ISBN 13 : 1420009273
Total Pages : 363 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Combinatorial Synthesis of Natural Product-Based Libraries by : Armen M. Boldi

Download or read book Combinatorial Synthesis of Natural Product-Based Libraries written by Armen M. Boldi and published by CRC Press. This book was released on 2006-05-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato

Combinatorial Chemistry

Author : Stephen R. Wilson
Publisher : John Wiley & Sons
ISBN 13 : 9780471126874
Total Pages : 288 pages
Book Rating : 4.1/5 (268 download)

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Book Synopsis Combinatorial Chemistry by : Stephen R. Wilson

Download or read book Combinatorial Chemistry written by Stephen R. Wilson and published by John Wiley & Sons. This book was released on 1997-03-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Combinatorial Peptide and Nonpeptide Libraries

Author : Günther Jung
Publisher : John Wiley & Sons
ISBN 13 : 3527614907
Total Pages : 571 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Combinatorial Peptide and Nonpeptide Libraries by : Günther Jung

Download or read book Combinatorial Peptide and Nonpeptide Libraries written by Günther Jung and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.

Combinatorial Chemistry and Technologies

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 1420027840
Total Pages : 597 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Combinatorial Chemistry and Technologies by : Stanislav Miertus

Download or read book Combinatorial Chemistry and Technologies written by Stanislav Miertus and published by CRC Press. This book was released on 2005-04-12 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the

Structure-based Design of Combinatorial Libraries

Author : Allan Geoffrey Skillman
Publisher :
ISBN 13 :
Total Pages : 840 pages
Book Rating : 4.:/5 (82 download)

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Book Synopsis Structure-based Design of Combinatorial Libraries by : Allan Geoffrey Skillman

Download or read book Structure-based Design of Combinatorial Libraries written by Allan Geoffrey Skillman and published by . This book was released on 1999 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Combinatorial Peptide Library Protocols

Author : Shmuel Cabilly
Publisher : Springer Science & Business Media
ISBN 13 : 1592595715
Total Pages : 320 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Peptide Library Protocols by : Shmuel Cabilly

Download or read book Combinatorial Peptide Library Protocols written by Shmuel Cabilly and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the course of evolution, an imbalance was created between the rate of vertebrate genetic adaptation and that of the lower forms of living organisms, such as bacteria and viruses. This imbalance has given the latter the advantage of generating, relatively quickly, molecules with unexpected structures and features that carry a threat to vertebrates. To compensate for their weakness, vertebrates have accelerated their own evolutionary processes, not at the level of whole organism, but in specialized cells containing the genes that code for antibody molecules or for T-cell receptors. That is, when an immediate requirement for molecules capable of specific interactions arose, nature has preferred to speed up the mode of Darwinian evolution in pref- ence to any other approach (such as the use of X-ray diffraction studies and computergraphic analysis). Recently, Darwinian rules have been adapted for test tube research, and the concept of selecting molecules having particular characteristics from r- dom pools has been realized in the form of various chemical and biological combinatorial libraries. While working with these libraries, we noticed the interesting fact that when combinatorial libraries of oligopeptides were allowed to interact with different selector proteins, only the actual binding sites of these proteins showed binding properties, whereas the rest of the p- tein surface seemed "inert. " This seemingly common feature of protein- having no extra potential binding sites--was probably selected during evolution in order to minimize nonspecific interactions with the surrounding milieu.

Computational Phytochemistry

Author : Satyajit Dey Sarker
Publisher : Elsevier
ISBN 13 : 0443161038
Total Pages : 532 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Computational Phytochemistry by : Satyajit Dey Sarker

Download or read book Computational Phytochemistry written by Satyajit Dey Sarker and published by Elsevier. This book was released on 2024-03-15 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products. This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research Features clearly illustrated chapters contributed by highly reputable researchers Covers all key areas in phytochemical research, including virtual screening and metabolomics

Combinatorial Libraries

Author : Riccardo Cortese
Publisher : Walter de Gruyter
ISBN 13 : 3110808900
Total Pages : 248 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Combinatorial Libraries by : Riccardo Cortese

Download or read book Combinatorial Libraries written by Riccardo Cortese and published by Walter de Gruyter. This book was released on 2013-08-26 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comprehensive Chirality

Author :
Publisher : Newnes
ISBN 13 : 0080951686
Total Pages : 5635 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Chirality by :

Download or read book Comprehensive Chirality written by and published by Newnes. This book was released on 2012-12-31 with total page 5635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

An Introduction to Chemoinformatics

Author : Andrew R. Leach
Publisher : Springer
ISBN 13 : 1402062915
Total Pages : 260 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis An Introduction to Chemoinformatics by : Andrew R. Leach

Download or read book An Introduction to Chemoinformatics written by Andrew R. Leach and published by Springer. This book was released on 2007-09-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide an introduction to the major techniques of chemoinformatics. It is the first text written specifically for this field. The first part of the book deals with the representation of 2D and 3D molecular structures, the calculation of molecular descriptors and the construction of mathematical models. The second part describes other important topics including molecular similarity and diversity, the analysis of large data sets, virtual screening, and library design. Simple illustrative examples are used throughout to illustrate key concepts, supplemented with case studies from the literature.

Macrocyclic and Supramolecular Chemistry

Author : Reed M. Izatt
Publisher : John Wiley & Sons
ISBN 13 : 1119053846
Total Pages : 501 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Macrocyclic and Supramolecular Chemistry by : Reed M. Izatt

Download or read book Macrocyclic and Supramolecular Chemistry written by Reed M. Izatt and published by John Wiley & Sons. This book was released on 2016-08-01 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book commemorates the 25th anniversary of the International Izatt-Christensen Award in Macrocyclic and Supramolecular Chemistry. The award, one of the most prestigious of small awards in chemistry, recognizes excellence in the developing field of macrocyclic and supramolecular chemistry Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field features chapters written by the award recipients who provide unique perspectives on the spectacular growth in these expanding and vibrant fields of chemistry over the past half century, and on the role of these awardees in shaping this growth. During this time there has been an upsurge of interest in the design, synthesis and characterization of increasingly more complex macrocyclic ligands and in the application of this knowledge to understanding molecular recognition processes in host-guest chemistry in ways that were scarcely envisioned decades earlier. In October 2016, Professor Jean-Pierre Sauvage and Sir J. Fraser Stoddart (author for chapter 22 "Contractile and Extensile Molecular Systems: Towards Molecular Muscles" by Jean -Pierre Sauvage, Vincent Duplan, and Frédéric Niess and 20 "Serendipity" by Paul R. McGonigal and J. Fraser Stoddart respectively) were awarded the Nobel Prize in Chemistry alongside fellow Wiley author Bernard Feringa, for the design and synthesis of molecular machines.

Combinatorial Chemistry

Author : Günther Jung
Publisher : John Wiley & Sons
ISBN 13 : 352761351X
Total Pages : 634 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Combinatorial Chemistry by : Günther Jung

Download or read book Combinatorial Chemistry written by Günther Jung and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.

Chemical Modelling

Author : Alan Hinchliffe
Publisher : Royal Society of Chemistry
ISBN 13 : 9780854042647
Total Pages : 454 pages
Book Rating : 4.0/5 (426 download)

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Book Synopsis Chemical Modelling by : Alan Hinchliffe

Download or read book Chemical Modelling written by Alan Hinchliffe and published by Royal Society of Chemistry. This book was released on 2004 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Modelling: Applications and Theory comprises critical literature reviews of molecular modelling, both theoretical and applied. Molecular modelling in this context refers to modelling the structure, properties and reactions of atoms, molecules & materials. Each chapter is compiled by experts in their fields and provides a selective review of recent literature, incorporating sufficient historical perspective for the non-specialist to gain an understanding. With chemical modelling covering such a wide range of subjects, this Specialist Periodical Report serves as the first port of call to any chemist, biochemist, materials scientist or molecular physicist needing to acquaint themselves with major developments in the area.

Drug Addiction

Author : Rao S. Rapaka
Publisher : Springer Science & Business Media
ISBN 13 : 0387766782
Total Pages : 791 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Drug Addiction by : Rao S. Rapaka

Download or read book Drug Addiction written by Rao S. Rapaka and published by Springer Science & Business Media. This book was released on 2008-06-19 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction and other CNS disorders where the neurophysiological processes overlap, such as treatment of pain. The volume focuses on the translation of fundamental addiction research to a variety of treatments and brings together scientists with wide ranging expertise.

Organic Synthesis and Molecular Engineering

Author : Mogens Brøndsted Nielsen
Publisher : John Wiley & Sons
ISBN 13 : 1118736486
Total Pages : 462 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Organic Synthesis and Molecular Engineering by : Mogens Brøndsted Nielsen

Download or read book Organic Synthesis and Molecular Engineering written by Mogens Brøndsted Nielsen and published by John Wiley & Sons. This book was released on 2013-10-18 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The theory, methods, and practices needed to build molecules and supramolecular systems Using a synthetic approach to organic materials chemistry, this book sets forth tested and proven methods and practices that make it possible to engineer organic molecules offering special properties and functions. Throughout the book, plenty of real-world examples demonstrate the countless possibilities of creating one-of-a-kind molecules and supramolecular systems to support a broad range of applications. The book explores applications in both materials and bioorganic chemistry, including molecular electronics, energy storage, sensors, nanomedicine, and enzyme engineering. Organic Synthesis and Molecular Engineering consists of fourteen chapters, each one contributed by one or more leading international experts in the field. The contributions are based on a thorough review and analysis of the current literature as well as the authors' firsthand experience in the lab engineering new organic molecules. Designed as a practical lab reference, the book offers: Tested and proven synthetic approaches to organic materials chemistry Methods and practices to successfully engineer functionality into organic molecules Explanations of the principles and concepts underlying self-assembly and supramolecular chemistry Guidance in selecting appropriate structural units used in the design and synthesis of functional molecules and materials Coverage of the full range of applications in materials and bioorganic chemistry A full chapter on graphene, a new topic generating intense research Organic Synthesis and Molecular Engineering begins with core concepts, molecular building blocks, and synthetic tools. Next, it explores molecular electronics, supramolecular chemistry and self-assembly, graphene, and photoresponsive materials engineering. In short, it offers everything researchers need to fully grasp the underlying theory and then build new molecules and supramolecular systems.

Small Molecule Medicinal Chemistry

Author : Werngard Czechtizky
Publisher : John Wiley & Sons
ISBN 13 : 1118771605
Total Pages : 546 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Small Molecule Medicinal Chemistry by : Werngard Czechtizky

Download or read book Small Molecule Medicinal Chemistry written by Werngard Czechtizky and published by John Wiley & Sons. This book was released on 2015-11-02 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting