Combinational Chemistry High Throughput Screening

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Advances in Combinatorial Chemistry & High Throughput Screening

Author : Rathnam Chaguturu
Publisher : Bentham Science Publishers
ISBN 13 : 1608057453
Total Pages : 274 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Advances in Combinatorial Chemistry & High Throughput Screening by : Rathnam Chaguturu

Download or read book Advances in Combinatorial Chemistry & High Throughput Screening written by Rathnam Chaguturu and published by Bentham Science Publishers. This book was released on 2013-08-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). A wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers – including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

Advances in Combinatorial Chemistry and High Throughput Screening

Author : Rathnam Chaguturu
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Advances in Combinatorial Chemistry and High Throughput Screening by : Rathnam Chaguturu

Download or read book Advances in Combinatorial Chemistry and High Throughput Screening written by Rathnam Chaguturu and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Advances in Combinatorial Chemistry & High Throughput Screening, is an e-book series comprising updated research articles previously published in the impact factor journal, Combinatorial Chemistry & High Throughput Screening (CCHTS). a wide range of topics are covered by these articles including chemical biology, high throughput screening, combinatorial chemistry, chemoinformatics, laboratory automation and compound management. This series is, therefore, a testament to CCHTS contributions in advancing drug discovery on full throttle. This eBook series opens up a new avenue for rapid access for readers - including academic researchers and industry professionals - to a focused collection of highly regarded contributions in the field.

High-Throughput Screening in Drug Discovery

Author : Jörg Hüser
Publisher : John Wiley & Sons
ISBN 13 : 3527609369
Total Pages : 362 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis High-Throughput Screening in Drug Discovery by : Jörg Hüser

Download or read book High-Throughput Screening in Drug Discovery written by Jörg Hüser and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

High Throughput Screening

Author : John P. Devlin
Publisher : CRC Press
ISBN 13 : 1482269805
Total Pages : 700 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis High Throughput Screening by : John P. Devlin

Download or read book High Throughput Screening written by John P. Devlin and published by CRC Press. This book was released on 1997-05-06 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high

High-Throughput Lead Optimization in Drug Discovery

Author : Tushar Kshirsagar
Publisher : CRC Press
ISBN 13 : 1420006967
Total Pages : 256 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis High-Throughput Lead Optimization in Drug Discovery by : Tushar Kshirsagar

Download or read book High-Throughput Lead Optimization in Drug Discovery written by Tushar Kshirsagar and published by CRC Press. This book was released on 2008-03-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high qualit

High-Throughput Analysis

Author : Radislav A. Potyrailo
Publisher : Springer Science & Business Media
ISBN 13 : 1441989897
Total Pages : 642 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis High-Throughput Analysis by : Radislav A. Potyrailo

Download or read book High-Throughput Analysis written by Radislav A. Potyrailo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, edited by Potyrailo and Amis, addresses a new paradigm-shifting approach in the search for new materials-Combinatorial Materials Science. One way to consider such an approach is to imagine an adventurous chef who decides to look for new entrees by cooking food ingredients in many pots using different combinations in every pot, and boil ing, steaming, or frying them in various ways. Although most of the pots will not have the tastiest food ever devised, some recipes will taste intriguing, and some eventually will lead to a discovery of a new fascinating cuisine. Of course, having a skilled chef design the com binatorial formulation will certainly be helpful in ensuring a successful outcome. Similar to food, each engineering material is a complex product of its chemical composition, structure, and processing. Generally, each of these components matters---change one and you get another material. Most of these "new" materials will be less good than ones we use now since existing materials have been refined with the extensive work of scientists and engi neers. At the same time if one prepares diverse materials like our adventurous chef, chang ing material composition, processing conditions and time, etc. , some of these materials will be superior to existing ones and a few might represent breakout technology.

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

Author : Taosheng Chen
Publisher : CRC Press
ISBN 13 : 9780367384708
Total Pages : 291 pages
Book Rating : 4.3/5 (847 download)

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Book Synopsis A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery by : Taosheng Chen

Download or read book A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery written by Taosheng Chen and published by CRC Press. This book was released on 2019-08-30 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics. Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials

Author : Radislav A. Potyrailo
Publisher : CRC Press
ISBN 13 : 1420005383
Total Pages : 504 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials by : Radislav A. Potyrailo

Download or read book Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials written by Radislav A. Potyrailo and published by CRC Press. This book was released on 2006-07-19 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions. Written by renowned contributors to the field, Combina

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

Author : Taosheng Chen
Publisher : CRC Press
ISBN 13 : 1420070517
Total Pages : 291 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery by : Taosheng Chen

High-throughput Screening in Combinatorial Chemistry for Drug Discovery

Author : Ante M. Krstulović
Publisher :
ISBN 13 :
Total Pages : 137 pages
Book Rating : 4.:/5 (246 download)

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Book Synopsis High-throughput Screening in Combinatorial Chemistry for Drug Discovery by : Ante M. Krstulović

Download or read book High-throughput Screening in Combinatorial Chemistry for Drug Discovery written by Ante M. Krstulović and published by . This book was released on 1999 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Combinatorial Chemistry

Author : Günther Jung
Publisher : John Wiley & Sons
ISBN 13 : 352761351X
Total Pages : 634 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Combinatorial Chemistry by : Günther Jung

Download or read book Combinatorial Chemistry written by Günther Jung and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.

Combinatorial Chemistry

Author : Willi Bannwarth
Publisher : John Wiley & Sons
ISBN 13 : 3527607382
Total Pages : 694 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Combinatorial Chemistry by : Willi Bannwarth

Download or read book Combinatorial Chemistry written by Willi Bannwarth and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)

Combinatorial Library

Author : Lisa B. English
Publisher : Springer Science & Business Media
ISBN 13 : 1592592856
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Library by : Lisa B. English

Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

Combinatorial Chemistry and Technology

Author : Stanislav Miertus
Publisher : CRC Press
ISBN 13 : 9781420000566
Total Pages : 456 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Combinatorial Chemistry and Technology by : Stanislav Miertus

Download or read book Combinatorial Chemistry and Technology written by Stanislav Miertus and published by CRC Press. This book was released on 1999-07-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Combinatorial Chemistry & High Throughput Screening

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (523 download)

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Book Synopsis Combinatorial Chemistry & High Throughput Screening by :

Download or read book Combinatorial Chemistry & High Throughput Screening written by and published by . This book was released on 200? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Analytical Techniques in Combinatorial Chemistry

Author : Michael E. Swartz
Publisher : CRC Press
ISBN 13 : 9780203909966
Total Pages : 320 pages
Book Rating : 4.9/5 (99 download)

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Book Synopsis Analytical Techniques in Combinatorial Chemistry by : Michael E. Swartz

Download or read book Analytical Techniques in Combinatorial Chemistry written by Michael E. Swartz and published by CRC Press. This book was released on 2000-02-18 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the necessary tools for developing methods and analyzing results in the drug discovery process, and supports documenting and managing the process in a combinatorial setting. It describes the chromatographic and spectroscopic techniques used to generate chemical and molecular diversity in new compounds, focusing on applications

High-Throughput Synthesis

Author : Irving Sucholeiki
Publisher : CRC Press
ISBN 13 : 9781420056518
Total Pages : 398 pages
Book Rating : 4.0/5 (565 download)

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Book Synopsis High-Throughput Synthesis by : Irving Sucholeiki

Download or read book High-Throughput Synthesis written by Irving Sucholeiki and published by CRC Press. This book was released on 2001-02-22 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.