Cognitive Deficits In Schizophrenia And Other Neuropsychiatric Disorders Convergence Of Preclinical And Clinical Evidence

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Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence

Author : Ales Stuchlik
Publisher : Frontiers Media SA
ISBN 13 : 2889196798
Total Pages : 285 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence by : Ales Stuchlik

Download or read book Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence written by Ales Stuchlik and published by Frontiers Media SA. This book was released on 2015-10-23 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.

Cannabis

Author : Marco Colizzi
Publisher : MDPI
ISBN 13 : 3039439952
Total Pages : 204 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Cannabis by : Marco Colizzi

Download or read book Cannabis written by Marco Colizzi and published by MDPI. This book was released on 2021-02-05 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, there has been increasing interest into the public health impact of cannabis use, especially by young adults. This follows the evidence of a growing prevalence of regular cannabis use worldwide, with approximately 200 million users. Recreational cannabis use, especially a frequent use of products with high levels of its main psychoactive ingredient delta-9-tetrahydrocannabinol (Δ 9-THC), can cause dependence and have transient and long-lasting detrimental mental health effects, also negatively impacting cognitive processing and brain function and metabolism. In regular users, the development of tolerance to some of the effects of cannabis, especially the pleasurable ones, may lead to progressively heavier use in order to obtain the same effects in terms of their intensity, with higher health risks. However, the Cannabis Sativa plant contains different chemicals with different potential effects. In this regard, cannabidiol has gained interest because of its potential therapeutic properties, in line with evidence that CBD and Δ9-THC may exhibit opposite effects at the cannabinoid receptor type 1 (CB1), Δ9-THC being a partial agonist and CBD an antagonist/inverse agonist. Different cannabinoids may modulate human brain function and behavior in different ways, with different risk–benefit profiles.

The Role of Immediate Early Genes in Neuropsychiatric Illness

Author : Amelia L. Gallitano
Publisher : Frontiers Media SA
ISBN 13 : 2889636178
Total Pages : 177 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis The Role of Immediate Early Genes in Neuropsychiatric Illness by : Amelia L. Gallitano

Download or read book The Role of Immediate Early Genes in Neuropsychiatric Illness written by Amelia L. Gallitano and published by Frontiers Media SA. This book was released on 2020-03-30 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Adenosine Receptors

Author : Pier Andrea Borea
Publisher : Humana Press
ISBN 13 : 3319908081
Total Pages : 593 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis The Adenosine Receptors by : Pier Andrea Borea

Download or read book The Adenosine Receptors written by Pier Andrea Borea and published by Humana Press. This book was released on 2018-07-28 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Cognition in Schizophrenia

Author : Tonmoy Sharma
Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cognition in Schizophrenia by : Tonmoy Sharma

Download or read book Cognition in Schizophrenia written by Tonmoy Sharma and published by . This book was released on 2000 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although it has been known for 100 years that cognitive functioning is impaired in schizophrenia, the implications of this impairment have only recently been clearly understood. While in the past, cognitive deficits were thought to be the result of other aspects of the illness, such as poor co-operation, or as a result of the treatment of the illness, it is now known that these factors exert only a very minor influence on cognitive deficit. This book, with contributions from the major international names in the field, reviews the most recent research on the impairment of cognitive functioning in schizophrenia, covering: what it is, how wide-ranging it can be, what the clinical implications are, and how it can be treated? A detailed insight into cognitive deficit is the key to understanding why previous treatments have failed, and the key by which new treatments may change this terrible illness, treatments significantly more effective than earlier interventions.

Cognitive Impairment in Schizophrenia

Author : Philip D. Harvey
Publisher : Cambridge University Press
ISBN 13 : 1107013208
Total Pages : 341 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Cognitive Impairment in Schizophrenia by : Philip D. Harvey

Download or read book Cognitive Impairment in Schizophrenia written by Philip D. Harvey and published by Cambridge University Press. This book was released on 2013-01-24 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.

Secondary Schizophrenia

Author : Perminder S. Sachdev
Publisher : Cambridge University Press
ISBN 13 : 1139485229
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Secondary Schizophrenia by : Perminder S. Sachdev

Download or read book Secondary Schizophrenia written by Perminder S. Sachdev and published by Cambridge University Press. This book was released on 2010-02-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience – understanding and conquering this most mysterious of human diseases.

The Neurobiology of the Prefrontal Cortex

Author : Richard E. Passingham
Publisher : Oxford University Press
ISBN 13 : 0199552916
Total Pages : 422 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis The Neurobiology of the Prefrontal Cortex by : Richard E. Passingham

Download or read book The Neurobiology of the Prefrontal Cortex written by Richard E. Passingham and published by Oxford University Press. This book was released on 2012-07-12 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prefrontal cortex makes up almost a quarter of the human brain. The Neurobiology of the Prefrontal Cortex presents a new theory about its fundamental function. Written by two leading brain scientists, it is an important contribution to our understanding of the evolution and functioning of the human brain.

Schizophrenia

Author : Neil A. Rector
Publisher : Guilford Press
ISBN 13 : 1609182383
Total Pages : 433 pages
Book Rating : 4.6/5 (91 download)

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Book Synopsis Schizophrenia by : Neil A. Rector

Download or read book Schizophrenia written by Neil A. Rector and published by Guilford Press. This book was released on 2011-03-01 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Aaron T. Beck and colleagues, this is the definitive work on the cognitive model of schizophrenia and its treatment. The volume integrates cognitive-behavioral and biological knowledge into a comprehensive conceptual framework. It examines the origins, development, and maintenance of key symptom areas: delusions, hallucinations, negative symptoms, and formal thought disorder. Treatment chapters then offer concrete guidance for addressing each type of symptom, complete with case examples and session outlines. Anyone who treats or studies serious mental illness will find a new level of understanding together with theoretically and empirically grounded clinical techniques.

Schizophrenia and Psychotic Spectrum Disorders

Author : S. Charles Schulz
Publisher : Oxford University Press
ISBN 13 : 019937807X
Total Pages : 424 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Schizophrenia and Psychotic Spectrum Disorders by : S. Charles Schulz

Download or read book Schizophrenia and Psychotic Spectrum Disorders written by S. Charles Schulz and published by Oxford University Press. This book was released on 2016-04-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.

Proteomics and Metabolomics in Psychiatry

Author : D. Martins-de-Souza
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 331802600X
Total Pages : 152 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Proteomics and Metabolomics in Psychiatry by : D. Martins-de-Souza

Download or read book Proteomics and Metabolomics in Psychiatry written by D. Martins-de-Souza and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-23 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

Neuroimaging in Psychiatry

Author : Cynthia H. Y. Fu
Publisher : CRC Press
ISBN 13 : 9781135414009
Total Pages : 0 pages
Book Rating : 4.4/5 (14 download)

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Book Synopsis Neuroimaging in Psychiatry by : Cynthia H. Y. Fu

Download or read book Neuroimaging in Psychiatry written by Cynthia H. Y. Fu and published by CRC Press. This book was released on 2004-08-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: New neuroimaging techniques are developing at a break neck pace-every academic journal contains glossy pictures of brain activity corresponding to a particular task emblazoned in glorious technicolor. Discoveries about brain function in psychiatric disorders have been made at an equally rapid rate. However, most books on the subject have been written from a technical point of view. An introductory, easy-to-read guide, Neuroimaging in Psychiatry provides an overview and the clinical relevance of the latest neuroimaging findings. With contributions from an international panel of experts, this book reviews current findings from neuroimaging in schizophrenia, obsessive-compulsive disorder, depression, eating disorders, psychopathy, aging, and drug addiction. Chapter authors explore innovative and imaginative uses of neuro imaging technology, implications for our understanding of these disorders, and their impact on clinical practice. The book gives you a general overview of the main techniques to help you successfully complete a neuroimaging project.

Schizophrenia

Author : Eckhart R. Straube
Publisher : Springer Science & Business Media
ISBN 13 : 3642743080
Total Pages : 244 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Schizophrenia by : Eckhart R. Straube

Download or read book Schizophrenia written by Eckhart R. Straube and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia remains the most complex, puzzling, and because of its tendency towards chronicity, the most severe of the mental disorders. It is a very heterogeneous disorder characterized by extreme disruptions of thought, per ception, behavior, and emotion. About I % of the population worldwide will experience at least one schizophrenic episode. Most of the patients will have a number of exacerbations leading in about 30% of cases to a chronic residual state, due either to the illness itself or to psychosocial environmental factors, or-most likely-to the interaction of both. Given the enormous personal hardship for patients and their relatives as well as the staggering costs of the illness for our societies, research in schizo phrenia has become the number one priority in many countries, especially in the United States. However, research on the etiology of schizophrenia has failed to establish a single causal factor, and it is nowadays accepted to be multifactorial. A combjnation of biological predisposition and enviromnental circumstances is assumed to be necessary for the manifestation of the illness. This shift in orientation away from an either/or (biological or environmental, e.g., family interaction) point of view, as evident in the work of the 1950s and 1960s, was certainly desirable to encourage research.

Modeling the Psychopathological Dimensions of Schizophrenia

Author : Mikhail Pletnikov
Publisher : Academic Press
ISBN 13 : 012801184X
Total Pages : 548 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Modeling the Psychopathological Dimensions of Schizophrenia by : Mikhail Pletnikov

Download or read book Modeling the Psychopathological Dimensions of Schizophrenia written by Mikhail Pletnikov and published by Academic Press. This book was released on 2015-11-05 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis

Download Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis PDF Online Free

Author : Karl Bechter
Publisher : Frontiers Media SA
ISBN 13 : 2889459500
Total Pages : 189 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis by : Karl Bechter

Download or read book Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis written by Karl Bechter and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

Handbook of Computational Neurodegeneration

Author : Panagiotis Vlamos
Publisher : Springer Nature
ISBN 13 : 3319759221
Total Pages : 1031 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Handbook of Computational Neurodegeneration by : Panagiotis Vlamos

Download or read book Handbook of Computational Neurodegeneration written by Panagiotis Vlamos and published by Springer Nature. This book was released on 2023-07-25 with total page 1031 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.

Biomarkers in Psychiatry

Author : Judith Pratt
Publisher : Springer
ISBN 13 : 3319996428
Total Pages : 437 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Biomarkers in Psychiatry by : Judith Pratt

Download or read book Biomarkers in Psychiatry written by Judith Pratt and published by Springer. This book was released on 2019-01-05 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.